Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-11-25

AUTHORS

F. Kyle Satterstrom, Raymond K. Walters, Tarjinder Singh, Emilie M. Wigdor, Francesco Lescai, Ditte Demontis, Jack A. Kosmicki, Jakob Grove, Christine Stevens, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Duncan S. Palmer, Julian B. Maller, Merete Nordentoft, Ole Mors, Elise B. Robinson, David M. Hougaard, Thomas M. Werge, Preben Bo Mortensen, Benjamin M. Neale, Anders D. Børglum, Mark J. Daly

ABSTRACT

The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, finding that individuals with ASD and individuals with ADHD had a similar burden of rare protein-truncating variants in evolutionarily constrained genes, both significantly higher than controls. This motivated a combined analysis across ASD and ADHD, identifying microtubule-associated protein 1A (MAP1A) as a new exome-wide significant gene conferring risk for childhood psychiatric disorders. More... »

PAGES

1961-1965

References to SciGraph publications

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  • Journal

    TITLE

    Nature Neuroscience

    ISSUE

    12

    VOLUME

    22

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41593-019-0527-8

    DOI

    http://dx.doi.org/10.1038/s41593-019-0527-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1122863003

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31768057


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