Structure of general-population antibody titer distributions to influenza A virus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Nguyen Thi Duy Nhat, Stacy Todd, Erwin de Bruin, Tran Thi Nhu Thao, Nguyen Ha Thao Vy, Tran Minh Quan, Dao Nguyen Vinh, Janko van Beek, Pham Hong Anh, Ha Minh Lam, Nguyen Thanh Hung, Nguyen Thi Le Thanh, Huynh Le Anh Huy, Vo Thi Hong Ha, Stephen Baker, Guy E. Thwaites, Nguyen Thi Nam Lien, Tran Thi Kim Hong, Jeremy Farrar, Cameron P. Simmons, Nguyen Van Vinh Chau, Marion Koopmans, Maciej F. Boni

ABSTRACT

Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein using a continuous titer measurement from a protein microarray assay. We describe the distributions of antibody titers to subtypes 2009 H1N1 and H3N2. Using a model selection approach to fit mixture distributions, we show that 2009 H1N1 antibody titers fall into four titer subgroups and that H3N2 titers fall into three subgroups. For H1N1, our interpretation is that the two highest-titer subgroups correspond to recent and historical infection, which is consistent with 2009 pandemic attack rates. Similar interpretations are available for H3N2, but right-censoring of titers makes these interpretations difficult to validate. More... »

PAGES

6060

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-06177-0

DOI

http://dx.doi.org/10.1038/s41598-017-06177-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090717791

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28729702


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam", 
            "Centre for Tropical Medicine, Nuffield Department of Clinical, Medicine, University of Oxford, Oxford, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nhat", 
        "givenName": "Nguyen Thi Duy", 
        "id": "sg:person.01120243264.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120243264.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Liverpool School of Tropical Medicine", 
          "id": "https://www.grid.ac/institutes/grid.48004.38", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam", 
            "Liverpool School of Tropical Medicine, Liverpool, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Todd", 
        "givenName": "Stacy", 
        "id": "sg:person.01052130064.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052130064.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Public Health and the Environment", 
          "id": "https://www.grid.ac/institutes/grid.31147.30", 
          "name": [
            "Department of Viroscience, Erasmus Medical Centre, Rotterdam, Netherlands", 
            "National Institute for Public Health and the Environment, Bilthoven, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Bruin", 
        "givenName": "Erwin", 
        "id": "sg:person.01305170507.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305170507.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oxford University Clinical Research Unit", 
          "id": "https://www.grid.ac/institutes/grid.412433.3", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thao", 
        "givenName": "Tran Thi Nhu", 
        "id": "sg:person.011446767141.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011446767141.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oxford University Clinical Research Unit", 
          "id": "https://www.grid.ac/institutes/grid.412433.3", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vy", 
        "givenName": "Nguyen Ha Thao", 
        "id": "sg:person.013455223137.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013455223137.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oxford University Clinical Research Unit", 
          "id": "https://www.grid.ac/institutes/grid.412433.3", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quan", 
        "givenName": "Tran Minh", 
        "id": "sg:person.01346112147.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346112147.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oxford University Clinical Research Unit", 
          "id": "https://www.grid.ac/institutes/grid.412433.3", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vinh", 
        "givenName": "Dao Nguyen", 
        "id": "sg:person.01317232707.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317232707.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Public Health and the Environment", 
          "id": "https://www.grid.ac/institutes/grid.31147.30", 
          "name": [
            "National Institute for Public Health and the Environment, Bilthoven, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Beek", 
        "givenName": "Janko", 
        "id": "sg:person.01160767525.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160767525.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oxford University Clinical Research Unit", 
          "id": "https://www.grid.ac/institutes/grid.412433.3", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anh", 
        "givenName": "Pham Hong", 
        "id": "sg:person.0603674201.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603674201.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oxford University Clinical Research Unit", 
          "id": "https://www.grid.ac/institutes/grid.412433.3", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lam", 
        "givenName": "Ha Minh", 
        "id": "sg:person.01243166417.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243166417.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oxford University Clinical Research Unit", 
          "id": "https://www.grid.ac/institutes/grid.412433.3", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hung", 
        "givenName": "Nguyen Thanh", 
        "id": "sg:person.01155143203.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155143203.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oxford University Clinical Research Unit", 
          "id": "https://www.grid.ac/institutes/grid.412433.3", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Le Thanh", 
        "givenName": "Nguyen Thi", 
        "id": "sg:person.013757400241.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013757400241.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oxford University Clinical Research Unit", 
          "id": "https://www.grid.ac/institutes/grid.412433.3", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Le Anh Huy", 
        "givenName": "Huynh", 
        "id": "sg:person.016147721641.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016147721641.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Khanh Hoa Provincial Hospital, Nha Trang, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ha", 
        "givenName": "Vo Thi Hong", 
        "id": "sg:person.013660621301.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013660621301.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam", 
            "Centre for Tropical Medicine, Nuffield Department of Clinical, Medicine, University of Oxford, Oxford, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baker", 
        "givenName": "Stephen", 
        "id": "sg:person.0642552367.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642552367.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam", 
            "Centre for Tropical Medicine, Nuffield Department of Clinical, Medicine, University of Oxford, Oxford, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thwaites", 
        "givenName": "Guy E.", 
        "id": "sg:person.01135151135.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135151135.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hue Provincial Hospital, Thua Thien Hue province, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lien", 
        "givenName": "Nguyen Thi Nam", 
        "id": "sg:person.0644073321.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644073321.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dak Lak General Hospital, Buon Ma Thuot, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Tran Thi Kim", 
        "id": "sg:person.0576242614.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576242614.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Trust", 
          "id": "https://www.grid.ac/institutes/grid.52788.30", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam", 
            "The Wellcome Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Farrar", 
        "givenName": "Jeremy", 
        "id": "sg:person.0640227120.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640227120.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Microbiology and Immunology Department, University of Melbourne, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simmons", 
        "givenName": "Cameron P.", 
        "id": "sg:person.014137144137.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014137144137.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Tropical Diseases", 
          "id": "https://www.grid.ac/institutes/grid.414273.7", 
          "name": [
            "Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Vinh Chau", 
        "givenName": "Nguyen", 
        "id": "sg:person.01221731345.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221731345.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Public Health and the Environment", 
          "id": "https://www.grid.ac/institutes/grid.31147.30", 
          "name": [
            "Department of Viroscience, Erasmus Medical Centre, Rotterdam, Netherlands", 
            "National Institute for Public Health and the Environment, Bilthoven, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koopmans", 
        "givenName": "Marion", 
        "id": "sg:person.013117453357.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013117453357.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pennsylvania State University", 
          "id": "https://www.grid.ac/institutes/grid.29857.31", 
          "name": [
            "Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam", 
            "Centre for Tropical Medicine, Nuffield Department of Clinical, Medicine, University of Oxford, Oxford, United Kingdom", 
            "Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boni", 
        "givenName": "Maciej F.", 
        "id": "sg:person.01303734420.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303734420.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/aje/kwr245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000306273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.74.5.433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003996129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cvi.05072-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005697222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0054890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006569802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2008.05.094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007578990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-0691.2011.03701.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008063978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/kwm012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008808283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jiu047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010720180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1003061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011080511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1012320209", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4614-4072-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012320209", 
          "https://doi.org/10.1007/978-1-4614-4072-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4614-4072-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012320209", 
          "https://doi.org/10.1007/978-1-4614-4072-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rsif.2014.1244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014592453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jiu034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015823210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017809603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jis526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018850046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/155.7.654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019045660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jiu033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019297373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2013.07.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021357657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0003040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021899427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinf.2005.10.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024497448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0030089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024641626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0030089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024641626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.3592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025506481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1911.130349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025903652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0113021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025931261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jit372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027380772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2010.404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027739937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1004054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027848674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2010.11.081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028290230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/656740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030194615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.2442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036508160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.2442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036508160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1000277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036899127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cdli.8.2.314-319.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037629376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)62126-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039880362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.124.3.331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040284086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.5322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040896001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0001-706x(94)90044-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044296190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0001-706x(94)90044-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044296190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jit224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044592879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.epidem.2015.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051071430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/kws121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051236843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1004882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051438073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268808000393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053844437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268802008051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054004166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268804003140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054047049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268805003833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054076080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3978/j.issn.2072-1439.2013.08.09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078776284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/100222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085111805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/100222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085111805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/100222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085111805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/zph.12364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085942609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/zph.12364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085942609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1109491899", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1109491899", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naivet\u00e9, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein using a continuous titer measurement from a protein microarray assay. We describe the distributions of antibody titers to subtypes 2009 H1N1 and H3N2. Using a model selection approach to fit mixture distributions, we show that 2009 H1N1 antibody titers fall into four titer subgroups and that H3N2 titers fall into three subgroups. For H1N1, our interpretation is that the two highest-titer subgroups correspond to recent and historical infection, which is consistent with 2009 pandemic attack rates. Similar interpretations are available for H3N2, but right-censoring of titers makes these interpretations difficult to validate.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-017-06177-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3642950", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3636985", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3638643", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Structure of general-population antibody titer distributions to influenza A virus", 
    "pagination": "6060", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3c19d140e2d1e57d81f40a1b6421d219a31c9c507869642aeee3396dd97a7e11"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28729702"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-017-06177-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1090717791"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-017-06177-0", 
      "https://app.dimensions.ai/details/publication/pub.1090717791"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000600.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-017-06177-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-06177-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-06177-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-06177-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-06177-0'


 

This table displays all metadata directly associated to this object as RDF triples.

404 TRIPLES      21 PREDICATES      77 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-017-06177-0 schema:about anzsrc-for:11
2 anzsrc-for:1117
3 schema:author Nd3060b37ac734f0f8eed734af5b49ffb
4 schema:citation sg:pub.10.1007/978-1-4614-4072-7
5 https://app.dimensions.ai/details/publication/pub.1012320209
6 https://app.dimensions.ai/details/publication/pub.1109491899
7 https://doi.org/10.1001/jama.2010.404
8 https://doi.org/10.1002/sim.2442
9 https://doi.org/10.1002/sim.3592
10 https://doi.org/10.1002/sim.5322
11 https://doi.org/10.1016/0001-706x(94)90044-2
12 https://doi.org/10.1016/j.epidem.2015.02.005
13 https://doi.org/10.1016/j.jinf.2005.10.020
14 https://doi.org/10.1016/j.vaccine.2008.05.094
15 https://doi.org/10.1016/j.vaccine.2010.11.081
16 https://doi.org/10.1016/j.vaccine.2013.07.018
17 https://doi.org/10.1016/s0140-6736(09)62126-7
18 https://doi.org/10.1017/s0950268802008051
19 https://doi.org/10.1017/s0950268804003140
20 https://doi.org/10.1017/s0950268805003833
21 https://doi.org/10.1017/s0950268808000393
22 https://doi.org/10.1084/jem.124.3.331
23 https://doi.org/10.1084/jem.74.5.433
24 https://doi.org/10.1086/656740
25 https://doi.org/10.1093/aje/155.7.654
26 https://doi.org/10.1093/aje/kwm012
27 https://doi.org/10.1093/aje/kwr245
28 https://doi.org/10.1093/aje/kws121
29 https://doi.org/10.1093/infdis/jis526
30 https://doi.org/10.1093/infdis/jit224
31 https://doi.org/10.1093/infdis/jit372
32 https://doi.org/10.1093/infdis/jiu033
33 https://doi.org/10.1093/infdis/jiu034
34 https://doi.org/10.1093/infdis/jiu047
35 https://doi.org/10.1098/rsif.2014.1244
36 https://doi.org/10.1101/100222
37 https://doi.org/10.1111/j.1469-0691.2011.03701.x
38 https://doi.org/10.1111/zph.12364
39 https://doi.org/10.1128/cdli.8.2.314-319.2001
40 https://doi.org/10.1128/cvi.05072-11
41 https://doi.org/10.1371/journal.pcbi.1004882
42 https://doi.org/10.1371/journal.pmed.0030089
43 https://doi.org/10.1371/journal.pmed.1000277
44 https://doi.org/10.1371/journal.pntd.0003040
45 https://doi.org/10.1371/journal.pone.0054890
46 https://doi.org/10.1371/journal.pone.0113021
47 https://doi.org/10.1371/journal.ppat.1002802
48 https://doi.org/10.1371/journal.ppat.1003061
49 https://doi.org/10.1371/journal.ppat.1004054
50 https://doi.org/10.3201/eid1911.130349
51 https://doi.org/10.3978/j.issn.2072-1439.2013.08.09
52 schema:datePublished 2017-12
53 schema:datePublishedReg 2017-12-01
54 schema:description Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein using a continuous titer measurement from a protein microarray assay. We describe the distributions of antibody titers to subtypes 2009 H1N1 and H3N2. Using a model selection approach to fit mixture distributions, we show that 2009 H1N1 antibody titers fall into four titer subgroups and that H3N2 titers fall into three subgroups. For H1N1, our interpretation is that the two highest-titer subgroups correspond to recent and historical infection, which is consistent with 2009 pandemic attack rates. Similar interpretations are available for H3N2, but right-censoring of titers makes these interpretations difficult to validate.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N1a2917941cb94fc08ea11c79e22c7833
59 N45f99532c3474506a9bc6e39425e86ea
60 sg:journal.1045337
61 schema:name Structure of general-population antibody titer distributions to influenza A virus
62 schema:pagination 6060
63 schema:productId N109f4d0ea8204c0c858b314f2fa2a606
64 N152032c47f1745b2a5fc1034f883301f
65 N18112e528059466daed99b3182f4fe06
66 N8ca283ead9c94b92923ab4ab487b93ac
67 Nc45b889ecc7a4834ae746f1c327c4371
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090717791
69 https://doi.org/10.1038/s41598-017-06177-0
70 schema:sdDatePublished 2019-04-10T19:21
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Nb5ec1c2c9d6c4a11b416939681db139c
73 schema:url https://www.nature.com/articles/s41598-017-06177-0
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N0c56784f1c8d412d8bb8daa06a81c3ce schema:name Hue Provincial Hospital, Thua Thien Hue province, Vietnam
78 rdf:type schema:Organization
79 N109f4d0ea8204c0c858b314f2fa2a606 schema:name doi
80 schema:value 10.1038/s41598-017-06177-0
81 rdf:type schema:PropertyValue
82 N152032c47f1745b2a5fc1034f883301f schema:name pubmed_id
83 schema:value 28729702
84 rdf:type schema:PropertyValue
85 N18112e528059466daed99b3182f4fe06 schema:name readcube_id
86 schema:value 3c19d140e2d1e57d81f40a1b6421d219a31c9c507869642aeee3396dd97a7e11
87 rdf:type schema:PropertyValue
88 N18f0e526e451448ea3aa875c8e3da536 rdf:first sg:person.01135151135.80
89 rdf:rest Na4645d6d59f64307a2719c8ea0fa06ff
90 N1a2917941cb94fc08ea11c79e22c7833 schema:issueNumber 1
91 rdf:type schema:PublicationIssue
92 N21fa4263390e4582b457fe705ea27953 rdf:first sg:person.01221731345.27
93 rdf:rest Ne5973f9bc4094360bae7f3c7ab7db13c
94 N3215e9ef677c4721aa2ad36117723eab rdf:first sg:person.01346112147.96
95 rdf:rest N4afa2815c5364a74a1e669d13683dc96
96 N3f2c2cc70e6740499a897ef93b31056d rdf:first sg:person.01305170507.51
97 rdf:rest N82da3353394e47c7a0d9e0a41ce70907
98 N45f99532c3474506a9bc6e39425e86ea schema:volumeNumber 7
99 rdf:type schema:PublicationVolume
100 N4afa2815c5364a74a1e669d13683dc96 rdf:first sg:person.01317232707.76
101 rdf:rest Ndb2f4052e28e471db30502eef833843c
102 N5f94217eab9541698bcb339c5fdaac77 schema:name Dak Lak General Hospital, Buon Ma Thuot, Vietnam
103 rdf:type schema:Organization
104 N645c62bca2954cf1b0439b50d725b763 rdf:first sg:person.01155143203.98
105 rdf:rest Nfc8e4aa2d90340fd99dc4435ae6382fc
106 N7738262151e44fa098cefd3dcfff2cc3 rdf:first sg:person.01243166417.10
107 rdf:rest N645c62bca2954cf1b0439b50d725b763
108 N82da3353394e47c7a0d9e0a41ce70907 rdf:first sg:person.011446767141.35
109 rdf:rest Naea25ee66f114a41b3679776c3b22902
110 N86efc5932ca74c22aaf73f5c854f3207 rdf:first sg:person.0603674201.73
111 rdf:rest N7738262151e44fa098cefd3dcfff2cc3
112 N8ba54e2fc3334410ad10a3d6b746bac5 rdf:first sg:person.0642552367.39
113 rdf:rest N18f0e526e451448ea3aa875c8e3da536
114 N8ca283ead9c94b92923ab4ab487b93ac schema:name dimensions_id
115 schema:value pub.1090717791
116 rdf:type schema:PropertyValue
117 N8ca74539c11242149b5a96be5797396e schema:name Khanh Hoa Provincial Hospital, Nha Trang, Vietnam
118 rdf:type schema:Organization
119 Na4645d6d59f64307a2719c8ea0fa06ff rdf:first sg:person.0644073321.43
120 rdf:rest Ndeb523cbeb164741b0bc2b205ed014ee
121 Na5037a51f8a749e191a0d329018ce01c rdf:first sg:person.016147721641.21
122 rdf:rest Nbbe37fe356004bdc8715509855c46ad0
123 Nabcd7ff0d3584f668ce3869ad7cbb539 rdf:first sg:person.0640227120.31
124 rdf:rest Nb6a7e79f17ed45498a28cf5ebe45cef3
125 Naea25ee66f114a41b3679776c3b22902 rdf:first sg:person.013455223137.18
126 rdf:rest N3215e9ef677c4721aa2ad36117723eab
127 Nb5ec1c2c9d6c4a11b416939681db139c schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 Nb6a7e79f17ed45498a28cf5ebe45cef3 rdf:first sg:person.014137144137.31
130 rdf:rest N21fa4263390e4582b457fe705ea27953
131 Nbbe37fe356004bdc8715509855c46ad0 rdf:first sg:person.013660621301.70
132 rdf:rest N8ba54e2fc3334410ad10a3d6b746bac5
133 Nc45b889ecc7a4834ae746f1c327c4371 schema:name nlm_unique_id
134 schema:value 101563288
135 rdf:type schema:PropertyValue
136 Nd3060b37ac734f0f8eed734af5b49ffb rdf:first sg:person.01120243264.96
137 rdf:rest Nd5bf3f7a8b8e49bc88c0e80b5535634f
138 Nd5bf3f7a8b8e49bc88c0e80b5535634f rdf:first sg:person.01052130064.01
139 rdf:rest N3f2c2cc70e6740499a897ef93b31056d
140 Ndb2f4052e28e471db30502eef833843c rdf:first sg:person.01160767525.75
141 rdf:rest N86efc5932ca74c22aaf73f5c854f3207
142 Ndeb523cbeb164741b0bc2b205ed014ee rdf:first sg:person.0576242614.97
143 rdf:rest Nabcd7ff0d3584f668ce3869ad7cbb539
144 Ne5973f9bc4094360bae7f3c7ab7db13c rdf:first sg:person.013117453357.11
145 rdf:rest Ne63d488ac51f469ebe42c1c8afcbd421
146 Ne63d488ac51f469ebe42c1c8afcbd421 rdf:first sg:person.01303734420.99
147 rdf:rest rdf:nil
148 Nfc8e4aa2d90340fd99dc4435ae6382fc rdf:first sg:person.013757400241.27
149 rdf:rest Na5037a51f8a749e191a0d329018ce01c
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
154 schema:name Public Health and Health Services
155 rdf:type schema:DefinedTerm
156 sg:grant.3636985 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-06177-0
157 rdf:type schema:MonetaryGrant
158 sg:grant.3638643 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-06177-0
159 rdf:type schema:MonetaryGrant
160 sg:grant.3642950 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-06177-0
161 rdf:type schema:MonetaryGrant
162 sg:journal.1045337 schema:issn 2045-2322
163 schema:name Scientific Reports
164 rdf:type schema:Periodical
165 sg:person.01052130064.01 schema:affiliation https://www.grid.ac/institutes/grid.48004.38
166 schema:familyName Todd
167 schema:givenName Stacy
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052130064.01
169 rdf:type schema:Person
170 sg:person.01120243264.96 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
171 schema:familyName Nhat
172 schema:givenName Nguyen Thi Duy
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120243264.96
174 rdf:type schema:Person
175 sg:person.01135151135.80 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
176 schema:familyName Thwaites
177 schema:givenName Guy E.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135151135.80
179 rdf:type schema:Person
180 sg:person.011446767141.35 schema:affiliation https://www.grid.ac/institutes/grid.412433.3
181 schema:familyName Thao
182 schema:givenName Tran Thi Nhu
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011446767141.35
184 rdf:type schema:Person
185 sg:person.01155143203.98 schema:affiliation https://www.grid.ac/institutes/grid.412433.3
186 schema:familyName Hung
187 schema:givenName Nguyen Thanh
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155143203.98
189 rdf:type schema:Person
190 sg:person.01160767525.75 schema:affiliation https://www.grid.ac/institutes/grid.31147.30
191 schema:familyName van Beek
192 schema:givenName Janko
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160767525.75
194 rdf:type schema:Person
195 sg:person.01221731345.27 schema:affiliation https://www.grid.ac/institutes/grid.414273.7
196 schema:familyName Van Vinh Chau
197 schema:givenName Nguyen
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221731345.27
199 rdf:type schema:Person
200 sg:person.01243166417.10 schema:affiliation https://www.grid.ac/institutes/grid.412433.3
201 schema:familyName Lam
202 schema:givenName Ha Minh
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243166417.10
204 rdf:type schema:Person
205 sg:person.01303734420.99 schema:affiliation https://www.grid.ac/institutes/grid.29857.31
206 schema:familyName Boni
207 schema:givenName Maciej F.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303734420.99
209 rdf:type schema:Person
210 sg:person.01305170507.51 schema:affiliation https://www.grid.ac/institutes/grid.31147.30
211 schema:familyName de Bruin
212 schema:givenName Erwin
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305170507.51
214 rdf:type schema:Person
215 sg:person.013117453357.11 schema:affiliation https://www.grid.ac/institutes/grid.31147.30
216 schema:familyName Koopmans
217 schema:givenName Marion
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013117453357.11
219 rdf:type schema:Person
220 sg:person.01317232707.76 schema:affiliation https://www.grid.ac/institutes/grid.412433.3
221 schema:familyName Vinh
222 schema:givenName Dao Nguyen
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317232707.76
224 rdf:type schema:Person
225 sg:person.013455223137.18 schema:affiliation https://www.grid.ac/institutes/grid.412433.3
226 schema:familyName Vy
227 schema:givenName Nguyen Ha Thao
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013455223137.18
229 rdf:type schema:Person
230 sg:person.01346112147.96 schema:affiliation https://www.grid.ac/institutes/grid.412433.3
231 schema:familyName Quan
232 schema:givenName Tran Minh
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346112147.96
234 rdf:type schema:Person
235 sg:person.013660621301.70 schema:affiliation N8ca74539c11242149b5a96be5797396e
236 schema:familyName Ha
237 schema:givenName Vo Thi Hong
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013660621301.70
239 rdf:type schema:Person
240 sg:person.013757400241.27 schema:affiliation https://www.grid.ac/institutes/grid.412433.3
241 schema:familyName Le Thanh
242 schema:givenName Nguyen Thi
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013757400241.27
244 rdf:type schema:Person
245 sg:person.014137144137.31 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
246 schema:familyName Simmons
247 schema:givenName Cameron P.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014137144137.31
249 rdf:type schema:Person
250 sg:person.016147721641.21 schema:affiliation https://www.grid.ac/institutes/grid.412433.3
251 schema:familyName Le Anh Huy
252 schema:givenName Huynh
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016147721641.21
254 rdf:type schema:Person
255 sg:person.0576242614.97 schema:affiliation N5f94217eab9541698bcb339c5fdaac77
256 schema:familyName Hong
257 schema:givenName Tran Thi Kim
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576242614.97
259 rdf:type schema:Person
260 sg:person.0603674201.73 schema:affiliation https://www.grid.ac/institutes/grid.412433.3
261 schema:familyName Anh
262 schema:givenName Pham Hong
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603674201.73
264 rdf:type schema:Person
265 sg:person.0640227120.31 schema:affiliation https://www.grid.ac/institutes/grid.52788.30
266 schema:familyName Farrar
267 schema:givenName Jeremy
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640227120.31
269 rdf:type schema:Person
270 sg:person.0642552367.39 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
271 schema:familyName Baker
272 schema:givenName Stephen
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642552367.39
274 rdf:type schema:Person
275 sg:person.0644073321.43 schema:affiliation N0c56784f1c8d412d8bb8daa06a81c3ce
276 schema:familyName Lien
277 schema:givenName Nguyen Thi Nam
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644073321.43
279 rdf:type schema:Person
280 sg:pub.10.1007/978-1-4614-4072-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012320209
281 https://doi.org/10.1007/978-1-4614-4072-7
282 rdf:type schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1012320209 schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1109491899 schema:CreativeWork
285 https://doi.org/10.1001/jama.2010.404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027739937
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1002/sim.2442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036508160
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1002/sim.3592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025506481
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1002/sim.5322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040896001
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/0001-706x(94)90044-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044296190
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.epidem.2015.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051071430
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.jinf.2005.10.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024497448
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.vaccine.2008.05.094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007578990
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.vaccine.2010.11.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028290230
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.vaccine.2013.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021357657
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/s0140-6736(09)62126-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039880362
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1017/s0950268802008051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054004166
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1017/s0950268804003140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054047049
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1017/s0950268805003833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054076080
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1017/s0950268808000393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053844437
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1084/jem.124.3.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040284086
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1084/jem.74.5.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003996129
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1086/656740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030194615
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1093/aje/155.7.654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019045660
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/aje/kwm012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008808283
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1093/aje/kwr245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000306273
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1093/aje/kws121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051236843
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1093/infdis/jis526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018850046
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1093/infdis/jit224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044592879
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1093/infdis/jit372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027380772
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1093/infdis/jiu033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019297373
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/infdis/jiu034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015823210
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1093/infdis/jiu047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010720180
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1098/rsif.2014.1244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014592453
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1101/100222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085111805
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1111/j.1469-0691.2011.03701.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008063978
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1111/zph.12364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085942609
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1128/cdli.8.2.314-319.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037629376
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1128/cvi.05072-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005697222
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1371/journal.pcbi.1004882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051438073
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1371/journal.pmed.0030089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024641626
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1371/journal.pmed.1000277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036899127
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1371/journal.pntd.0003040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021899427
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1371/journal.pone.0054890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006569802
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1371/journal.pone.0113021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025931261
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1371/journal.ppat.1002802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017809603
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1371/journal.ppat.1003061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011080511
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1371/journal.ppat.1004054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027848674
370 rdf:type schema:CreativeWork
371 https://doi.org/10.3201/eid1911.130349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025903652
372 rdf:type schema:CreativeWork
373 https://doi.org/10.3978/j.issn.2072-1439.2013.08.09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078776284
374 rdf:type schema:CreativeWork
375 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
376 schema:name Microbiology and Immunology Department, University of Melbourne, Melbourne, Australia
377 rdf:type schema:Organization
378 https://www.grid.ac/institutes/grid.29857.31 schema:alternateName Pennsylvania State University
379 schema:name Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA
380 Centre for Tropical Medicine, Nuffield Department of Clinical, Medicine, University of Oxford, Oxford, United Kingdom
381 Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.31147.30 schema:alternateName National Institute for Public Health and the Environment
384 schema:name Department of Viroscience, Erasmus Medical Centre, Rotterdam, Netherlands
385 National Institute for Public Health and the Environment, Bilthoven, Netherlands
386 rdf:type schema:Organization
387 https://www.grid.ac/institutes/grid.412433.3 schema:alternateName Oxford University Clinical Research Unit
388 schema:name Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
389 rdf:type schema:Organization
390 https://www.grid.ac/institutes/grid.414273.7 schema:alternateName Hospital for Tropical Diseases
391 schema:name Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
392 rdf:type schema:Organization
393 https://www.grid.ac/institutes/grid.48004.38 schema:alternateName Liverpool School of Tropical Medicine
394 schema:name Liverpool School of Tropical Medicine, Liverpool, United Kingdom
395 Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
396 rdf:type schema:Organization
397 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
398 schema:name Centre for Tropical Medicine, Nuffield Department of Clinical, Medicine, University of Oxford, Oxford, United Kingdom
399 Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
400 rdf:type schema:Organization
401 https://www.grid.ac/institutes/grid.52788.30 schema:alternateName Wellcome Trust
402 schema:name The Wellcome Trust, London, UK
403 Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
404 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...