SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Chia Rou Yeo, Madhur Agrawal, Shawn Hoon, Asim Shabbir, Manu Kunaal Shrivastava, Shiqi Huang, Chin Meng Khoo, Vanna Chhay, M. Shabeer Yassin, E. Shyong Tai, Antonio Vidal-Puig, Sue-Anne Toh

ABSTRACT

The Simpson Golabi Behmel Syndrome (SGBS) pre-adipocyte cell strain is widely considered to be a representative in vitro model of human white pre-adipocytes. A recent study suggested that SGBS adipocytes exhibit an unexpected transient brown phenotype. Here, we comprehensively examined key differences between SGBS adipocytes and primary human white subcutaneous (PHWSC) adipocytes. RNA-Seq analysis revealed that extracellular matrix (ECM)-receptor interaction and metabolic pathways were the top two KEGG pathways significantly enriched in SGBS adipocytes, which included positively enriched mitochondrial respiration and oxidation pathways. Compared to PHWSC adipocytes, SGBS adipocytes showed not only greater induction of adipogenic gene expression during differentiation but also increased levels of UCP1 mRNA and protein expression. Functionally, SGBS adipocytes displayed higher ISO-induced basal leak respiration and overall oxygen consumption rate, along with increased triglyceride accumulation and insulin-stimulated glucose uptake. In conclusion, we confirmed that SGBS adipocytes, which are considered of white adipose tissue origin can shift towards a brown/beige adipocyte phenotype. These differences indicate SGBS cells may help to identify mechanisms leading to browning, and inform our understanding for the use of SGBS vis-à-vis primary human subcutaneous adipocytes as a human white adipocyte model, guiding the selection of appropriate cell models in future metabolic research. More... »

PAGES

4031

References to SciGraph publications

  • 2016-08. Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production in SCIENTIFIC REPORTS
  • 2014-09. Calcium-dependent release of adipocyte fatty acid binding protein from human adipocytes in INTERNATIONAL JOURNAL OF OBESITY
  • 2008-09. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity in GENOME BIOLOGY
  • 2011-12. Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c in JOURNAL OF BIOMEDICAL SCIENCE
  • 2001-01. Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation in INTERNATIONAL JOURNAL OF OBESITY
  • 2014-12. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2014-12. Simpson-Golabi-Behmel syndrome types I and II in ORPHANET JOURNAL OF RARE DISEASES
  • 2015-12. Comprehensive molecular characterization of human adipocytes reveals a transient brown phenotype in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2013-10. Brown and beige fat: development, function and therapeutic potential in NATURE MEDICINE
  • 2008-12. Characterisation of aromatase expression in the human adipocyte cell line SGBS in BREAST CANCER RESEARCH AND TREATMENT
  • 2011-02. LIGHT (TNFSF14) inhibits adipose differentiation without affecting adipocyte metabolism in INTERNATIONAL JOURNAL OF OBESITY
  • 1996-03. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome in NATURE GENETICS
  • 2015-10. Angiotensin II directly impairs adipogenic differentiation of human preadipose cells in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2012-10. The SGBS cell strain as a model for the in vitro study of obesity and cancer in CLINICAL AND TRANSLATIONAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-04369-2

    DOI

    http://dx.doi.org/10.1038/s41598-017-04369-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1086115935

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28642596


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