Genome-Wide Linkage Analysis of Large Multiple Multigenerational Families Identifies Novel Genetic Loci for Coronary Artery Disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Yang Guo, Fan Wang, Lin Li, Hanxiang Gao, Stephen Arckacki, Isabel Z. Wang, John Barnard, Stephen Ellis, Carlos Hubbard, Eric J. Topol, Qiuyun Chen, Qing K. Wang

ABSTRACT

Coronary artery disease (CAD) is the leading cause of death, and genetic factors contribute significantly to risk of CAD. This study aims to identify new CAD genetic loci through a large-scale linkage analysis of 24 large and multigenerational families with 433 family members (GeneQuest II). All family members were genotyped with markers spaced by every 10 cM and a model-free nonparametric linkage (NPL-all) analysis was carried out. Two highly significant CAD loci were identified on chromosome 17q21.2 (NPL score of 6.20) and 7p22.2 (NPL score of 5.19). We also identified four loci with significant NPL scores between 4.09 and 4.99 on 2q33.3, 3q29, 5q13.2 and 9q22.33. Similar analyses in individual families confirmed the six significant CAD loci and identified seven new highly significant linkages on 9p24.2, 9q34.2, 12q13.13, 15q26.1, 17q22, 20p12.3, and 22q12.1, and two significant loci on 2q11.2 and 11q14.1. Two loci on 3q29 and 9q22.33 were also successfully replicated in our previous linkage analysis of 428 nuclear families. Moreover, two published risk variants, SNP rs46522 in UBE2Z and SNP rs6725887 in WDR12 by GWAS, were found within the 17q21.2 and 2q33.3 loci. These studies lay a foundation for future identification of causative variants and genes for CAD. More... »

PAGES

5472

References to SciGraph publications

  • 2012-08. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing in NATURE GENETICS
  • 2016-01. Molecular genetics of coronary artery disease in JOURNAL OF HUMAN GENETICS
  • 2013-06. The Genotype-Tissue Expression (GTEx) project in NATURE GENETICS
  • 2013-01. Large-scale association analysis identifies new risk loci for coronary artery disease in NATURE GENETICS
  • 2008-01. Identification of a chromosome 8p locus for early-onset coronary heart disease in a French Canadian population in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2015-10. A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease in NATURE GENETICS
  • 2011-01. SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population in JOURNAL OF HUMAN GENETICS
  • 2015-09. Population-specific genotype imputations using minimac or IMPUTE2 in NATURE PROTOCOLS
  • 2002-02. A comprehensive linkage analysis for myocardial infarction and its related risk factors in NATURE GENETICS
  • 2009-03. New susceptibility locus for coronary artery disease on chromosome 3q22.3 in NATURE GENETICS
  • 2000-09. Atherosclerosis in NATURE
  • 2009-03. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction in NATURE GENETICS
  • 2009-03. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants in NATURE GENETICS
  • 2006. Human Urotensin II as a Link between Hypertension and Coronary Artery Disease in HYPERTENSION RESEARCH
  • 2015-10. Erratum: G Protein-coupled Estrogen Receptor Protects from Atherosclerosis in SCIENTIFIC REPORTS
  • 2016-12. Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes? in CARDIOVASCULAR DIABETOLOGY
  • 2013-12. Genome-wide linkage analysis of congenital heart defects using MOD score analysis identifies two novel loci in BMC GENETICS
  • 2012-03. Genome-wide association study of coronary artery disease in the Japanese in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2011-03-06. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease in NATURE GENETICS
  • 1995-11. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results in NATURE GENETICS
  • 2011-03-06. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease in NATURE GENETICS
  • 2011-03-06. Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population in NATURE GENETICS
  • 2005-01. Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: the IRAS Family Study in INTERNATIONAL JOURNAL OF OBESITY
  • 2015-06. Joint-multiple family linkage analysis predicts within-family variation better than single-family analysis of the maize nested association mapping population in HEREDITY
  • 2015-03. A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2014-12. Mega2: validated data-reformatting for linkage and association analyses in SOURCE CODE FOR BIOLOGY AND MEDICINE
  • 2009-03. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease in NATURE GENETICS
  • 2012-08. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease in NATURE GENETICS
  • 2014-12. miRNome traits analysis on endothelial lineage cells discloses biomarker potential circulating microRNAs which affect progenitor activities in BMC GENOMICS
  • 2015-05. G Protein-coupled Estrogen Receptor Protects from Atherosclerosis in SCIENTIFIC REPORTS
  • 2004-03. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke in NATURE GENETICS
  • 2013-03. A genome-wide association study of a coronary artery disease risk variant in JOURNAL OF HUMAN GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-05381-2

    DOI

    http://dx.doi.org/10.1038/s41598-017-05381-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090627115

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28710368


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic Lerner College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.254293.b", 
              "name": [
                "Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA", 
                "Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 44195, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guo", 
            "givenName": "Yang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic Lerner College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.254293.b", 
              "name": [
                "Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA", 
                "Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 44195, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Fan", 
            "id": "sg:person.01125652613.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125652613.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic Lerner College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.254293.b", 
              "name": [
                "Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA", 
                "Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 44195, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Lin", 
            "id": "sg:person.0666071666.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666071666.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lanzhou University", 
              "id": "https://www.grid.ac/institutes/grid.32566.34", 
              "name": [
                "Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA", 
                "Heart Center, the First Affiliated Hospital, Lanzhou University, 730000, Lanzhou, Gansu, P. R. China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gao", 
            "givenName": "Hanxiang", 
            "id": "sg:person.01114301752.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114301752.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic Lerner College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.254293.b", 
              "name": [
                "Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA", 
                "Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 44195, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arckacki", 
            "givenName": "Stephen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic", 
              "id": "https://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA", 
                "Shaker Heights High School, 44120, Shaker Heights, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Isabel Z.", 
            "id": "sg:person.010176550173.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010176550173.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic", 
              "id": "https://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Department of Quantitative Health Sciences, Cleveland Clinic, 44195, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barnard", 
            "givenName": "John", 
            "id": "sg:person.01303061642.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303061642.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic", 
              "id": "https://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Department of Cardiovascular Medicine, Sydell & Arnold Miller Family Heart & Vascular Institute, Cleveland Clinic, 44195, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ellis", 
            "givenName": "Stephen", 
            "id": "sg:person.013543075537.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013543075537.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic", 
              "id": "https://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Department of Cardiovascular Medicine, Sydell & Arnold Miller Family Heart & Vascular Institute, Cleveland Clinic, 44195, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hubbard", 
            "givenName": "Carlos", 
            "id": "sg:person.07731411267.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07731411267.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Scripps Clinic", 
              "id": "https://www.grid.ac/institutes/grid.419794.6", 
              "name": [
                "Scripps Translational Science Institute, Scripps Research Institute, Scripps Clinic, 92037, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Topol", 
            "givenName": "Eric J.", 
            "id": "sg:person.0731336524.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731336524.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic Lerner College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.254293.b", 
              "name": [
                "Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA", 
                "Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 44195, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Qiuyun", 
            "id": "sg:person.01074026502.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074026502.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Case Western Reserve University", 
              "id": "https://www.grid.ac/institutes/grid.67105.35", 
              "name": [
                "Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA", 
                "Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 44195, Cleveland, OH, USA", 
                "Department of Cardiovascular Medicine, Sydell & Arnold Miller Family Heart & Vascular Institute, Cleveland Clinic, 44195, Cleveland, OH, USA", 
                "Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, 44106, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Qing K.", 
            "id": "sg:person.01147565502.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147565502.48"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/jhg.2012.124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000393061", 
              "https://doi.org/10.1038/jhg.2012.124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.784", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000937327", 
              "https://doi.org/10.1038/ng.784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.784", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000937327", 
              "https://doi.org/10.1038/ng.784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0019908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000963330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep13510", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001883424", 
              "https://doi.org/10.1038/srep13510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2015.11.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004064487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2156-14-44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006495418", 
              "https://doi.org/10.1186/1471-2156-14-44"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35025203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007574646", 
              "https://doi.org/10.1038/35025203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35025203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007574646", 
              "https://doi.org/10.1038/35025203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0802793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007614343", 
              "https://doi.org/10.1038/sj.ijo.0802793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0802793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007614343", 
              "https://doi.org/10.1038/sj.ijo.0802793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/jaha.113.000235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008431584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009668443", 
              "https://doi.org/10.1038/ng.2337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/10.24.2751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011146975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.0020072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011458950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.112.300857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013132021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.112.300857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013132021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ejhg.5201920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016647137", 
              "https://doi.org/10.1038/sj.ejhg.5201920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/database/bav028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016887040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000016258.40568.f1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016956329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1003723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016966585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017012113", 
              "https://doi.org/10.1038/ng827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017012113", 
              "https://doi.org/10.1038/ng827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2272(1997)14:6<659::aid-gepi18>3.0.co;2-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021062607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2014.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021860041", 
              "https://doi.org/10.1038/ejhg.2014.110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.113.002707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022500998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.113.002707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022500998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep07564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023076581", 
              "https://doi.org/10.1038/srep07564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0113935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023669689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024063292", 
              "https://doi.org/10.1038/ng.314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024601187", 
              "https://doi.org/10.1038/ng.2480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/423900", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025323520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13029-014-0026-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025437716", 
              "https://doi.org/10.1186/s13029-014-0026-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13029-014-0026-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025437716", 
              "https://doi.org/10.1186/s13029-014-0026-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circgenetics.113.000305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026462830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circgenetics.113.000305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026462830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hdy.2014.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026940311", 
              "https://doi.org/10.1038/hdy.2014.123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1001300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027088240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028234922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2015.077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029262615", 
              "https://doi.org/10.1038/nprot.2015.077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029478415", 
              "https://doi.org/10.1038/ng.783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029723318", 
              "https://doi.org/10.1038/ng.2354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.115.306566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030282688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.115.306566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030282688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2011.184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030923334", 
              "https://doi.org/10.1038/ejhg.2011.184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1538-7836.2007.02372.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031956687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032444369", 
              "https://doi.org/10.1038/ng.2653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jhg.2015.70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034025030", 
              "https://doi.org/10.1038/jhg.2015.70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034378235", 
              "https://doi.org/10.1038/ng.3396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.thromres.2007.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034760936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)61996-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035789214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037689298", 
              "https://doi.org/10.1038/ng.782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2009.142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037789927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1088477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039231865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1195-241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040726560", 
              "https://doi.org/10.1038/ng1195-241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041608555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12933-016-0439-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042106911", 
              "https://doi.org/10.1186/s12933-016-0439-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12933-016-0439-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042106911", 
              "https://doi.org/10.1186/s12933-016-0439-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00045415-199405000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042173543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00045415-199405000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042173543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jhg.2010.141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042803232", 
              "https://doi.org/10.1038/jhg.2010.141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043447232", 
              "https://doi.org/10.1038/ng.307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.2003.016584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043471053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000093281.10213.db", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043909186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000093281.10213.db", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043909186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2012.03.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046657194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047319287", 
              "https://doi.org/10.1038/ng.323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0902604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048022432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0071537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049606265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.110.578369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049948693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.110.578369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049948693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050004376", 
              "https://doi.org/10.1038/ng.327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050004376", 
              "https://doi.org/10.1038/ng.327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050287806", 
              "https://doi.org/10.1038/ng1311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050287806", 
              "https://doi.org/10.1038/ng1311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000187470.31662.fe", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051511750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000187470.31662.fe", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051511750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/eurheartj/ehq405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051863036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m203421200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052244457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1291/hypres.29.375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053224351", 
              "https://doi.org/10.1291/hypres.29.375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-15-802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053440480", 
              "https://doi.org/10.1186/1471-2164-15-802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0008-6363(97)00033-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054579682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/ajh.2009.190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056440690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/316902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058621845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/381560", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058673340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/426405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058714689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/498653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058781795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/498653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058781795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/521581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058793204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1136370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062455032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074659604", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12", 
        "datePublishedReg": "2017-12-01", 
        "description": "Coronary artery disease (CAD) is the leading cause of death, and genetic factors contribute significantly to risk of CAD. This study aims to identify new CAD genetic loci through a large-scale linkage analysis of 24 large and multigenerational families with 433 family members (GeneQuest II). All family members were genotyped with markers spaced by every 10\u2009cM and a model-free nonparametric linkage (NPL-all) analysis was carried out. Two highly significant CAD loci were identified on chromosome 17q21.2 (NPL score of 6.20) and 7p22.2 (NPL score of 5.19). We also identified four loci with significant NPL scores between 4.09 and 4.99 on 2q33.3, 3q29, 5q13.2 and 9q22.33. Similar analyses in individual families confirmed the six significant CAD loci and identified seven new highly significant linkages on 9p24.2, 9q34.2, 12q13.13, 15q26.1, 17q22, 20p12.3, and 22q12.1, and two significant loci on 2q11.2 and 11q14.1. Two loci on 3q29 and 9q22.33 were also successfully replicated in our previous linkage analysis of 428 nuclear families. Moreover, two published risk variants, SNP rs46522 in UBE2Z and SNP rs6725887 in WDR12 by GWAS, were found within the 17q21.2 and 2q33.3 loci. These studies lay a foundation for future identification of causative variants and genes for CAD.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-017-05381-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3933366", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3803654", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "Genome-Wide Linkage Analysis of Large Multiple Multigenerational Families Identifies Novel Genetic Loci for Coronary Artery Disease", 
        "pagination": "5472", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "410e4c995342dd2ae491b65a76ca2a8f5aae242f88c7b0709b3f826991e22ad7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28710368"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-017-05381-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1090627115"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-017-05381-2", 
          "https://app.dimensions.ai/details/publication/pub.1090627115"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T20:43", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000493.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-017-05381-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-05381-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-05381-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-05381-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-05381-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    420 TRIPLES      21 PREDICATES      103 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-017-05381-2 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author Ne04892f52ee84b339cb0bf068af8823d
    4 schema:citation sg:pub.10.1038/35025203
    5 sg:pub.10.1038/ejhg.2011.184
    6 sg:pub.10.1038/ejhg.2014.110
    7 sg:pub.10.1038/hdy.2014.123
    8 sg:pub.10.1038/jhg.2010.141
    9 sg:pub.10.1038/jhg.2012.124
    10 sg:pub.10.1038/jhg.2015.70
    11 sg:pub.10.1038/ng.2337
    12 sg:pub.10.1038/ng.2354
    13 sg:pub.10.1038/ng.2480
    14 sg:pub.10.1038/ng.2653
    15 sg:pub.10.1038/ng.307
    16 sg:pub.10.1038/ng.314
    17 sg:pub.10.1038/ng.323
    18 sg:pub.10.1038/ng.327
    19 sg:pub.10.1038/ng.3396
    20 sg:pub.10.1038/ng.782
    21 sg:pub.10.1038/ng.783
    22 sg:pub.10.1038/ng.784
    23 sg:pub.10.1038/ng1195-241
    24 sg:pub.10.1038/ng1311
    25 sg:pub.10.1038/ng827
    26 sg:pub.10.1038/nprot.2015.077
    27 sg:pub.10.1038/sj.ejhg.5201920
    28 sg:pub.10.1038/sj.ijo.0802793
    29 sg:pub.10.1038/srep07564
    30 sg:pub.10.1038/srep13510
    31 sg:pub.10.1186/1471-2156-14-44
    32 sg:pub.10.1186/1471-2164-15-802
    33 sg:pub.10.1186/s12933-016-0439-9
    34 sg:pub.10.1186/s13029-014-0026-y
    35 sg:pub.10.1291/hypres.29.375
    36 https://app.dimensions.ai/details/publication/pub.1074659604
    37 https://doi.org/10.1002/(sici)1098-2272(1997)14:6<659::aid-gepi18>3.0.co;2-p
    38 https://doi.org/10.1016/j.ajhg.2015.11.020
    39 https://doi.org/10.1016/j.thromres.2007.04.013
    40 https://doi.org/10.1016/j.tig.2012.03.001
    41 https://doi.org/10.1016/s0008-6363(97)00033-3
    42 https://doi.org/10.1016/s0140-6736(10)61996-4
    43 https://doi.org/10.1038/ajh.2009.190
    44 https://doi.org/10.1038/oby.2009.142
    45 https://doi.org/10.1056/nejmoa0902604
    46 https://doi.org/10.1074/jbc.m203421200
    47 https://doi.org/10.1086/316902
    48 https://doi.org/10.1086/381560
    49 https://doi.org/10.1086/423900
    50 https://doi.org/10.1086/426405
    51 https://doi.org/10.1086/498653
    52 https://doi.org/10.1086/521581
    53 https://doi.org/10.1093/bioinformatics/btq538
    54 https://doi.org/10.1093/database/bav028
    55 https://doi.org/10.1093/eurheartj/ehq405
    56 https://doi.org/10.1093/hmg/10.24.2751
    57 https://doi.org/10.1097/00045415-199405000-00003
    58 https://doi.org/10.1111/j.1538-7836.2007.02372.x
    59 https://doi.org/10.1126/science.1088477
    60 https://doi.org/10.1126/science.1136370
    61 https://doi.org/10.1136/jmg.2003.016584
    62 https://doi.org/10.1161/01.atv.0000016258.40568.f1
    63 https://doi.org/10.1161/01.atv.0000093281.10213.db
    64 https://doi.org/10.1161/01.atv.0000187470.31662.fe
    65 https://doi.org/10.1161/atvbaha.112.300857
    66 https://doi.org/10.1161/circgenetics.113.000305
    67 https://doi.org/10.1161/circresaha.115.306566
    68 https://doi.org/10.1161/jaha.113.000235
    69 https://doi.org/10.1161/strokeaha.110.578369
    70 https://doi.org/10.1161/strokeaha.113.002707
    71 https://doi.org/10.1371/journal.pgen.0020072
    72 https://doi.org/10.1371/journal.pgen.1001300
    73 https://doi.org/10.1371/journal.pgen.1002260
    74 https://doi.org/10.1371/journal.pgen.1003723
    75 https://doi.org/10.1371/journal.pone.0019908
    76 https://doi.org/10.1371/journal.pone.0071537
    77 https://doi.org/10.1371/journal.pone.0113935
    78 schema:datePublished 2017-12
    79 schema:datePublishedReg 2017-12-01
    80 schema:description Coronary artery disease (CAD) is the leading cause of death, and genetic factors contribute significantly to risk of CAD. This study aims to identify new CAD genetic loci through a large-scale linkage analysis of 24 large and multigenerational families with 433 family members (GeneQuest II). All family members were genotyped with markers spaced by every 10 cM and a model-free nonparametric linkage (NPL-all) analysis was carried out. Two highly significant CAD loci were identified on chromosome 17q21.2 (NPL score of 6.20) and 7p22.2 (NPL score of 5.19). We also identified four loci with significant NPL scores between 4.09 and 4.99 on 2q33.3, 3q29, 5q13.2 and 9q22.33. Similar analyses in individual families confirmed the six significant CAD loci and identified seven new highly significant linkages on 9p24.2, 9q34.2, 12q13.13, 15q26.1, 17q22, 20p12.3, and 22q12.1, and two significant loci on 2q11.2 and 11q14.1. Two loci on 3q29 and 9q22.33 were also successfully replicated in our previous linkage analysis of 428 nuclear families. Moreover, two published risk variants, SNP rs46522 in UBE2Z and SNP rs6725887 in WDR12 by GWAS, were found within the 17q21.2 and 2q33.3 loci. These studies lay a foundation for future identification of causative variants and genes for CAD.
    81 schema:genre research_article
    82 schema:inLanguage en
    83 schema:isAccessibleForFree true
    84 schema:isPartOf N1903237d292042dcb3ee91a0c9f6568b
    85 N35bb1666b2c9424292ba78bd52c3977d
    86 sg:journal.1045337
    87 schema:name Genome-Wide Linkage Analysis of Large Multiple Multigenerational Families Identifies Novel Genetic Loci for Coronary Artery Disease
    88 schema:pagination 5472
    89 schema:productId N111f5fef92194aea82e1800a264a1aa7
    90 N1fc2168ad914414186b4fe298dcedadd
    91 N4561ce0d848041018f15e3589b5e0f6a
    92 N6f3c282b81b644ed9f8846c35b23fd46
    93 Nd363ee4536c640f28af17eca6221b25e
    94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090627115
    95 https://doi.org/10.1038/s41598-017-05381-2
    96 schema:sdDatePublished 2019-04-10T20:43
    97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    98 schema:sdPublisher N5dcf298e646546d79bba2ffceb58b325
    99 schema:url https://www.nature.com/articles/s41598-017-05381-2
    100 sgo:license sg:explorer/license/
    101 sgo:sdDataset articles
    102 rdf:type schema:ScholarlyArticle
    103 N111f5fef92194aea82e1800a264a1aa7 schema:name pubmed_id
    104 schema:value 28710368
    105 rdf:type schema:PropertyValue
    106 N1903237d292042dcb3ee91a0c9f6568b schema:issueNumber 1
    107 rdf:type schema:PublicationIssue
    108 N1fc2168ad914414186b4fe298dcedadd schema:name readcube_id
    109 schema:value 410e4c995342dd2ae491b65a76ca2a8f5aae242f88c7b0709b3f826991e22ad7
    110 rdf:type schema:PropertyValue
    111 N217220adbff24e9cb2753c663652b0e4 rdf:first sg:person.01074026502.53
    112 rdf:rest N8bfd2cfdb3da4c228d108dab4bd9e976
    113 N35bb1666b2c9424292ba78bd52c3977d schema:volumeNumber 7
    114 rdf:type schema:PublicationVolume
    115 N4561ce0d848041018f15e3589b5e0f6a schema:name nlm_unique_id
    116 schema:value 101563288
    117 rdf:type schema:PropertyValue
    118 N45bd253a2b064636b171b256a31ed4a9 rdf:first sg:person.010176550173.81
    119 rdf:rest N5336f213cd7142baa67aee5bdba16dff
    120 N45fe1a882cf0485399a47fcc03dba390 rdf:first N5103be20b02b4caba7c3a3e0ed564017
    121 rdf:rest N45bd253a2b064636b171b256a31ed4a9
    122 N487c5521b0424138af6d2d3b25c78e86 schema:affiliation https://www.grid.ac/institutes/grid.254293.b
    123 schema:familyName Guo
    124 schema:givenName Yang
    125 rdf:type schema:Person
    126 N5103be20b02b4caba7c3a3e0ed564017 schema:affiliation https://www.grid.ac/institutes/grid.254293.b
    127 schema:familyName Arckacki
    128 schema:givenName Stephen
    129 rdf:type schema:Person
    130 N5336f213cd7142baa67aee5bdba16dff rdf:first sg:person.01303061642.91
    131 rdf:rest N9f98b37a4f3540c79bc074de671b31d9
    132 N567ed42af510418aa010ce40a32a8b4d rdf:first sg:person.01125652613.73
    133 rdf:rest Nc00dc2862dbc4796a2b61c97159cffc6
    134 N5dcf298e646546d79bba2ffceb58b325 schema:name Springer Nature - SN SciGraph project
    135 rdf:type schema:Organization
    136 N6f3c282b81b644ed9f8846c35b23fd46 schema:name dimensions_id
    137 schema:value pub.1090627115
    138 rdf:type schema:PropertyValue
    139 N8bfd2cfdb3da4c228d108dab4bd9e976 rdf:first sg:person.01147565502.48
    140 rdf:rest rdf:nil
    141 N9a9e9c9f76b1447ba49878c91592d947 rdf:first sg:person.0731336524.18
    142 rdf:rest N217220adbff24e9cb2753c663652b0e4
    143 N9e50624b8d814d9d865a078374571fc3 rdf:first sg:person.01114301752.89
    144 rdf:rest N45fe1a882cf0485399a47fcc03dba390
    145 N9f98b37a4f3540c79bc074de671b31d9 rdf:first sg:person.013543075537.29
    146 rdf:rest Nca887999d2a14c2cbe3acbcc8e9d5540
    147 Nc00dc2862dbc4796a2b61c97159cffc6 rdf:first sg:person.0666071666.01
    148 rdf:rest N9e50624b8d814d9d865a078374571fc3
    149 Nca887999d2a14c2cbe3acbcc8e9d5540 rdf:first sg:person.07731411267.16
    150 rdf:rest N9a9e9c9f76b1447ba49878c91592d947
    151 Nd363ee4536c640f28af17eca6221b25e schema:name doi
    152 schema:value 10.1038/s41598-017-05381-2
    153 rdf:type schema:PropertyValue
    154 Ne04892f52ee84b339cb0bf068af8823d rdf:first N487c5521b0424138af6d2d3b25c78e86
    155 rdf:rest N567ed42af510418aa010ce40a32a8b4d
    156 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    157 schema:name Biological Sciences
    158 rdf:type schema:DefinedTerm
    159 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Genetics
    161 rdf:type schema:DefinedTerm
    162 sg:grant.3803654 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-05381-2
    163 rdf:type schema:MonetaryGrant
    164 sg:grant.3933366 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-05381-2
    165 rdf:type schema:MonetaryGrant
    166 sg:journal.1045337 schema:issn 2045-2322
    167 schema:name Scientific Reports
    168 rdf:type schema:Periodical
    169 sg:person.010176550173.81 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
    170 schema:familyName Wang
    171 schema:givenName Isabel Z.
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010176550173.81
    173 rdf:type schema:Person
    174 sg:person.01074026502.53 schema:affiliation https://www.grid.ac/institutes/grid.254293.b
    175 schema:familyName Chen
    176 schema:givenName Qiuyun
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074026502.53
    178 rdf:type schema:Person
    179 sg:person.01114301752.89 schema:affiliation https://www.grid.ac/institutes/grid.32566.34
    180 schema:familyName Gao
    181 schema:givenName Hanxiang
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114301752.89
    183 rdf:type schema:Person
    184 sg:person.01125652613.73 schema:affiliation https://www.grid.ac/institutes/grid.254293.b
    185 schema:familyName Wang
    186 schema:givenName Fan
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125652613.73
    188 rdf:type schema:Person
    189 sg:person.01147565502.48 schema:affiliation https://www.grid.ac/institutes/grid.67105.35
    190 schema:familyName Wang
    191 schema:givenName Qing K.
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147565502.48
    193 rdf:type schema:Person
    194 sg:person.01303061642.91 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
    195 schema:familyName Barnard
    196 schema:givenName John
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303061642.91
    198 rdf:type schema:Person
    199 sg:person.013543075537.29 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
    200 schema:familyName Ellis
    201 schema:givenName Stephen
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013543075537.29
    203 rdf:type schema:Person
    204 sg:person.0666071666.01 schema:affiliation https://www.grid.ac/institutes/grid.254293.b
    205 schema:familyName Li
    206 schema:givenName Lin
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666071666.01
    208 rdf:type schema:Person
    209 sg:person.0731336524.18 schema:affiliation https://www.grid.ac/institutes/grid.419794.6
    210 schema:familyName Topol
    211 schema:givenName Eric J.
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731336524.18
    213 rdf:type schema:Person
    214 sg:person.07731411267.16 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
    215 schema:familyName Hubbard
    216 schema:givenName Carlos
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07731411267.16
    218 rdf:type schema:Person
    219 sg:pub.10.1038/35025203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007574646
    220 https://doi.org/10.1038/35025203
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/ejhg.2011.184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030923334
    223 https://doi.org/10.1038/ejhg.2011.184
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/ejhg.2014.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021860041
    226 https://doi.org/10.1038/ejhg.2014.110
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/hdy.2014.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026940311
    229 https://doi.org/10.1038/hdy.2014.123
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/jhg.2010.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042803232
    232 https://doi.org/10.1038/jhg.2010.141
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/jhg.2012.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000393061
    235 https://doi.org/10.1038/jhg.2012.124
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/jhg.2015.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034025030
    238 https://doi.org/10.1038/jhg.2015.70
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/ng.2337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009668443
    241 https://doi.org/10.1038/ng.2337
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/ng.2354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029723318
    244 https://doi.org/10.1038/ng.2354
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/ng.2480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024601187
    247 https://doi.org/10.1038/ng.2480
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/ng.2653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032444369
    250 https://doi.org/10.1038/ng.2653
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/ng.307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043447232
    253 https://doi.org/10.1038/ng.307
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/ng.314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024063292
    256 https://doi.org/10.1038/ng.314
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/ng.323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047319287
    259 https://doi.org/10.1038/ng.323
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/ng.327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050004376
    262 https://doi.org/10.1038/ng.327
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/ng.3396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034378235
    265 https://doi.org/10.1038/ng.3396
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/ng.782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037689298
    268 https://doi.org/10.1038/ng.782
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/ng.783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029478415
    271 https://doi.org/10.1038/ng.783
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/ng.784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000937327
    274 https://doi.org/10.1038/ng.784
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/ng1195-241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040726560
    277 https://doi.org/10.1038/ng1195-241
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/ng1311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050287806
    280 https://doi.org/10.1038/ng1311
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/ng827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017012113
    283 https://doi.org/10.1038/ng827
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/nprot.2015.077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029262615
    286 https://doi.org/10.1038/nprot.2015.077
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/sj.ejhg.5201920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016647137
    289 https://doi.org/10.1038/sj.ejhg.5201920
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/sj.ijo.0802793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007614343
    292 https://doi.org/10.1038/sj.ijo.0802793
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/srep07564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023076581
    295 https://doi.org/10.1038/srep07564
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/srep13510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001883424
    298 https://doi.org/10.1038/srep13510
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1186/1471-2156-14-44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006495418
    301 https://doi.org/10.1186/1471-2156-14-44
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1186/1471-2164-15-802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053440480
    304 https://doi.org/10.1186/1471-2164-15-802
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1186/s12933-016-0439-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042106911
    307 https://doi.org/10.1186/s12933-016-0439-9
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1186/s13029-014-0026-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1025437716
    310 https://doi.org/10.1186/s13029-014-0026-y
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1291/hypres.29.375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053224351
    313 https://doi.org/10.1291/hypres.29.375
    314 rdf:type schema:CreativeWork
    315 https://app.dimensions.ai/details/publication/pub.1074659604 schema:CreativeWork
    316 https://doi.org/10.1002/(sici)1098-2272(1997)14:6<659::aid-gepi18>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1021062607
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/j.ajhg.2015.11.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004064487
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/j.thromres.2007.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034760936
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/j.tig.2012.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046657194
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/s0008-6363(97)00033-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054579682
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/s0140-6736(10)61996-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035789214
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1038/ajh.2009.190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056440690
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1038/oby.2009.142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037789927
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1056/nejmoa0902604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048022432
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1074/jbc.m203421200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052244457
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1086/316902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058621845
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1086/381560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058673340
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1086/423900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025323520
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1086/426405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058714689
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1086/498653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058781795
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1086/521581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058793204
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1093/bioinformatics/btq538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028234922
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1093/database/bav028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016887040
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1093/eurheartj/ehq405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051863036
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1093/hmg/10.24.2751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011146975
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1097/00045415-199405000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042173543
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1111/j.1538-7836.2007.02372.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031956687
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1126/science.1088477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039231865
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1126/science.1136370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062455032
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1136/jmg.2003.016584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043471053
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1161/01.atv.0000016258.40568.f1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016956329
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1161/01.atv.0000093281.10213.db schema:sameAs https://app.dimensions.ai/details/publication/pub.1043909186
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1161/01.atv.0000187470.31662.fe schema:sameAs https://app.dimensions.ai/details/publication/pub.1051511750
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1161/atvbaha.112.300857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013132021
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1161/circgenetics.113.000305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026462830
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1161/circresaha.115.306566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030282688
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1161/jaha.113.000235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008431584
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1161/strokeaha.110.578369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049948693
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1161/strokeaha.113.002707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022500998
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1371/journal.pgen.0020072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011458950
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1371/journal.pgen.1001300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027088240
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1371/journal.pgen.1002260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041608555
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1371/journal.pgen.1003723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016966585
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1371/journal.pone.0019908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000963330
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1371/journal.pone.0071537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049606265
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1371/journal.pone.0113935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023669689
    397 rdf:type schema:CreativeWork
    398 https://www.grid.ac/institutes/grid.239578.2 schema:alternateName Cleveland Clinic
    399 schema:name Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA
    400 Department of Cardiovascular Medicine, Sydell & Arnold Miller Family Heart & Vascular Institute, Cleveland Clinic, 44195, Cleveland, OH, USA
    401 Department of Quantitative Health Sciences, Cleveland Clinic, 44195, Cleveland, OH, USA
    402 Shaker Heights High School, 44120, Shaker Heights, OH, USA
    403 rdf:type schema:Organization
    404 https://www.grid.ac/institutes/grid.254293.b schema:alternateName Cleveland Clinic Lerner College of Medicine
    405 schema:name Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA
    406 Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 44195, Cleveland, OH, USA
    407 rdf:type schema:Organization
    408 https://www.grid.ac/institutes/grid.32566.34 schema:alternateName Lanzhou University
    409 schema:name Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA
    410 Heart Center, the First Affiliated Hospital, Lanzhou University, 730000, Lanzhou, Gansu, P. R. China
    411 rdf:type schema:Organization
    412 https://www.grid.ac/institutes/grid.419794.6 schema:alternateName Scripps Clinic
    413 schema:name Scripps Translational Science Institute, Scripps Research Institute, Scripps Clinic, 92037, La Jolla, CA, USA
    414 rdf:type schema:Organization
    415 https://www.grid.ac/institutes/grid.67105.35 schema:alternateName Case Western Reserve University
    416 schema:name Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 44195, Cleveland, OH, USA
    417 Department of Cardiovascular Medicine, Sydell & Arnold Miller Family Heart & Vascular Institute, Cleveland Clinic, 44195, Cleveland, OH, USA
    418 Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, 44106, Cleveland, OH, USA
    419 Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 44195, Cleveland, OH, USA
    420 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...