ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08-18

AUTHORS

Pierre-Raphaël Rothschild, Sawsen Salah, Marianne Berdugo, Emmanuelle Gélizé, Kimberley Delaunay, Marie-Christine Naud, Christophe Klein, Alexandre Moulin, Michèle Savoldelli, Ciara Bergin, Jean-Claude Jeanny, Laurent Jonet, Yvan Arsenijevic, Francine Behar-Cohen, Patricia Crisanti

ABSTRACT

In diabetic retinopathy, the exact mechanisms leading to retinal capillary closure and to retinal barriers breakdown remain imperfectly understood. Rho-associated kinase (ROCK), an effector of the small GTPase Rho, involved in cytoskeleton dynamic regulation and cell polarity is activated by hyperglycemia. In one year-old Goto Kakizaki (GK) type 2 diabetic rats retina, ROCK-1 activation was assessed by its cellular distribution and by phosphorylation of its substrates, MYPT1 and MLC. In both GK rat and in human type 2 diabetic retinas, ROCK-1 is activated and associated with non-apoptotic membrane blebbing in retinal vessels and in retinal pigment epithelium (RPE) that respectively form the inner and the outer barriers. Activation of ROCK-1 induces focal vascular constrictions, endoluminal blebbing and subsequent retinal hypoxia. In RPE cells, actin cytoskeleton remodeling and membrane blebs in RPE cells contributes to outer barrier breakdown. Intraocular injection of fasudil, significantly reduces both retinal hypoxia and RPE barrier breakdown. Diabetes-induced cell blebbing may contribute to ischemic maculopathy and represent an intervention target. More... »

PAGES

8834

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-07329-y

DOI

http://dx.doi.org/10.1038/s41598-017-07329-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091232775

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28821742


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ophthalmology and Optometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeleton", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetic Retinopathy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Antibody Technique", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoxia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinal Pigment Epithelium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinal Vessels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "rho-Associated Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rothschild", 
        "givenName": "Pierre-Rapha\u00ebl", 
        "id": "sg:person.01171474632.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171474632.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salah", 
        "givenName": "Sawsen", 
        "id": "sg:person.012272354327.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012272354327.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berdugo", 
        "givenName": "Marianne", 
        "id": "sg:person.0624725631.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624725631.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00e9liz\u00e9", 
        "givenName": "Emmanuelle", 
        "id": "sg:person.01201467343.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201467343.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delaunay", 
        "givenName": "Kimberley", 
        "id": "sg:person.0620175453.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620175453.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naud", 
        "givenName": "Marie-Christine", 
        "id": "sg:person.01174722666.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174722666.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klein", 
        "givenName": "Christophe", 
        "id": "sg:person.011434217642.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011434217642.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology of University of Lausanne 1000 Lausanne, Jules Gonin Hospital, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.9851.5", 
          "name": [
            "Department of Ophthalmology of University of Lausanne 1000 Lausanne, Jules Gonin Hospital, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moulin", 
        "givenName": "Alexandre", 
        "id": "sg:person.0721211516.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721211516.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Savoldelli", 
        "givenName": "Mich\u00e8le", 
        "id": "sg:person.01364657737.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364657737.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology of University of Lausanne 1000 Lausanne, Jules Gonin Hospital, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.9851.5", 
          "name": [
            "Department of Ophthalmology of University of Lausanne 1000 Lausanne, Jules Gonin Hospital, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergin", 
        "givenName": "Ciara", 
        "id": "sg:person.01362454230.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362454230.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeanny", 
        "givenName": "Jean-Claude", 
        "id": "sg:person.01340415621.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340415621.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jonet", 
        "givenName": "Laurent", 
        "id": "sg:person.01052425027.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052425027.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology of University of Lausanne 1000 Lausanne, Jules Gonin Hospital, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.9851.5", 
          "name": [
            "Department of Ophthalmology of University of Lausanne 1000 Lausanne, Jules Gonin Hospital, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arsenijevic", 
        "givenName": "Yvan", 
        "id": "sg:person.01140406010.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140406010.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lausanne, Lausanne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.9851.5", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Department of Ophthalmology, Assistance Publique-Hopitaux de Paris, H\u00f4tel-Dieu de Paris Hospital, 75004, Paris, France", 
            "INSERM U1138 Team 17, Le Centre de Recherches des Cordeliers (CRC), 75006, Paris, France", 
            "University of Lausanne, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Behar-Cohen", 
        "givenName": "Francine", 
        "id": "sg:person.01126642706.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126642706.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France", 
            "Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France", 
            "Paris Descartes University, Sorbonne Paris Cit\u00e9, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crisanti", 
        "givenName": "Patricia", 
        "id": "sg:person.01030121556.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030121556.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/aps.2013.188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021199972", 
          "https://doi.org/10.1038/aps.2013.188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00380-013-0458-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025633658", 
          "https://doi.org/10.1007/s00380-013-0458-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000604254", 
          "https://doi.org/10.1038/nrm1128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10384-007-0487-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033496558", 
          "https://doi.org/10.1007/s10384-007-0487-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35070009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003887142", 
          "https://doi.org/10.1038/35070009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrcardio.2010.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017947771", 
          "https://doi.org/10.1038/nrcardio.2010.136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00234-011-0856-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016283076", 
          "https://doi.org/10.1007/s00234-011-0856-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2251-6581-12-34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006129604", 
          "https://doi.org/10.1186/2251-6581-12-34"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-005-0805-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016443899", 
          "https://doi.org/10.1007/s10495-005-0805-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020890126", 
          "https://doi.org/10.1038/ncb2274"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-08-18", 
    "datePublishedReg": "2017-08-18", 
    "description": "In diabetic retinopathy, the exact mechanisms leading to retinal capillary closure and to retinal barriers breakdown remain imperfectly understood. Rho-associated kinase (ROCK), an effector of the small GTPase Rho, involved in cytoskeleton dynamic regulation and cell polarity is activated by hyperglycemia. In one year-old Goto Kakizaki (GK) type 2 diabetic rats retina, ROCK-1 activation was assessed by its cellular distribution and by phosphorylation of its substrates, MYPT1 and MLC. In both GK rat and in human type 2 diabetic retinas, ROCK-1 is activated and associated with non-apoptotic membrane blebbing in retinal vessels and in retinal pigment epithelium (RPE) that respectively form the inner and the outer barriers. Activation of ROCK-1 induces focal vascular constrictions, endoluminal blebbing and subsequent retinal hypoxia. In RPE cells, actin cytoskeleton remodeling and membrane blebs in RPE cells contributes to outer barrier breakdown. Intraocular injection of fasudil, significantly reduces both retinal hypoxia and RPE barrier breakdown. Diabetes-induced cell blebbing may contribute to ischemic maculopathy and represent an intervention target.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-017-07329-y", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6416760", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "keywords": [
      "retinal pigment epithelium", 
      "retinal hypoxia", 
      "barrier breakdown", 
      "type 2 diabetic retinas", 
      "RPE cells", 
      "retinal capillary closure", 
      "diabetic rat retina", 
      "ROCK-1", 
      "ischemic maculopathy", 
      "diabetic retina", 
      "retinal barrier", 
      "vascular constriction", 
      "intraocular injection", 
      "GK rats", 
      "capillary closure", 
      "diabetic retinopathy", 
      "rat retina", 
      "pigment epithelium", 
      "retinal vessels", 
      "cell blebbing", 
      "retinal pigment", 
      "intervention targets", 
      "exact mechanism", 
      "retinopathy", 
      "cellular distribution", 
      "retina", 
      "hypoxia", 
      "small GTPase Rho", 
      "activation", 
      "actin cytoskeleton remodeling", 
      "maculopathy", 
      "cells", 
      "hyperglycemia", 
      "rats", 
      "cytoskeleton remodeling", 
      "fasudil", 
      "membrane blebs", 
      "GTPase Rho", 
      "epithelium", 
      "blebbing", 
      "remodeling", 
      "injection", 
      "dynamic regulation", 
      "blebs", 
      "vessels", 
      "MYPT1", 
      "constriction", 
      "Rho", 
      "barriers", 
      "effectors", 
      "phosphorylation", 
      "MLC", 
      "closure", 
      "kinase", 
      "target", 
      "outer barrier", 
      "regulation", 
      "breakdown", 
      "mechanism", 
      "membrane", 
      "cell polarity", 
      "pigments", 
      "contribution", 
      "distribution", 
      "inner", 
      "substrate", 
      "polarity"
    ], 
    "name": "ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy", 
    "pagination": "8834", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091232775"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-07329-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28821742"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-07329-y", 
      "https://app.dimensions.ai/details/publication/pub.1091232775"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_729.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-017-07329-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-07329-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-07329-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-07329-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-07329-y'


 

This table displays all metadata directly associated to this object as RDF triples.

368 TRIPLES      22 PREDICATES      125 URIs      107 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-07329-y schema:about N00aa316c8e35491384d56e43c06fe18c
2 N044fec4db74a42459d0168a4819218dd
3 N0ed80cf6243d4d58aff4bf1f18e7976c
4 N16dae8a5f78b4de6a825b96c95776fa5
5 N25498a17f01d4ef993510a8041f3ffcf
6 N372916b3c28c4c3fbfa0fc9d344dc661
7 N3cfbd09d39474cc680977c3926d82143
8 N4685bc92094e40a6bc03571baf0d02f5
9 N47c2328c64dc41319f4d6704fcf3f93f
10 N4ee62924d0524b4fb78784c7c3d49fb6
11 N62d650442a254bda8c887f972925cd31
12 N6a5b479e6e1d4e059687e21f223ab170
13 N6d6a1f8005174577a4e1f96d36cbf397
14 N73187e95b6044469a85323806f5e65ae
15 N7bc8b7978ead43d4970e126bdd94f71e
16 Na8ebb61d07aa4571b27cec5a4ce2e695
17 Na9fc8b10aba046b4bbc1b43994cd5810
18 Nb1597055dc1b4173bddbad17c27d8c94
19 Nc154888b8d0c4ff4a1c100aa724ea32f
20 Ned3eb1b1b8044b43b18a35bed59c1b87
21 Ned793fa047b54c459d8a22a835a13699
22 Nffdcba96931847e0afe63ce991dde1b6
23 anzsrc-for:11
24 anzsrc-for:1113
25 schema:author N5f672ccb0d4545f39257b3915586e9a5
26 schema:citation sg:pub.10.1007/s00234-011-0856-0
27 sg:pub.10.1007/s00380-013-0458-3
28 sg:pub.10.1007/s10384-007-0487-5
29 sg:pub.10.1007/s10495-005-0805-7
30 sg:pub.10.1038/35070009
31 sg:pub.10.1038/aps.2013.188
32 sg:pub.10.1038/ncb2274
33 sg:pub.10.1038/nrcardio.2010.136
34 sg:pub.10.1038/nrm1128
35 sg:pub.10.1186/2251-6581-12-34
36 schema:datePublished 2017-08-18
37 schema:datePublishedReg 2017-08-18
38 schema:description In diabetic retinopathy, the exact mechanisms leading to retinal capillary closure and to retinal barriers breakdown remain imperfectly understood. Rho-associated kinase (ROCK), an effector of the small GTPase Rho, involved in cytoskeleton dynamic regulation and cell polarity is activated by hyperglycemia. In one year-old Goto Kakizaki (GK) type 2 diabetic rats retina, ROCK-1 activation was assessed by its cellular distribution and by phosphorylation of its substrates, MYPT1 and MLC. In both GK rat and in human type 2 diabetic retinas, ROCK-1 is activated and associated with non-apoptotic membrane blebbing in retinal vessels and in retinal pigment epithelium (RPE) that respectively form the inner and the outer barriers. Activation of ROCK-1 induces focal vascular constrictions, endoluminal blebbing and subsequent retinal hypoxia. In RPE cells, actin cytoskeleton remodeling and membrane blebs in RPE cells contributes to outer barrier breakdown. Intraocular injection of fasudil, significantly reduces both retinal hypoxia and RPE barrier breakdown. Diabetes-induced cell blebbing may contribute to ischemic maculopathy and represent an intervention target.
39 schema:genre article
40 schema:inLanguage en
41 schema:isAccessibleForFree true
42 schema:isPartOf N3288ebee28514024bf66997f275e670b
43 Ndc5c38c7a19242dd8b4e6ee301029cdc
44 sg:journal.1045337
45 schema:keywords GK rats
46 GTPase Rho
47 MLC
48 MYPT1
49 ROCK-1
50 RPE cells
51 Rho
52 actin cytoskeleton remodeling
53 activation
54 barrier breakdown
55 barriers
56 blebbing
57 blebs
58 breakdown
59 capillary closure
60 cell blebbing
61 cell polarity
62 cells
63 cellular distribution
64 closure
65 constriction
66 contribution
67 cytoskeleton remodeling
68 diabetic rat retina
69 diabetic retina
70 diabetic retinopathy
71 distribution
72 dynamic regulation
73 effectors
74 epithelium
75 exact mechanism
76 fasudil
77 hyperglycemia
78 hypoxia
79 injection
80 inner
81 intervention targets
82 intraocular injection
83 ischemic maculopathy
84 kinase
85 maculopathy
86 mechanism
87 membrane
88 membrane blebs
89 outer barrier
90 phosphorylation
91 pigment epithelium
92 pigments
93 polarity
94 rat retina
95 rats
96 regulation
97 remodeling
98 retina
99 retinal barrier
100 retinal capillary closure
101 retinal hypoxia
102 retinal pigment
103 retinal pigment epithelium
104 retinal vessels
105 retinopathy
106 small GTPase Rho
107 substrate
108 target
109 type 2 diabetic retinas
110 vascular constriction
111 vessels
112 schema:name ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy
113 schema:pagination 8834
114 schema:productId N39fad64e7de349eebff184dc12b940dc
115 Nb3769d982622446693b8d6e5df580390
116 Nd8d305d2cd2e44598d79e1230ecffc1a
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091232775
118 https://doi.org/10.1038/s41598-017-07329-y
119 schema:sdDatePublished 2022-05-20T07:32
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher Nd4dba77729154e2aafffb1efb041a6df
122 schema:url https://doi.org/10.1038/s41598-017-07329-y
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N00aa316c8e35491384d56e43c06fe18c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Hypoxia
128 rdf:type schema:DefinedTerm
129 N044fec4db74a42459d0168a4819218dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Fluorescent Antibody Technique
131 rdf:type schema:DefinedTerm
132 N0ed80cf6243d4d58aff4bf1f18e7976c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Female
134 rdf:type schema:DefinedTerm
135 N1157e1526bec45cf9b24aafc1d0c758e rdf:first sg:person.0620175453.15
136 rdf:rest N369ca6520671463a952518c9c37d0c9a
137 N16dae8a5f78b4de6a825b96c95776fa5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Diabetes Mellitus, Experimental
139 rdf:type schema:DefinedTerm
140 N1afe748a891c4aa89ccadb69e648dd97 rdf:first sg:person.01052425027.09
141 rdf:rest N4feedeb6ac2d46faa9367ba555944a57
142 N1c5ef93aab814dc980548e07473d56ff rdf:first sg:person.01201467343.35
143 rdf:rest N1157e1526bec45cf9b24aafc1d0c758e
144 N1ddef12c40bf41a3ac1460894c37b61b rdf:first sg:person.01340415621.24
145 rdf:rest N1afe748a891c4aa89ccadb69e648dd97
146 N1e856d8efa324aaf8b1b0252f05d396b rdf:first sg:person.0624725631.97
147 rdf:rest N1c5ef93aab814dc980548e07473d56ff
148 N25498a17f01d4ef993510a8041f3ffcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Animals
150 rdf:type schema:DefinedTerm
151 N3288ebee28514024bf66997f275e670b schema:issueNumber 1
152 rdf:type schema:PublicationIssue
153 N32af249df71f4273b26e7a46f72d8362 rdf:first sg:person.01030121556.37
154 rdf:rest rdf:nil
155 N369ca6520671463a952518c9c37d0c9a rdf:first sg:person.01174722666.47
156 rdf:rest Nff7db89d98b64bfabb6458d8001c1329
157 N372916b3c28c4c3fbfa0fc9d344dc661 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Disease Models, Animal
159 rdf:type schema:DefinedTerm
160 N39fad64e7de349eebff184dc12b940dc schema:name dimensions_id
161 schema:value pub.1091232775
162 rdf:type schema:PropertyValue
163 N3cfbd09d39474cc680977c3926d82143 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Immunohistochemistry
165 rdf:type schema:DefinedTerm
166 N41c5a97c129d463b8d2b191c9f892ccc rdf:first sg:person.01362454230.37
167 rdf:rest N1ddef12c40bf41a3ac1460894c37b61b
168 N4685bc92094e40a6bc03571baf0d02f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Male
170 rdf:type schema:DefinedTerm
171 N47c2328c64dc41319f4d6704fcf3f93f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Endothelial Cells
173 rdf:type schema:DefinedTerm
174 N4ee62924d0524b4fb78784c7c3d49fb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Middle Aged
176 rdf:type schema:DefinedTerm
177 N4feedeb6ac2d46faa9367ba555944a57 rdf:first sg:person.01140406010.87
178 rdf:rest N8fa3f023e461440aae8651dd46dc6934
179 N5f672ccb0d4545f39257b3915586e9a5 rdf:first sg:person.01171474632.46
180 rdf:rest Nd564d4fcb0074a2aba8b89c0c369768a
181 N62d650442a254bda8c887f972925cd31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Retinal Vessels
183 rdf:type schema:DefinedTerm
184 N6a5b479e6e1d4e059687e21f223ab170 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Retinal Pigment Epithelium
186 rdf:type schema:DefinedTerm
187 N6d6a1f8005174577a4e1f96d36cbf397 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Case-Control Studies
189 rdf:type schema:DefinedTerm
190 N73187e95b6044469a85323806f5e65ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Diabetes Mellitus, Type 2
192 rdf:type schema:DefinedTerm
193 N7bc8b7978ead43d4970e126bdd94f71e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
195 rdf:type schema:DefinedTerm
196 N8fa3f023e461440aae8651dd46dc6934 rdf:first sg:person.01126642706.53
197 rdf:rest N32af249df71f4273b26e7a46f72d8362
198 Na8ebb61d07aa4571b27cec5a4ce2e695 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Diabetic Retinopathy
200 rdf:type schema:DefinedTerm
201 Na9fc8b10aba046b4bbc1b43994cd5810 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Cytoskeleton
203 rdf:type schema:DefinedTerm
204 Nab5f35e3f9e14b80bf136b02a6117f96 rdf:first sg:person.01364657737.84
205 rdf:rest N41c5a97c129d463b8d2b191c9f892ccc
206 Nb1597055dc1b4173bddbad17c27d8c94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Aged
208 rdf:type schema:DefinedTerm
209 Nb3769d982622446693b8d6e5df580390 schema:name doi
210 schema:value 10.1038/s41598-017-07329-y
211 rdf:type schema:PropertyValue
212 Nc154888b8d0c4ff4a1c100aa724ea32f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Biomarkers
214 rdf:type schema:DefinedTerm
215 Nd0b32ac0eab6440bae948418ae130433 rdf:first sg:person.0721211516.89
216 rdf:rest Nab5f35e3f9e14b80bf136b02a6117f96
217 Nd4dba77729154e2aafffb1efb041a6df schema:name Springer Nature - SN SciGraph project
218 rdf:type schema:Organization
219 Nd564d4fcb0074a2aba8b89c0c369768a rdf:first sg:person.012272354327.40
220 rdf:rest N1e856d8efa324aaf8b1b0252f05d396b
221 Nd8d305d2cd2e44598d79e1230ecffc1a schema:name pubmed_id
222 schema:value 28821742
223 rdf:type schema:PropertyValue
224 Ndc5c38c7a19242dd8b4e6ee301029cdc schema:volumeNumber 7
225 rdf:type schema:PublicationVolume
226 Ned3eb1b1b8044b43b18a35bed59c1b87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Rats
228 rdf:type schema:DefinedTerm
229 Ned793fa047b54c459d8a22a835a13699 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Humans
231 rdf:type schema:DefinedTerm
232 Nff7db89d98b64bfabb6458d8001c1329 rdf:first sg:person.011434217642.09
233 rdf:rest Nd0b32ac0eab6440bae948418ae130433
234 Nffdcba96931847e0afe63ce991dde1b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name rho-Associated Kinases
236 rdf:type schema:DefinedTerm
237 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
238 schema:name Medical and Health Sciences
239 rdf:type schema:DefinedTerm
240 anzsrc-for:1113 schema:inDefinedTermSet anzsrc-for:
241 schema:name Ophthalmology and Optometry
242 rdf:type schema:DefinedTerm
243 sg:grant.6416760 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-07329-y
244 rdf:type schema:MonetaryGrant
245 sg:journal.1045337 schema:issn 2045-2322
246 schema:name Scientific Reports
247 schema:publisher Springer Nature
248 rdf:type schema:Periodical
249 sg:person.01030121556.37 schema:affiliation grid-institutes:grid.417925.c
250 schema:familyName Crisanti
251 schema:givenName Patricia
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030121556.37
253 rdf:type schema:Person
254 sg:person.01052425027.09 schema:affiliation grid-institutes:grid.417925.c
255 schema:familyName Jonet
256 schema:givenName Laurent
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052425027.09
258 rdf:type schema:Person
259 sg:person.01126642706.53 schema:affiliation grid-institutes:grid.9851.5
260 schema:familyName Behar-Cohen
261 schema:givenName Francine
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126642706.53
263 rdf:type schema:Person
264 sg:person.01140406010.87 schema:affiliation grid-institutes:grid.9851.5
265 schema:familyName Arsenijevic
266 schema:givenName Yvan
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140406010.87
268 rdf:type schema:Person
269 sg:person.011434217642.09 schema:affiliation grid-institutes:grid.417925.c
270 schema:familyName Klein
271 schema:givenName Christophe
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011434217642.09
273 rdf:type schema:Person
274 sg:person.01171474632.46 schema:affiliation grid-institutes:grid.417925.c
275 schema:familyName Rothschild
276 schema:givenName Pierre-Raphaël
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171474632.46
278 rdf:type schema:Person
279 sg:person.01174722666.47 schema:affiliation grid-institutes:grid.417925.c
280 schema:familyName Naud
281 schema:givenName Marie-Christine
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174722666.47
283 rdf:type schema:Person
284 sg:person.01201467343.35 schema:affiliation grid-institutes:grid.417925.c
285 schema:familyName Gélizé
286 schema:givenName Emmanuelle
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201467343.35
288 rdf:type schema:Person
289 sg:person.012272354327.40 schema:affiliation grid-institutes:grid.417925.c
290 schema:familyName Salah
291 schema:givenName Sawsen
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012272354327.40
293 rdf:type schema:Person
294 sg:person.01340415621.24 schema:affiliation grid-institutes:grid.417925.c
295 schema:familyName Jeanny
296 schema:givenName Jean-Claude
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340415621.24
298 rdf:type schema:Person
299 sg:person.01362454230.37 schema:affiliation grid-institutes:grid.9851.5
300 schema:familyName Bergin
301 schema:givenName Ciara
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362454230.37
303 rdf:type schema:Person
304 sg:person.01364657737.84 schema:affiliation grid-institutes:grid.417925.c
305 schema:familyName Savoldelli
306 schema:givenName Michèle
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364657737.84
308 rdf:type schema:Person
309 sg:person.0620175453.15 schema:affiliation grid-institutes:grid.417925.c
310 schema:familyName Delaunay
311 schema:givenName Kimberley
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620175453.15
313 rdf:type schema:Person
314 sg:person.0624725631.97 schema:affiliation grid-institutes:grid.417925.c
315 schema:familyName Berdugo
316 schema:givenName Marianne
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624725631.97
318 rdf:type schema:Person
319 sg:person.0721211516.89 schema:affiliation grid-institutes:grid.9851.5
320 schema:familyName Moulin
321 schema:givenName Alexandre
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721211516.89
323 rdf:type schema:Person
324 sg:pub.10.1007/s00234-011-0856-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016283076
325 https://doi.org/10.1007/s00234-011-0856-0
326 rdf:type schema:CreativeWork
327 sg:pub.10.1007/s00380-013-0458-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025633658
328 https://doi.org/10.1007/s00380-013-0458-3
329 rdf:type schema:CreativeWork
330 sg:pub.10.1007/s10384-007-0487-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033496558
331 https://doi.org/10.1007/s10384-007-0487-5
332 rdf:type schema:CreativeWork
333 sg:pub.10.1007/s10495-005-0805-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016443899
334 https://doi.org/10.1007/s10495-005-0805-7
335 rdf:type schema:CreativeWork
336 sg:pub.10.1038/35070009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003887142
337 https://doi.org/10.1038/35070009
338 rdf:type schema:CreativeWork
339 sg:pub.10.1038/aps.2013.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021199972
340 https://doi.org/10.1038/aps.2013.188
341 rdf:type schema:CreativeWork
342 sg:pub.10.1038/ncb2274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020890126
343 https://doi.org/10.1038/ncb2274
344 rdf:type schema:CreativeWork
345 sg:pub.10.1038/nrcardio.2010.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017947771
346 https://doi.org/10.1038/nrcardio.2010.136
347 rdf:type schema:CreativeWork
348 sg:pub.10.1038/nrm1128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000604254
349 https://doi.org/10.1038/nrm1128
350 rdf:type schema:CreativeWork
351 sg:pub.10.1186/2251-6581-12-34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006129604
352 https://doi.org/10.1186/2251-6581-12-34
353 rdf:type schema:CreativeWork
354 grid-institutes:grid.417925.c schema:alternateName Paris Descartes University, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France
355 schema:name Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France
356 Paris Descartes University, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France
357 Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France
358 rdf:type schema:Organization
359 grid-institutes:grid.9851.5 schema:alternateName Department of Ophthalmology of University of Lausanne 1000 Lausanne, Jules Gonin Hospital, Lausanne, Switzerland
360 University of Lausanne, Lausanne, Switzerland
361 schema:name Department of Ophthalmology of University of Lausanne 1000 Lausanne, Jules Gonin Hospital, Lausanne, Switzerland
362 Department of Ophthalmology, Assistance Publique-Hopitaux de Paris, Hôtel-Dieu de Paris Hospital, 75004, Paris, France
363 INSERM U1138 Team 17, Le Centre de Recherches des Cordeliers (CRC), 75006, Paris, France
364 Inserm UMR_S 1138, Team 17: From physiopathology of retinal diseases to clinical advances, Centre de Recherche des Cordeliers, Paris, France
365 Paris Descartes University, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France
366 Sorbonne University, University of Pierre et Marie Curie, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France
367 University of Lausanne, Lausanne, Switzerland
368 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...