Expression profile of intestinal stem cell markers in colitis-associated carcinogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-26

AUTHORS

Hye Sung Kim, Cheol Lee, Woo Ho Kim, Young Hee Maeng, Bo Gun Jang

ABSTRACT

The intestinal epithelium has two distinct two stem cell populations, namely, crypt base columnar (CBC) cells and +4 cells. Several specific markers have been identified for each stem cell population. In this study, we examined the expression profiles of these markers in colitis-associated carcinogenesis (CAC) to investigate whether they can be used as biomarkers for the early detection of dysplasia. The expression of intestinal stem cell (ISC) markers was measured by real-time polymerase chain reaction during CAC that was induced by azoxymethane and dextran sodium sulfate treatment. CBC stem cell markers increased continuously with tumor development, whereas a +4 cell expression profile was not present. CBC stem cell population was suppressed in the acute colitis and then expanded to repopulate the crypts during the regeneration period. Notably, RNA in situ hybridization revealed that all dysplasia and cancer samples showed increased expression of CBC stem cell markers in more than one-third of the tumor height, whereas regenerative glands had CBC stem cell markers confined to the lower one-third of the crypt. These results suggest that CBC stem cell markers could be a useful tool for the early detection of colitis-induced tumors. More... »

PAGES

6533

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-06900-x

DOI

http://dx.doi.org/10.1038/s41598-017-06900-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090836401

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28747693


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