Bacteriocin Gene-Trait matching across the complete Lactobacillus Pan-genome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06-14

AUTHORS

Fergus W. J. Collins, Paula M. O’Connor, Orla O’Sullivan, Beatriz Gómez-Sala, Mary C. Rea, Colin Hill, R. Paul Ross

ABSTRACT

Lactobacilli constitute a large genus of Gram-positive lactic acid bacteria which have widespread roles ranging from gut commensals to starters in fermented foods. A combination of in silico and laboratory-based screening allowed us to determine the overall bacteriocin producing potential of representative strains of each species of the genus. The genomes of 175 lactobacilli and 38 associated species were screened for the presence of antimicrobial producing genes and combined with screening for antimicrobial activity against a range of indicators. There also appears to be a link between the strains’ environment and bacteriocin production, with those from the animal and human microbiota encoding over twice as many bacteriocins as those from other sources. Five novel bacteriocins were identified belonging to differing bacteriocin classes, including two-peptide bacteriocins (muricidin and acidocin X) and circular bacteriocins (paracyclicin). In addition, there was a clear clustering of helveticin type bacteriolysins in the Lactobacillus acidophilus group of species. This combined in silico and in vitro approach to screening has demonstrated the true diversity and complexity of bacteriocins across the genus. It also highlights their biological importance in terms of communication and competition between closely related strains in diverse complex microbial environments. More... »

PAGES

3481

References to SciGraph publications

  • 2014-11-18. Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria in BMC GENOMICS
  • 2008-12-01. The dual role of bacteriocins as anti- and probiotics in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2011-08-08. Streptolysin S-like virulence factors: the continuing sagA in NATURE REVIEWS MICROBIOLOGY
  • 2015-09-16. In silico identification of bacteriocin gene clusters in the gastrointestinal tract, based on the Human Microbiome Project’s reference genome database in BMC MICROBIOLOGY
  • 2016-11-21. Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans in SCIENTIFIC REPORTS
  • 2009-04-21. A strain-variable bacteriocin in Bacillus anthracis and Bacillus cereus with repeated Cys-Xaa-Xaa motifs in BIOLOGY DIRECT
  • 2014-01-02. A genome-wide association study of seed protein and oil content in soybean in BMC GENOMICS
  • 2009-11-03. Structure and Mode-of-Action of the Two-Peptide (Class-IIb) Bacteriocins in PROBIOTICS AND ANTIMICROBIAL PROTEINS
  • 2005-10. Bacteriocins: developing innate immunity for food in NATURE REVIEWS MICROBIOLOGY
  • 2010-11-30. In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria in BMC GENOMICS
  • 2009-08-12. Persistence of colicinogenic Escherichia coli in the mouse gastrointestinal tract in BMC MICROBIOLOGY
  • 2016-11-07. Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species in BMC GENOMICS
  • 2012-02-26. The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A in NATURE CHEMICAL BIOLOGY
  • 2012-12-24. Bacteriocins — a viable alternative to antibiotics? in NATURE REVIEWS MICROBIOLOGY
  • 2015-09-29. Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera in NATURE COMMUNICATIONS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-03339-y

    DOI

    http://dx.doi.org/10.1038/s41598-017-03339-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085943267

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28615683


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Bacterial Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bacteriocins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lactobacillus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Operon", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "School of Microbiology, University College Cork, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "Teagasc Food Research Centre, Teagasc Moorepark, Fermoy, Cork, Ireland", 
                "APC Microbiome Institute, University College Cork, Cork, Ireland", 
                "School of Microbiology, University College Cork, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Collins", 
            "givenName": "Fergus W. J.", 
            "id": "sg:person.01161152247.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161152247.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "APC Microbiome Institute, University College Cork, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "Teagasc Food Research Centre, Teagasc Moorepark, Fermoy, Cork, Ireland", 
                "APC Microbiome Institute, University College Cork, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "O\u2019Connor", 
            "givenName": "Paula M.", 
            "id": "sg:person.0721110445.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721110445.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "APC Microbiome Institute, University College Cork, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "Teagasc Food Research Centre, Teagasc Moorepark, Fermoy, Cork, Ireland", 
                "APC Microbiome Institute, University College Cork, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "O\u2019Sullivan", 
            "givenName": "Orla", 
            "id": "sg:person.01204776264.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204776264.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teagasc Food Research Centre, Teagasc Moorepark, Fermoy, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.6435.4", 
              "name": [
                "Teagasc Food Research Centre, Teagasc Moorepark, Fermoy, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "G\u00f3mez-Sala", 
            "givenName": "Beatriz", 
            "id": "sg:person.0766165171.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766165171.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "APC Microbiome Institute, University College Cork, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "Teagasc Food Research Centre, Teagasc Moorepark, Fermoy, Cork, Ireland", 
                "APC Microbiome Institute, University College Cork, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rea", 
            "givenName": "Mary C.", 
            "id": "sg:person.0737720307.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737720307.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Microbiology, University College Cork, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "APC Microbiome Institute, University College Cork, Cork, Ireland", 
                "School of Microbiology, University College Cork, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hill", 
            "givenName": "Colin", 
            "id": "sg:person.01202224511.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202224511.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Microbiology, University College Cork, Cork, Ireland", 
              "id": "http://www.grid.ac/institutes/grid.7872.a", 
              "name": [
                "Teagasc Food Research Centre, Teagasc Moorepark, Fermoy, Cork, Ireland", 
                "APC Microbiome Institute, University College Cork, Cork, Ireland", 
                "School of Microbiology, University College Cork, Cork, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ross", 
            "givenName": "R. Paul", 
            "id": "sg:person.014605670062.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014605670062.43"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00253-008-1726-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046466940", 
              "https://doi.org/10.1007/s00253-008-1726-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms9322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036078654", 
              "https://doi.org/10.1038/ncomms9322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro2624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019971854", 
              "https://doi.org/10.1038/nrmicro2624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12866-015-0515-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006218857", 
              "https://doi.org/10.1186/s12866-015-0515-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-15-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023623483", 
              "https://doi.org/10.1186/1471-2164-15-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046122524", 
              "https://doi.org/10.1038/nchembio.798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro2937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036017430", 
              "https://doi.org/10.1038/nrmicro2937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-016-3224-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035271988", 
              "https://doi.org/10.1186/s12864-016-3224-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro1273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016346318", 
              "https://doi.org/10.1038/nrmicro1273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-11-679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051652260", 
              "https://doi.org/10.1186/1471-2164-11-679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12602-009-9021-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005215375", 
              "https://doi.org/10.1007/s12602-009-9021-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1745-6150-4-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001890620", 
              "https://doi.org/10.1186/1745-6150-4-15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-15-983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030499599", 
              "https://doi.org/10.1186/1471-2164-15-983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep37479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012846919", 
              "https://doi.org/10.1038/srep37479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2180-9-165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043179441", 
              "https://doi.org/10.1186/1471-2180-9-165"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-06-14", 
        "datePublishedReg": "2017-06-14", 
        "description": "Lactobacilli constitute a large genus of Gram-positive lactic acid bacteria which have widespread roles ranging from gut commensals to starters in fermented foods. A combination of in silico and laboratory-based screening allowed us to determine the overall bacteriocin producing potential of representative strains of each species of the genus. The genomes of 175 lactobacilli and 38 associated species were screened for the presence of antimicrobial producing genes and combined with screening for antimicrobial activity against a range of indicators. There also appears to be a link between the strains\u2019 environment and bacteriocin production, with those from the animal and human microbiota encoding over twice as many bacteriocins as those from other sources. Five novel bacteriocins were identified belonging to differing bacteriocin classes, including two-peptide bacteriocins (muricidin and acidocin X) and circular bacteriocins (paracyclicin). In addition, there was a clear clustering of helveticin type bacteriolysins in the Lactobacillus acidophilus group of species. This combined in silico and in vitro approach to screening has demonstrated the true diversity and complexity of bacteriocins across the genus. It also highlights their biological importance in terms of communication and competition between closely related strains in diverse complex microbial environments.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41598-017-03339-y", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7668902", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "keywords": [
          "Gram-positive lactic acid bacteria", 
          "complex microbial environments", 
          "gene-trait matching", 
          "two-peptide bacteriocin", 
          "pan-genome", 
          "Lactobacillus acidophilus group", 
          "largest genus", 
          "true diversity", 
          "bacteriocin class", 
          "widespread role", 
          "circular bacteriocins", 
          "related strains", 
          "microbial environment", 
          "biological importance", 
          "genus", 
          "gut commensals", 
          "lactic acid bacteria", 
          "human microbiota", 
          "representative strains", 
          "novel bacteriocin", 
          "acidophilus group", 
          "clear clustering", 
          "species", 
          "bacteriocin", 
          "acid bacteria", 
          "bacteriocin production", 
          "silico", 
          "genome", 
          "strains", 
          "genes", 
          "diversity", 
          "commensal", 
          "bacteria", 
          "antimicrobial activity", 
          "bacteriolysins", 
          "microbiota", 
          "Lactobacillus", 
          "animals", 
          "screening", 
          "laboratory-based screening", 
          "role", 
          "production", 
          "competition", 
          "environment", 
          "activity", 
          "starter", 
          "food", 
          "presence", 
          "importance", 
          "clustering", 
          "potential", 
          "addition", 
          "link", 
          "combination", 
          "class", 
          "source", 
          "range", 
          "range of indicators", 
          "complexity", 
          "indicators", 
          "group", 
          "approach", 
          "communication", 
          "terms", 
          "matching", 
          "terms of communication"
        ], 
        "name": "Bacteriocin Gene-Trait matching across the complete Lactobacillus Pan-genome", 
        "pagination": "3481", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085943267"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-017-03339-y"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28615683"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-017-03339-y", 
          "https://app.dimensions.ai/details/publication/pub.1085943267"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:32", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_719.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41598-017-03339-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-03339-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-03339-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-03339-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-03339-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    253 TRIPLES      22 PREDICATES      111 URIs      88 LITERALS      11 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-017-03339-y schema:about N42918ca72dbf4029891828fb33abd569
    2 Na9c01cd4759f4e69b40108d2272ed96b
    3 Nd7efe594cf684f99ba3b6b5d51a2fb71
    4 Nf36ff86a35244ee6984ea73b6881f527
    5 anzsrc-for:06
    6 anzsrc-for:0605
    7 schema:author N87ef74ecafe44f9d829e69cb51c1aeb2
    8 schema:citation sg:pub.10.1007/s00253-008-1726-5
    9 sg:pub.10.1007/s12602-009-9021-z
    10 sg:pub.10.1038/nchembio.798
    11 sg:pub.10.1038/ncomms9322
    12 sg:pub.10.1038/nrmicro1273
    13 sg:pub.10.1038/nrmicro2624
    14 sg:pub.10.1038/nrmicro2937
    15 sg:pub.10.1038/srep37479
    16 sg:pub.10.1186/1471-2164-11-679
    17 sg:pub.10.1186/1471-2164-15-1
    18 sg:pub.10.1186/1471-2164-15-983
    19 sg:pub.10.1186/1471-2180-9-165
    20 sg:pub.10.1186/1745-6150-4-15
    21 sg:pub.10.1186/s12864-016-3224-y
    22 sg:pub.10.1186/s12866-015-0515-4
    23 schema:datePublished 2017-06-14
    24 schema:datePublishedReg 2017-06-14
    25 schema:description Lactobacilli constitute a large genus of Gram-positive lactic acid bacteria which have widespread roles ranging from gut commensals to starters in fermented foods. A combination of in silico and laboratory-based screening allowed us to determine the overall bacteriocin producing potential of representative strains of each species of the genus. The genomes of 175 lactobacilli and 38 associated species were screened for the presence of antimicrobial producing genes and combined with screening for antimicrobial activity against a range of indicators. There also appears to be a link between the strains’ environment and bacteriocin production, with those from the animal and human microbiota encoding over twice as many bacteriocins as those from other sources. Five novel bacteriocins were identified belonging to differing bacteriocin classes, including two-peptide bacteriocins (muricidin and acidocin X) and circular bacteriocins (paracyclicin). In addition, there was a clear clustering of helveticin type bacteriolysins in the Lactobacillus acidophilus group of species. This combined in silico and in vitro approach to screening has demonstrated the true diversity and complexity of bacteriocins across the genus. It also highlights their biological importance in terms of communication and competition between closely related strains in diverse complex microbial environments.
    26 schema:genre article
    27 schema:inLanguage en
    28 schema:isAccessibleForFree true
    29 schema:isPartOf N1163c6082aa14736b35c7c67562c1576
    30 N591d77c18fdd451c8eeb935bc628ba76
    31 sg:journal.1045337
    32 schema:keywords Gram-positive lactic acid bacteria
    33 Lactobacillus
    34 Lactobacillus acidophilus group
    35 acid bacteria
    36 acidophilus group
    37 activity
    38 addition
    39 animals
    40 antimicrobial activity
    41 approach
    42 bacteria
    43 bacteriocin
    44 bacteriocin class
    45 bacteriocin production
    46 bacteriolysins
    47 biological importance
    48 circular bacteriocins
    49 class
    50 clear clustering
    51 clustering
    52 combination
    53 commensal
    54 communication
    55 competition
    56 complex microbial environments
    57 complexity
    58 diversity
    59 environment
    60 food
    61 gene-trait matching
    62 genes
    63 genome
    64 genus
    65 group
    66 gut commensals
    67 human microbiota
    68 importance
    69 indicators
    70 laboratory-based screening
    71 lactic acid bacteria
    72 largest genus
    73 link
    74 matching
    75 microbial environment
    76 microbiota
    77 novel bacteriocin
    78 pan-genome
    79 potential
    80 presence
    81 production
    82 range
    83 range of indicators
    84 related strains
    85 representative strains
    86 role
    87 screening
    88 silico
    89 source
    90 species
    91 starter
    92 strains
    93 terms
    94 terms of communication
    95 true diversity
    96 two-peptide bacteriocin
    97 widespread role
    98 schema:name Bacteriocin Gene-Trait matching across the complete Lactobacillus Pan-genome
    99 schema:pagination 3481
    100 schema:productId N3f62dd995f55401ab2ca1a6992d8d71c
    101 Nc35a2f93a99d49eeaaa0ad29ecc6039e
    102 Nfa94ae1a36fb42bd96141295aea04d63
    103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085943267
    104 https://doi.org/10.1038/s41598-017-03339-y
    105 schema:sdDatePublished 2022-05-20T07:32
    106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    107 schema:sdPublisher Nd26e2e4db2ae4ce98c4f58ab45dffabf
    108 schema:url https://doi.org/10.1038/s41598-017-03339-y
    109 sgo:license sg:explorer/license/
    110 sgo:sdDataset articles
    111 rdf:type schema:ScholarlyArticle
    112 N1163c6082aa14736b35c7c67562c1576 schema:issueNumber 1
    113 rdf:type schema:PublicationIssue
    114 N301907c67d8f4e338c9a261c9e11ab0d rdf:first sg:person.01204776264.89
    115 rdf:rest N40767a428eb3407ba5024676dee338b6
    116 N3be3e2b2c5444df4bf62d5bce8c8a348 rdf:first sg:person.014605670062.43
    117 rdf:rest rdf:nil
    118 N3f62dd995f55401ab2ca1a6992d8d71c schema:name doi
    119 schema:value 10.1038/s41598-017-03339-y
    120 rdf:type schema:PropertyValue
    121 N40767a428eb3407ba5024676dee338b6 rdf:first sg:person.0766165171.42
    122 rdf:rest Nc0de03bd216442fd8e29c1495fbd7539
    123 N42918ca72dbf4029891828fb33abd569 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Lactobacillus
    125 rdf:type schema:DefinedTerm
    126 N591d77c18fdd451c8eeb935bc628ba76 schema:volumeNumber 7
    127 rdf:type schema:PublicationVolume
    128 N87ef74ecafe44f9d829e69cb51c1aeb2 rdf:first sg:person.01161152247.43
    129 rdf:rest Nb203862ac85245c7b3b1c168d07cf970
    130 Na101812a9b904ddfbc40d783b436aba4 rdf:first sg:person.01202224511.99
    131 rdf:rest N3be3e2b2c5444df4bf62d5bce8c8a348
    132 Na9c01cd4759f4e69b40108d2272ed96b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Anti-Bacterial Agents
    134 rdf:type schema:DefinedTerm
    135 Nb203862ac85245c7b3b1c168d07cf970 rdf:first sg:person.0721110445.25
    136 rdf:rest N301907c67d8f4e338c9a261c9e11ab0d
    137 Nc0de03bd216442fd8e29c1495fbd7539 rdf:first sg:person.0737720307.11
    138 rdf:rest Na101812a9b904ddfbc40d783b436aba4
    139 Nc35a2f93a99d49eeaaa0ad29ecc6039e schema:name pubmed_id
    140 schema:value 28615683
    141 rdf:type schema:PropertyValue
    142 Nd26e2e4db2ae4ce98c4f58ab45dffabf schema:name Springer Nature - SN SciGraph project
    143 rdf:type schema:Organization
    144 Nd7efe594cf684f99ba3b6b5d51a2fb71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Bacteriocins
    146 rdf:type schema:DefinedTerm
    147 Nf36ff86a35244ee6984ea73b6881f527 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Operon
    149 rdf:type schema:DefinedTerm
    150 Nfa94ae1a36fb42bd96141295aea04d63 schema:name dimensions_id
    151 schema:value pub.1085943267
    152 rdf:type schema:PropertyValue
    153 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    154 schema:name Biological Sciences
    155 rdf:type schema:DefinedTerm
    156 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
    157 schema:name Microbiology
    158 rdf:type schema:DefinedTerm
    159 sg:grant.7668902 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-017-03339-y
    160 rdf:type schema:MonetaryGrant
    161 sg:journal.1045337 schema:issn 2045-2322
    162 schema:name Scientific Reports
    163 schema:publisher Springer Nature
    164 rdf:type schema:Periodical
    165 sg:person.01161152247.43 schema:affiliation grid-institutes:grid.7872.a
    166 schema:familyName Collins
    167 schema:givenName Fergus W. J.
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161152247.43
    169 rdf:type schema:Person
    170 sg:person.01202224511.99 schema:affiliation grid-institutes:grid.7872.a
    171 schema:familyName Hill
    172 schema:givenName Colin
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202224511.99
    174 rdf:type schema:Person
    175 sg:person.01204776264.89 schema:affiliation grid-institutes:grid.7872.a
    176 schema:familyName O’Sullivan
    177 schema:givenName Orla
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204776264.89
    179 rdf:type schema:Person
    180 sg:person.014605670062.43 schema:affiliation grid-institutes:grid.7872.a
    181 schema:familyName Ross
    182 schema:givenName R. Paul
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014605670062.43
    184 rdf:type schema:Person
    185 sg:person.0721110445.25 schema:affiliation grid-institutes:grid.7872.a
    186 schema:familyName O’Connor
    187 schema:givenName Paula M.
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721110445.25
    189 rdf:type schema:Person
    190 sg:person.0737720307.11 schema:affiliation grid-institutes:grid.7872.a
    191 schema:familyName Rea
    192 schema:givenName Mary C.
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737720307.11
    194 rdf:type schema:Person
    195 sg:person.0766165171.42 schema:affiliation grid-institutes:grid.6435.4
    196 schema:familyName Gómez-Sala
    197 schema:givenName Beatriz
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766165171.42
    199 rdf:type schema:Person
    200 sg:pub.10.1007/s00253-008-1726-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046466940
    201 https://doi.org/10.1007/s00253-008-1726-5
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1007/s12602-009-9021-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1005215375
    204 https://doi.org/10.1007/s12602-009-9021-z
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/nchembio.798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046122524
    207 https://doi.org/10.1038/nchembio.798
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/ncomms9322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036078654
    210 https://doi.org/10.1038/ncomms9322
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/nrmicro1273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016346318
    213 https://doi.org/10.1038/nrmicro1273
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/nrmicro2624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019971854
    216 https://doi.org/10.1038/nrmicro2624
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nrmicro2937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036017430
    219 https://doi.org/10.1038/nrmicro2937
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/srep37479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012846919
    222 https://doi.org/10.1038/srep37479
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1186/1471-2164-11-679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051652260
    225 https://doi.org/10.1186/1471-2164-11-679
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1186/1471-2164-15-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023623483
    228 https://doi.org/10.1186/1471-2164-15-1
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1186/1471-2164-15-983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030499599
    231 https://doi.org/10.1186/1471-2164-15-983
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1186/1471-2180-9-165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043179441
    234 https://doi.org/10.1186/1471-2180-9-165
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1186/1745-6150-4-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001890620
    237 https://doi.org/10.1186/1745-6150-4-15
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1186/s12864-016-3224-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1035271988
    240 https://doi.org/10.1186/s12864-016-3224-y
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1186/s12866-015-0515-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006218857
    243 https://doi.org/10.1186/s12866-015-0515-4
    244 rdf:type schema:CreativeWork
    245 grid-institutes:grid.6435.4 schema:alternateName Teagasc Food Research Centre, Teagasc Moorepark, Fermoy, Cork, Ireland
    246 schema:name Teagasc Food Research Centre, Teagasc Moorepark, Fermoy, Cork, Ireland
    247 rdf:type schema:Organization
    248 grid-institutes:grid.7872.a schema:alternateName APC Microbiome Institute, University College Cork, Cork, Ireland
    249 School of Microbiology, University College Cork, Cork, Ireland
    250 schema:name APC Microbiome Institute, University College Cork, Cork, Ireland
    251 School of Microbiology, University College Cork, Cork, Ireland
    252 Teagasc Food Research Centre, Teagasc Moorepark, Fermoy, Cork, Ireland
    253 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...