Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-07

AUTHORS

Kathryn E. Stephenson, Boris Julg, C. Sabrina Tan, Rebecca Zash, Stephen R. Walsh, Charlotte-Paige Rolle, Ana N. Monczor, Sofia Lupo, Huub C. Gelderblom, Jessica L. Ansel, Diane G. Kanjilal, Lori F. Maxfield, Joseph Nkolola, Erica N. Borducchi, Peter Abbink, Jinyan Liu, Lauren Peter, Abishek Chandrashekar, Ramya Nityanandam, Zijin Lin, Alessandra Setaro, Joseph Sapiente, Zhilin Chen, Lisa Sunner, Tyler Cassidy, Chelsey Bennett, Alicia Sato, Bryan Mayer, Alan S. Perelson, Allan deCamp, Frances H. Priddy, Kshitij Wagh, Elena E. Giorgi, Nicole L. Yates, Roberto C. Arduino, Edwin DeJesus, Georgia D. Tomaras, Michael S. Seaman, Bette Korber, Dan H. Barouch

ABSTRACT

Human immunodeficiency virus (HIV)-1-specific broadly neutralizing monoclonal antibodies are currently under development to treat and prevent HIV-1 infection. We performed a single-center, randomized, double-blind, dose-escalation, placebo-controlled trial of a single administration of the HIV-1 V3-glycan-specific antibody PGT121 at 3, 10 and 30 mg kg-1 in HIV-uninfected adults and HIV-infected adults on antiretroviral therapy (ART), as well as a multicenter, open-label trial of one infusion of PGT121 at 30 mg kg-1 in viremic HIV-infected adults not on ART (no. NCT02960581). The primary endpoints were safety and tolerability, pharmacokinetics (PK) and antiviral activity in viremic HIV-infected adults not on ART. The secondary endpoints were changes in anti-PGT121 antibody titers and CD4+ T-cell count, and development of HIV-1 sequence variations associated with PGT121 resistance. Among 48 participants enrolled, no treatment-related serious adverse events, potential immune-mediated diseases or Grade 3 or higher adverse events were reported. The most common reactions among PGT121 recipients were intravenous/injection site tenderness, pain and headache. Absolute and relative CD4+ T-cell counts did not change following PGT121 infusion in HIV-infected participants. Neutralizing anti-drug antibodies were not elicited. PGT121 reduced plasma HIV RNA levels by a median of 1.77 log in viremic participants, with a viral load nadir at a median of 8.5 days. Two individuals with low baseline viral loads experienced ART-free viral suppression for ≥168 days following antibody infusion, and rebound viruses in these individuals demonstrated full or partial PGT121 sensitivity. The trial met the prespecified endpoints. These data suggest that further investigation of the potential of antibody-based therapeutic strategies for long-term suppression of HIV is warranted, including in individuals off ART and with low viral load. More... »

PAGES

1718-1724

References to SciGraph publications

  • 2013-01-09. HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life in MUCOSAL IMMUNOLOGY
  • 2012-01-04. Vaccine Protection Against Acquisition of Neutralization-Resistant SIV Challenges in Rhesus Monkeys in NATURE
  • 2017-03-13. Early antibody therapy can induce long-lasting immunity to SHIV in NATURE
  • 2007-04-21. Emergence of HIV-1 Drug Resistance During Antiretroviral Treatment in BULLETIN OF MATHEMATICAL BIOLOGY
  • 2018-09-26. Safety and anti-viral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals in NATURE MEDICINE
  • <error retrieving object. in <ERROR RETRIEVING OBJECT
  • 2018-10-03. Antibody and TLR7 Agonist Delay Viral Rebound in SHIV-Infected Monkeys in NATURE
  • 2011-09-22. Broad neutralization coverage of HIV by multiple highly potent antibodies in NATURE
  • 2016-06-22. HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption in NATURE
  • 2016-11-09. Ad26/MVA Therapeutic Vaccination with TLR7 Stimulation in SIV-Infected Rhesus Monkeys in NATURE
  • 2020-02-03. Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity in NATURE MEDICINE
  • 2017-01-16. Antibody 10-1074 suppresses viremia in HIV-1-infected individuals in NATURE MEDICINE
  • 2013-10-30. Therapeutic Efficacy of Potent Neutralizing HIV-1-Specific Monoclonal Antibodies in SHIV-Infected Rhesus Monkeys in NATURE
  • 2015-04-08. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 in NATURE
  • 2018-05-15. Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection in NATURE COMMUNICATIONS
  • 2018-09-26. Combination therapy with anti-HIV-1 antibodies maintains viral suppression in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41591-021-01509-0

    DOI

    http://dx.doi.org/10.1038/s41591-021-01509-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1141685804

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34621054


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    40 schema:description Human immunodeficiency virus (HIV)-1-specific broadly neutralizing monoclonal antibodies are currently under development to treat and prevent HIV-1 infection. We performed a single-center, randomized, double-blind, dose-escalation, placebo-controlled trial of a single administration of the HIV-1 V3-glycan-specific antibody PGT121 at 3, 10 and 30 mg kg<sup>-1</sup> in HIV-uninfected adults and HIV-infected adults on antiretroviral therapy (ART), as well as a multicenter, open-label trial of one infusion of PGT121 at 30 mg kg<sup>-1</sup> in viremic HIV-infected adults not on ART (no. NCT02960581). The primary endpoints were safety and tolerability, pharmacokinetics (PK) and antiviral activity in viremic HIV-infected adults not on ART. The secondary endpoints were changes in anti-PGT121 antibody titers and CD4<sup>+</sup> T-cell count, and development of HIV-1 sequence variations associated with PGT121 resistance. Among 48 participants enrolled, no treatment-related serious adverse events, potential immune-mediated diseases or Grade 3 or higher adverse events were reported. The most common reactions among PGT121 recipients were intravenous/injection site tenderness, pain and headache. Absolute and relative CD4<sup>+</sup> T-cell counts did not change following PGT121 infusion in HIV-infected participants. Neutralizing anti-drug antibodies were not elicited. PGT121 reduced plasma HIV RNA levels by a median of 1.77 log in viremic participants, with a viral load nadir at a median of 8.5 days. Two individuals with low baseline viral loads experienced ART-free viral suppression for ≥168 days following antibody infusion, and rebound viruses in these individuals demonstrated full or partial PGT121 sensitivity. The trial met the prespecified endpoints. These data suggest that further investigation of the potential of antibody-based therapeutic strategies for long-term suppression of HIV is warranted, including in individuals off ART and with low viral load.
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