Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Lucas Patel, Rhea Kang, Scott C. Rosenberg, Yunjiang Qiu, Ramya Raviram, Sora Chee, Rong Hu, Bing Ren, Francesca Cole, Kevin D. Corbett

ABSTRACT

In meiotic prophase, chromosomes are organized into compacted loop arrays to promote homolog pairing and recombination. Here, we probe the architecture of the mouse spermatocyte genome in early and late meiotic prophase using chromosome conformation capture (Hi-C). Our data support the established loop array model of meiotic chromosomes, and infer loops averaging 0.8-1.0 megabase pairs (Mb) in early prophase and extending to 1.5-2.0 Mb in late prophase as chromosomes compact and homologs undergo synapsis. Topologically associating domains (TADs) are lost in meiotic prophase, suggesting that assembly of the meiotic chromosome axis alters the activity of chromosome-associated cohesin complexes. While TADs are lost, physically separated A and B compartments are maintained in meiotic prophase. Moreover, meiotic DNA breaks and interhomolog crossovers preferentially form in the gene-dense A compartment, revealing a role for chromatin organization in meiotic recombination. Finally, direct detection of interhomolog contacts genome-wide reveals the structural basis for homolog alignment and juxtaposition by the synaptonemal complex. More... »

PAGES

164-174

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41594-019-0187-0

    DOI

    http://dx.doi.org/10.1038/s41594-019-0187-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112197917

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30778236


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