Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-02-28

AUTHORS

Karla A. Lee, Andrew Maltez Thomas, Laura A. Bolte, Johannes R. Björk, Laura Kist de Ruijter, Federica Armanini, Francesco Asnicar, Aitor Blanco-Miguez, Ruth Board, Neus Calbet-Llopart, Lisa Derosa, Nathalie Dhomen, Kelly Brooks, Mark Harland, Mark Harries, Emily R. Leeming, Paul Lorigan, Paolo Manghi, Richard Marais, Julia Newton-Bishop, Luigi Nezi, Federica Pinto, Miriam Potrony, Susana Puig, Patricio Serra-Bellver, Heather M. Shaw, Sabrina Tamburini, Sara Valpione, Amrita Vijay, Levi Waldron, Laurence Zitvogel, Moreno Zolfo, Elisabeth G. E. de Vries, Paul Nathan, Rudolf S. N. Fehrmann, Véronique Bataille, Geke A. P. Hospers, Tim D. Spector, Rinse K. Weersma, Nicola Segata

ABSTRACT

The composition of the gut microbiome has been associated with clinical responses to immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific microbiome characteristics linked to the clinical benefits of ICIs. We performed shotgun metagenomic sequencing of stool samples collected before ICI initiation from five observational cohorts recruiting ICI-naive patients with advanced cutaneous melanoma (n = 165). Integrating the dataset with 147 metagenomic samples from previously published studies, we found that the gut microbiome has a relevant, but cohort-dependent, association with the response to ICIs. A machine learning analysis confirmed the link between the microbiome and overall response rates (ORRs) and progression-free survival (PFS) with ICIs but also revealed limited reproducibility of microbiome-based signatures across cohorts. Accordingly, a panel of species, including Bifidobacterium pseudocatenulatum, Roseburia spp. and Akkermansia muciniphila, associated with responders was identified, but no single species could be regarded as a fully consistent biomarker across studies. Overall, the role of the human gut microbiome in ICI response appears more complex than previously thought, extending beyond differing microbial species simply present or absent in responders and nonresponders. Future studies should adopt larger sample sizes and take into account the complex interplay of clinical factors with the gut microbiome over the treatment course. More... »

PAGES

535-544

References to SciGraph publications

  • 2018-10-08. Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma in NATURE MEDICINE
  • 2017-11-28. A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients in GENOME MEDICINE
  • 2019-02-04. The neuroactive potential of the human gut microbiota in quality of life and depression in NATURE MICROBIOLOGY
  • 2019-06-20. Establishing microbial composition measurement standards with reference frames in NATURE COMMUNICATIONS
  • 2017-09-12. Shotgun metagenomics, from sampling to analysis in NATURE BIOTECHNOLOGY
  • 2014-12-05. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2017-10-16. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus in NATURE COMMUNICATIONS
  • 2015-09-29. MetaPhlAn2 for enhanced metagenomic taxonomic profiling in NATURE METHODS
  • 2016-02-02. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis in NATURE COMMUNICATIONS
  • 2017-08-22. Large-scale comparative metagenomics of Blastocystis, a common member of the human gut microbiome in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2020-07-14. Analysis of compositions of microbiomes with bias correction in NATURE COMMUNICATIONS
  • 2021-07-08. Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade in NATURE MEDICINE
  • 2012-03-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • 2020-06-24. Gut Microbiome Modulation Via Fecal Microbiota Transplant to Augment Immunotherapy in Patients with Melanoma or Other Cancers in CURRENT ONCOLOGY REPORTS
  • 2018-01-18. A general and flexible method for signal extraction from single-cell RNA-seq data in NATURE COMMUNICATIONS
  • 2021-03-30. Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox in GENOME BIOLOGY
  • 2020-08-03. Assessment of statistical methods from single cell, bulk RNA-seq, and metagenomics applied to microbiome data in GENOME BIOLOGY
  • 2018-10-30. Species-level functional profiling of metagenomes and metatranscriptomes in NATURE METHODS
  • 2020-06-08. Analysis of 1321 Eubacterium rectale genomes from metagenomes uncovers complex phylogeographic population structure and subspecies functional adaptations in GENOME BIOLOGY
  • 2019-04-01. Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer in NATURE MEDICINE
  • 2019-11-20. Detecting contamination in viromes using ViromeQC in NATURE BIOTECHNOLOGY
  • 2019-04-01. Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation in NATURE MEDICINE
  • 2019-10-09. Relating the gut metagenome and metatranscriptome to immunotherapy responses in melanoma patients in GENOME MEDICINE
  • 2021-01-11. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals in NATURE MEDICINE
  • Journal

    TITLE

    Nature Medicine

    ISSUE

    3

    VOLUME

    28

    Author Affiliations

  • Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK
  • Department CIBIO, University of Trento, Trento, Italy
  • Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands
  • Department of Medical Oncology, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands
  • Department of Oncology, Lancashire Teaching Hospitals NHS Trust, Preston, UK
  • Centro de Investigación Biomédica en Red en Enfermedades Raras, Instituto de Salud Carlos III, Barcelona, Spain
  • U1015 INSERM, University Paris Saclay, Gustave Roussy Cancer Center and Oncobiome Network, Villejuif-Grand-Paris, France
  • Molecular Oncology Group, CRUK Manchester Institute, University of Manchester, Manchester, UK
  • Division of Haematology and Immunology, Institute of Medical Research at St. James’s, University of Leeds, Leeds, UK
  • Department of Medical Oncology, Guys Cancer Centre, Guys and St Thomas’s NHS Trust, London, UK
  • Division of Cancer Sciences, University of Manchester, Manchester, UK
  • European Institute of Oncology (Istituto Europeo di Oncologia, IRCSS), Milan, Italy
  • Biochemical and Molecular Genetics Department, Hospital Clínic de Barcelona, IDIBAPS and University of Barcelona, Barcelona, Spain
  • The Christie NHS Foundation Trust, Manchester, UK
  • Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, UK
  • Rheumatology & Orthopaedics Division, School of Medicine, University of Nottingham, Nottingham, UK
  • Graduate School of Public Health and Health Policy, City University of New York, New York, NY, USA
  • Department of Dermatology, Mount Vernon Cancer Centre, Northwood, UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41591-022-01695-5

    DOI

    http://dx.doi.org/10.1038/s41591-022-01695-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1145892649

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35228751


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