Rapid generation of a transgene-free powdery mildew resistant tomato by genome deletion View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Vladimir Nekrasov, Congmao Wang, Joe Win, Christa Lanz, Detlef Weigel, Sophien Kamoun

ABSTRACT

Genome editing has emerged as a technology with a potential to revolutionize plant breeding. In this study, we report on generating, in less than ten months, Tomelo, a non-transgenic tomato variety resistant to the powdery mildew fungal pathogen using the CRISPR/Cas9 technology. We used whole-genome sequencing to show that Tomelo does not carry any foreign DNA sequences but only carries a deletion that is indistinguishable from naturally occurring mutations. We also present evidence for CRISPR/Cas9 being a highly precise tool, as we did not detect off-target mutations in Tomelo. Using our pipeline, mutations can be readily introduced into elite or locally adapted tomato varieties in less than a year with relatively minimal effort and investment. More... »

PAGES

482

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-00578-x

DOI

http://dx.doi.org/10.1038/s41598-017-00578-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084130705

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28352080


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