Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06-01

AUTHORS

Yoo Jin Hong, Heae Surng Park, Jeffrey Kihyun Park, Kyunghwa Han, Chul Hwan Park, Tai Kyung Kim, Sae Jong Yoo, Ji Yeon Lee, Pan Ki Kim, Jin Hur, Hye-Jeong Lee, Young Jin Kim, Young Joo Suh, Mun Young Paek, Byoung Wook Choi

ABSTRACT

A reliable, non-invasive diagnostic method is needed for early detection and serial monitoring of cardiotoxicity, a well-known side effect of chemotherapy. This study aimed to assess the feasibility of T1-mapping cardiac magnetic resonance imaging (CMR) for evaluating subclinical myocardial changes in a doxorubicin-induced cardiotoxicity rabbit model. Adult male New Zealand White rabbits were injected twice-weekly with doxorubicin and subjected to CMR on a clinical 3T MR system before and every 2–4 weeks post-drug administration. Native T1 and extracellular volume (ECV) values were measured at six mid-left ventricle (LV) and specific LV lesions. Histological assessments evaluated myocardial injury and fibrosis. Three pre-model and 11 post-model animals were included. Myocardial injury was observed from 3 weeks. Mean LV myocardium ECV values increased significantly from week 3 before LV ejection fraction decreases (week 6), and ECVs of the RV upper/lower insertion sites and papillary muscle exceeded those of the LV. The mean native T1 value in the mid-LV increased significantly increased from week 6, and LV myocardium ECV correlated strongly with the degree of fibrosis (r = 0.979, p < 0.001). Myocardial T1 mapping, particularly ECV values, reliably and non-invasively detected early cardiotoxicity, allowing serial monitoring of chemotherapy-induced cardiotoxicity. More... »

PAGES

2663

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-02627-x

DOI

http://dx.doi.org/10.1038/s41598-017-02627-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085640590

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28572614


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52 detection
53 diagnostic methods
54 doxorubicin
55 early cardiotoxicity
56 early detection
57 effect
58 ejection fraction decrease
59 extracellular volume values
60 feasibility
61 fibrosis
62 fraction decreases
63 histological assessment
64 imaging
65 injury
66 insertion site
67 lesions
68 magnetic resonance imaging
69 male New Zealand white rabbits
70 mapping
71 mean native T1 value
72 method
73 mid-LV
74 mid-left ventricle
75 model
76 monitoring
77 muscle
78 myocardial T1 mapping
79 myocardial changes
80 myocardial injury
81 native T1
82 native T1 values
83 non-invasive diagnostic method
84 papillary muscles
85 post drug administration
86 rabbit model
87 rabbits
88 resonance imaging
89 serial monitoring
90 side effects
91 sites
92 study
93 subclinical myocardial changes
94 system
95 values
96 ventricle
97 volume values
98 week 3
99 week 6
100 weekly
101 weeks
102 weeks post-drug administration
103 white rabbits
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