Serum resistin is causally related to mortality risk in patients with type 2 diabetes: preliminary evidences from genetic data View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-03

AUTHORS

Andrea Fontana, Lorena Ortega Moreno, Olga Lamacchia, Concetta De Bonis, Lucia Salvemini, Salvatore De Cosmo, Mauro Cignarelli, Massimiliano Copetti, Vincenzo Trischitta, Claudia Menzaghi

ABSTRACT

Resistin has been firmly associated with all-cause mortality. We investigated, whether, in patients with type 2 diabetes (T2D), this association is sustained by a cause-effect relationship. A genotype risk score (GRS), created by summing the number of resistin increasing alleles of two genome-wide association studies (GWAS)-derived single nucleotide polymorphisms (SNPs), serum resistin measurements and all-cause death records were obtained in 1,479 (403 events/12,454 person-years), patients with T2D from three cohorts, Gargano Heart Study-prospective design (n = 350), Gargano Mortality Study (n = 698) and Foggia Mortality Study (n = 431), from Italy. GRS was strongly associated with serum resistin in a non-linear fashion (overall p = 3.5 * 10-7) with effect size modest for GRS = 1 and 2 and much higher for GRS >3, with respect to GRS = 0. A significant non-linear association was observed also between GRS and all-cause mortality (overall p = 3.3 * 10-2), with a low effect size for GRS = 1 and 2, and nearly doubled for GRS ≥ 3, with respect to GRS = 0. Based on the above-reported associations, each genetic equivalent SD increase in log-resistin levels showed a causal hazard ratio of all-cause mortality equal to 2.17 (95%CI: 1.22-3.87), thus providing evidence for a causal role of resistin in shaping the risk of mortality in diabetic patients. More... »

PAGES

61

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-017-00138-3

DOI

http://dx.doi.org/10.1038/s41598-017-00138-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084130275

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28246403


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