miR-200c-driven Mesenchymal-To-Epithelial Transition is a Therapeutic Target in Uterine Carcinosarcomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Jill H. Tseng, Maria Bisogna, Lien N. Hoang, Narciso Olvera, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Anil K. Sood, Douglas A. Levine, Petar Jelinic

ABSTRACT

Uterine carcinosarcomas (UCSs) are highly aggressive malignancies associated with poor prognoses and limited treatment options. These tumors are hypothesized to develop from the endometrial adenocarcinoma (EAC) through epithelial-mesenchymal transition (EMT). We test this long-standing hypothesis by depleting miR-200, a family of microRNAs critical for EMT, in EAC cell lines. Our data suggest that UCSs do not develop from EACs via EMT. Clinically more relevant, we show that miR-200 expression in UCS cells induces a robust mesenchymal-epithelial transition (MET). Using in vitro and murine xenograft models, we demonstrate decreased growth and aggressiveness of miR-200-overexpressing UCS cell lines. Whole transcriptome analysis confirmed changes consistent with an MET and also revealed changes in angiogenic genes expression. Finally, by treatment of UCS-xenografted mice with miR-200c incorporated in DOPC nanoliposomes, we demonstrate anti-tumor activities. These findings suggest that ectopic miR-200 expression using advanced microRNA therapeutics may be a potential treatment approach for patients with UCS. More... »

PAGES

3614

References to SciGraph publications

  • 2010-08. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer in ONCOGENE
  • 2009-01. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources in NATURE PROTOCOLS
  • 2014-12. Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes in NATURE COMMUNICATIONS
  • 2008-05. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 in NATURE CELL BIOLOGY
  • 2016-01. miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes in ONCOGENE
  • 2006-08. Immunophenotypic diversity of endometrial adenocarcinomas: implications for differential diagnosis in MODERN PATHOLOGY
  • 2013-05-01. Integrated genomic characterization of endometrial carcinoma in NATURE
  • 2013-12. Tumour angiogenesis regulation by the miR-200 family in NATURE COMMUNICATIONS
  • 2014-05. Tumour-initiating capacity is independent of epithelial–mesenchymal transition status in breast cancer cell lines in BRITISH JOURNAL OF CANCER
  • 2009-02. TGF-β-induced epithelial to mesenchymal transition in CELL RESEARCH
  • 2011-12. Stressed tumor cell, chemosensitized cancer in NATURE MEDICINE
  • 2016-04-04. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer in NATURE COMMUNICATIONS
  • 2015-11. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance in NATURE
  • 2014-03. Molecular mechanisms of epithelial–mesenchymal transition in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-03972-7

    DOI

    http://dx.doi.org/10.1038/s41598-017-03972-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085969896

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28620240


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Memorial Sloan Kettering Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tseng", 
            "givenName": "Jill H.", 
            "id": "sg:person.01103610460.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103610460.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Memorial Sloan Kettering Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bisogna", 
            "givenName": "Maria", 
            "id": "sg:person.01165557174.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165557174.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Memorial Sloan Kettering Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Pathology, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hoang", 
            "givenName": "Lien N.", 
            "id": "sg:person.01073423372.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073423372.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University Langone Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.240324.3", 
              "name": [
                "Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Olvera", 
            "givenName": "Narciso", 
            "id": "sg:person.0621167576.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621167576.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Experimental Therapeutics, 77030, Houston, TX, USA", 
                "Center for RNA Interference and Non-Coding RNA, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rodriguez-Aguayo", 
            "givenName": "Cristian", 
            "id": "sg:person.01257563174.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257563174.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Experimental Therapeutics, 77030, Houston, TX, USA", 
                "Center for RNA Interference and Non-Coding RNA, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lopez-Berestein", 
            "givenName": "Gabriel", 
            "id": "sg:person.0650504273.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650504273.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Center for RNA Interference and Non-Coding RNA, 77030, Houston, TX, USA", 
                "Department of Gynecologic Oncology and Reproductive Medicine, 77030, Houston, TX, USA", 
                "Department of Cancer Biology, University of Texas, MD Anderson, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sood", 
            "givenName": "Anil K.", 
            "id": "sg:person.01074353043.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074353043.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University Langone Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.240324.3", 
              "name": [
                "Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Levine", 
            "givenName": "Douglas A.", 
            "id": "sg:person.0632441651.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632441651.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University Langone Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.240324.3", 
              "name": [
                "Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, 10016, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jelinic", 
            "givenName": "Petar", 
            "id": "sg:person.01276460476.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276460476.98"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrm3758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000491787", 
              "https://doi.org/10.1038/nrm3758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.4289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002019487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003528429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1525-1438.1999.09905.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003728198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1640608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004123559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2009.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004224732", 
              "https://doi.org/10.1038/cr.2009.5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3181161ba3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004825114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pas.0b013e3181161ba3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004825114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004984574", 
              "https://doi.org/10.1038/nature12113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007511382", 
              "https://doi.org/10.1038/modpathol.3800620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007511382", 
              "https://doi.org/10.1038/modpathol.3800620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-1558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007656844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0050469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008684442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.1994.tb00512.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008955322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.1994.tb00512.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008955322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2014.79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009500801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2010/821717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009629786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-15-0876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017152601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/his.12057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017330701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2014.153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017928019", 
              "https://doi.org/10.1038/bjc.2014.153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2015.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020145005", 
              "https://doi.org/10.1038/onc.2015.69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020707098", 
              "https://doi.org/10.1038/onc.2010.215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020707098", 
              "https://doi.org/10.1038/onc.2010.215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-12-0463", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022470651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.4056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023283092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023912062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023912062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2006.06.4907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024658278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci39104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026879393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci39104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026879393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.drudis.2015.08.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029568684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.m110.000240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031251742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(19961215)78:12<2543::aid-cncr14>3.0.co;2-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031324123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004347-199001000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032393398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004347-199001000-00001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032393398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0090-8258(89)90176-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037171595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djs345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037640504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0046-8177(98)90394-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038610994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039214086", 
              "https://doi.org/10.1038/nm.2593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039214086", 
              "https://doi.org/10.1038/nm.2593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2008.211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039987283", 
              "https://doi.org/10.1038/nprot.2008.211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199712)183:4<424::aid-path949>3.0.co;2-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040970761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199712)183:4<424::aid-path949>3.0.co;2-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040970761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041615476", 
              "https://doi.org/10.1038/ncomms6006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045603885", 
              "https://doi.org/10.1038/nature15748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0046-8177(93)90291-n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046401353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms11169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046416991", 
              "https://doi.org/10.1038/ncomms11169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047429448", 
              "https://doi.org/10.1038/ncb1722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms3427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049966583", 
              "https://doi.org/10.1038/ncomms3427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2015.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050620379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2015.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050620379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2015.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050620379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2015.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050620379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.semdp.2010.09.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050859718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0083991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051411545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0010105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052307269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0010105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052307269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19870515)59:10<1781::aid-cncr2820591017>3.0.co;2-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053686010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000478-199603000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060121998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/0929867311320290004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069163199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/rna.5.3.6558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072310391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075287162", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080270330", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083182839", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/030089169808400316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083296394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/030089169808400316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083296394"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12", 
        "datePublishedReg": "2017-12-01", 
        "description": "Uterine carcinosarcomas (UCSs) are highly aggressive malignancies associated with poor prognoses and limited treatment options. These tumors are hypothesized to develop from the endometrial adenocarcinoma (EAC) through epithelial-mesenchymal transition (EMT). We test this long-standing hypothesis by depleting miR-200, a family of microRNAs critical for EMT, in EAC cell lines. Our data suggest that UCSs do not develop from EACs via EMT. Clinically more relevant, we show that miR-200 expression in UCS cells induces a robust mesenchymal-epithelial transition (MET). Using in vitro and murine xenograft models, we demonstrate decreased growth and aggressiveness of miR-200-overexpressing UCS cell lines. Whole transcriptome analysis confirmed changes consistent with an MET and also revealed changes in angiogenic genes expression. Finally, by treatment of UCS-xenografted mice with miR-200c incorporated in DOPC nanoliposomes, we demonstrate anti-tumor activities. These findings suggest that ectopic miR-200 expression using advanced microRNA therapeutics may be a potential treatment approach for patients with UCS.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-017-03972-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2440196", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438793", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "miR-200c-driven Mesenchymal-To-Epithelial Transition is a Therapeutic Target in Uterine Carcinosarcomas", 
        "pagination": "3614", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "417ec65833d78acd3e2f370b52dc912b828dead42acc29fb801dc024ed1f3485"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28620240"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-017-03972-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085969896"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-017-03972-7", 
          "https://app.dimensions.ai/details/publication/pub.1085969896"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:27", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000493.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-017-03972-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-03972-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-03972-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-03972-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-03972-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    309 TRIPLES      21 PREDICATES      81 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-017-03972-7 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N04cea5098de646aea49220e95d531447
    4 schema:citation sg:pub.10.1038/bjc.2014.153
    5 sg:pub.10.1038/cr.2009.5
    6 sg:pub.10.1038/modpathol.3800620
    7 sg:pub.10.1038/nature12113
    8 sg:pub.10.1038/nature15748
    9 sg:pub.10.1038/ncb1722
    10 sg:pub.10.1038/ncomms11169
    11 sg:pub.10.1038/ncomms3427
    12 sg:pub.10.1038/ncomms6006
    13 sg:pub.10.1038/nm.2593
    14 sg:pub.10.1038/nprot.2008.211
    15 sg:pub.10.1038/nrm3758
    16 sg:pub.10.1038/onc.2010.215
    17 sg:pub.10.1038/onc.2015.69
    18 https://app.dimensions.ai/details/publication/pub.1075287162
    19 https://app.dimensions.ai/details/publication/pub.1080270330
    20 https://app.dimensions.ai/details/publication/pub.1083182839
    21 https://doi.org/10.1002/(sici)1096-9896(199712)183:4<424::aid-path949>3.0.co;2-l
    22 https://doi.org/10.1002/(sici)1097-0142(19961215)78:12<2543::aid-cncr14>3.0.co;2-w
    23 https://doi.org/10.1002/1097-0142(19870515)59:10<1781::aid-cncr2820591017>3.0.co;2-3
    24 https://doi.org/10.1002/gcc.20947
    25 https://doi.org/10.1002/path.2802
    26 https://doi.org/10.1002/path.4056
    27 https://doi.org/10.1002/path.4289
    28 https://doi.org/10.1016/0046-8177(93)90291-n
    29 https://doi.org/10.1016/0090-8258(89)90176-5
    30 https://doi.org/10.1016/j.addr.2015.01.007
    31 https://doi.org/10.1016/j.drudis.2015.08.005
    32 https://doi.org/10.1016/s0046-8177(98)90394-x
    33 https://doi.org/10.1038/mt.2014.79
    34 https://doi.org/10.1046/j.1525-1438.1999.09905.x
    35 https://doi.org/10.1053/j.semdp.2010.09.005
    36 https://doi.org/10.1074/mcp.m110.000240
    37 https://doi.org/10.1093/jnci/djs345
    38 https://doi.org/10.1097/00000478-199603000-00003
    39 https://doi.org/10.1097/00004347-199001000-00001
    40 https://doi.org/10.1097/pas.0b013e3181161ba3
    41 https://doi.org/10.1101/gad.1640608
    42 https://doi.org/10.1111/his.12057
    43 https://doi.org/10.1111/j.1365-2559.1994.tb00512.x
    44 https://doi.org/10.1155/2010/821717
    45 https://doi.org/10.1158/1078-0432.ccr-12-1558
    46 https://doi.org/10.1158/1078-0432.ccr-15-0876
    47 https://doi.org/10.1158/1535-7163.mct-12-0463
    48 https://doi.org/10.1172/jci39104
    49 https://doi.org/10.1177/030089169808400316
    50 https://doi.org/10.1200/jco.2006.06.4907
    51 https://doi.org/10.1371/journal.pone.0010105
    52 https://doi.org/10.1371/journal.pone.0050469
    53 https://doi.org/10.1371/journal.pone.0083991
    54 https://doi.org/10.2174/0929867311320290004
    55 https://doi.org/10.4161/rna.5.3.6558
    56 schema:datePublished 2017-12
    57 schema:datePublishedReg 2017-12-01
    58 schema:description Uterine carcinosarcomas (UCSs) are highly aggressive malignancies associated with poor prognoses and limited treatment options. These tumors are hypothesized to develop from the endometrial adenocarcinoma (EAC) through epithelial-mesenchymal transition (EMT). We test this long-standing hypothesis by depleting miR-200, a family of microRNAs critical for EMT, in EAC cell lines. Our data suggest that UCSs do not develop from EACs via EMT. Clinically more relevant, we show that miR-200 expression in UCS cells induces a robust mesenchymal-epithelial transition (MET). Using in vitro and murine xenograft models, we demonstrate decreased growth and aggressiveness of miR-200-overexpressing UCS cell lines. Whole transcriptome analysis confirmed changes consistent with an MET and also revealed changes in angiogenic genes expression. Finally, by treatment of UCS-xenografted mice with miR-200c incorporated in DOPC nanoliposomes, we demonstrate anti-tumor activities. These findings suggest that ectopic miR-200 expression using advanced microRNA therapeutics may be a potential treatment approach for patients with UCS.
    59 schema:genre research_article
    60 schema:inLanguage en
    61 schema:isAccessibleForFree true
    62 schema:isPartOf Nb567f760b0cf401a88285c4a3eade29c
    63 Nc264502c1e4d4a0ab7112a3189f1142d
    64 sg:journal.1045337
    65 schema:name miR-200c-driven Mesenchymal-To-Epithelial Transition is a Therapeutic Target in Uterine Carcinosarcomas
    66 schema:pagination 3614
    67 schema:productId N124c8d05813f40bb8e18e82ee327900b
    68 N466efb915bc246518f5866e36de4f9a1
    69 Na08e53404a804c8bbb34ef1bf6a2987c
    70 Nb04d279449244d32bfba5ee4f86e7a17
    71 Nf66981e9dcff418c922d601fcef42a01
    72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085969896
    73 https://doi.org/10.1038/s41598-017-03972-7
    74 schema:sdDatePublished 2019-04-10T17:27
    75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    76 schema:sdPublisher N57de3d242ecc499ebbb3e2b1b27ba8f5
    77 schema:url https://www.nature.com/articles/s41598-017-03972-7
    78 sgo:license sg:explorer/license/
    79 sgo:sdDataset articles
    80 rdf:type schema:ScholarlyArticle
    81 N04cea5098de646aea49220e95d531447 rdf:first sg:person.01103610460.17
    82 rdf:rest Na044b241565349e88194e7a0ed85de04
    83 N124c8d05813f40bb8e18e82ee327900b schema:name pubmed_id
    84 schema:value 28620240
    85 rdf:type schema:PropertyValue
    86 N1677f9f8050d4bdc8572f1afc1466b79 rdf:first sg:person.01073423372.37
    87 rdf:rest Nab7b284d896641f3be05430b269f99cf
    88 N1b1b6e82e9674cb5b60f88aeceed12f2 rdf:first sg:person.0632441651.51
    89 rdf:rest Nc811d25d80954432bf56fdfa251d8fe3
    90 N466efb915bc246518f5866e36de4f9a1 schema:name nlm_unique_id
    91 schema:value 101563288
    92 rdf:type schema:PropertyValue
    93 N5308f6de80a446aca705a6919d2d2c7e schema:name Center for RNA Interference and Non-Coding RNA, 77030, Houston, TX, USA
    94 Department of Experimental Therapeutics, 77030, Houston, TX, USA
    95 rdf:type schema:Organization
    96 N57de3d242ecc499ebbb3e2b1b27ba8f5 schema:name Springer Nature - SN SciGraph project
    97 rdf:type schema:Organization
    98 N8a8dd53dbe2e45e2bb9d0c51985d3c16 schema:name Center for RNA Interference and Non-Coding RNA, 77030, Houston, TX, USA
    99 Department of Experimental Therapeutics, 77030, Houston, TX, USA
    100 rdf:type schema:Organization
    101 N8ac4f0612438464eb3c8bf0c6eb6f261 rdf:first sg:person.01257563174.54
    102 rdf:rest Nd20166bfaf414154b48f3a4e50fe18cd
    103 Na044b241565349e88194e7a0ed85de04 rdf:first sg:person.01165557174.37
    104 rdf:rest N1677f9f8050d4bdc8572f1afc1466b79
    105 Na08e53404a804c8bbb34ef1bf6a2987c schema:name doi
    106 schema:value 10.1038/s41598-017-03972-7
    107 rdf:type schema:PropertyValue
    108 Nab7b284d896641f3be05430b269f99cf rdf:first sg:person.0621167576.85
    109 rdf:rest N8ac4f0612438464eb3c8bf0c6eb6f261
    110 Nb04d279449244d32bfba5ee4f86e7a17 schema:name dimensions_id
    111 schema:value pub.1085969896
    112 rdf:type schema:PropertyValue
    113 Nb567f760b0cf401a88285c4a3eade29c schema:issueNumber 1
    114 rdf:type schema:PublicationIssue
    115 Nc264502c1e4d4a0ab7112a3189f1142d schema:volumeNumber 7
    116 rdf:type schema:PublicationVolume
    117 Nc811d25d80954432bf56fdfa251d8fe3 rdf:first sg:person.01276460476.98
    118 rdf:rest rdf:nil
    119 Nd20166bfaf414154b48f3a4e50fe18cd rdf:first sg:person.0650504273.00
    120 rdf:rest Ned6ad2e78392476fbdbb78719ed060bd
    121 Ned6ad2e78392476fbdbb78719ed060bd rdf:first sg:person.01074353043.17
    122 rdf:rest N1b1b6e82e9674cb5b60f88aeceed12f2
    123 Nee89fbaa179b4c4ab8f46f97c1966584 schema:name Center for RNA Interference and Non-Coding RNA, 77030, Houston, TX, USA
    124 Department of Cancer Biology, University of Texas, MD Anderson, 77030, Houston, TX, USA
    125 Department of Gynecologic Oncology and Reproductive Medicine, 77030, Houston, TX, USA
    126 rdf:type schema:Organization
    127 Nf66981e9dcff418c922d601fcef42a01 schema:name readcube_id
    128 schema:value 417ec65833d78acd3e2f370b52dc912b828dead42acc29fb801dc024ed1f3485
    129 rdf:type schema:PropertyValue
    130 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    131 schema:name Medical and Health Sciences
    132 rdf:type schema:DefinedTerm
    133 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    134 schema:name Oncology and Carcinogenesis
    135 rdf:type schema:DefinedTerm
    136 sg:grant.2438793 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-03972-7
    137 rdf:type schema:MonetaryGrant
    138 sg:grant.2440196 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-03972-7
    139 rdf:type schema:MonetaryGrant
    140 sg:journal.1045337 schema:issn 2045-2322
    141 schema:name Scientific Reports
    142 rdf:type schema:Periodical
    143 sg:person.01073423372.37 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
    144 schema:familyName Hoang
    145 schema:givenName Lien N.
    146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073423372.37
    147 rdf:type schema:Person
    148 sg:person.01074353043.17 schema:affiliation Nee89fbaa179b4c4ab8f46f97c1966584
    149 schema:familyName Sood
    150 schema:givenName Anil K.
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074353043.17
    152 rdf:type schema:Person
    153 sg:person.01103610460.17 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
    154 schema:familyName Tseng
    155 schema:givenName Jill H.
    156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103610460.17
    157 rdf:type schema:Person
    158 sg:person.01165557174.37 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
    159 schema:familyName Bisogna
    160 schema:givenName Maria
    161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165557174.37
    162 rdf:type schema:Person
    163 sg:person.01257563174.54 schema:affiliation N8a8dd53dbe2e45e2bb9d0c51985d3c16
    164 schema:familyName Rodriguez-Aguayo
    165 schema:givenName Cristian
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257563174.54
    167 rdf:type schema:Person
    168 sg:person.01276460476.98 schema:affiliation https://www.grid.ac/institutes/grid.240324.3
    169 schema:familyName Jelinic
    170 schema:givenName Petar
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276460476.98
    172 rdf:type schema:Person
    173 sg:person.0621167576.85 schema:affiliation https://www.grid.ac/institutes/grid.240324.3
    174 schema:familyName Olvera
    175 schema:givenName Narciso
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621167576.85
    177 rdf:type schema:Person
    178 sg:person.0632441651.51 schema:affiliation https://www.grid.ac/institutes/grid.240324.3
    179 schema:familyName Levine
    180 schema:givenName Douglas A.
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632441651.51
    182 rdf:type schema:Person
    183 sg:person.0650504273.00 schema:affiliation N5308f6de80a446aca705a6919d2d2c7e
    184 schema:familyName Lopez-Berestein
    185 schema:givenName Gabriel
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650504273.00
    187 rdf:type schema:Person
    188 sg:pub.10.1038/bjc.2014.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017928019
    189 https://doi.org/10.1038/bjc.2014.153
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1038/cr.2009.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004224732
    192 https://doi.org/10.1038/cr.2009.5
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/modpathol.3800620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007511382
    195 https://doi.org/10.1038/modpathol.3800620
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/nature12113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004984574
    198 https://doi.org/10.1038/nature12113
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/nature15748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045603885
    201 https://doi.org/10.1038/nature15748
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/ncb1722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047429448
    204 https://doi.org/10.1038/ncb1722
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/ncomms11169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046416991
    207 https://doi.org/10.1038/ncomms11169
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/ncomms3427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049966583
    210 https://doi.org/10.1038/ncomms3427
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/ncomms6006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041615476
    213 https://doi.org/10.1038/ncomms6006
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/nm.2593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039214086
    216 https://doi.org/10.1038/nm.2593
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nprot.2008.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039987283
    219 https://doi.org/10.1038/nprot.2008.211
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/nrm3758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000491787
    222 https://doi.org/10.1038/nrm3758
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/onc.2010.215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020707098
    225 https://doi.org/10.1038/onc.2010.215
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/onc.2015.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020145005
    228 https://doi.org/10.1038/onc.2015.69
    229 rdf:type schema:CreativeWork
    230 https://app.dimensions.ai/details/publication/pub.1075287162 schema:CreativeWork
    231 https://app.dimensions.ai/details/publication/pub.1080270330 schema:CreativeWork
    232 https://app.dimensions.ai/details/publication/pub.1083182839 schema:CreativeWork
    233 https://doi.org/10.1002/(sici)1096-9896(199712)183:4<424::aid-path949>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1040970761
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1002/(sici)1097-0142(19961215)78:12<2543::aid-cncr14>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1031324123
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1002/1097-0142(19870515)59:10<1781::aid-cncr2820591017>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053686010
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1002/gcc.20947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003528429
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1002/path.2802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023912062
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1002/path.4056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023283092
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1002/path.4289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002019487
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/0046-8177(93)90291-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1046401353
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/0090-8258(89)90176-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037171595
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.addr.2015.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050620379
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.drudis.2015.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029568684
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/s0046-8177(98)90394-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038610994
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1038/mt.2014.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009500801
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1046/j.1525-1438.1999.09905.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003728198
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1053/j.semdp.2010.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050859718
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1074/mcp.m110.000240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031251742
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1093/jnci/djs345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037640504
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1097/00000478-199603000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060121998
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1097/00004347-199001000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032393398
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1097/pas.0b013e3181161ba3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004825114
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1101/gad.1640608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004123559
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1111/his.12057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017330701
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1111/j.1365-2559.1994.tb00512.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008955322
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1155/2010/821717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009629786
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1158/1078-0432.ccr-12-1558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007656844
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1158/1078-0432.ccr-15-0876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017152601
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1158/1535-7163.mct-12-0463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022470651
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1172/jci39104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026879393
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1177/030089169808400316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083296394
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1200/jco.2006.06.4907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024658278
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1371/journal.pone.0010105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052307269
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1371/journal.pone.0050469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008684442
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1371/journal.pone.0083991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051411545
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.2174/0929867311320290004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069163199
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.4161/rna.5.3.6558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072310391
    302 rdf:type schema:CreativeWork
    303 https://www.grid.ac/institutes/grid.240324.3 schema:alternateName New York University Langone Medical Center
    304 schema:name Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, 10016, New York, NY, USA
    305 rdf:type schema:Organization
    306 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
    307 schema:name Department of Pathology, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA
    308 Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA
    309 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...