Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-07

AUTHORS

Tristan Pascart, Guillaume Falgayrac, Henri Migaud, Jean-François Quinchon, Laurène Norberciak, Jean-François Budzik, Julien Paccou, Anne Cotten, Guillaume Penel, Bernard Cortet

ABSTRACT

Non-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting a young population as the peak age of diagnosis is in the 40 s. The natural history of non-traumatic ON leads to a collapse of the femoral head requiring prosthetic replacement in a 60% of cases. Although trabecular bone involvement in the collapse is suspected, the underlying modifications induced at a molecular level have not been explored in humans. Here, we examine changes in the molecular composition and structure of bone as evaluated by Raman spectroscopy in human end-stage ON. Comparing samples from femoral heads harvested from 11 patients and 11 cadaveric controls, we show that the mineral and organic chemical composition of trabecular bone in ON is not modified apart from age-related differences. We also show that the molecular composition in the necrotic part of the femoral head is not different from the composition of the remaining ‘healthy’ trabecular bone of the femoral head. These findings support that quality of trabecular bone is not modified during ON despite extensive bone marrow necrosis and osteocyte death observed even in the ‘healthy’ zones on histological examination. More... »

PAGES

97

References to SciGraph publications

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  • 2011-02-22. Experimental animal models of osteonecrosis in RHEUMATOLOGY INTERNATIONAL
  • 2015-01-07. Contributions of Raman spectroscopy to the understanding of bone strength in BONEKEY REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-017-00162-3

    DOI

    http://dx.doi.org/10.1038/s41598-017-00162-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084130299

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28273910


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    30 schema:description Non-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting a young population as the peak age of diagnosis is in the 40 s. The natural history of non-traumatic ON leads to a collapse of the femoral head requiring prosthetic replacement in a 60% of cases. Although trabecular bone involvement in the collapse is suspected, the underlying modifications induced at a molecular level have not been explored in humans. Here, we examine changes in the molecular composition and structure of bone as evaluated by Raman spectroscopy in human end-stage ON. Comparing samples from femoral heads harvested from 11 patients and 11 cadaveric controls, we show that the mineral and organic chemical composition of trabecular bone in ON is not modified apart from age-related differences. We also show that the molecular composition in the necrotic part of the femoral head is not different from the composition of the remaining ‘healthy’ trabecular bone of the femoral head. These findings support that quality of trabecular bone is not modified during ON despite extensive bone marrow necrosis and osteocyte death observed even in the ‘healthy’ zones on histological examination.
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