Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06-23

AUTHORS

Chuanhui Peng, Wendi Hu, Xiaoyu Weng, Rongliang Tong, Shaobing Cheng, Chaofeng Ding, Heng Xiao, Zhen Lv, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng

ABSTRACT

It has been reported that long non-coding RNA PANDA was disregulated in varieties types of tumor, but its expression level and biological role in hepatocellular carcinoma (HCC) remains contradictory. We detected PANDA expression in two independent cohorts (48 HCC patients following liver transplantation and 84 HCC patients following liver resection), and found that PANDA was down-regulated in HCC. Thereafter we explored its function in cancer biology by inversing its low expression. Surprisingly, overexpression of PANDA promoted HCC proliferation and carcinogenesis in vitro and in vivo. Mechanistically, PANDA repressed transcriptional activity of senescence associated inflammatory factor IL8, which leaded to inhibition of cellular senescence. Therefore, our research help to better understand the complex role of PANDA in HCC, and suggest more thoughtful strategies should be applied before it can be treated as a potential therapeutic target. More... »

PAGES

4186

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-04045-5

DOI

http://dx.doi.org/10.1038/s41598-017-04045-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1086123704

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28646235


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36 IL8
37 Mechanistically
38 activity
39 biological role
40 biology
41 cancer biology
42 carcinogenesis
43 carcinoma
44 cellular senescence
45 cohort
46 complex role
47 expression
48 expression levels
49 function
50 help
51 hepatocellular carcinoma
52 independent cohort
53 inhibition
54 levels
55 low expression
56 overexpression
57 pandas
58 potential therapeutic target
59 proliferation
60 research help
61 role
62 senescence
63 strategies
64 target
65 therapeutic target
66 thoughtful strategies
67 transcriptional activity
68 tumors
69 types
70 variety types
71 vitro
72 vivo
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