Partial recovery of visual function in a blind patient after optogenetic therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-05-24

AUTHORS

José-Alain Sahel, Elise Boulanger-Scemama, Chloé Pagot, Angelo Arleo, Francesco Galluppi, Joseph N. Martel, Simona Degli Esposti, Alexandre Delaux, Jean-Baptiste de Saint Aubert, Caroline de Montleau, Emmanuel Gutman, Isabelle Audo, Jens Duebel, Serge Picaud, Deniz Dalkara, Laure Blouin, Magali Taiel, Botond Roska

ABSTRACT

Optogenetics may enable mutation-independent, circuit-specific restoration of neuronal function in neurological diseases. Retinitis pigmentosa is a neurodegenerative eye disease where loss of photoreceptors can lead to complete blindness. In a blind patient, we combined intraocular injection of an adeno-associated viral vector encoding ChrimsonR with light stimulation via engineered goggles. The goggles detect local changes in light intensity and project corresponding light pulses onto the retina in real time to activate optogenetically transduced retinal ganglion cells. The patient perceived, located, counted and touched different objects using the vector-treated eye alone while wearing the goggles. During visual perception, multichannel electroencephalographic recordings revealed object-related activity above the visual cortex. The patient could not visually detect any objects before injection with or without the goggles or after injection without the goggles. This is the first reported case of partial functional recovery in a neurodegenerative disease after optogenetic therapy. More... »

PAGES

1223-1229

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41591-021-01351-4

DOI

http://dx.doi.org/10.1038/s41591-021-01351-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138290983

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34031601


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361 Département d’Ophtalmologie, Fondation Ophtalmologique Rothschild, Paris, France
362 Institut National de la Santé et de la Recherche Médicale-Centre d’Investigation Clinique 1423, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Paris, France
363 Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris, France
364 rdf:type schema:Organization
365 grid-institutes:grid.418241.a schema:alternateName Streetlab, Institut de la Vision, Paris, France
366 schema:name Streetlab, Institut de la Vision, Paris, France
367 rdf:type schema:Organization
368 grid-institutes:grid.451056.3 schema:alternateName National Institute for Health Research Moorfields Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK
369 schema:name National Institute for Health Research Moorfields Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK
370 rdf:type schema:Organization
371 grid-institutes:grid.476286.9 schema:alternateName GenSight Biologics, Paris, France
372 schema:name GenSight Biologics, Paris, France
373 rdf:type schema:Organization
374 grid-institutes:grid.6612.3 schema:alternateName Department of Ophthalmology, University of Basel, Basel, Switzerland
375 schema:name Department of Ophthalmology, University of Basel, Basel, Switzerland
376 Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland
377 rdf:type schema:Organization
 




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