Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-04-13

AUTHORS

Eva Pérez-Guijarro, Howard H. Yang, Romina E. Araya, Rajaa El Meskini, Helen T. Michael, Suman Kumar Vodnala, Kerrie L. Marie, Cari Smith, Sung Chin, Khiem C. Lam, Andres Thorkelsson, Anthony J. Iacovelli, Alan Kulaga, Anyen Fon, Aleksandra M. Michalowski, Willy Hugo, Roger S. Lo, Nicholas P. Restifo, Shyam K. Sharan, Terry Van Dyke, Romina S. Goldszmid, Zoe Weaver Ohler, Maxwell P. Lee, Chi-Ping Day, Glenn Merlino

ABSTRACT

Although immunotherapy has revolutionized cancer treatment, only a subset of patients demonstrate durable clinical benefit. Definitive predictive biomarkers and targets to overcome resistance remain unidentified, underscoring the urgency to develop reliable immunocompetent models for mechanistic assessment. Here we characterize a panel of syngeneic mouse models, representing a variety of molecular and phenotypic subtypes of human melanomas and exhibiting their diverse range of responses to immune checkpoint blockade (ICB). Comparative analysis of genomic, transcriptomic and tumor-infiltrating immune cell profiles demonstrated alignment with clinical observations and validated the correlation of T cell dysfunction and exclusion programs with resistance. Notably, genome-wide expression analysis uncovered a melanocytic plasticity signature predictive of patient outcome in response to ICB, suggesting that the multipotency and differentiation status of melanoma can determine ICB benefit. Our comparative preclinical platform recapitulates melanoma clinical behavior and can be employed to identify mechanisms and treatment strategies to improve patient care. More... »

PAGES

781-791

References to SciGraph publications

  • 2018-08-20. Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response in NATURE MEDICINE
  • 2018-08-20. Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma in NATURE MEDICINE
  • 2012-10-10. Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation in NATURE
  • 2014-11-26. PD-1 blockade induces responses by inhibiting adaptive immune resistance in NATURE
  • 2014-02-26. Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma in NATURE
  • 2019-03-04. From neural crest cells to melanocytes: cellular plasticity during development and beyond in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2011-08-04. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome in BMC BIOINFORMATICS
  • 2018-06-25. A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments in NATURE MEDICINE
  • 2014-12-05. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2009-03-12. BrafV600E cooperates with Pten loss to induce metastatic melanoma in NATURE GENETICS
  • 1973-06. A system of nomenclature for band patterns of mouse chromosomes in CHROMOSOMA
  • 2017-01-16. Mouse models of UV-induced melanoma: genetics, pathology, and clinical relevance in LABORATORY INVESTIGATION
  • 2017-08-07. Identification of essential genes for cancer immunotherapy in NATURE
  • 2020-01-16. Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis in NATURE COMMUNICATIONS
  • 2015-03-30. Robust enumeration of cell subsets from tissue expression profiles in NATURE METHODS
  • 2017-01-13. Inference of immune cell composition on the expression profiles of mouse tissue in SCIENTIFIC REPORTS
  • 2018-06-25. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing in NATURE MEDICINE
  • 2001-09-20. Neonatal sunburn and melanoma in mice in NATURE
  • 2017-05-03. Whole-genome landscapes of major melanoma subtypes in NATURE
  • 2013-08-14. Signatures of mutational processes in human cancer in NATURE
  • 2017-05-17. Chromatin states define tumour-specific T cell dysfunction and reprogramming in NATURE
  • Journal

    TITLE

    Nature Medicine

    ISSUE

    5

    VOLUME

    26

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41591-020-0818-3

    DOI

    http://dx.doi.org/10.1038/s41591-020-0818-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1126634024

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32284588


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents, Immunological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CTLA-4 Antigen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Screening Assays, Antitumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Heterogeneity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunotherapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ipilimumab", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Melanoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Transgenic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Programmed Cell Death 1 Receptor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA-Seq", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Whole Genome Sequencing", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "P\u00e9rez-Guijarro", 
            "givenName": "Eva", 
            "id": "sg:person.01350776723.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350776723.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Howard H.", 
            "id": "sg:person.01265423374.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265423374.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Araya", 
            "givenName": "Romina E.", 
            "id": "sg:person.01061176646.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061176646.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "El Meskini", 
            "givenName": "Rajaa", 
            "id": "sg:person.0637301071.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637301071.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Michael", 
            "givenName": "Helen T.", 
            "id": "sg:person.0753705004.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753705004.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lyell Immunopharma, South San Francisco, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.510010.5", 
              "name": [
                "Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
                "Lyell Immunopharma, South San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vodnala", 
            "givenName": "Suman Kumar", 
            "id": "sg:person.01063733037.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063733037.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marie", 
            "givenName": "Kerrie L.", 
            "id": "sg:person.01201562005.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201562005.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory Animal Science Program, Leidos Biomedical Research Inc, Frederick, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.419407.f", 
              "name": [
                "Laboratory Animal Science Program, Leidos Biomedical Research Inc, Frederick, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smith", 
            "givenName": "Cari", 
            "id": "sg:person.016167100711.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016167100711.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory Animal Science Program, Leidos Biomedical Research Inc, Frederick, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.419407.f", 
              "name": [
                "Laboratory Animal Science Program, Leidos Biomedical Research Inc, Frederick, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chin", 
            "givenName": "Sung", 
            "id": "sg:person.07456645233.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07456645233.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lam", 
            "givenName": "Khiem C.", 
            "id": "sg:person.012462106177.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012462106177.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thorkelsson", 
            "givenName": "Andres", 
            "id": "sg:person.015666005071.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015666005071.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iacovelli", 
            "givenName": "Anthony J.", 
            "id": "sg:person.01032374022.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032374022.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kulaga", 
            "givenName": "Alan", 
            "id": "sg:person.015026237361.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015026237361.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fon", 
            "givenName": "Anyen", 
            "id": "sg:person.016451101230.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016451101230.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Michalowski", 
            "givenName": "Aleksandra M.", 
            "id": "sg:person.01326633261.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326633261.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hugo", 
            "givenName": "Willy", 
            "id": "sg:person.0637120274.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637120274.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lo", 
            "givenName": "Roger S.", 
            "id": "sg:person.0701722423.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701722423.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lyell Immunopharma, South San Francisco, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.510010.5", 
              "name": [
                "Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
                "Lyell Immunopharma, South San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Restifo", 
            "givenName": "Nicholas P.", 
            "id": "sg:person.01257633341.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257633341.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA", 
                "Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sharan", 
            "givenName": "Shyam K.", 
            "id": "sg:person.0777537437.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777537437.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Path Forward Solutions, Frederick, MD, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA", 
                "Path Forward Solutions, Frederick, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Van Dyke", 
            "givenName": "Terry", 
            "id": "sg:person.01364737107.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364737107.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goldszmid", 
            "givenName": "Romina S.", 
            "id": "sg:person.0624024223.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624024223.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weaver Ohler", 
            "givenName": "Zoe", 
            "id": "sg:person.013276023353.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013276023353.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Maxwell P.", 
            "id": "sg:person.0730222174.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730222174.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Day", 
            "givenName": "Chi-Ping", 
            "id": "sg:person.01272622475.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272622475.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.417768.b", 
              "name": [
                "Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Merlino", 
            "givenName": "Glenn", 
            "id": "sg:person.01027062651.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027062651.28"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/35095108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045448662", 
              "https://doi.org/10.1038/35095108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-019-03049-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112513840", 
              "https://doi.org/10.1007/s00018-019-03049-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046208212", 
              "https://doi.org/10.1038/nature13111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-019-14085-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1124121200", 
              "https://doi.org/10.1038/s41467-019-14085-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050004918", 
              "https://doi.org/10.1038/nature12477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-12-323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021902674", 
              "https://doi.org/10.1186/1471-2105-12-323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085428066", 
              "https://doi.org/10.1038/nature22367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0157-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106133485", 
              "https://doi.org/10.1038/s41591-018-0157-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085123990", 
              "https://doi.org/10.1038/nature22071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00319691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018285551", 
              "https://doi.org/10.1007/bf00319691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004732944", 
              "https://doi.org/10.1038/nmeth.3337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020455470", 
              "https://doi.org/10.1038/nature13954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0045-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105071631", 
              "https://doi.org/10.1038/s41591-018-0045-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2016.155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031160147", 
              "https://doi.org/10.1038/labinvest.2016.155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0085-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105071638", 
              "https://doi.org/10.1038/s41591-018-0085-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep40508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004946403", 
              "https://doi.org/10.1038/srep40508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019872106", 
              "https://doi.org/10.1038/ng.356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001689247", 
              "https://doi.org/10.1038/nature11538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0136-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106133483", 
              "https://doi.org/10.1038/s41591-018-0136-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature23477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091081816", 
              "https://doi.org/10.1038/nature23477"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-04-13", 
        "datePublishedReg": "2020-04-13", 
        "description": "Although immunotherapy has revolutionized cancer treatment, only a subset of patients demonstrate durable clinical benefit. Definitive predictive biomarkers and targets to overcome resistance remain unidentified, underscoring the urgency to develop reliable immunocompetent models for mechanistic assessment. Here we characterize a panel of syngeneic mouse models, representing a variety of molecular and phenotypic subtypes of human melanomas and exhibiting their diverse range of responses to immune checkpoint blockade (ICB). Comparative analysis of genomic, transcriptomic and tumor-infiltrating immune cell profiles demonstrated alignment with clinical observations and validated the correlation of T cell dysfunction and exclusion programs with resistance. Notably, genome-wide expression analysis uncovered a melanocytic plasticity signature predictive of patient outcome in response to ICB, suggesting that the multipotency and differentiation status of melanoma can determine ICB benefit. Our comparative preclinical platform recapitulates melanoma clinical behavior and can be employed to identify mechanisms and treatment strategies to improve patient care.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41591-020-0818-3", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7910676", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4730439", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6501592", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2724091", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2723583", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6500229", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "26"
          }
        ], 
        "keywords": [
          "immune checkpoint blockade", 
          "preclinical platform", 
          "tumor-infiltrating immune cell profiles", 
          "definitive predictive biomarkers", 
          "durable clinical benefit", 
          "immune cell profiles", 
          "subset of patients", 
          "T cell dysfunction", 
          "syngeneic mouse model", 
          "checkpoint blockade", 
          "clinical response", 
          "immunocompetent model", 
          "clinical benefit", 
          "predictive biomarkers", 
          "clinical behavior", 
          "patient outcomes", 
          "treatment strategies", 
          "cell dysfunction", 
          "mouse model", 
          "clinical observations", 
          "ICB benefit", 
          "cell profiles", 
          "patient care", 
          "human melanoma", 
          "phenotypic subtypes", 
          "cancer treatment", 
          "melanoma", 
          "differentiation status", 
          "genome-wide expression analysis", 
          "mechanistic assessment", 
          "immunotherapy", 
          "response", 
          "patients", 
          "dysfunction", 
          "blockade", 
          "subtypes", 
          "expression analysis", 
          "biomarkers", 
          "care", 
          "outcomes", 
          "treatment", 
          "benefits", 
          "status", 
          "multipotency", 
          "resistance", 
          "subset", 
          "assessment", 
          "target", 
          "exclusion program", 
          "urgency", 
          "correlation", 
          "analysis", 
          "panel", 
          "profile", 
          "mechanism", 
          "diverse range", 
          "program", 
          "strategies", 
          "model", 
          "variety", 
          "comparative analysis", 
          "observations", 
          "signatures", 
          "range", 
          "alignment", 
          "behavior", 
          "platform"
        ], 
        "name": "Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy", 
        "pagination": "781-791", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1126634024"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41591-020-0818-3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "32284588"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41591-020-0818-3", 
          "https://app.dimensions.ai/details/publication/pub.1126634024"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_840.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41591-020-0818-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41591-020-0818-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41591-020-0818-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41591-020-0818-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41591-020-0818-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    500 TRIPLES      21 PREDICATES      135 URIs      105 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41591-020-0818-3 schema:about N07a6fa8237a448d8b6b57546699608ae
    2 N43b73d4eea894d958a1ad2b0e6bcd522
    3 N4418b0415e834be4ae020ddb10c20e7a
    4 N4a675cd78b8f4cde89fd845d7b4c41c7
    5 N509ee21923a04cb58363e3797fe93114
    6 N53c20319160843e6b1a10a61be883c2a
    7 N591ef3bd38a84ddeb0c44c22ba3193b8
    8 N5b6ae83a114e4cc58ea5b8e2c7984291
    9 N5c218a8edd084604b598b101e07fdb3e
    10 N7070a503e32a41178b15a6b7f43e2ca7
    11 N83a8bc1251d549d197f8cb5eb81ffa35
    12 N9623ad46a147491997abed9bf1423152
    13 N97a0c0c3fc4447cbbbf1678ae8ac3f04
    14 N9e0bb39a08014b9abe8c608216b6091a
    15 Na35a75e3261e4a90bf3b0eb8a7228f85
    16 Nb6d608e3de8d428b81d567631de8cefc
    17 Nba244164ac3c48219a66252863443215
    18 Nba4d34ff817d4f63ba81dde3a41b354b
    19 Nde591086b32c45289a2fb9970ad4b627
    20 Ndfcf19b188c2477590c7456cd6861182
    21 Nf09ed3060f914db4ac6743d6c1beeea7
    22 anzsrc-for:11
    23 anzsrc-for:1107
    24 anzsrc-for:1112
    25 schema:author N192c2526f3f64bf98119a2d331645369
    26 schema:citation sg:pub.10.1007/bf00319691
    27 sg:pub.10.1007/s00018-019-03049-w
    28 sg:pub.10.1038/35095108
    29 sg:pub.10.1038/labinvest.2016.155
    30 sg:pub.10.1038/nature11538
    31 sg:pub.10.1038/nature12477
    32 sg:pub.10.1038/nature13111
    33 sg:pub.10.1038/nature13954
    34 sg:pub.10.1038/nature22071
    35 sg:pub.10.1038/nature22367
    36 sg:pub.10.1038/nature23477
    37 sg:pub.10.1038/ng.356
    38 sg:pub.10.1038/nmeth.3337
    39 sg:pub.10.1038/s41467-019-14085-2
    40 sg:pub.10.1038/s41591-018-0045-3
    41 sg:pub.10.1038/s41591-018-0085-8
    42 sg:pub.10.1038/s41591-018-0136-1
    43 sg:pub.10.1038/s41591-018-0157-9
    44 sg:pub.10.1038/srep40508
    45 sg:pub.10.1186/1471-2105-12-323
    46 sg:pub.10.1186/s13059-014-0550-8
    47 schema:datePublished 2020-04-13
    48 schema:datePublishedReg 2020-04-13
    49 schema:description Although immunotherapy has revolutionized cancer treatment, only a subset of patients demonstrate durable clinical benefit. Definitive predictive biomarkers and targets to overcome resistance remain unidentified, underscoring the urgency to develop reliable immunocompetent models for mechanistic assessment. Here we characterize a panel of syngeneic mouse models, representing a variety of molecular and phenotypic subtypes of human melanomas and exhibiting their diverse range of responses to immune checkpoint blockade (ICB). Comparative analysis of genomic, transcriptomic and tumor-infiltrating immune cell profiles demonstrated alignment with clinical observations and validated the correlation of T cell dysfunction and exclusion programs with resistance. Notably, genome-wide expression analysis uncovered a melanocytic plasticity signature predictive of patient outcome in response to ICB, suggesting that the multipotency and differentiation status of melanoma can determine ICB benefit. Our comparative preclinical platform recapitulates melanoma clinical behavior and can be employed to identify mechanisms and treatment strategies to improve patient care.
    50 schema:genre article
    51 schema:isAccessibleForFree true
    52 schema:isPartOf N3b60b3ddfffd40bc8232e8b7cf6aa8f3
    53 Nb494b9905e904a14bd5ee6c6cabd3aaa
    54 sg:journal.1113716
    55 schema:keywords ICB benefit
    56 T cell dysfunction
    57 alignment
    58 analysis
    59 assessment
    60 behavior
    61 benefits
    62 biomarkers
    63 blockade
    64 cancer treatment
    65 care
    66 cell dysfunction
    67 cell profiles
    68 checkpoint blockade
    69 clinical behavior
    70 clinical benefit
    71 clinical observations
    72 clinical response
    73 comparative analysis
    74 correlation
    75 definitive predictive biomarkers
    76 differentiation status
    77 diverse range
    78 durable clinical benefit
    79 dysfunction
    80 exclusion program
    81 expression analysis
    82 genome-wide expression analysis
    83 human melanoma
    84 immune cell profiles
    85 immune checkpoint blockade
    86 immunocompetent model
    87 immunotherapy
    88 mechanism
    89 mechanistic assessment
    90 melanoma
    91 model
    92 mouse model
    93 multipotency
    94 observations
    95 outcomes
    96 panel
    97 patient care
    98 patient outcomes
    99 patients
    100 phenotypic subtypes
    101 platform
    102 preclinical platform
    103 predictive biomarkers
    104 profile
    105 program
    106 range
    107 resistance
    108 response
    109 signatures
    110 status
    111 strategies
    112 subset
    113 subset of patients
    114 subtypes
    115 syngeneic mouse model
    116 target
    117 treatment
    118 treatment strategies
    119 tumor-infiltrating immune cell profiles
    120 urgency
    121 variety
    122 schema:name Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy
    123 schema:pagination 781-791
    124 schema:productId N284a21cee2bb4f9e80e9edee02af37fd
    125 N4a404a45c42d460b99f9c780478b2800
    126 N4b07b3ec68bd4c92ab37d9ed1c6a9bc3
    127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1126634024
    128 https://doi.org/10.1038/s41591-020-0818-3
    129 schema:sdDatePublished 2022-10-01T06:46
    130 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    131 schema:sdPublisher Nc04a85c20c634931a2149cf256b23fc0
    132 schema:url https://doi.org/10.1038/s41591-020-0818-3
    133 sgo:license sg:explorer/license/
    134 sgo:sdDataset articles
    135 rdf:type schema:ScholarlyArticle
    136 N07a6fa8237a448d8b6b57546699608ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Mice
    138 rdf:type schema:DefinedTerm
    139 N0bd9878b61254d78a4c28b104848af79 rdf:first sg:person.0637120274.72
    140 rdf:rest N8261fca594f7450692d64b963f21a579
    141 N13b4e672200b466a8410a7cb969f4a29 rdf:first sg:person.012462106177.44
    142 rdf:rest Nae797ba532534a7e8c1259784fab4d8c
    143 N192c2526f3f64bf98119a2d331645369 rdf:first sg:person.01350776723.38
    144 rdf:rest Nc28c9350f6dc4a2c9fac4bec346277ea
    145 N214857264d744e6681e426912d745aea rdf:first sg:person.016167100711.34
    146 rdf:rest N492dedf05e4a455790187539adcbb1a4
    147 N25f9a8ca0bd84af5ab74d446d999e8f3 rdf:first sg:person.0637301071.16
    148 rdf:rest Nd12c6f3d63a9497fb8e51a0726c5403d
    149 N284a21cee2bb4f9e80e9edee02af37fd schema:name doi
    150 schema:value 10.1038/s41591-020-0818-3
    151 rdf:type schema:PropertyValue
    152 N2a838f86901b4840b2b6e6a76a51b604 rdf:first sg:person.016451101230.65
    153 rdf:rest N32f15da5ab104c04b27f6b3e6e03207c
    154 N32f15da5ab104c04b27f6b3e6e03207c rdf:first sg:person.01326633261.33
    155 rdf:rest N0bd9878b61254d78a4c28b104848af79
    156 N34de02f9f7a84419ac1344a19540e0fe rdf:first sg:person.013276023353.30
    157 rdf:rest Ndacdfea2fe934d13acc86e607007c319
    158 N3aa12177f3ce41808da940edd12de014 rdf:first sg:person.01027062651.28
    159 rdf:rest rdf:nil
    160 N3b60b3ddfffd40bc8232e8b7cf6aa8f3 schema:volumeNumber 26
    161 rdf:type schema:PublicationVolume
    162 N3d28f8198cc54a34a1dd68860ad1b785 rdf:first sg:person.0777537437.68
    163 rdf:rest Nc517f7c818754989b19b624ed8877faa
    164 N3e006785e31548508fa97b7f1ef1a172 rdf:first sg:person.01257633341.37
    165 rdf:rest N3d28f8198cc54a34a1dd68860ad1b785
    166 N43b73d4eea894d958a1ad2b0e6bcd522 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name RNA-Seq
    168 rdf:type schema:DefinedTerm
    169 N4418b0415e834be4ae020ddb10c20e7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Antineoplastic Agents, Immunological
    171 rdf:type schema:DefinedTerm
    172 N492dedf05e4a455790187539adcbb1a4 rdf:first sg:person.07456645233.25
    173 rdf:rest N13b4e672200b466a8410a7cb969f4a29
    174 N4a404a45c42d460b99f9c780478b2800 schema:name dimensions_id
    175 schema:value pub.1126634024
    176 rdf:type schema:PropertyValue
    177 N4a675cd78b8f4cde89fd845d7b4c41c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Prognosis
    179 rdf:type schema:DefinedTerm
    180 N4b07b3ec68bd4c92ab37d9ed1c6a9bc3 schema:name pubmed_id
    181 schema:value 32284588
    182 rdf:type schema:PropertyValue
    183 N509ee21923a04cb58363e3797fe93114 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Treatment Outcome
    185 rdf:type schema:DefinedTerm
    186 N53c20319160843e6b1a10a61be883c2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Humans
    188 rdf:type schema:DefinedTerm
    189 N591ef3bd38a84ddeb0c44c22ba3193b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Mice, Transgenic
    191 rdf:type schema:DefinedTerm
    192 N5b6ae83a114e4cc58ea5b8e2c7984291 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name CTLA-4 Antigen
    194 rdf:type schema:DefinedTerm
    195 N5c218a8edd084604b598b101e07fdb3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Gene Expression Regulation, Neoplastic
    197 rdf:type schema:DefinedTerm
    198 N5fa9c83fc1e142c896bd18f4cb9c1575 rdf:first sg:person.0624024223.78
    199 rdf:rest N34de02f9f7a84419ac1344a19540e0fe
    200 N7070a503e32a41178b15a6b7f43e2ca7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Mice, Inbred C57BL
    202 rdf:type schema:DefinedTerm
    203 N722836f26a274039a3bd216b17890932 rdf:first sg:person.01063733037.99
    204 rdf:rest Nc5436c80709c444bbd1ada3885ee326e
    205 N8261fca594f7450692d64b963f21a579 rdf:first sg:person.0701722423.70
    206 rdf:rest N3e006785e31548508fa97b7f1ef1a172
    207 N83a8bc1251d549d197f8cb5eb81ffa35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Cells, Cultured
    209 rdf:type schema:DefinedTerm
    210 N93de729c402a4b9cb39ccffc9df9f8c2 rdf:first sg:person.015026237361.01
    211 rdf:rest N2a838f86901b4840b2b6e6a76a51b604
    212 N9623ad46a147491997abed9bf1423152 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Programmed Cell Death 1 Receptor
    214 rdf:type schema:DefinedTerm
    215 N96eafa61ef3c4cc28eab6fa96580fce3 rdf:first sg:person.01061176646.83
    216 rdf:rest N25f9a8ca0bd84af5ab74d446d999e8f3
    217 N97a0c0c3fc4447cbbbf1678ae8ac3f04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Animals
    219 rdf:type schema:DefinedTerm
    220 N9e0bb39a08014b9abe8c608216b6091a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Genetic Heterogeneity
    222 rdf:type schema:DefinedTerm
    223 Na35a75e3261e4a90bf3b0eb8a7228f85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Immunotherapy
    225 rdf:type schema:DefinedTerm
    226 Nae797ba532534a7e8c1259784fab4d8c rdf:first sg:person.015666005071.69
    227 rdf:rest Ndcbef558e5ae47428dabf77302b66456
    228 Nb494b9905e904a14bd5ee6c6cabd3aaa schema:issueNumber 5
    229 rdf:type schema:PublicationIssue
    230 Nb6d608e3de8d428b81d567631de8cefc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    231 schema:name Melanoma
    232 rdf:type schema:DefinedTerm
    233 Nba244164ac3c48219a66252863443215 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Female
    235 rdf:type schema:DefinedTerm
    236 Nba4d34ff817d4f63ba81dde3a41b354b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Ipilimumab
    238 rdf:type schema:DefinedTerm
    239 Nbf0af87b3eb34a2283767d524766267f rdf:first sg:person.01272622475.04
    240 rdf:rest N3aa12177f3ce41808da940edd12de014
    241 Nc04a85c20c634931a2149cf256b23fc0 schema:name Springer Nature - SN SciGraph project
    242 rdf:type schema:Organization
    243 Nc28c9350f6dc4a2c9fac4bec346277ea rdf:first sg:person.01265423374.16
    244 rdf:rest N96eafa61ef3c4cc28eab6fa96580fce3
    245 Nc517f7c818754989b19b624ed8877faa rdf:first sg:person.01364737107.00
    246 rdf:rest N5fa9c83fc1e142c896bd18f4cb9c1575
    247 Nc5436c80709c444bbd1ada3885ee326e rdf:first sg:person.01201562005.35
    248 rdf:rest N214857264d744e6681e426912d745aea
    249 Nd12c6f3d63a9497fb8e51a0726c5403d rdf:first sg:person.0753705004.41
    250 rdf:rest N722836f26a274039a3bd216b17890932
    251 Ndacdfea2fe934d13acc86e607007c319 rdf:first sg:person.0730222174.29
    252 rdf:rest Nbf0af87b3eb34a2283767d524766267f
    253 Ndcbef558e5ae47428dabf77302b66456 rdf:first sg:person.01032374022.44
    254 rdf:rest N93de729c402a4b9cb39ccffc9df9f8c2
    255 Nde591086b32c45289a2fb9970ad4b627 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    256 schema:name Drug Screening Assays, Antitumor
    257 rdf:type schema:DefinedTerm
    258 Ndfcf19b188c2477590c7456cd6861182 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    259 schema:name Disease Models, Animal
    260 rdf:type schema:DefinedTerm
    261 Nf09ed3060f914db4ac6743d6c1beeea7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    262 schema:name Whole Genome Sequencing
    263 rdf:type schema:DefinedTerm
    264 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    265 schema:name Medical and Health Sciences
    266 rdf:type schema:DefinedTerm
    267 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    268 schema:name Immunology
    269 rdf:type schema:DefinedTerm
    270 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    271 schema:name Oncology and Carcinogenesis
    272 rdf:type schema:DefinedTerm
    273 sg:grant.2723583 http://pending.schema.org/fundedItem sg:pub.10.1038/s41591-020-0818-3
    274 rdf:type schema:MonetaryGrant
    275 sg:grant.2724091 http://pending.schema.org/fundedItem sg:pub.10.1038/s41591-020-0818-3
    276 rdf:type schema:MonetaryGrant
    277 sg:grant.4730439 http://pending.schema.org/fundedItem sg:pub.10.1038/s41591-020-0818-3
    278 rdf:type schema:MonetaryGrant
    279 sg:grant.6500229 http://pending.schema.org/fundedItem sg:pub.10.1038/s41591-020-0818-3
    280 rdf:type schema:MonetaryGrant
    281 sg:grant.6501592 http://pending.schema.org/fundedItem sg:pub.10.1038/s41591-020-0818-3
    282 rdf:type schema:MonetaryGrant
    283 sg:grant.7910676 http://pending.schema.org/fundedItem sg:pub.10.1038/s41591-020-0818-3
    284 rdf:type schema:MonetaryGrant
    285 sg:journal.1113716 schema:issn 1078-8956
    286 1546-170X
    287 schema:name Nature Medicine
    288 schema:publisher Springer Nature
    289 rdf:type schema:Periodical
    290 sg:person.01027062651.28 schema:affiliation grid-institutes:grid.417768.b
    291 schema:familyName Merlino
    292 schema:givenName Glenn
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027062651.28
    294 rdf:type schema:Person
    295 sg:person.01032374022.44 schema:affiliation grid-institutes:grid.417768.b
    296 schema:familyName Iacovelli
    297 schema:givenName Anthony J.
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032374022.44
    299 rdf:type schema:Person
    300 sg:person.01061176646.83 schema:affiliation grid-institutes:grid.417768.b
    301 schema:familyName Araya
    302 schema:givenName Romina E.
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061176646.83
    304 rdf:type schema:Person
    305 sg:person.01063733037.99 schema:affiliation grid-institutes:grid.510010.5
    306 schema:familyName Vodnala
    307 schema:givenName Suman Kumar
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063733037.99
    309 rdf:type schema:Person
    310 sg:person.01201562005.35 schema:affiliation grid-institutes:grid.417768.b
    311 schema:familyName Marie
    312 schema:givenName Kerrie L.
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201562005.35
    314 rdf:type schema:Person
    315 sg:person.012462106177.44 schema:affiliation grid-institutes:grid.417768.b
    316 schema:familyName Lam
    317 schema:givenName Khiem C.
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012462106177.44
    319 rdf:type schema:Person
    320 sg:person.01257633341.37 schema:affiliation grid-institutes:grid.510010.5
    321 schema:familyName Restifo
    322 schema:givenName Nicholas P.
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257633341.37
    324 rdf:type schema:Person
    325 sg:person.01265423374.16 schema:affiliation grid-institutes:grid.417768.b
    326 schema:familyName Yang
    327 schema:givenName Howard H.
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265423374.16
    329 rdf:type schema:Person
    330 sg:person.01272622475.04 schema:affiliation grid-institutes:grid.417768.b
    331 schema:familyName Day
    332 schema:givenName Chi-Ping
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272622475.04
    334 rdf:type schema:Person
    335 sg:person.01326633261.33 schema:affiliation grid-institutes:grid.417768.b
    336 schema:familyName Michalowski
    337 schema:givenName Aleksandra M.
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326633261.33
    339 rdf:type schema:Person
    340 sg:person.013276023353.30 schema:affiliation grid-institutes:grid.417768.b
    341 schema:familyName Weaver Ohler
    342 schema:givenName Zoe
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013276023353.30
    344 rdf:type schema:Person
    345 sg:person.01350776723.38 schema:affiliation grid-institutes:grid.417768.b
    346 schema:familyName Pérez-Guijarro
    347 schema:givenName Eva
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350776723.38
    349 rdf:type schema:Person
    350 sg:person.01364737107.00 schema:affiliation grid-institutes:None
    351 schema:familyName Van Dyke
    352 schema:givenName Terry
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364737107.00
    354 rdf:type schema:Person
    355 sg:person.015026237361.01 schema:affiliation grid-institutes:grid.417768.b
    356 schema:familyName Kulaga
    357 schema:givenName Alan
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015026237361.01
    359 rdf:type schema:Person
    360 sg:person.015666005071.69 schema:affiliation grid-institutes:grid.417768.b
    361 schema:familyName Thorkelsson
    362 schema:givenName Andres
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015666005071.69
    364 rdf:type schema:Person
    365 sg:person.016167100711.34 schema:affiliation grid-institutes:grid.419407.f
    366 schema:familyName Smith
    367 schema:givenName Cari
    368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016167100711.34
    369 rdf:type schema:Person
    370 sg:person.016451101230.65 schema:affiliation grid-institutes:grid.417768.b
    371 schema:familyName Fon
    372 schema:givenName Anyen
    373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016451101230.65
    374 rdf:type schema:Person
    375 sg:person.0624024223.78 schema:affiliation grid-institutes:grid.417768.b
    376 schema:familyName Goldszmid
    377 schema:givenName Romina S.
    378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624024223.78
    379 rdf:type schema:Person
    380 sg:person.0637120274.72 schema:affiliation grid-institutes:grid.19006.3e
    381 schema:familyName Hugo
    382 schema:givenName Willy
    383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637120274.72
    384 rdf:type schema:Person
    385 sg:person.0637301071.16 schema:affiliation grid-institutes:grid.417768.b
    386 schema:familyName El Meskini
    387 schema:givenName Rajaa
    388 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637301071.16
    389 rdf:type schema:Person
    390 sg:person.0701722423.70 schema:affiliation grid-institutes:grid.19006.3e
    391 schema:familyName Lo
    392 schema:givenName Roger S.
    393 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701722423.70
    394 rdf:type schema:Person
    395 sg:person.0730222174.29 schema:affiliation grid-institutes:grid.417768.b
    396 schema:familyName Lee
    397 schema:givenName Maxwell P.
    398 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730222174.29
    399 rdf:type schema:Person
    400 sg:person.07456645233.25 schema:affiliation grid-institutes:grid.419407.f
    401 schema:familyName Chin
    402 schema:givenName Sung
    403 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07456645233.25
    404 rdf:type schema:Person
    405 sg:person.0753705004.41 schema:affiliation grid-institutes:grid.417768.b
    406 schema:familyName Michael
    407 schema:givenName Helen T.
    408 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753705004.41
    409 rdf:type schema:Person
    410 sg:person.0777537437.68 schema:affiliation grid-institutes:grid.417768.b
    411 schema:familyName Sharan
    412 schema:givenName Shyam K.
    413 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777537437.68
    414 rdf:type schema:Person
    415 sg:pub.10.1007/bf00319691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018285551
    416 https://doi.org/10.1007/bf00319691
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1007/s00018-019-03049-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1112513840
    419 https://doi.org/10.1007/s00018-019-03049-w
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1038/35095108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045448662
    422 https://doi.org/10.1038/35095108
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1038/labinvest.2016.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031160147
    425 https://doi.org/10.1038/labinvest.2016.155
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1038/nature11538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001689247
    428 https://doi.org/10.1038/nature11538
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.1038/nature12477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050004918
    431 https://doi.org/10.1038/nature12477
    432 rdf:type schema:CreativeWork
    433 sg:pub.10.1038/nature13111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046208212
    434 https://doi.org/10.1038/nature13111
    435 rdf:type schema:CreativeWork
    436 sg:pub.10.1038/nature13954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020455470
    437 https://doi.org/10.1038/nature13954
    438 rdf:type schema:CreativeWork
    439 sg:pub.10.1038/nature22071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085123990
    440 https://doi.org/10.1038/nature22071
    441 rdf:type schema:CreativeWork
    442 sg:pub.10.1038/nature22367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085428066
    443 https://doi.org/10.1038/nature22367
    444 rdf:type schema:CreativeWork
    445 sg:pub.10.1038/nature23477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091081816
    446 https://doi.org/10.1038/nature23477
    447 rdf:type schema:CreativeWork
    448 sg:pub.10.1038/ng.356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019872106
    449 https://doi.org/10.1038/ng.356
    450 rdf:type schema:CreativeWork
    451 sg:pub.10.1038/nmeth.3337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004732944
    452 https://doi.org/10.1038/nmeth.3337
    453 rdf:type schema:CreativeWork
    454 sg:pub.10.1038/s41467-019-14085-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124121200
    455 https://doi.org/10.1038/s41467-019-14085-2
    456 rdf:type schema:CreativeWork
    457 sg:pub.10.1038/s41591-018-0045-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105071631
    458 https://doi.org/10.1038/s41591-018-0045-3
    459 rdf:type schema:CreativeWork
    460 sg:pub.10.1038/s41591-018-0085-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105071638
    461 https://doi.org/10.1038/s41591-018-0085-8
    462 rdf:type schema:CreativeWork
    463 sg:pub.10.1038/s41591-018-0136-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106133483
    464 https://doi.org/10.1038/s41591-018-0136-1
    465 rdf:type schema:CreativeWork
    466 sg:pub.10.1038/s41591-018-0157-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106133485
    467 https://doi.org/10.1038/s41591-018-0157-9
    468 rdf:type schema:CreativeWork
    469 sg:pub.10.1038/srep40508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004946403
    470 https://doi.org/10.1038/srep40508
    471 rdf:type schema:CreativeWork
    472 sg:pub.10.1186/1471-2105-12-323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021902674
    473 https://doi.org/10.1186/1471-2105-12-323
    474 rdf:type schema:CreativeWork
    475 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
    476 https://doi.org/10.1186/s13059-014-0550-8
    477 rdf:type schema:CreativeWork
    478 grid-institutes:None schema:alternateName Path Forward Solutions, Frederick, MD, USA
    479 schema:name Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA
    480 Path Forward Solutions, Frederick, MD, USA
    481 rdf:type schema:Organization
    482 grid-institutes:grid.19006.3e schema:alternateName Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    483 schema:name Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    484 rdf:type schema:Organization
    485 grid-institutes:grid.417768.b schema:alternateName Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    486 Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA
    487 Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    488 Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA
    489 schema:name Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    490 Center for Advanced Preclinical Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA
    491 Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    492 Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA
    493 rdf:type schema:Organization
    494 grid-institutes:grid.419407.f schema:alternateName Laboratory Animal Science Program, Leidos Biomedical Research Inc, Frederick, MD, USA
    495 schema:name Laboratory Animal Science Program, Leidos Biomedical Research Inc, Frederick, MD, USA
    496 rdf:type schema:Organization
    497 grid-institutes:grid.510010.5 schema:alternateName Lyell Immunopharma, South San Francisco, CA, USA
    498 schema:name Lyell Immunopharma, South San Francisco, CA, USA
    499 Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    500 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...