A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06-20

AUTHORS

Seiji Yamamoto, Masashi Muramatsu, Erika Azuma, Masashi Ikutani, Yoshinori Nagai, Hiroshi Sagara, Bon-Nyeo Koo, Satomi Kita, Erin O’Donnell, Tsuyoshi Osawa, Hiroyuki Takahashi, Ken-ichi Takano, Mitsuko Dohmoto, Michiya Sugimori, Isao Usui, Yasuhide Watanabe, Noboru Hatakeyama, Takahiro Iwamoto, Issei Komuro, Kiyoshi Takatsu, Kazuyuki Tobe, Shumpei Niida, Naoyuki Matsuda, Masabumi Shibuya, Masakiyo Sasahara

ABSTRACT

Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the central nervous system (CNS) by regulating blood-brain barrier homeostasis and blood flow at the capillary level. However, the origin of CNS microvascular pericytes and the mechanism of their recruitment remain unknown. Here, we show a new source of cerebrovascular pericytes during neurogenesis. In the CNS of embryonic day 10.5 mouse embryos, CD31+F4/80+ hematopoietic lineage cells were observed in the avascular region around the dorsal midline of the developing midbrain. These cells expressed additional macrophage markers such as CD206 and CD11b. Moreover, the CD31+F4/80+ cells phagocytosed apoptotic cells as functionally matured macrophages, adhered to the newly formed subventricular vascular plexus, and then divided into daughter cells. Eventually, these CD31+F4/80+ cells transdifferentiated into NG2/PDGFRβ/desmin-expressing cerebrovascular pericytes, enwrapping and associating with vascular endothelial cells. These data indicate that a subset of cerebrovascular pericytes derive from mature macrophages in the very early phase of CNS vascular development, which in turn are recruited from sites of embryonic hematopoiesis such as the yolk sac by way of blood flow. More... »

PAGES

3855

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

7

Author Affiliations

  • Department of Pathology, University of Toyama, Toyama, Japan
  • Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan
  • Department of Technology Development, Astellas Pharma Tech Co., Ltd., Toyama, Japan
  • Department of Immunobiology and Pharmacological Genetics, University of Toyama, Toyama, Japan
  • JST, PRESTO, Kawaguchi, Saitama, Japan
  • Medical Proteomics Laboratory, Institute of Medical Science, University of Tokyo, Tokyo, Japan
  • Laboratory of Stem Cell and Neuro-Vascular Biology, Genetics and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Maryland, USA
  • Department of Pharmacology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
  • Laboratry for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
  • Division for Health Service Promotion, The University of Tokyo, Tokyo, Japan
  • Departments of Pharmacology, Weill Cornell Medical College, New York, USA
  • Genome Biotechnology Laboratory, Kanazawa Institute of Technology, Ishikawa, Japan
  • Department of Integrative Neuroscience, University of Toyama, Toyama, Japan
  • First Department of Internal Medicine, University of Toyama, Toyama, Japan
  • Faculty of Medicine, School of Nursing, Hamamatsu University School of Medicine, Shizuoka, Japan
  • Department of Anesthesiology, Graduate School of Medicine, Aichi Medical University, Aichi, Japan
  • Department of Cardiovascular Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
  • Toyama Prefectural Institute for Pharmaceutical Research, Toyama, Japan
  • Medical Genome Center, Center for Geriatrics and Gerontology, Aichi, Japan
  • Department of Emergency and Critical Care Medicine, Nagoya University, Nagoya, Japan
  • Department of Research and Education, Jobu University, Gunma, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-03994-1

    DOI

    http://dx.doi.org/10.1038/s41598-017-03994-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1086057712

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28634350


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