Ontology type: schema:ScholarlyArticle
2018-07
AUTHORSHidetsugu Asada, Shoichiro Horita, Kunio Hirata, Mitsunori Shiroishi, Yuki Shiimura, Hiroko Iwanari, Takao Hamakubo, Tatsuro Shimamura, Norimichi Nomura, Osamu Kusano-Arai, Tomoko Uemura, Chiyo Suno, Takuya Kobayashi, So Iwata
ABSTRACTAngiotensin II (AngII) plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngII and the G-protein-coupled receptors (GPCRs) AngII type 1 receptor (AT1R) and AngII type 2 receptor (AT2R). We have solved the crystal structure of human AT2R binding the peptide ligand [Sar1, Ile8]AngII and its specific antibody at 3.2-Å resolution. [Sar1, Ile8]AngII interacts with both the 'core' binding domain, where the small-molecule ligands of AT1R and AT2R bind, and the 'extended' binding domain, which is equivalent to the allosteric modulator binding site of muscarinic acetylcholine receptor. We generated an antibody fragment to stabilize the extended binding domain that functions as a positive allosteric modulator. We also identified a signature positively charged cluster, which is conserved among peptide-binding receptors, to locate C termini at the bottom of the binding pocket. The reported results should help with designing ligands for angiotensin receptors and possibly to other peptide GPCRs. More... »
PAGES570-576
http://scigraph.springernature.com/pub.10.1038/s41594-018-0079-8
DOIhttp://dx.doi.org/10.1038/s41594-018-0079-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1105180709
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29967536
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Pharmacology and Pharmaceutical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Kyoto University",
"id": "https://www.grid.ac/institutes/grid.258799.8",
"name": [
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Asada",
"givenName": "Hidetsugu",
"id": "sg:person.0615102152.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615102152.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyoto University",
"id": "https://www.grid.ac/institutes/grid.258799.8",
"name": [
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Horita",
"givenName": "Shoichiro",
"id": "sg:person.01105557461.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105557461.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Japan Science and Technology Agency",
"id": "https://www.grid.ac/institutes/grid.419082.6",
"name": [
"RIKEN, SPring-8 Center, Hyogo, Japan",
"Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO), Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Hirata",
"givenName": "Kunio",
"id": "sg:person.01256470305.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256470305.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyushu University",
"id": "https://www.grid.ac/institutes/grid.177174.3",
"name": [
"Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Shiroishi",
"givenName": "Mitsunori",
"id": "sg:person.01217320452.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217320452.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kurume University",
"id": "https://www.grid.ac/institutes/grid.410781.b",
"name": [
"Molecular Genetics, Institute of Life Science, Kurume University, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Shiimura",
"givenName": "Yuki",
"id": "sg:person.01272401021.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272401021.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Iwanari",
"givenName": "Hiroko",
"id": "sg:person.0667121234.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667121234.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Hamakubo",
"givenName": "Takao",
"id": "sg:person.01041036543.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041036543.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyoto University",
"id": "https://www.grid.ac/institutes/grid.258799.8",
"name": [
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Shimamura",
"givenName": "Tatsuro",
"id": "sg:person.01072476103.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072476103.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyoto University",
"id": "https://www.grid.ac/institutes/grid.258799.8",
"name": [
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Nomura",
"givenName": "Norimichi",
"id": "sg:person.016142502205.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016142502205.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Kusano-Arai",
"givenName": "Osamu",
"id": "sg:person.01134532745.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134532745.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyoto University",
"id": "https://www.grid.ac/institutes/grid.258799.8",
"name": [
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Uemura",
"givenName": "Tomoko",
"id": "sg:person.0625327152.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625327152.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyoto University",
"id": "https://www.grid.ac/institutes/grid.258799.8",
"name": [
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Suno",
"givenName": "Chiyo",
"id": "sg:person.01305506430.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305506430.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Japan Science and Technology Agency",
"id": "https://www.grid.ac/institutes/grid.419082.6",
"name": [
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan",
"Japan Agency for Medical Research and Development (AMED), Core Research for Evolutional Science and Technology (CREST), Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Kobayashi",
"givenName": "Takuya",
"id": "sg:person.0676254044.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676254044.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan",
"RIKEN, SPring-8 Center, Hyogo, Japan"
],
"type": "Organization"
},
"familyName": "Iwata",
"givenName": "So",
"id": "sg:person.01337410152.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337410152.19"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.str.2012.04.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002549522"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1124/mol.63.6.1256",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003054041"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444913012274",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004081535"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuropharm.2010.07.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004860729"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1124/pr.114.010454",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005174455"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2015.04.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005670140"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2015.04.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005670140"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcc.21303",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007257888"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jcc.21303",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007257888"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909047374",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008344603"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909047374",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008344603"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.82.7.1881",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010735838"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0014-2999(97)01549-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013204869"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444905036693",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013232159"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1218231",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014005434"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cardiores.2003.12.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014869176"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1530/jme-14-0125",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015729640"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0002-9440(10)64130-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018335345"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0021889897006766",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019562892"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molmed.2010.11.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021742230"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444910006724",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022138395"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444910006724",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022138395"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/377748a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023509840",
"https://doi.org/10.1038/377748a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpcell.00287.2006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023776104"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1471-4159.2005.03275.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024150152"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1471-4159.2005.03275.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024150152"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs20110036",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026068547"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs20110036",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026068547"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1432-1033.2003.03573.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026158550"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.res.86.12.1266",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026486406"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/physrev.00040.2005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027702384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0006-2952(03)00072-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028372150"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0006-2952(03)00072-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028372150"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1124/mol.115.099176",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029343746"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd4308",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032059331",
"https://doi.org/10.1038/nrd4308"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444911001314",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032555428"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/377744a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035670321",
"https://doi.org/10.1038/377744a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbrc.2009.11.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036019235"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12735",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037825045",
"https://doi.org/10.1038/nature12735"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m602144200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038796601"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd873",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040995770",
"https://doi.org/10.1038/nrd873"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd873",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040995770",
"https://doi.org/10.1038/nrd873"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/hypertensionaha.108.128488",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042119803"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/hypertensionaha.108.128488",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042119803"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.pharmtox.47.120505.105159",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043037704"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/1742-6596/425/1/012002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044156712"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0167-0115(02)00002-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046883767"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00004872-199917030-00013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048085515"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00004872-199917030-00013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048085515"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m114.627356",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049369096"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature19319",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049411693",
"https://doi.org/10.1038/nature19319"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1039/c002938f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050959253"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1039/c002938f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050959253"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/b978-0-12-417197-8.00006-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052604936"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1043-9471(05)80049-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052703851"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0021889893005588",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053164838"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi002780u",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055168350"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi002780u",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055168350"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m115.689000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058214061"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/stke.2003.181.pe16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062691503"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/stke.3112005cm14",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062693003"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2741/3289",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070915466"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074695866",
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature22035",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084537619",
"https://doi.org/10.1038/nature22035"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tips.2017.05.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1086118139"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s2059798318004576",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103628910"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-07",
"datePublishedReg": "2018-07-01",
"description": "Angiotensin II (AngII) plays a central role in regulating human blood pressure, which is mainly mediated by interactions between AngII and the G-protein-coupled receptors (GPCRs) AngII type 1 receptor (AT1R) and AngII type 2 receptor (AT2R). We have solved the crystal structure of human AT2R binding the peptide ligand [Sar1, Ile8]AngII and its specific antibody at 3.2-\u00c5 resolution. [Sar1, Ile8]AngII interacts with both the 'core' binding domain, where the small-molecule ligands of AT1R and AT2R bind, and the 'extended' binding domain, which is equivalent to the allosteric modulator binding site of muscarinic acetylcholine receptor. We generated an antibody fragment to stabilize the extended binding domain that functions as a positive allosteric modulator. We also identified a signature positively charged cluster, which is conserved among peptide-binding receptors, to locate C termini at the bottom of the binding pocket. The reported results should help with designing ligands for angiotensin receptors and possibly to other peptide GPCRs.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41594-018-0079-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.5862314",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6037961",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1295033",
"issn": [
"1545-9993",
"2331-365X"
],
"name": "Nature Structural & Molecular Biology",
"type": "Periodical"
},
{
"issueNumber": "7",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "25"
}
],
"name": "Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog",
"pagination": "570-576",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"df7b1a2b0f2d7488461a2db697482e2599ed6c9a4b7f5a01dd6ddefee6c10477"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29967536"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101186374"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41594-018-0079-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1105180709"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41594-018-0079-8",
"https://app.dimensions.ai/details/publication/pub.1105180709"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:06",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000570.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41594-018-0079-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41594-018-0079-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41594-018-0079-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41594-018-0079-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41594-018-0079-8'
This table displays all metadata directly associated to this object as RDF triples.
351 TRIPLES
21 PREDICATES
83 URIs
21 LITERALS
9 BLANK NODES