Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Jinwook Kim, Brooks D. Lindsey, Wei-Yi Chang, Xuming Dai, Joseph M. Stavas, Paul A. Dayton, Xiaoning Jiang

ABSTRACT

Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7 ± 0.15 percent mass loss/min in vitro without any use of thrombolytic drugs. More... »

PAGES

3454

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-03492-4

DOI

http://dx.doi.org/10.1038/s41598-017-03492-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085943276

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28615645


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