Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota View Full Text


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Article Info

DATE

2021-07-19

AUTHORS

Thomas Vogl, Shelley Klompus, Sigal Leviatan, Iris N. Kalka, Adina Weinberger, Cisca Wijmenga, Jingyuan Fu, Alexandra Zhernakova, Rinse K. Weersma, Eran Segal

ABSTRACT

Serum antibodies can recognize both pathogens and commensal gut microbiota. However, our current understanding of antibody repertoires is largely based on DNA sequencing of the corresponding B-cell receptor genes, and actual bacterial antigen targets remain incompletely characterized. Here we have profiled the serum antibody responses of 997 healthy individuals against 244,000 rationally selected peptide antigens derived from gut microbiota and pathogenic and probiotic bacteria. Leveraging phage immunoprecipitation sequencing (PhIP-Seq) based on phage-displayed synthetic oligo libraries, we detect a wide breadth of individual-specific as well as shared antibody responses against microbiota that associate with age and gender. We also demonstrate that these antibody epitope repertoires are more longitudinally stable than gut microbiome species abundances. Serum samples of more than 200 individuals collected five years apart could be accurately matched and could serve as an immunologic fingerprint. Overall, our results suggest that systemic antibody responses provide a non-redundant layer of information about microbiota beyond gut microbial species composition. More... »

PAGES

1442-1450

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41591-021-01409-3

    DOI

    http://dx.doi.org/10.1038/s41591-021-01409-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1139786743

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34282338


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