Mechanisms of systems memory consolidation during sleep View Full Text


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Article Info

DATE

2019-08-26

AUTHORS

Jens G. Klinzing, Niels Niethard, Jan Born

ABSTRACT

Long-term memory formation is a major function of sleep. Based on evidence from neurophysiological and behavioral studies mainly in humans and rodents, we consider the formation of long-term memory during sleep as an active systems consolidation process that is embedded in a process of global synaptic downscaling. Repeated neuronal replay of representations originating from the hippocampus during slow-wave sleep leads to a gradual transformation and integration of representations in neocortical networks. We highlight three features of this process: (i) hippocampal replay that, by capturing episodic memory aspects, drives consolidation of both hippocampus-dependent and non-hippocampus-dependent memory; (ii) brain oscillations hallmarking slow-wave and rapid-eye movement sleep that provide mechanisms for regulating both information flow across distant brain networks and local synaptic plasticity; and (iii) qualitative transformations of memories during systems consolidation resulting in abstracted, gist-like representations. More... »

PAGES

1598-1610

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41593-019-0467-3

    DOI

    http://dx.doi.org/10.1038/s41593-019-0467-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1120601868

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31451802


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