Characterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoforms View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Adam Kim, Jean Popovici, Amélie Vantaux, Reingsey Samreth, Sophalai Bin, Saorin Kim, Camille Roesch, Li Liang, Huw Davies, Philip Felgner, Sócrates Herrera, Myriam Arévalo-Herrera, Didier Ménard, David Serre

ABSTRACT

Our understanding of the structure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must therefore rely on patient samples, which typically display a low proportion of parasites and asynchronous parasites. Here, we present stranded RNA-seq data generated directly from a small volume of blood from three Cambodian vivax malaria patients collected before treatment. Our analyses show surprising similarities of the parasite gene expression patterns across infections, despite extensive variations in parasite stage proportion. These similarities contrast with the unique gene expression patterns observed in sporozoites isolated from salivary glands of infected Colombian mosquitoes. Our analyses also indicate that more than 10% of P. vivax genes encode multiple, often undescribed, protein-coding sequences, potentially increasing the diversity of proteins synthesized by blood stage parasites. These data also greatly improve the annotations of P. vivax gene untranslated regions, providing an important resource for future studies of specific genes. More... »

PAGES

7761

References to SciGraph publications

  • 2015-12. Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA in BMC GENOMICS
  • 2016-04. New insights into the Plasmodium vivax transcriptome using RNA-Seq in SCIENTIFIC REPORTS
  • 2013-08. De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis in NATURE PROTOCOLS
  • 2014-04. Genome-wide identification and functional annotation of Plasmodium falciparum long noncoding RNAs from RNA-seq data in PARASITOLOGY RESEARCH
  • 2016-12. Global genetic diversity of the Plasmodium vivax transmission-blocking vaccine candidate Pvs48/45 in MALARIA JOURNAL
  • 2016-12. Plasmodium vivaxmdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas in MALARIA JOURNAL
  • 2011-07. Full-length transcriptome assembly from RNA-Seq data without a reference genome in NATURE BIOTECHNOLOGY
  • 2011-06. A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs in GENOME BIOLOGY
  • 2008-10-09. Comparative genomics of the neglected human malaria parasite Plasmodium vivax in NATURE
  • 2013-07. Improved RNA-seq of blood-derived RNA increases gene discovery and coverage in NATURE METHODS
  • 2014-12. A comprehensive evaluation of rodent malaria parasite genomes and gene expression in BMC BIOLOGY
  • 2016-12. UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies in MALARIA JOURNAL
  • 2013-12. An innovative tool for moving malaria PCR detection of parasite reservoir into the field in MALARIA JOURNAL
  • 2014-12. Strand-specific RNA-Seq reveals widespread and developmentally regulated transcription of natural antisense transcripts in Plasmodium falciparum in BMC GENOMICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-07275-9

    DOI

    http://dx.doi.org/10.1038/s41598-017-07275-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091144428

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28798400


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Malaria, Vivax", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plasmodium vivax", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Isoforms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protozoan Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sporozoites", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcriptome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Institute for Genome Sciences, University of Maryland, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Adam", 
            "id": "sg:person.0712643573.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712643573.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge", 
              "id": "https://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Malaria Molecular Epidemiology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Popovici", 
            "givenName": "Jean", 
            "id": "sg:person.01317620405.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317620405.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge", 
              "id": "https://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Malaria Molecular Epidemiology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vantaux", 
            "givenName": "Am\u00e9lie", 
            "id": "sg:person.0742570176.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742570176.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge", 
              "id": "https://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Malaria Molecular Epidemiology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Samreth", 
            "givenName": "Reingsey", 
            "id": "sg:person.07360176527.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07360176527.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge", 
              "id": "https://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Malaria Molecular Epidemiology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bin", 
            "givenName": "Sophalai", 
            "id": "sg:person.01053260400.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053260400.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge", 
              "id": "https://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Malaria Molecular Epidemiology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Saorin", 
            "id": "sg:person.0667736036.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667736036.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge", 
              "id": "https://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Malaria Molecular Epidemiology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roesch", 
            "givenName": "Camille", 
            "id": "sg:person.011550520127.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011550520127.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Irvine", 
              "id": "https://www.grid.ac/institutes/grid.266093.8", 
              "name": [
                "Division of Infectious Diseases, University of California Irvine, Irvine, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liang", 
            "givenName": "Li", 
            "id": "sg:person.01273427470.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273427470.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Irvine", 
              "id": "https://www.grid.ac/institutes/grid.266093.8", 
              "name": [
                "Division of Infectious Diseases, University of California Irvine, Irvine, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davies", 
            "givenName": "Huw", 
            "id": "sg:person.01101523216.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101523216.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Irvine", 
              "id": "https://www.grid.ac/institutes/grid.266093.8", 
              "name": [
                "Division of Infectious Diseases, University of California Irvine, Irvine, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Felgner", 
            "givenName": "Philip", 
            "id": "sg:person.013147704677.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013147704677.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Caucaseco Scientific Research Center", 
              "id": "https://www.grid.ac/institutes/grid.492585.7", 
              "name": [
                "Caucaseco Scientific Research Center, Cali, Colombia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herrera", 
            "givenName": "S\u00f3crates", 
            "id": "sg:person.0652062167.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652062167.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Valle", 
              "id": "https://www.grid.ac/institutes/grid.8271.c", 
              "name": [
                "Caucaseco Scientific Research Center, Cali, Colombia", 
                "School of Health, University of Valle, Cali, Colombia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ar\u00e9valo-Herrera", 
            "givenName": "Myriam", 
            "id": "sg:person.0720567773.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720567773.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Cochin", 
              "id": "https://www.grid.ac/institutes/grid.462098.1", 
              "name": [
                "Malaria Molecular Epidemiology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia", 
                "Unit\u00e9 Biologie des Interactions H\u00f4te-Parasite, Institut Pasteur, Paris, France", 
                "Inserm U1016, CNRS UMR8104, Institut Cochin, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00e9nard", 
            "givenName": "Didier", 
            "id": "sg:person.0755351436.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755351436.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute for Genome Sciences, University of Maryland, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Serre", 
            "givenName": "David", 
            "id": "sg:person.0711223171.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711223171.58"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1371/journal.ppat.1002964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000583045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/426830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002305124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq1223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002794714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.15-0232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005346109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.15-0232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005346109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijpara.2015.09.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005966362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep20498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007362257", 
              "https://doi.org/10.1038/srep20498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0092946", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012335929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2958.2011.07823.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012894736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cmi.12363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012983799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-014-3765-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014402036", 
              "https://doi.org/10.1007/s00436-014-3765-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-014-3765-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014402036", 
              "https://doi.org/10.1007/s00436-014-3765-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bti310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015580011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015803168", 
              "https://doi.org/10.1038/nbt.1883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-1119(02)00552-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016452802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-016-1141-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017557632", 
              "https://doi.org/10.1186/s12936-016-1141-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1420855112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019638414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/wrna.30", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020628929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022364060", 
              "https://doi.org/10.1038/nature07327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/infdis/jiw323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028863265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pntd.0000653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030476601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.vaccine.2012.01.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032262067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-12-405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033011151", 
              "https://doi.org/10.1186/1475-2875-12-405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pntd.0001811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033296833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-015-1081-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033821573", 
              "https://doi.org/10.1186/s12936-015-1081-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molmed.2015.10.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034014269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.f.366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034108117", 
              "https://doi.org/10.1038/nmeth.f.366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0166-6851(98)00130-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034240500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-015-1603-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034252665", 
              "https://doi.org/10.1186/s12864-015-1603-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-015-1603-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034252665", 
              "https://doi.org/10.1186/s12864-015-1603-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molbiopara.2006.08.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038785233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-6-r56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039854340", 
              "https://doi.org/10.1186/gb-2011-12-6-r56"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12915-014-0086-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041708404", 
              "https://doi.org/10.1186/s12915-014-0086-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12915-014-0086-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041708404", 
              "https://doi.org/10.1186/s12915-014-0086-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-15-150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042565940", 
              "https://doi.org/10.1186/1471-2164-15-150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pntd.0004526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042779992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1997.1038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044752686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1004882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045476851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.14-0841", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046341971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.14-0841", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046341971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.14-0841", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046341971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-016-1263-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048045710", 
              "https://doi.org/10.1186/s12936-016-1263-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1656508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049419285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051115056", 
              "https://doi.org/10.1038/nprot.2013.084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0807404105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051155891"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12", 
        "datePublishedReg": "2017-12-01", 
        "description": "Our understanding of the structure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must therefore rely on patient samples, which typically display a low proportion of parasites and asynchronous parasites. Here, we present stranded RNA-seq data generated directly from a small volume of blood from three Cambodian vivax malaria patients collected before treatment. Our analyses show surprising similarities of the parasite gene expression patterns across infections, despite extensive variations in parasite stage proportion. These similarities contrast with the unique gene expression patterns observed in sporozoites isolated from salivary glands of infected Colombian mosquitoes. Our analyses also indicate that more than 10% of P. vivax genes encode multiple, often undescribed, protein-coding sequences, potentially increasing the diversity of proteins synthesized by blood stage parasites. These data also greatly improve the annotations of P. vivax gene untranslated regions, providing an important resource for future studies of specific genes.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-017-07275-9", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2695870", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2459791", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "Characterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoforms", 
        "pagination": "7761", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d1e42dccaa695bee2b45740a39a872574b01d47b8e30157b42ec41e85ffa7452"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28798400"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-017-07275-9"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1091144428"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-017-07275-9", 
          "https://app.dimensions.ai/details/publication/pub.1091144428"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99832_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-017-07275-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-07275-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-07275-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-07275-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-07275-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    341 TRIPLES      21 PREDICATES      75 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-017-07275-9 schema:about N18eb4502e00142318c0c5d9c33caf127
    2 N481af6fe5b0f49cbb23a24c104f51cc7
    3 N516dd990a7d147b4a6e0bd7ec08035db
    4 N5c073a14dec445a5a1621b260272e0e2
    5 N75ea72cc90d74afa97f9fc67cd4a6539
    6 N7ee30e81c3ab4fbfa06f69a4da13cbec
    7 N8b5fbb3f9c6e414b870117964130e0a7
    8 anzsrc-for:06
    9 anzsrc-for:0604
    10 schema:author Nc256c629532740a1ad3fef9cc8a0e5e5
    11 schema:citation sg:pub.10.1007/s00436-014-3765-4
    12 sg:pub.10.1038/nature07327
    13 sg:pub.10.1038/nbt.1883
    14 sg:pub.10.1038/nmeth.f.366
    15 sg:pub.10.1038/nprot.2013.084
    16 sg:pub.10.1038/srep20498
    17 sg:pub.10.1186/1471-2164-15-150
    18 sg:pub.10.1186/1475-2875-12-405
    19 sg:pub.10.1186/gb-2011-12-6-r56
    20 sg:pub.10.1186/s12864-015-1603-4
    21 sg:pub.10.1186/s12915-014-0086-0
    22 sg:pub.10.1186/s12936-015-1081-9
    23 sg:pub.10.1186/s12936-016-1141-9
    24 sg:pub.10.1186/s12936-016-1263-0
    25 https://doi.org/10.1002/wrna.30
    26 https://doi.org/10.1006/jmbi.1997.1038
    27 https://doi.org/10.1016/j.ijpara.2015.09.007
    28 https://doi.org/10.1016/j.molbiopara.2006.08.006
    29 https://doi.org/10.1016/j.molmed.2015.10.004
    30 https://doi.org/10.1016/j.vaccine.2012.01.003
    31 https://doi.org/10.1016/s0166-6851(98)00130-3
    32 https://doi.org/10.1016/s0378-1119(02)00552-8
    33 https://doi.org/10.1073/pnas.0807404105
    34 https://doi.org/10.1073/pnas.1420855112
    35 https://doi.org/10.1086/426830
    36 https://doi.org/10.1093/bioinformatics/bti310
    37 https://doi.org/10.1093/infdis/jiw323
    38 https://doi.org/10.1093/nar/gkq1223
    39 https://doi.org/10.1101/gad.1656508
    40 https://doi.org/10.1111/cmi.12363
    41 https://doi.org/10.1111/j.1365-2958.2011.07823.x
    42 https://doi.org/10.1371/journal.pntd.0000653
    43 https://doi.org/10.1371/journal.pntd.0001811
    44 https://doi.org/10.1371/journal.pntd.0004526
    45 https://doi.org/10.1371/journal.pone.0092946
    46 https://doi.org/10.1371/journal.ppat.1002964
    47 https://doi.org/10.1371/journal.ppat.1004882
    48 https://doi.org/10.4269/ajtmh.14-0841
    49 https://doi.org/10.4269/ajtmh.15-0232
    50 schema:datePublished 2017-12
    51 schema:datePublishedReg 2017-12-01
    52 schema:description Our understanding of the structure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must therefore rely on patient samples, which typically display a low proportion of parasites and asynchronous parasites. Here, we present stranded RNA-seq data generated directly from a small volume of blood from three Cambodian vivax malaria patients collected before treatment. Our analyses show surprising similarities of the parasite gene expression patterns across infections, despite extensive variations in parasite stage proportion. These similarities contrast with the unique gene expression patterns observed in sporozoites isolated from salivary glands of infected Colombian mosquitoes. Our analyses also indicate that more than 10% of P. vivax genes encode multiple, often undescribed, protein-coding sequences, potentially increasing the diversity of proteins synthesized by blood stage parasites. These data also greatly improve the annotations of P. vivax gene untranslated regions, providing an important resource for future studies of specific genes.
    53 schema:genre research_article
    54 schema:inLanguage en
    55 schema:isAccessibleForFree true
    56 schema:isPartOf N38c9bb57bc96454ebb88105c840e44a7
    57 Nab4e910469214f0aae02bc240608bbc2
    58 sg:journal.1045337
    59 schema:name Characterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoforms
    60 schema:pagination 7761
    61 schema:productId N059c249b38664f92b929ad584e253469
    62 N52cded0b3e554c838dd9f5cce6059e26
    63 N66ad5a7a5bfb4313b699728967711def
    64 N983613edd342452dadd9e9a48ec5bd8a
    65 Nc7c91c398eb74a4c988f26194f89aaa1
    66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091144428
    67 https://doi.org/10.1038/s41598-017-07275-9
    68 schema:sdDatePublished 2019-04-11T09:38
    69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    70 schema:sdPublisher N9bfb1759c9fb44f89af496c1e256b648
    71 schema:url https://www.nature.com/articles/s41598-017-07275-9
    72 sgo:license sg:explorer/license/
    73 sgo:sdDataset articles
    74 rdf:type schema:ScholarlyArticle
    75 N059c249b38664f92b929ad584e253469 schema:name dimensions_id
    76 schema:value pub.1091144428
    77 rdf:type schema:PropertyValue
    78 N18eb4502e00142318c0c5d9c33caf127 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    79 schema:name Sporozoites
    80 rdf:type schema:DefinedTerm
    81 N1f1b202a006142148463e84b80ba928e schema:name Institute for Genome Sciences, University of Maryland, Baltimore, Maryland, USA
    82 rdf:type schema:Organization
    83 N1f5eccd24c95428b90526a118b91cc7b rdf:first sg:person.01053260400.75
    84 rdf:rest Ndb5d3241abc0458aaa6971cac5cf6246
    85 N25e9ecfc552c4fb48b73d0a1fe066037 rdf:first sg:person.01101523216.22
    86 rdf:rest N44e47cd32bf74401aeabcb2f4b8ebdcd
    87 N2f644e6ca6d34590bf9c8ae6fdbccf3c rdf:first sg:person.01273427470.99
    88 rdf:rest N25e9ecfc552c4fb48b73d0a1fe066037
    89 N38c9bb57bc96454ebb88105c840e44a7 schema:volumeNumber 7
    90 rdf:type schema:PublicationVolume
    91 N44e47cd32bf74401aeabcb2f4b8ebdcd rdf:first sg:person.013147704677.05
    92 rdf:rest Ndd1d4363f18e467cbce4860dae3aeef8
    93 N481af6fe5b0f49cbb23a24c104f51cc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Transcriptome
    95 rdf:type schema:DefinedTerm
    96 N516dd990a7d147b4a6e0bd7ec08035db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Plasmodium vivax
    98 rdf:type schema:DefinedTerm
    99 N52cded0b3e554c838dd9f5cce6059e26 schema:name doi
    100 schema:value 10.1038/s41598-017-07275-9
    101 rdf:type schema:PropertyValue
    102 N5c073a14dec445a5a1621b260272e0e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Protein Isoforms
    104 rdf:type schema:DefinedTerm
    105 N60641599bcd643ada353763ba2d3d7fc schema:name Institute for Genome Sciences, University of Maryland, Baltimore, Maryland, USA
    106 rdf:type schema:Organization
    107 N66ad5a7a5bfb4313b699728967711def schema:name nlm_unique_id
    108 schema:value 101563288
    109 rdf:type schema:PropertyValue
    110 N75ea72cc90d74afa97f9fc67cd4a6539 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Malaria, Vivax
    112 rdf:type schema:DefinedTerm
    113 N7ee30e81c3ab4fbfa06f69a4da13cbec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Humans
    115 rdf:type schema:DefinedTerm
    116 N7f28e80451984b64a4ea0b846c69def9 rdf:first sg:person.0755351436.01
    117 rdf:rest Nc1a05a7b17a04da094b16df004bd806b
    118 N7fc26ecefb3743a0950782108a9c157a rdf:first sg:person.011550520127.59
    119 rdf:rest N2f644e6ca6d34590bf9c8ae6fdbccf3c
    120 N8b5fbb3f9c6e414b870117964130e0a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Protozoan Proteins
    122 rdf:type schema:DefinedTerm
    123 N970dec2a119f4868bc6a7ba60759c4ea rdf:first sg:person.0720567773.45
    124 rdf:rest N7f28e80451984b64a4ea0b846c69def9
    125 N983613edd342452dadd9e9a48ec5bd8a schema:name pubmed_id
    126 schema:value 28798400
    127 rdf:type schema:PropertyValue
    128 N9bfb1759c9fb44f89af496c1e256b648 schema:name Springer Nature - SN SciGraph project
    129 rdf:type schema:Organization
    130 Nab4e910469214f0aae02bc240608bbc2 schema:issueNumber 1
    131 rdf:type schema:PublicationIssue
    132 Nc1a05a7b17a04da094b16df004bd806b rdf:first sg:person.0711223171.58
    133 rdf:rest rdf:nil
    134 Nc256c629532740a1ad3fef9cc8a0e5e5 rdf:first sg:person.0712643573.53
    135 rdf:rest Nd3f17781849f4894beae5e939e02b14c
    136 Nc7c91c398eb74a4c988f26194f89aaa1 schema:name readcube_id
    137 schema:value d1e42dccaa695bee2b45740a39a872574b01d47b8e30157b42ec41e85ffa7452
    138 rdf:type schema:PropertyValue
    139 Nd3f17781849f4894beae5e939e02b14c rdf:first sg:person.01317620405.29
    140 rdf:rest Nd4461d843bf54771a8c16577c5b93c13
    141 Nd4461d843bf54771a8c16577c5b93c13 rdf:first sg:person.0742570176.85
    142 rdf:rest Nfbdefadba91c4b7a98168095a716e84f
    143 Ndb5d3241abc0458aaa6971cac5cf6246 rdf:first sg:person.0667736036.69
    144 rdf:rest N7fc26ecefb3743a0950782108a9c157a
    145 Ndd1d4363f18e467cbce4860dae3aeef8 rdf:first sg:person.0652062167.09
    146 rdf:rest N970dec2a119f4868bc6a7ba60759c4ea
    147 Nfbdefadba91c4b7a98168095a716e84f rdf:first sg:person.07360176527.07
    148 rdf:rest N1f5eccd24c95428b90526a118b91cc7b
    149 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    150 schema:name Biological Sciences
    151 rdf:type schema:DefinedTerm
    152 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    153 schema:name Genetics
    154 rdf:type schema:DefinedTerm
    155 sg:grant.2459791 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-07275-9
    156 rdf:type schema:MonetaryGrant
    157 sg:grant.2695870 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-07275-9
    158 rdf:type schema:MonetaryGrant
    159 sg:journal.1045337 schema:issn 2045-2322
    160 schema:name Scientific Reports
    161 rdf:type schema:Periodical
    162 sg:person.01053260400.75 schema:affiliation https://www.grid.ac/institutes/grid.418537.c
    163 schema:familyName Bin
    164 schema:givenName Sophalai
    165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053260400.75
    166 rdf:type schema:Person
    167 sg:person.01101523216.22 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
    168 schema:familyName Davies
    169 schema:givenName Huw
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101523216.22
    171 rdf:type schema:Person
    172 sg:person.011550520127.59 schema:affiliation https://www.grid.ac/institutes/grid.418537.c
    173 schema:familyName Roesch
    174 schema:givenName Camille
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011550520127.59
    176 rdf:type schema:Person
    177 sg:person.01273427470.99 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
    178 schema:familyName Liang
    179 schema:givenName Li
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273427470.99
    181 rdf:type schema:Person
    182 sg:person.013147704677.05 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
    183 schema:familyName Felgner
    184 schema:givenName Philip
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013147704677.05
    186 rdf:type schema:Person
    187 sg:person.01317620405.29 schema:affiliation https://www.grid.ac/institutes/grid.418537.c
    188 schema:familyName Popovici
    189 schema:givenName Jean
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317620405.29
    191 rdf:type schema:Person
    192 sg:person.0652062167.09 schema:affiliation https://www.grid.ac/institutes/grid.492585.7
    193 schema:familyName Herrera
    194 schema:givenName Sócrates
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652062167.09
    196 rdf:type schema:Person
    197 sg:person.0667736036.69 schema:affiliation https://www.grid.ac/institutes/grid.418537.c
    198 schema:familyName Kim
    199 schema:givenName Saorin
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667736036.69
    201 rdf:type schema:Person
    202 sg:person.0711223171.58 schema:affiliation N1f1b202a006142148463e84b80ba928e
    203 schema:familyName Serre
    204 schema:givenName David
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711223171.58
    206 rdf:type schema:Person
    207 sg:person.0712643573.53 schema:affiliation N60641599bcd643ada353763ba2d3d7fc
    208 schema:familyName Kim
    209 schema:givenName Adam
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712643573.53
    211 rdf:type schema:Person
    212 sg:person.0720567773.45 schema:affiliation https://www.grid.ac/institutes/grid.8271.c
    213 schema:familyName Arévalo-Herrera
    214 schema:givenName Myriam
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720567773.45
    216 rdf:type schema:Person
    217 sg:person.07360176527.07 schema:affiliation https://www.grid.ac/institutes/grid.418537.c
    218 schema:familyName Samreth
    219 schema:givenName Reingsey
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07360176527.07
    221 rdf:type schema:Person
    222 sg:person.0742570176.85 schema:affiliation https://www.grid.ac/institutes/grid.418537.c
    223 schema:familyName Vantaux
    224 schema:givenName Amélie
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742570176.85
    226 rdf:type schema:Person
    227 sg:person.0755351436.01 schema:affiliation https://www.grid.ac/institutes/grid.462098.1
    228 schema:familyName Ménard
    229 schema:givenName Didier
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755351436.01
    231 rdf:type schema:Person
    232 sg:pub.10.1007/s00436-014-3765-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014402036
    233 https://doi.org/10.1007/s00436-014-3765-4
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nature07327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022364060
    236 https://doi.org/10.1038/nature07327
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/nbt.1883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015803168
    239 https://doi.org/10.1038/nbt.1883
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/nmeth.f.366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034108117
    242 https://doi.org/10.1038/nmeth.f.366
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/nprot.2013.084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051115056
    245 https://doi.org/10.1038/nprot.2013.084
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/srep20498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007362257
    248 https://doi.org/10.1038/srep20498
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1186/1471-2164-15-150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042565940
    251 https://doi.org/10.1186/1471-2164-15-150
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1186/1475-2875-12-405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033011151
    254 https://doi.org/10.1186/1475-2875-12-405
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1186/gb-2011-12-6-r56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039854340
    257 https://doi.org/10.1186/gb-2011-12-6-r56
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1186/s12864-015-1603-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034252665
    260 https://doi.org/10.1186/s12864-015-1603-4
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1186/s12915-014-0086-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041708404
    263 https://doi.org/10.1186/s12915-014-0086-0
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1186/s12936-015-1081-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033821573
    266 https://doi.org/10.1186/s12936-015-1081-9
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1186/s12936-016-1141-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017557632
    269 https://doi.org/10.1186/s12936-016-1141-9
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1186/s12936-016-1263-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048045710
    272 https://doi.org/10.1186/s12936-016-1263-0
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1002/wrna.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020628929
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1006/jmbi.1997.1038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044752686
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.ijpara.2015.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005966362
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.molbiopara.2006.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038785233
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.molmed.2015.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034014269
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.vaccine.2012.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032262067
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/s0166-6851(98)00130-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034240500
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/s0378-1119(02)00552-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016452802
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1073/pnas.0807404105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051155891
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1073/pnas.1420855112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019638414
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1086/426830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002305124
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1093/bioinformatics/bti310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015580011
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1093/infdis/jiw323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028863265
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1093/nar/gkq1223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002794714
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1101/gad.1656508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049419285
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1111/cmi.12363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012983799
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1111/j.1365-2958.2011.07823.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012894736
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1371/journal.pntd.0000653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030476601
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1371/journal.pntd.0001811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033296833
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1371/journal.pntd.0004526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042779992
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1371/journal.pone.0092946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012335929
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1371/journal.ppat.1002964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000583045
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1371/journal.ppat.1004882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045476851
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.4269/ajtmh.14-0841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046341971
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.4269/ajtmh.15-0232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005346109
    323 rdf:type schema:CreativeWork
    324 https://www.grid.ac/institutes/grid.266093.8 schema:alternateName University of California, Irvine
    325 schema:name Division of Infectious Diseases, University of California Irvine, Irvine, California, USA
    326 rdf:type schema:Organization
    327 https://www.grid.ac/institutes/grid.418537.c schema:alternateName Institut Pasteur du Cambodge
    328 schema:name Malaria Molecular Epidemiology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia
    329 rdf:type schema:Organization
    330 https://www.grid.ac/institutes/grid.462098.1 schema:alternateName Institut Cochin
    331 schema:name Inserm U1016, CNRS UMR8104, Institut Cochin, Paris, France
    332 Malaria Molecular Epidemiology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia
    333 Unité Biologie des Interactions Hôte-Parasite, Institut Pasteur, Paris, France
    334 rdf:type schema:Organization
    335 https://www.grid.ac/institutes/grid.492585.7 schema:alternateName Caucaseco Scientific Research Center
    336 schema:name Caucaseco Scientific Research Center, Cali, Colombia
    337 rdf:type schema:Organization
    338 https://www.grid.ac/institutes/grid.8271.c schema:alternateName University of Valle
    339 schema:name Caucaseco Scientific Research Center, Cali, Colombia
    340 School of Health, University of Valle, Cali, Colombia
    341 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...