Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis View Full Text


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Article Info

DATE

2018-08

AUTHORS

Andrew E. Jaffe, Richard E. Straub, Joo Heon Shin, Ran Tao, Yuan Gao, Leonardo Collado-Torres, Tony Kam-Thong, Hualin S. Xi, Jie Quan, Qiang Chen, Carlo Colantuoni, William S. Ulrich, Brady J. Maher, Amy Deep-Soboslay, , Alan J. Cross, Nicholas J. Brandon, Jeffrey T. Leek, Thomas M. Hyde, Joel E. Kleinman, Daniel R. Weinberger

ABSTRACT

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological mechanisms for individual loci are largely unknown. Using developmental, genetic and illness-based RNA sequencing expression analysis in human brain, we characterized the human brain transcriptome around these loci and found enrichment for developmentally regulated genes with novel examples of shifting isoform usage across pre- and postnatal life. We found widespread expression quantitative trait loci (eQTLs), including many with transcript specificity and previously unannotated sequence that were independently replicated. We leveraged this general eQTL database to show that 48.1% of risk variants for schizophrenia associate with nearby expression. We lastly found 237 genes significantly differentially expressed between patients and controls, which replicated in an independent dataset, implicated synaptic processes, and were strongly regulated in early development. These findings together offer genetics- and diagnosis-related targets for better modeling of schizophrenia risk. This resource is publicly available at http://eqtl.brainseq.org/phase1 . More... »

PAGES

1117-1125

References to SciGraph publications

  • 2010-02. Abnormal neural oscillations and synchrony in schizophrenia in NATURE REVIEWS NEUROSCIENCE
  • 2012-12. DNA methylation arrays as surrogate measures of cell mixture distribution in BMC BIOINFORMATICS
  • 2017-10-26. Genetic insights into the neurodevelopmental origins of schizophrenia in NATURE REVIEWS NEUROSCIENCE
  • 2016-12. Human splicing diversity and the extent of unannotated splice junctions across human RNA-seq samples on the Sequence Read Archive in GENOME BIOLOGY
  • 2010-05. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation in NATURE BIOTECHNOLOGY
  • 2013-04. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions in GENOME BIOLOGY
  • 2008-12. Shape-IT: new rapid and accurate algorithm for haplotype inference in BMC BIOINFORMATICS
  • 2015-03. StringTie enables improved reconstruction of a transcriptome from RNA-seq reads in NATURE BIOTECHNOLOGY
  • 2013-12. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease in NATURE GENETICS
  • 2016-11. Gene expression elucidates functional impact of polygenic risk for schizophrenia in NATURE NEUROSCIENCE
  • 2015-03. Ballgown bridges the gap between transcriptome assembly and expression analysis in NATURE BIOTECHNOLOGY
  • 2013-12. Assessment of transcript reconstruction methods for RNA-seq in NATURE METHODS
  • 2015-01. Developmental regulation of human cortex transcription and its clinical relevance at single base resolution in NATURE NEUROSCIENCE
  • 2012-09. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes in NATURE GENETICS
  • 2014-02. Accounting for cellular heterogeneity is critical in epigenome-wide association studies in GENOME BIOLOGY
  • 2014-09. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease in NATURE GENETICS
  • 2016-01. Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex in NATURE NEUROSCIENCE
  • 2015-02. Integrative analysis of 111 reference human epigenomes in NATURE
  • 2014-07. Biological insights from 108 schizophrenia-associated genetic loci in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41593-018-0197-y

    DOI

    http://dx.doi.org/10.1038/s41593-018-0197-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105714193

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30050107


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    429 McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD USA
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