Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03

AUTHORS

Tengfei Ma, Yifeng Cheng, Emily Roltsch Hellard, Xuehua Wang, Jiayi Lu, Xinsheng Gao, Cathy C. Y. Huang, Xiao-Yan Wei, Jun-Yuan Ji, Jun Wang

ABSTRACT

Addiction is proposed to arise from alterations in synaptic strength via mechanisms of long-term potentiation (LTP) and depression (LTD). However, the causality between these synaptic processes and addictive behaviors is difficult to demonstrate. Here we report that LTP and LTD induction altered operant alcohol self-administration, a motivated drug-seeking behavior. We first induced LTP by pairing presynaptic glutamatergic stimulation with optogenetic postsynaptic depolarization in the dorsomedial striatum, a brain region known to control goal-directed behavior. Blockade of this LTP by NMDA-receptor inhibition unmasked an endocannabinoid-dependent LTD. In vivo application of the LTP-inducing protocol caused a long-lasting increase in alcohol-seeking behavior, while the LTD protocol decreased this behavior. We further identified that optogenetic LTP and LTD induction at cortical inputs onto striatal dopamine D1 receptor-expressing neurons controlled these behavioral changes. Our results demonstrate a causal link between synaptic plasticity and alcohol-seeking behavior and suggest that modulation of this plasticity may inspire a therapeutic strategy for addiction. More... »

PAGES

373-383

References to SciGraph publications

  • 2014-03. Independent optical excitation of distinct neural populations in NATURE METHODS
  • 2002-05. Postsynaptic endocannabinoid release is critical to long-term depression in the striatum in NATURE NEUROSCIENCE
  • 2013-11. Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving in NATURE NEUROSCIENCE
  • 2014-05. Contrasting forms of cocaine-evoked plasticity control components of relapse in NATURE
  • 2012-02. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins in NATURE METHODS
  • 2011-09. Neocortical excitation/inhibition balance in information processing and social dysfunction in NATURE
  • 2014-09. Cocaine exposure reorganizes cell type- and input-specific connectivity in the nucleus accumbens in NATURE NEUROSCIENCE
  • 2010-06. Long-Evans Rats Acquire Operant Self-Administration of 20% Ethanol Without Sucrose Fading in NEUROPSYCHOPHARMACOLOGY
  • 2013-07. Ultrasensitive fluorescent proteins for imaging neuronal activity in NATURE
  • 2014-07. Effects of Repeated Cocaine Exposure on Habit Learning and Reversal by N-Acetylcysteine in NEUROPSYCHOPHARMACOLOGY
  • 2007-02. Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models in NATURE
  • 2009-10. Alcohol Exposure Alters NMDAR Function in the Bed Nucleus of the Stria Terminalis in NEUROPSYCHOPHARMACOLOGY
  • 2017-12. Stroke triggers nigrostriatal plasticity and increases alcohol consumption in rats in SCIENTIFIC REPORTS
  • 2010-01. Neurocircuitry of Addiction in NEUROPSYCHOPHARMACOLOGY
  • 2010-01. Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action in NEUROPSYCHOPHARMACOLOGY
  • 2016-03. Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making in NATURE
  • 2006-06. The role of the basal ganglia in habit formation in NATURE REVIEWS NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41593-018-0081-9

    DOI

    http://dx.doi.org/10.1038/s41593-018-0081-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100951740

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29434375


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Texas A&M Health Science Center", 
              "id": "https://www.grid.ac/institutes/grid.416970.d", 
              "name": [
                "Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ma", 
            "givenName": "Tengfei", 
            "id": "sg:person.01111730352.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111730352.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Texas A&M Health Science Center", 
              "id": "https://www.grid.ac/institutes/grid.416970.d", 
              "name": [
                "Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cheng", 
            "givenName": "Yifeng", 
            "id": "sg:person.0735231637.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735231637.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Texas A&M Health Science Center", 
              "id": "https://www.grid.ac/institutes/grid.416970.d", 
              "name": [
                "Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hellard", 
            "givenName": "Emily Roltsch", 
            "id": "sg:person.015370001446.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015370001446.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Texas A&M Health Science Center", 
              "id": "https://www.grid.ac/institutes/grid.416970.d", 
              "name": [
                "Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Xuehua", 
            "id": "sg:person.01003345037.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003345037.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Texas A&M Health Science Center", 
              "id": "https://www.grid.ac/institutes/grid.416970.d", 
              "name": [
                "Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lu", 
            "givenName": "Jiayi", 
            "id": "sg:person.01133731120.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133731120.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Texas A&M Health Science Center", 
              "id": "https://www.grid.ac/institutes/grid.412408.b", 
              "name": [
                "Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, College Station, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gao", 
            "givenName": "Xinsheng", 
            "id": "sg:person.0576257240.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576257240.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Texas A&M Health Science Center", 
              "id": "https://www.grid.ac/institutes/grid.416970.d", 
              "name": [
                "Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "Cathy C. Y.", 
            "id": "sg:person.010020561675.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010020561675.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Texas A&M Health Science Center", 
              "id": "https://www.grid.ac/institutes/grid.416970.d", 
              "name": [
                "Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wei", 
            "givenName": "Xiao-Yan", 
            "id": "sg:person.011413522675.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011413522675.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Texas A&M Health Science Center", 
              "id": "https://www.grid.ac/institutes/grid.412408.b", 
              "name": [
                "Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, College Station, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ji", 
            "givenName": "Jun-Yuan", 
            "id": "sg:person.01045135431.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045135431.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Texas A&M Health Science Center", 
              "id": "https://www.grid.ac/institutes/grid.416970.d", 
              "name": [
                "Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Jun", 
            "id": "sg:person.01230131156.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230131156.75"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2010.12.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000533775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001398307", 
              "https://doi.org/10.1038/nmeth.1808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci61462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001745421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-neuro-061010-113641", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002006012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2006.04.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002809077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2015.10.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003510595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature17400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005303768", 
              "https://doi.org/10.1038/nature17400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005979668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.07.046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006867196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2011.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009462554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2014.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010581811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1113820109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011268024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471142301.ns0912s51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011330823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471142301.ns0912s51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011330823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2268-10.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011681718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2011.05.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011707253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012821865", 
              "https://doi.org/10.1038/nature13257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.conb.2009.10.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013018645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fphar.2012.00066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013436899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1260776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015359259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2009.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015586529", 
              "https://doi.org/10.1038/npp.2009.110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2009.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015586529", 
              "https://doi.org/10.1038/npp.2009.110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tips.2014.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015804504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016032465", 
              "https://doi.org/10.1038/nature05506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016032465", 
              "https://doi.org/10.1038/nature05506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2016.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016323228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1524739113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018220130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)80146-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019086956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.1992.tb00119.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019540725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.1992.tb00119.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019540725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2783-12.2012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019889357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-psych-122414-033457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020507508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2009.12.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021947415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2007.05606.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023473932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1919", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024505883", 
              "https://doi.org/10.1038/nrn1919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1919", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024505883", 
              "https://doi.org/10.1038/nrn1919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025518115", 
              "https://doi.org/10.1038/nn.3533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2009.06.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029253008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030639357", 
              "https://doi.org/10.1038/nature10360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030668007", 
              "https://doi.org/10.1038/nmeth.2836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2010.01.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032472847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2016.05.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033126930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0003-15.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033206682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2009.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034194354", 
              "https://doi.org/10.1038/npp.2009.69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2009.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034194354", 
              "https://doi.org/10.1038/npp.2009.69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2014.37", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035109737", 
              "https://doi.org/10.1038/npp.2014.37"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnmol.2015.00078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036049374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.alcohol.2008.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037464630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coph.2006.08.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038597756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2016.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039048663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2016.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039048663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039098675", 
              "https://doi.org/10.1038/nn832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039098675", 
              "https://doi.org/10.1038/nn832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2009.131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041054380", 
              "https://doi.org/10.1038/npp.2009.131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2009.131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041054380", 
              "https://doi.org/10.1038/npp.2009.131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043516362", 
              "https://doi.org/10.1038/nature12354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/jn.01073.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045324249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4749-06.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047646158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-neuro-061010-113817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049168571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051318826", 
              "https://doi.org/10.1038/nn.3783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2010.15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051472374", 
              "https://doi.org/10.1038/npp.2010.15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnana.2011.00041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051538249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1160575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052413184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2014.08.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052784904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079130776", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/adb.12512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085051884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/adb.12512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085051884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/adb.12512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085051884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2017.05.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085420297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-02714-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085626871", 
              "https://doi.org/10.1038/s41598-017-02714-z"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-03", 
        "datePublishedReg": "2018-03-01", 
        "description": "Addiction is proposed to arise from alterations in synaptic strength via mechanisms of long-term potentiation (LTP) and depression (LTD). However, the causality between these synaptic processes and addictive behaviors is difficult to demonstrate. Here we report that LTP and LTD induction altered operant alcohol self-administration, a motivated drug-seeking behavior. We first induced LTP by pairing presynaptic glutamatergic stimulation with optogenetic postsynaptic depolarization in the dorsomedial striatum, a brain region known to control goal-directed behavior. Blockade of this LTP by NMDA-receptor inhibition unmasked an endocannabinoid-dependent LTD. In vivo application of the LTP-inducing protocol caused a long-lasting increase in alcohol-seeking behavior, while the LTD protocol decreased this behavior. We further identified that optogenetic LTP and LTD induction at cortical inputs onto striatal dopamine D1 receptor-expressing neurons controlled these behavioral changes. Our results demonstrate a causal link between synaptic plasticity and alcohol-seeking behavior and suggest that modulation of this plasticity may inspire a therapeutic strategy for addiction.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41593-018-0081-9", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2500613", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2444622", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6952891", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1118362", 
            "issn": [
              "1097-6256", 
              "1546-1726"
            ], 
            "name": "Nature Neuroscience", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "21"
          }
        ], 
        "name": "Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD", 
        "pagination": "373-383", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "f3d8f2a376d6e46e31f37958c039bd8869bcdebd24b79eeeff155395544f2d2b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29434375"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9809671"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41593-018-0081-9"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1100951740"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41593-018-0081-9", 
          "https://app.dimensions.ai/details/publication/pub.1100951740"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:53", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000493.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41593-018-0081-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41593-018-0081-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41593-018-0081-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41593-018-0081-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41593-018-0081-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    334 TRIPLES      21 PREDICATES      88 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41593-018-0081-9 schema:about anzsrc-for:11
    2 anzsrc-for:1109
    3 schema:author N423252d07e53406b85e7b997731f91b7
    4 schema:citation sg:pub.10.1038/nature05506
    5 sg:pub.10.1038/nature10360
    6 sg:pub.10.1038/nature12354
    7 sg:pub.10.1038/nature13257
    8 sg:pub.10.1038/nature17400
    9 sg:pub.10.1038/nmeth.1808
    10 sg:pub.10.1038/nmeth.2836
    11 sg:pub.10.1038/nn.3533
    12 sg:pub.10.1038/nn.3783
    13 sg:pub.10.1038/nn832
    14 sg:pub.10.1038/npp.2009.110
    15 sg:pub.10.1038/npp.2009.131
    16 sg:pub.10.1038/npp.2009.69
    17 sg:pub.10.1038/npp.2010.15
    18 sg:pub.10.1038/npp.2014.37
    19 sg:pub.10.1038/nrn1919
    20 sg:pub.10.1038/s41598-017-02714-z
    21 https://app.dimensions.ai/details/publication/pub.1079130776
    22 https://doi.org/10.1002/0471142301.ns0912s51
    23 https://doi.org/10.1016/j.alcohol.2008.12.001
    24 https://doi.org/10.1016/j.biopsych.2016.05.016
    25 https://doi.org/10.1016/j.cell.2015.07.046
    26 https://doi.org/10.1016/j.cell.2016.05.010
    27 https://doi.org/10.1016/j.celrep.2014.12.005
    28 https://doi.org/10.1016/j.conb.2009.10.003
    29 https://doi.org/10.1016/j.coph.2006.08.012
    30 https://doi.org/10.1016/j.neuron.2006.04.010
    31 https://doi.org/10.1016/j.neuron.2009.06.007
    32 https://doi.org/10.1016/j.neuron.2009.12.025
    33 https://doi.org/10.1016/j.neuron.2011.01.017
    34 https://doi.org/10.1016/j.neuron.2014.08.023
    35 https://doi.org/10.1016/j.neuron.2016.09.001
    36 https://doi.org/10.1016/j.neuropharm.2010.01.008
    37 https://doi.org/10.1016/j.neuropharm.2010.12.028
    38 https://doi.org/10.1016/j.neuropharm.2011.05.034
    39 https://doi.org/10.1016/j.neuropharm.2015.10.015
    40 https://doi.org/10.1016/j.neuropharm.2017.05.014
    41 https://doi.org/10.1016/j.tins.2016.02.003
    42 https://doi.org/10.1016/j.tips.2014.05.005
    43 https://doi.org/10.1016/s0896-6273(00)80146-4
    44 https://doi.org/10.1073/pnas.1113820109
    45 https://doi.org/10.1073/pnas.1524739113
    46 https://doi.org/10.1111/adb.12512
    47 https://doi.org/10.1111/j.1460-9568.1992.tb00119.x
    48 https://doi.org/10.1111/j.1460-9568.2007.05606.x
    49 https://doi.org/10.1126/science.1160575
    50 https://doi.org/10.1126/science.1260776
    51 https://doi.org/10.1146/annurev-neuro-061010-113641
    52 https://doi.org/10.1146/annurev-neuro-061010-113817
    53 https://doi.org/10.1146/annurev-psych-122414-033457
    54 https://doi.org/10.1152/jn.01073.2003
    55 https://doi.org/10.1172/jci61462
    56 https://doi.org/10.1523/jneurosci.0003-15.2015
    57 https://doi.org/10.1523/jneurosci.2268-10.2010
    58 https://doi.org/10.1523/jneurosci.2783-12.2012
    59 https://doi.org/10.1523/jneurosci.4749-06.2007
    60 https://doi.org/10.3389/fnana.2011.00041
    61 https://doi.org/10.3389/fnmol.2015.00078
    62 https://doi.org/10.3389/fphar.2012.00066
    63 schema:datePublished 2018-03
    64 schema:datePublishedReg 2018-03-01
    65 schema:description Addiction is proposed to arise from alterations in synaptic strength via mechanisms of long-term potentiation (LTP) and depression (LTD). However, the causality between these synaptic processes and addictive behaviors is difficult to demonstrate. Here we report that LTP and LTD induction altered operant alcohol self-administration, a motivated drug-seeking behavior. We first induced LTP by pairing presynaptic glutamatergic stimulation with optogenetic postsynaptic depolarization in the dorsomedial striatum, a brain region known to control goal-directed behavior. Blockade of this LTP by NMDA-receptor inhibition unmasked an endocannabinoid-dependent LTD. In vivo application of the LTP-inducing protocol caused a long-lasting increase in alcohol-seeking behavior, while the LTD protocol decreased this behavior. We further identified that optogenetic LTP and LTD induction at cortical inputs onto striatal dopamine D1 receptor-expressing neurons controlled these behavioral changes. Our results demonstrate a causal link between synaptic plasticity and alcohol-seeking behavior and suggest that modulation of this plasticity may inspire a therapeutic strategy for addiction.
    66 schema:genre research_article
    67 schema:inLanguage en
    68 schema:isAccessibleForFree false
    69 schema:isPartOf N4239a65eac8641bbb869ddb11f1aa8e8
    70 N5f1196a3418249af97c3aed792dd1277
    71 sg:journal.1118362
    72 schema:name Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD
    73 schema:pagination 373-383
    74 schema:productId N11fa8e83989e477e86c605ce80c54d39
    75 N50df79d6d1f3451daf92b0867c0c9ad7
    76 N5d598a3e19fa468090922bed9ffbeeee
    77 N7447e18e7f13452db3c3fc42286241d8
    78 N8e208bc0940e444695ee72d739795052
    79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100951740
    80 https://doi.org/10.1038/s41593-018-0081-9
    81 schema:sdDatePublished 2019-04-10T19:53
    82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    83 schema:sdPublisher Nc89e22da257f40428b78305fea84f23c
    84 schema:url https://www.nature.com/articles/s41593-018-0081-9
    85 sgo:license sg:explorer/license/
    86 sgo:sdDataset articles
    87 rdf:type schema:ScholarlyArticle
    88 N10d99d61d1234a608b73c4e0afd9884e rdf:first sg:person.0735231637.28
    89 rdf:rest Nd6ba694e6b7e4dffa40f613721818a56
    90 N11ae5c9bb0c24a49b3cfdfc1244fdcd4 rdf:first sg:person.0576257240.92
    91 rdf:rest N5f99998ce8594675bcfb7949b4b225de
    92 N11fa8e83989e477e86c605ce80c54d39 schema:name nlm_unique_id
    93 schema:value 9809671
    94 rdf:type schema:PropertyValue
    95 N423252d07e53406b85e7b997731f91b7 rdf:first sg:person.01111730352.60
    96 rdf:rest N10d99d61d1234a608b73c4e0afd9884e
    97 N4239a65eac8641bbb869ddb11f1aa8e8 schema:volumeNumber 21
    98 rdf:type schema:PublicationVolume
    99 N4c770bd7e5674669a6fe943a2e6fc4bf rdf:first sg:person.01133731120.14
    100 rdf:rest N11ae5c9bb0c24a49b3cfdfc1244fdcd4
    101 N50df79d6d1f3451daf92b0867c0c9ad7 schema:name doi
    102 schema:value 10.1038/s41593-018-0081-9
    103 rdf:type schema:PropertyValue
    104 N5d598a3e19fa468090922bed9ffbeeee schema:name readcube_id
    105 schema:value f3d8f2a376d6e46e31f37958c039bd8869bcdebd24b79eeeff155395544f2d2b
    106 rdf:type schema:PropertyValue
    107 N5f1196a3418249af97c3aed792dd1277 schema:issueNumber 3
    108 rdf:type schema:PublicationIssue
    109 N5f99998ce8594675bcfb7949b4b225de rdf:first sg:person.010020561675.11
    110 rdf:rest N74941825a8fb43aeade7c603daea7cd8
    111 N7447e18e7f13452db3c3fc42286241d8 schema:name pubmed_id
    112 schema:value 29434375
    113 rdf:type schema:PropertyValue
    114 N74941825a8fb43aeade7c603daea7cd8 rdf:first sg:person.011413522675.63
    115 rdf:rest Nb66cf3ce656e4b319c2688d5110d9d45
    116 N8e208bc0940e444695ee72d739795052 schema:name dimensions_id
    117 schema:value pub.1100951740
    118 rdf:type schema:PropertyValue
    119 Nb66cf3ce656e4b319c2688d5110d9d45 rdf:first sg:person.01045135431.26
    120 rdf:rest Ndf3925597cd946d69c0678fb7317d66b
    121 Nc89e22da257f40428b78305fea84f23c schema:name Springer Nature - SN SciGraph project
    122 rdf:type schema:Organization
    123 Nd6ba694e6b7e4dffa40f613721818a56 rdf:first sg:person.015370001446.95
    124 rdf:rest Nfe82592cef7d40ce9e55fe97b2c97326
    125 Ndf3925597cd946d69c0678fb7317d66b rdf:first sg:person.01230131156.75
    126 rdf:rest rdf:nil
    127 Nfe82592cef7d40ce9e55fe97b2c97326 rdf:first sg:person.01003345037.54
    128 rdf:rest N4c770bd7e5674669a6fe943a2e6fc4bf
    129 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    130 schema:name Medical and Health Sciences
    131 rdf:type schema:DefinedTerm
    132 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    133 schema:name Neurosciences
    134 rdf:type schema:DefinedTerm
    135 sg:grant.2444622 http://pending.schema.org/fundedItem sg:pub.10.1038/s41593-018-0081-9
    136 rdf:type schema:MonetaryGrant
    137 sg:grant.2500613 http://pending.schema.org/fundedItem sg:pub.10.1038/s41593-018-0081-9
    138 rdf:type schema:MonetaryGrant
    139 sg:grant.6952891 http://pending.schema.org/fundedItem sg:pub.10.1038/s41593-018-0081-9
    140 rdf:type schema:MonetaryGrant
    141 sg:journal.1118362 schema:issn 1097-6256
    142 1546-1726
    143 schema:name Nature Neuroscience
    144 rdf:type schema:Periodical
    145 sg:person.010020561675.11 schema:affiliation https://www.grid.ac/institutes/grid.416970.d
    146 schema:familyName Huang
    147 schema:givenName Cathy C. Y.
    148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010020561675.11
    149 rdf:type schema:Person
    150 sg:person.01003345037.54 schema:affiliation https://www.grid.ac/institutes/grid.416970.d
    151 schema:familyName Wang
    152 schema:givenName Xuehua
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003345037.54
    154 rdf:type schema:Person
    155 sg:person.01045135431.26 schema:affiliation https://www.grid.ac/institutes/grid.412408.b
    156 schema:familyName Ji
    157 schema:givenName Jun-Yuan
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045135431.26
    159 rdf:type schema:Person
    160 sg:person.01111730352.60 schema:affiliation https://www.grid.ac/institutes/grid.416970.d
    161 schema:familyName Ma
    162 schema:givenName Tengfei
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111730352.60
    164 rdf:type schema:Person
    165 sg:person.01133731120.14 schema:affiliation https://www.grid.ac/institutes/grid.416970.d
    166 schema:familyName Lu
    167 schema:givenName Jiayi
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133731120.14
    169 rdf:type schema:Person
    170 sg:person.011413522675.63 schema:affiliation https://www.grid.ac/institutes/grid.416970.d
    171 schema:familyName Wei
    172 schema:givenName Xiao-Yan
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011413522675.63
    174 rdf:type schema:Person
    175 sg:person.01230131156.75 schema:affiliation https://www.grid.ac/institutes/grid.416970.d
    176 schema:familyName Wang
    177 schema:givenName Jun
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230131156.75
    179 rdf:type schema:Person
    180 sg:person.015370001446.95 schema:affiliation https://www.grid.ac/institutes/grid.416970.d
    181 schema:familyName Hellard
    182 schema:givenName Emily Roltsch
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015370001446.95
    184 rdf:type schema:Person
    185 sg:person.0576257240.92 schema:affiliation https://www.grid.ac/institutes/grid.412408.b
    186 schema:familyName Gao
    187 schema:givenName Xinsheng
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576257240.92
    189 rdf:type schema:Person
    190 sg:person.0735231637.28 schema:affiliation https://www.grid.ac/institutes/grid.416970.d
    191 schema:familyName Cheng
    192 schema:givenName Yifeng
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735231637.28
    194 rdf:type schema:Person
    195 sg:pub.10.1038/nature05506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016032465
    196 https://doi.org/10.1038/nature05506
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/nature10360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030639357
    199 https://doi.org/10.1038/nature10360
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/nature12354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043516362
    202 https://doi.org/10.1038/nature12354
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/nature13257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012821865
    205 https://doi.org/10.1038/nature13257
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/nature17400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005303768
    208 https://doi.org/10.1038/nature17400
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nmeth.1808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001398307
    211 https://doi.org/10.1038/nmeth.1808
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nmeth.2836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030668007
    214 https://doi.org/10.1038/nmeth.2836
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nn.3533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025518115
    217 https://doi.org/10.1038/nn.3533
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nn.3783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051318826
    220 https://doi.org/10.1038/nn.3783
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nn832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039098675
    223 https://doi.org/10.1038/nn832
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/npp.2009.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015586529
    226 https://doi.org/10.1038/npp.2009.110
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/npp.2009.131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041054380
    229 https://doi.org/10.1038/npp.2009.131
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/npp.2009.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034194354
    232 https://doi.org/10.1038/npp.2009.69
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/npp.2010.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051472374
    235 https://doi.org/10.1038/npp.2010.15
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/npp.2014.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035109737
    238 https://doi.org/10.1038/npp.2014.37
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/nrn1919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024505883
    241 https://doi.org/10.1038/nrn1919
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/s41598-017-02714-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1085626871
    244 https://doi.org/10.1038/s41598-017-02714-z
    245 rdf:type schema:CreativeWork
    246 https://app.dimensions.ai/details/publication/pub.1079130776 schema:CreativeWork
    247 https://doi.org/10.1002/0471142301.ns0912s51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011330823
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.alcohol.2008.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037464630
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.biopsych.2016.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033126930
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.cell.2015.07.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006867196
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.cell.2016.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005979668
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.celrep.2014.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010581811
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.conb.2009.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013018645
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.coph.2006.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038597756
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.neuron.2006.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002809077
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.neuron.2009.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029253008
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.neuron.2009.12.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021947415
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.neuron.2011.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009462554
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.neuron.2014.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052784904
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.neuron.2016.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039048663
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.neuropharm.2010.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032472847
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.neuropharm.2010.12.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000533775
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.neuropharm.2011.05.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011707253
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.neuropharm.2015.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003510595
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.neuropharm.2017.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085420297
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.tins.2016.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016323228
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.tips.2014.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015804504
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/s0896-6273(00)80146-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019086956
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1073/pnas.1113820109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011268024
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1073/pnas.1524739113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018220130
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1111/adb.12512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085051884
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1111/j.1460-9568.1992.tb00119.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019540725
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1111/j.1460-9568.2007.05606.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023473932
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1126/science.1160575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052413184
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1126/science.1260776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015359259
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1146/annurev-neuro-061010-113641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002006012
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1146/annurev-neuro-061010-113817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049168571
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1146/annurev-psych-122414-033457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020507508
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1152/jn.01073.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045324249
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1172/jci61462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001745421
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1523/jneurosci.0003-15.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033206682
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1523/jneurosci.2268-10.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011681718
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1523/jneurosci.2783-12.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019889357
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1523/jneurosci.4749-06.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047646158
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.3389/fnana.2011.00041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051538249
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.3389/fnmol.2015.00078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036049374
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.3389/fphar.2012.00066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013436899
    328 rdf:type schema:CreativeWork
    329 https://www.grid.ac/institutes/grid.412408.b schema:alternateName Texas A&M Health Science Center
    330 schema:name Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, College Station, TX, USA
    331 rdf:type schema:Organization
    332 https://www.grid.ac/institutes/grid.416970.d schema:alternateName Texas A&M Health Science Center
    333 schema:name Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA
    334 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...