Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Andras Boeszoermenyi, Sandeep Chhabra, Abhinav Dubey, Denitsa L. Radeva, Nikola T. Burdzhiev, Christo D. Chanev, Ognyan I. Petrov, Vladimir M. Gelev, Meng Zhang, Clemens Anklin, Helena Kovacs, Gerhard Wagner, Ilya Kuprov, Koh Takeuchi, Haribabu Arthanari

ABSTRACT

Atomic-level information about the structure and dynamics of biomolecules is critical for an understanding of their function. Nuclear magnetic resonance (NMR) spectroscopy provides unique insights into the dynamic nature of biomolecules and their interactions, capturing transient conformers and their features. However, relaxation-induced line broadening and signal overlap make it challenging to apply NMR spectroscopy to large biological systems. Here we took advantage of the high sensitivity and broad chemical shift range of 19F nuclei and leveraged the remarkable relaxation properties of the aromatic 19F-13C spin pair to disperse 19F resonances in a two-dimensional transverse relaxation-optimized spectroscopy spectrum. We demonstrate the application of 19F-13C transverse relaxation-optimized spectroscopy to investigate proteins and nucleic acids. This experiment expands the scope of 19F NMR in the study of the structure, dynamics, and function of large and complex biological systems and provides a powerful background-free NMR probe. More... »

PAGES

333-340

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41592-019-0334-x

DOI

http://dx.doi.org/10.1038/s41592-019-0334-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112676266

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30858598


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