Ontology type: schema:ScholarlyArticle Open Access: True
2017-12
AUTHORSA. Deshmukh, S. Kumar, F. Arfuso, P. Newsholme, A. Dharmarajan
ABSTRACTThis study investigated molecular signals essential to sustain cancer stem cells (CSCs) and assessed their activity in the presence of secreted frizzled-related protein 4 (sFRP4) alone or in combination with chemotherapeutic drugs. SFRP4 is a known Wnt antagonist, and is also pro-apoptotic and anti-angiogenic. Additionally, sFRP4 has been demonstrated to confer chemo-sensitization and improve chemotherapeutic efficacy. CSCs were isolated from breast, prostate, and ovary tumor cell lines, and characterized using tumor-specific markers such as CD44+/CD24-/CD133+. The post-transcription data from CSCs that have undergone combinatorial treatment with sFRP4 and chemotherapeutic drugs suggest downregulation of stemness genes and upregulation of pro-apoptotic markers. The post-translational modification of CSCs demonstrated a chemo-sensitization effect of sFRP4 when used in combination with tumor-specific drugs. SFRP4 in combination with doxorubicin/cisplatin reduced the proliferative capacity of the CSC population in vitro. Wnt/β-catenin signaling is important for proliferation and self-renewal of CSCs in association with human tumorigenesis. The silencing of this signaling pathway by the application of sFRP4 suggests potential for improved in vivo chemo-responses. More... »
PAGES2256
http://scigraph.springernature.com/pub.10.1038/s41598-017-02256-4
DOIhttp://dx.doi.org/10.1038/s41598-017-02256-4
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/28536422
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},
{
"name": "nlm_unique_id",
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},
{
"name": "doi",
"type": "PropertyValue",
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},
{
"name": "dimensions_id",
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],
"sameAs": [
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"https://app.dimensions.ai/details/publication/pub.1085530529"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T15:47",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
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"type": "ScholarlyArticle",
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-02256-4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-02256-4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-02256-4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-017-02256-4'
This table displays all metadata directly associated to this object as RDF triples.
301 TRIPLES
21 PREDICATES
90 URIs
21 LITERALS
9 BLANK NODES