Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05-22

AUTHORS

Tea Skaaby, Amy E. Taylor, Rikke K. Jacobsen, Lavinia Paternoster, Betina H. Thuesen, Tarunveer S. Ahluwalia, Sofus C. Larsen, Ang Zhou, Andrew Wong, Maiken E. Gabrielsen, Johan H. Bjørngaard, Claudia Flexeder, Satu Männistö, Rebecca Hardy, Diana Kuh, Sarah J. Barry, Line Tang Møllehave, Charlotte Cerqueira, Nele Friedrich, Tobias N. Bonten, Raymond Noordam, Dennis O. Mook-Kanamori, Christian Taube, Leon E. Jessen, Alex McConnachie, Naveed Sattar, Mark N. Upton, Charles McSharry, Klaus Bønnelykke, Hans Bisgaard, Holger Schulz, Konstantin Strauch, Thomas Meitinger, Annette Peters, Harald Grallert, Ellen A. Nohr, Mika Kivimaki, Meena Kumari, Uwe Völker, Matthias Nauck, Henry Völzke, Chris Power, Elina Hyppönen, Torben Hansen, Torben Jørgensen, Oluf Pedersen, Veikko Salomaa, Niels Grarup, Arnulf Langhammer, Pål R. Romundstad, Frank Skorpen, Jaakko Kaprio, Marcus R Munafò, Allan Linneberg

ABSTRACT

Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of exposures to examine causal effects. We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730. We included 231,020 participants from 22 population-based studies. Observational analyses showed that current vs never smokers had lower risk of hay fever (odds ratio (OR) = 0·68, 95% confidence interval (CI): 0·61, 0·76; P < 0·001) and allergic sensitization (OR = 0·74, 95% CI: 0·64, 0·86; P < 0·001), but similar asthma risk (OR = 1·00, 95% CI: 0·91, 1·09; P = 0·967). Mendelian randomization analyses in current smokers showed a slightly lower risk of hay fever (OR = 0·958, 95% CI: 0·920, 0·998; P = 0·041), a lower risk of allergic sensitization (OR = 0·92, 95% CI: 0·84, 1·02; P = 0·117), but higher risk of asthma (OR = 1·06, 95% CI: 1·01, 1·11; P = 0·020) per smoking-increasing allele. Our results suggest that smoking may be causally related to a higher risk of asthma and a slightly lower risk of hay fever. However, the adverse events associated with smoking limit its clinical significance. More... »

PAGES

2224

References to SciGraph publications

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

7

Author Affiliations

  • Research Centre for Prevention and Health, Centre for Health, Capital Region of Denmark, Copenhagen, Denmark
  • UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, UK
  • MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, UK
  • Steno Diabetes Center Copenhagen, 2820, Gentofte, Denmark
  • Research unit for Dietary Studies, the Parker Institute, Frederiksberg and Bispebjerg Hospitals, The Capital Region, Frederiksberg, Denmark
  • Centre for Population Health Research, School of Health Sciences and Sansom Institute of Health Research, University of South Australia, Adelaide, Australia
  • MRC Unit for Lifelong Health and Ageing at UCL, London, UK
  • Department of laboratory medicine, children’s and women’s health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway
  • Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
  • Institute of Epidemiology I, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
  • Department of Health, National Institute for Health and Welfare, Helsinki, Finland
  • Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
  • Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
  • Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
  • Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
  • Department of BESC, Epidemiology Section, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
  • Department of Pulmonary Medicine, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany
  • Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
  • Institute of Cardiovascular and Medical Sciences & Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
  • Helmsley Medical Centre, Helmsley, York, UK
  • Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
  • Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research, Munich, Germany
  • Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
  • German Center for Cardiovascular Research (DZHK e.V.), Partner Site Munich Heart Alliance, München, Germany
  • Research Unit Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
  • Institute of Epidemiology II, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
  • Research Unit for Gynaecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
  • Department of Epidemiology & Public Health, University College London, London, UK
  • ISER, University of Essex, Colchester, UK
  • Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany
  • Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
  • Population, Policy and Practice, University College London Institute of Child Health, London, UK
  • South Australian Health and Medical Research Institute, Adelaide, Australia
  • The Novo Nordisk Foundation Center for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • Faculty of Medicine, Aalborg University, Aalborg, Denmark
  • National Institute for Health and Welfare, Dept. of Health, Helsinki, Finland
  • HUNT Research Centre, Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Norwegian, Norway
  • University of Helsinki, Institute for Molecular Medicine, Helsinki, Finland
  • Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-01977-w

    DOI

    http://dx.doi.org/10.1038/s41598-017-01977-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085461702

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28533558


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