Super-resolution fight club: assessment of 2D and 3D single-molecule localization microscopy software. View Full Text


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Article Info

DATE

2019-04-08

AUTHORS

Daniel Sage, Thanh-An Pham, Hazen Babcock, Tomas Lukes, Thomas Pengo, Jerry Chao, Ramraj Velmurugan, Alex Herbert, Anurag Agrawal, Silvia Colabrese, Ann Wheeler, Anna Archetti, Bernd Rieger, Raimund Ober, Guy M Hagen, Jean-Baptiste Sibarita, Jonas Ries, Ricardo Henriques, Michael Unser, Seamus Holden

ABSTRACT

With the widespread uptake of two-dimensional (2D) and three-dimensional (3D) single-molecule localization microscopy (SMLM), a large set of different data analysis packages have been developed to generate super-resolution images. In a large community effort, we designed a competition to extensively characterize and rank the performance of 2D and 3D SMLM software packages. We generated realistic simulated datasets for popular imaging modalities-2D, astigmatic 3D, biplane 3D and double-helix 3D-and evaluated 36 participant packages against these data. This provides the first broad assessment of 3D SMLM software and provides a holistic view of how the latest 2D and 3D SMLM packages perform in realistic conditions. This resource allows researchers to identify optimal analytical software for their experiments, allows 3D SMLM software developers to benchmark new software against the current state of the art, and provides insight into the current limits of the field. More... »

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41592-019-0364-4

    DOI

    http://dx.doi.org/10.1038/s41592-019-0364-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113300833

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30962624


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