Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-05-26

AUTHORS

Lewis Au, Annika Fendler, Scott T. C. Shepherd, Karolina Rzeniewicz, Maddalena Cerrone, Fiona Byrne, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, John Shon, Winston A. Haynes, Barry Ward, Ben Shum, William Gordon, Camille L. Gerard, Wenyi Xie, Nalinie Joharatnam-Hogan, Kate Young, Lisa Pickering, Andrew J. S. Furness, James Larkin, Ruth Harvey, George Kassiotis, Sonia Gandhi, Charles Swanton, Charlotte Fribbens, Katalin A. Wilkinson, Robert J. Wilkinson, David K. Lau, Susana Banerjee, Naureen Starling, Ian Chau, Samra Turajlic

ABSTRACT

Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported with mRNA vaccines and is an extremely rare immune-related adverse event of immune checkpoint inhibitors. We present a case of CRS that occurred 5 d after vaccination with BTN162b2 (tozinameran)—the Pfizer-BioNTech mRNA COVID-19 vaccine—in a patient with colorectal cancer on long-standing anti-PD-1 monotherapy. The CRS was evidenced by raised inflammatory markers, thrombocytopenia, elevated cytokine levels (IFN-γ/IL-2R/IL-18/IL-16/IL-10) and steroid responsiveness. The close temporal association of vaccination and diagnosis of CRS in this case suggests that CRS was a vaccine-related adverse event; with anti-PD1 blockade as a potential contributor. Overall, further prospective pharmacovigillence data are needed in patients with cancer, but the benefit–risk profile remains strongly in favor of COVID-19 vaccination in this population. More... »

PAGES

1362-1366

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41591-021-01387-6

DOI

http://dx.doi.org/10.1038/s41591-021-01387-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138358643

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34040262


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