Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G. J. Surewaard, Dominik Rath, Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patrick Helbling, César Nombela-Arrieta, Anahita Rafiei, Martina Hinterleitner, Marcel Rall, Florian Baku, Oliver Borst, Caroline L. Wilson, Jack Leslie, Tracy O’Connor, Christopher J. Weston, David H. Adams, Lozan Sheriff, Ana Teijeiro, Marco Prinz, Ruzhica Bogeska, Natasha Anstee, Malte N. Bongers, Mike Notohamiprodjo, Tobias Geisler, Dominic J. Withers, Jerry Ware, Derek A. Mann, Hellmut G. Augustin, Alexandros Vegiopoulos, Michael D. Milsom, Adam J. Rose, Patricia F. Lalor, Josep M. Llovet, Roser Pinyol, Frank Tacke, Roland Rad, Matthias Matter, Nabil Djouder, Paul Kubes, Percy A. Knolle, Kristian Unger, Lars Zender, Bernhard Nieswandt, Meinrad Gawaz, Achim Weber, Mathias Heikenwalder

ABSTRACT

Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we show that platelet number, platelet activation and platelet aggregation are increased in NASH but not in steatosis or insulin resistance. Antiplatelet therapy (APT; aspirin/clopidogrel, ticagrelor) but not nonsteroidal anti-inflammatory drug (NSAID) treatment with sulindac prevented NASH and subsequent HCC development. Intravital microscopy showed that liver colonization by platelets depended primarily on Kupffer cells at early and late stages of NASH, involving hyaluronan-CD44 binding. APT reduced intrahepatic platelet accumulation and the frequency of platelet-immune cell interaction, thereby limiting hepatic immune cell trafficking. Consequently, intrahepatic cytokine and chemokine release, macrovesicular steatosis and liver damage were attenuated. Platelet cargo, platelet adhesion and platelet activation but not platelet aggregation were identified as pivotal for NASH and subsequent hepatocarcinogenesis. In particular, platelet-derived GPIbα proved critical for development of NASH and subsequent HCC, independent of its reported cognate ligands vWF, P-selectin or Mac-1, offering a potential target against NASH. More... »

PAGES

1-15

References to SciGraph publications

  • 2012. Platelets: Production, Morphology and Ultrastructure in ANTIPLATELET AGENTS
  • 2018-03. The immunology of hepatocellular carcinoma in NATURE IMMUNOLOGY
  • 2012-04. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials in DIABETOLOGIA
  • 2015-12-17. Nonalcoholic fatty liver disease in NATURE REVIEWS DISEASE PRIMERS
  • 2011-11. Arterial thrombosis—insidious, unpredictable and deadly in NATURE MEDICINE
  • 2017-05-30. Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα in NATURE COMMUNICATIONS
  • 2008-07. Aggravation of viral hepatitis by platelet-derived serotonin in NATURE MEDICINE
  • 2018-07. Mechanisms of NAFLD development and therapeutic strategies in NATURE MEDICINE
  • 2014-12. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2005-11. Platelets mediate cytotoxic T lymphocyte–induced liver damage in NATURE MEDICINE
  • 2003-08. How Platelets Work: Platelet Function and Dysfunction in JOURNAL OF THROMBOSIS AND THROMBOLYSIS
  • 2011-08. NBEAL2 is mutated in gray platelet syndrome and is required for biogenesis of platelet α-granules in NATURE GENETICS
  • 2017-02-23. Antithrombotic therapy for patients with STEMI undergoing primary PCI in NATURE REVIEWS CARDIOLOGY
  • 2011-08. Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome in NATURE GENETICS
  • 2011-08. Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome in NATURE GENETICS
  • 2016-07. The impact of amplification on differential expression analyses by RNA-seq in SCIENTIFIC REPORTS
  • 2013-05. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment in NATURE CELL BIOLOGY
  • 2017-06-15. A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis in NATURE COMMUNICATIONS
  • 2011-01. NF-κB and STAT3 – key players in liver inflammation and cancer in CELL RESEARCH
  • 2018-01. Neutrophils: driving progression and poor prognosis in hepatocellular carcinoma? in BRITISH JOURNAL OF CANCER
  • 2017-09. Global Epidemiology of Hepatocellular Carcinoma (HCC Epidemiology) in JOURNAL OF GASTROINTESTINAL CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41591-019-0379-5

    DOI

    http://dx.doi.org/10.1038/s41591-019-0379-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113159070

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30936549


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University Hospital of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.412004.3", 
              "name": [
                "Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Malehmir", 
            "givenName": "Mohsen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pfister", 
            "givenName": "Dominik", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gallage", 
            "givenName": "Suchira", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Szydlowska", 
            "givenName": "Marta", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany", 
                "European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Inverso", 
            "givenName": "Donato", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany", 
                "Institute for Virology, Technische Universit\u00e4t M\u00fcnchen/Helmholtz Zentrum M\u00fcnchen, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kotsiliti", 
            "givenName": "Elena", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany", 
                "Research Unit of Radiation Cytogenetics, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leone", 
            "givenName": "Valentina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Calgary", 
              "id": "https://www.grid.ac/institutes/grid.22072.35", 
              "name": [
                "Calvin Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada", 
                "Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peiseler", 
            "givenName": "Moritz", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Calgary", 
              "id": "https://www.grid.ac/institutes/grid.22072.35", 
              "name": [
                "Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada", 
                "Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada", 
                "Department of Medical Microbiology, University Medical Center, Utrmeecht, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Surewaard", 
            "givenName": "Bas G. J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Cardiology and Circulatory Diseases, Internal Medicine Clinic III, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rath", 
            "givenName": "Dominik", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ali", 
            "givenName": "Adnan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.412004.3", 
              "name": [
                "Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wolf", 
            "givenName": "Monika Julia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum Aachen", 
              "id": "https://www.grid.ac/institutes/grid.412301.5", 
              "name": [
                "Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Drescher", 
            "givenName": "Hannah", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.412004.3", 
              "name": [
                "Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Healy", 
            "givenName": "Marc E.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Internal Medicine VIII, University Hospital T\u00fcbingen, T\u00fcbingen, Germany", 
                "Department of Physiology I, Institute of Physiology, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dauch", 
            "givenName": "Daniel", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum Aachen", 
              "id": "https://www.grid.ac/institutes/grid.412301.5", 
              "name": [
                "Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kroy", 
            "givenName": "Daniela", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum Aachen", 
              "id": "https://www.grid.ac/institutes/grid.412301.5", 
              "name": [
                "Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krenkel", 
            "givenName": "Oliver", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum Aachen", 
              "id": "https://www.grid.ac/institutes/grid.412301.5", 
              "name": [
                "Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kohlhepp", 
            "givenName": "Marlene", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Center for Translational Cancer Research (TranslaTUM), Technische Universit\u00e4t M\u00fcnchen, Munich, Germany", 
                "Department of Medicine II, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Engleitner", 
            "givenName": "Thomas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany", 
                "Medical Faculty, University of Heidelberg, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Olkus", 
            "givenName": "Alexander", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sijmonsma", 
            "givenName": "Tjeerd", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of W\u00fcrzburg", 
              "id": "https://www.grid.ac/institutes/grid.8379.5", 
              "name": [
                "Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Volz", 
            "givenName": "Julia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of W\u00fcrzburg", 
              "id": "https://www.grid.ac/institutes/grid.8379.5", 
              "name": [
                "Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deppermann", 
            "givenName": "Carsten", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of W\u00fcrzburg", 
              "id": "https://www.grid.ac/institutes/grid.8379.5", 
              "name": [
                "Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stegner", 
            "givenName": "David", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.7400.3", 
              "name": [
                "Hematology, University Hospital and University of Zurich, Zurich, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Helbling", 
            "givenName": "Patrick", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.7400.3", 
              "name": [
                "Hematology, University Hospital and University of Zurich, Zurich, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nombela-Arrieta", 
            "givenName": "C\u00e9sar", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.7400.3", 
              "name": [
                "Hematology, University Hospital and University of Zurich, Zurich, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rafiei", 
            "givenName": "Anahita", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Internal Medicine VIII, University Hospital T\u00fcbingen, T\u00fcbingen, Germany", 
                "Department of Physiology I, Institute of Physiology, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hinterleitner", 
            "givenName": "Martina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Cardiology and Circulatory Diseases, Internal Medicine Clinic III, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rall", 
            "givenName": "Marcel", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Cardiology and Circulatory Diseases, Internal Medicine Clinic III, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baku", 
            "givenName": "Florian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Cardiology and Circulatory Diseases, Internal Medicine Clinic III, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Borst", 
            "givenName": "Oliver", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Newcastle University", 
              "id": "https://www.grid.ac/institutes/grid.1006.7", 
              "name": [
                "Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilson", 
            "givenName": "Caroline L.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Newcastle University", 
              "id": "https://www.grid.ac/institutes/grid.1006.7", 
              "name": [
                "Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leslie", 
            "givenName": "Jack", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Technical University Munich", 
              "id": "https://www.grid.ac/institutes/grid.6936.a", 
              "name": [
                "Institute for Virology, Technische Universit\u00e4t M\u00fcnchen/Helmholtz Zentrum M\u00fcnchen, Munich, Germany", 
                "Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "O\u2019Connor", 
            "givenName": "Tracy", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "NIHR Birmingham Liver Biomedical Research Unit", 
              "id": "https://www.grid.ac/institutes/grid.454366.6", 
              "name": [
                "Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weston", 
            "givenName": "Christopher J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospitals Birmingham NHS Foundation Trust", 
              "id": "https://www.grid.ac/institutes/grid.412563.7", 
              "name": [
                "Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham, UK", 
                "Liver Unit, University Hospitals Birmingham NHS Trust, Birmingham, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adams", 
            "givenName": "David H.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Birmingham", 
              "id": "https://www.grid.ac/institutes/grid.6572.6", 
              "name": [
                "Institute for Cardiovascular Sciences, University of Birmingham, Birmingham, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sheriff", 
            "givenName": "Lozan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Spanish National Cancer Research Centre", 
              "id": "https://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Cancer Cell Biology Programme, Growth Factors, Nutrients and Cancer Group, Spanish National Cancer Research Centre, CNIO, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Teijeiro", 
            "givenName": "Ana", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Freiburg", 
              "id": "https://www.grid.ac/institutes/grid.5963.9", 
              "name": [
                "Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany", 
                "Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany", 
                "Center for NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Prinz", 
            "givenName": "Marco", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Division of Experimental Hematology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany", 
                "DKFZ-ZMBH Alliance, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bogeska", 
            "givenName": "Ruzhica", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Division of Experimental Hematology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany", 
                "DKFZ-ZMBH Alliance, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Anstee", 
            "givenName": "Natasha", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.411544.1", 
              "name": [
                "Department of Diagnostic and Interventional Radiology, University Hospital of T\u00fcbingen, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bongers", 
            "givenName": "Malte N.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.411544.1", 
              "name": [
                "Department of Diagnostic and Interventional Radiology, University Hospital of T\u00fcbingen, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Notohamiprodjo", 
            "givenName": "Mike", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Cardiovascular Medicine, University Hospital, Eberhard Karls University of T\u00fcbingen, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Geisler", 
            "givenName": "Tobias", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "Metabolic Signalling Group, MRC London Institute of Medical Sciences, London, UK", 
                "Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Withers", 
            "givenName": "Dominic J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Arkansas for Medical Sciences", 
              "id": "https://www.grid.ac/institutes/grid.241054.6", 
              "name": [
                "Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ware", 
            "givenName": "Jerry", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Newcastle University", 
              "id": "https://www.grid.ac/institutes/grid.1006.7", 
              "name": [
                "Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mann", 
            "givenName": "Derek A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany", 
                "European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Augustin", 
            "givenName": "Hellmut G.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "DKFZ Junior Group Metabolism and Stem Cell Plasticity, German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vegiopoulos", 
            "givenName": "Alexandros", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Division of Experimental Hematology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany", 
                "DKFZ-ZMBH Alliance, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Milsom", 
            "givenName": "Michael D.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Monash University", 
              "id": "https://www.grid.ac/institutes/grid.1002.3", 
              "name": [
                "Nutrient Metabolism and Signalling Lab, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, and Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rose", 
            "givenName": "Adam J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "NIHR Birmingham Liver Biomedical Research Unit", 
              "id": "https://www.grid.ac/institutes/grid.454366.6", 
              "name": [
                "Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lalor", 
            "givenName": "Patricia F.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats", 
              "id": "https://www.grid.ac/institutes/grid.425902.8", 
              "name": [
                "Mount Sinai Liver Cancer Program (Divisions of Liver Diseases, Department of Medicine, Department of Pathology, Recanati Miller Transplantation Institute), Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA", 
                "Liver Cancer Translational Research Laboratory, IDIBAPS, Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain", 
                "Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Catalonia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Llovet", 
            "givenName": "Josep M.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Liver Cancer Translational Research Laboratory, IDIBAPS, Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pinyol", 
            "givenName": "Roser", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum Aachen", 
              "id": "https://www.grid.ac/institutes/grid.412301.5", 
              "name": [
                "Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tacke", 
            "givenName": "Frank", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Center for Translational Cancer Research (TranslaTUM), Technische Universit\u00e4t M\u00fcnchen, Munich, Germany", 
                "Department of Medicine II, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rad", 
            "givenName": "Roland", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Basel", 
              "id": "https://www.grid.ac/institutes/grid.410567.1", 
              "name": [
                "Institute of Pathology, University Hospital of Basel, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matter", 
            "givenName": "Matthias", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Spanish National Cancer Research Centre", 
              "id": "https://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Cancer Cell Biology Programme, Growth Factors, Nutrients and Cancer Group, Spanish National Cancer Research Centre, CNIO, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Djouder", 
            "givenName": "Nabil", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Calgary", 
              "id": "https://www.grid.ac/institutes/grid.22072.35", 
              "name": [
                "Calvin Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada", 
                "Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada", 
                "Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kubes", 
            "givenName": "Paul", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Technical University Munich", 
              "id": "https://www.grid.ac/institutes/grid.6936.a", 
              "name": [
                "Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knolle", 
            "givenName": "Percy A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "Research Unit of Radiation Cytogenetics, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Unger", 
            "givenName": "Kristian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Internal Medicine VIII, University Hospital T\u00fcbingen, T\u00fcbingen, Germany", 
                "Department of Physiology I, Institute of Physiology, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany", 
                "Translational Gastrointestinal Oncology Group, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zender", 
            "givenName": "Lars", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of W\u00fcrzburg", 
              "id": "https://www.grid.ac/institutes/grid.8379.5", 
              "name": [
                "Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nieswandt", 
            "givenName": "Bernhard", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of T\u00fcbingen", 
              "id": "https://www.grid.ac/institutes/grid.10392.39", 
              "name": [
                "Department of Cardiology and Circulatory Diseases, Internal Medicine Clinic III, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gawaz", 
            "givenName": "Meinrad", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.412004.3", 
              "name": [
                "Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weber", 
            "givenName": "Achim", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany", 
                "Institute for Virology, Technische Universit\u00e4t M\u00fcnchen/Helmholtz Zentrum M\u00fcnchen, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heikenwalder", 
            "givenName": "Mathias", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ccell.2016.05.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000483572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/b:thro.0000014586.77684.82", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000637611", 
              "https://doi.org/10.1023/b:thro.0000014586.77684.82"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cyto.10114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000802094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci73722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000810990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci73722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000810990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2007.144550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001245128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jmri.24193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001562281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2010.183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003266208", 
              "https://doi.org/10.1038/cr.2010.183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2010.183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003266208", 
              "https://doi.org/10.1038/cr.2010.183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2012.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004439955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006029874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci27196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006736246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-10-3242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006773292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1538-7836.2011.04328.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010625129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000444807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012326598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2014.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012515480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013257560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013411158", 
              "https://doi.org/10.1038/nm1317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013411158", 
              "https://doi.org/10.1038/nm1317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awq359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013802451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/apt.12944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014037749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014323452", 
              "https://doi.org/10.1038/nm1780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/cvi.00298-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015168327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1209182109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015389307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.111.256370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016040197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.111.256370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016040197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci69210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017754773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(00)02175-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017970852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep25533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018773010", 
              "https://doi.org/10.1038/srep25533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci115468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018830464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.00079.2013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019110566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.107.691279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019117629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019384180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s2468-1253(16)30011-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019791539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-011-2446-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021177494", 
              "https://doi.org/10.1007/s00125-011-2446-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-011-2446-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021177494", 
              "https://doi.org/10.1007/s00125-011-2446-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021186053", 
              "https://doi.org/10.1038/ng.883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-03-0997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022725292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(14)61933-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026026650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(14)61933-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026026650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrdp.2015.80", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026163676", 
              "https://doi.org/10.1038/nrdp.2015.80"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027006637", 
              "https://doi.org/10.1038/ncb2730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2003-05-1391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027734750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkw377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029021006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2015.04.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029532636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029833324", 
              "https://doi.org/10.1038/ng.884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-04-020362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030006582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.193.4.459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032036123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-29423-5_1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032340826", 
              "https://doi.org/10.1007/978-3-642-29423-5_1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000133317.49796.0e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035818241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.28526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036090210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.27222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036332826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0904327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038668813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0138655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041170889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1148/rg.265055711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042117130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1755-5922.2009.00096.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042146965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1755-5922.2009.00096.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042146965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-05-222273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043230273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-05-222273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043230273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m113.511220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045377864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048275766", 
              "https://doi.org/10.1038/nm.2515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2016.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048673364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2016.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048673364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.6.803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050132287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050432107", 
              "https://doi.org/10.1038/ng.885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1409312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051736615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-04-408724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052063370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0008-6363(97)00109-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054579758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bmb/ldw031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059436964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.29085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074238586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.29085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074238586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074690888", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074702414", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077138395", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082878502", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jhep.2017.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083757873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrcardio.2017.18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083860173", 
              "https://doi.org/10.1038/nrcardio.2017.18"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gtc.2017.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085401501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms15559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085712893", 
              "https://doi.org/10.1038/ncomms15559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1614362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085986666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1614362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085986666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms15838", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086032438", 
              "https://doi.org/10.1038/ncomms15838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12029-017-9959-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086110547", 
              "https://doi.org/10.1007/s12029-017-9959-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12029-017-9959-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086110547", 
              "https://doi.org/10.1007/s12029-017-9959-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci92744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090873728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2017.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091552091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2017.386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092589583", 
              "https://doi.org/10.1038/bjc.2017.386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2017.386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092589583", 
              "https://doi.org/10.1038/bjc.2017.386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41590-018-0044-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100671496", 
              "https://doi.org/10.1038/s41590-018-0044-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2018.03.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103212575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0104-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105236508", 
              "https://doi.org/10.1038/s41591-018-0104-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0104-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105236508", 
              "https://doi.org/10.1038/s41591-018-0104-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0104-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105236508", 
              "https://doi.org/10.1038/s41591-018-0104-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0104-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105236508", 
              "https://doi.org/10.1038/s41591-018-0104-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/emmm.201708613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105288811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.30251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106526881"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04", 
        "datePublishedReg": "2019-04-01", 
        "description": "Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we show that platelet number, platelet activation and platelet aggregation are increased in NASH but not in steatosis or insulin resistance. Antiplatelet therapy (APT; aspirin/clopidogrel, ticagrelor) but not nonsteroidal anti-inflammatory drug (NSAID) treatment with sulindac prevented NASH and subsequent HCC development. Intravital microscopy showed that liver colonization by platelets depended primarily on Kupffer cells at early and late stages of NASH, involving hyaluronan-CD44 binding. APT reduced intrahepatic platelet accumulation and the frequency of platelet-immune cell interaction, thereby limiting hepatic immune cell trafficking. Consequently, intrahepatic cytokine and chemokine release, macrovesicular steatosis and liver damage were attenuated. Platelet cargo, platelet adhesion and platelet activation but not platelet aggregation were identified as pivotal for NASH and subsequent hepatocarcinogenesis. In particular, platelet-derived GPIb\u03b1 proved critical for development of NASH and subsequent HCC, independent of its reported cognate ligands vWF, P-selectin or Mac-1, offering a potential target against NASH.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41591-019-0379-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4730734", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5051108", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7706944", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "25"
          }
        ], 
        "name": "Platelet GPIb\u03b1 is a mediator and potential interventional target for NASH and subsequent liver cancer", 
        "pagination": "1-15", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "620e37c9ee56357d72ff433f42500c51597eed01702273c26669908b2f6f5200"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30936549"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41591-019-0379-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113159070"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41591-019-0379-5", 
          "https://app.dimensions.ai/details/publication/pub.1113159070"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130792_00000006.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41591-019-0379-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41591-019-0379-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41591-019-0379-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41591-019-0379-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41591-019-0379-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    820 TRIPLES      21 PREDICATES      111 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41591-019-0379-5 schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author Nad5b4200dbe64407ba0141b843567cf8
    4 schema:citation sg:pub.10.1007/978-3-642-29423-5_1
    5 sg:pub.10.1007/s00125-011-2446-4
    6 sg:pub.10.1007/s12029-017-9959-0
    7 sg:pub.10.1023/b:thro.0000014586.77684.82
    8 sg:pub.10.1038/bjc.2017.386
    9 sg:pub.10.1038/cr.2010.183
    10 sg:pub.10.1038/ncb2730
    11 sg:pub.10.1038/ncomms15559
    12 sg:pub.10.1038/ncomms15838
    13 sg:pub.10.1038/ng.883
    14 sg:pub.10.1038/ng.884
    15 sg:pub.10.1038/ng.885
    16 sg:pub.10.1038/nm.2515
    17 sg:pub.10.1038/nm1317
    18 sg:pub.10.1038/nm1780
    19 sg:pub.10.1038/nrcardio.2017.18
    20 sg:pub.10.1038/nrdp.2015.80
    21 sg:pub.10.1038/s41590-018-0044-z
    22 sg:pub.10.1038/s41591-018-0104-9
    23 sg:pub.10.1038/srep25533
    24 sg:pub.10.1186/s13059-014-0550-8
    25 https://app.dimensions.ai/details/publication/pub.1074690888
    26 https://app.dimensions.ai/details/publication/pub.1074702414
    27 https://app.dimensions.ai/details/publication/pub.1077138395
    28 https://app.dimensions.ai/details/publication/pub.1082878502
    29 https://doi.org/10.1002/cyto.10114
    30 https://doi.org/10.1002/hep.27222
    31 https://doi.org/10.1002/hep.28526
    32 https://doi.org/10.1002/hep.29085
    33 https://doi.org/10.1002/hep.30251
    34 https://doi.org/10.1002/jmri.24193
    35 https://doi.org/10.1016/j.ccell.2014.09.003
    36 https://doi.org/10.1016/j.ccell.2016.05.020
    37 https://doi.org/10.1016/j.ccell.2017.08.010
    38 https://doi.org/10.1016/j.ccell.2018.03.002
    39 https://doi.org/10.1016/j.cell.2015.05.002
    40 https://doi.org/10.1016/j.cmet.2012.04.004
    41 https://doi.org/10.1016/j.cmet.2016.01.001
    42 https://doi.org/10.1016/j.gtc.2017.01.002
    43 https://doi.org/10.1016/j.jhep.2017.02.001
    44 https://doi.org/10.1016/s0008-6363(97)00109-0
    45 https://doi.org/10.1016/s0140-6736(00)02175-9
    46 https://doi.org/10.1016/s0140-6736(14)61933-4
    47 https://doi.org/10.1016/s2468-1253(16)30011-5
    48 https://doi.org/10.1053/j.gastro.2015.04.043
    49 https://doi.org/10.1056/nejmoa0904327
    50 https://doi.org/10.1056/nejmoa1409312
    51 https://doi.org/10.1056/nejmoa1614362
    52 https://doi.org/10.1073/pnas.0506580102
    53 https://doi.org/10.1073/pnas.1209182109
    54 https://doi.org/10.1074/jbc.m113.511220
    55 https://doi.org/10.1084/jem.190.6.803
    56 https://doi.org/10.1084/jem.193.4.459
    57 https://doi.org/10.1093/bmb/ldw031
    58 https://doi.org/10.1093/brain/awq359
    59 https://doi.org/10.1093/nar/gkw377
    60 https://doi.org/10.1111/apt.12944
    61 https://doi.org/10.1111/j.1538-7836.2011.04328.x
    62 https://doi.org/10.1111/j.1755-5922.2009.00096.x
    63 https://doi.org/10.1128/cvi.00298-07
    64 https://doi.org/10.1136/gut.2007.144550
    65 https://doi.org/10.1148/rg.265055711
    66 https://doi.org/10.1152/ajpgi.00079.2013
    67 https://doi.org/10.1159/000444807
    68 https://doi.org/10.1161/01.cir.0000133317.49796.0e
    69 https://doi.org/10.1161/circresaha.111.256370
    70 https://doi.org/10.1161/circulationaha.107.691279
    71 https://doi.org/10.1172/jci115468
    72 https://doi.org/10.1172/jci119468
    73 https://doi.org/10.1172/jci27196
    74 https://doi.org/10.1172/jci69210
    75 https://doi.org/10.1172/jci73722
    76 https://doi.org/10.1172/jci92744
    77 https://doi.org/10.1182/blood-2002-03-0997
    78 https://doi.org/10.1182/blood-2002-10-3242
    79 https://doi.org/10.1182/blood-2003-05-1391
    80 https://doi.org/10.1182/blood-2006-04-020362
    81 https://doi.org/10.1182/blood-2009-05-222273
    82 https://doi.org/10.1182/blood-2012-04-408724
    83 https://doi.org/10.1371/journal.pone.0138655
    84 https://doi.org/10.15252/emmm.201708613
    85 https://doi.org/10.3322/caac.21262
    86 schema:datePublished 2019-04
    87 schema:datePublishedReg 2019-04-01
    88 schema:description Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we show that platelet number, platelet activation and platelet aggregation are increased in NASH but not in steatosis or insulin resistance. Antiplatelet therapy (APT; aspirin/clopidogrel, ticagrelor) but not nonsteroidal anti-inflammatory drug (NSAID) treatment with sulindac prevented NASH and subsequent HCC development. Intravital microscopy showed that liver colonization by platelets depended primarily on Kupffer cells at early and late stages of NASH, involving hyaluronan-CD44 binding. APT reduced intrahepatic platelet accumulation and the frequency of platelet-immune cell interaction, thereby limiting hepatic immune cell trafficking. Consequently, intrahepatic cytokine and chemokine release, macrovesicular steatosis and liver damage were attenuated. Platelet cargo, platelet adhesion and platelet activation but not platelet aggregation were identified as pivotal for NASH and subsequent hepatocarcinogenesis. In particular, platelet-derived GPIbα proved critical for development of NASH and subsequent HCC, independent of its reported cognate ligands vWF, P-selectin or Mac-1, offering a potential target against NASH.
    89 schema:genre research_article
    90 schema:inLanguage en
    91 schema:isAccessibleForFree false
    92 schema:isPartOf N3a544fe389a74e8da200048a225a2596
    93 Nc0d699942f384ad7be6918a300cad082
    94 sg:journal.1113716
    95 schema:name Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
    96 schema:pagination 1-15
    97 schema:productId N6e50a0afb6ad42f180c23dd777df21d7
    98 N82630191f4744b2b8185191a75f51372
    99 N86cba1e6566a4973bb140281c717a439
    100 Na6fba1dff48d4d46980422428fb98739
    101 Nd31cf50c053a4461af40f7a3e045b43f
    102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113159070
    103 https://doi.org/10.1038/s41591-019-0379-5
    104 schema:sdDatePublished 2019-04-11T13:48
    105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    106 schema:sdPublisher N0614bbf02b9844c6b5b886bec3290be0
    107 schema:url https://www.nature.com/articles/s41591-019-0379-5
    108 sgo:license sg:explorer/license/
    109 sgo:sdDataset articles
    110 rdf:type schema:ScholarlyArticle
    111 N00aacab3148a49d1ad1a43732f03d2a4 rdf:first Nab61b4723f874e29a52e01b91f152fa5
    112 rdf:rest N75390d4a71014284957ecb2dd5d888fa
    113 N0194b2191f334c0d8bcf2824d75047bb schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    114 schema:familyName Rath
    115 schema:givenName Dominik
    116 rdf:type schema:Person
    117 N02cca0340d234524aef86a375fe30725 rdf:first Ne7653c319f2e42ab924dcda6f72b8627
    118 rdf:rest N8878287751e04e278b15dfe6905b5d6f
    119 N0614bbf02b9844c6b5b886bec3290be0 schema:name Springer Nature - SN SciGraph project
    120 rdf:type schema:Organization
    121 N07d41c7df4c74728a80ab433d61ca901 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
    122 schema:familyName Rafiei
    123 schema:givenName Anahita
    124 rdf:type schema:Person
    125 N081d0c9b4d0744eab0e2f40ed6132615 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
    126 schema:familyName Nombela-Arrieta
    127 schema:givenName César
    128 rdf:type schema:Person
    129 N090b96a0d6d54418a504c6918b4f4500 schema:affiliation https://www.grid.ac/institutes/grid.411544.1
    130 schema:familyName Notohamiprodjo
    131 schema:givenName Mike
    132 rdf:type schema:Person
    133 N0c0780e53a5246af99379ebb91516dec rdf:first N77301c0b6f0c4911b3c78c2ff5259d31
    134 rdf:rest N650ef84dd28d481cb2f91e1f271ec6ff
    135 N0f091228ca5840deb3b61efcacb5ad34 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    136 schema:familyName Milsom
    137 schema:givenName Michael D.
    138 rdf:type schema:Person
    139 N0fcd32243f7e4fb6bd423c12dd256005 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
    140 schema:familyName Matter
    141 schema:givenName Matthias
    142 rdf:type schema:Person
    143 N0ff2c89a6cf449d08863f1bc3f3c68ed rdf:first N739e4a92af9b40d08571a34bb7a65e1a
    144 rdf:rest Na172422a9fbb43a4bd57d68a77a46cb4
    145 N103e41f8c5e646e48a4f3e2c20dad1cb rdf:first N58b7979e02f04a7b88561e900c22d0f0
    146 rdf:rest Ned4262c16bb049c2bffb25e341fa6e77
    147 N119f907200e0432dabd281f400d0b3fa rdf:first Nef5862fcfbdd4e6ca72b83e2745b0e54
    148 rdf:rest N103e41f8c5e646e48a4f3e2c20dad1cb
    149 N15dcc730163f41ba8efe6bc7e3e62d7a schema:affiliation https://www.grid.ac/institutes/grid.412004.3
    150 schema:familyName Weber
    151 schema:givenName Achim
    152 rdf:type schema:Person
    153 N1912c7ea2aea455c9815526765ba8083 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
    154 schema:familyName Peiseler
    155 schema:givenName Moritz
    156 rdf:type schema:Person
    157 N1a05ed83df53429e963c8213fba434ce schema:affiliation https://www.grid.ac/institutes/grid.6936.a
    158 schema:familyName O’Connor
    159 schema:givenName Tracy
    160 rdf:type schema:Person
    161 N1d34a0b2b3be42478a91fe7a2e2c5efe schema:affiliation https://www.grid.ac/institutes/grid.241054.6
    162 schema:familyName Ware
    163 schema:givenName Jerry
    164 rdf:type schema:Person
    165 N1fc85249fb874368b2bfd6e70e3cecec rdf:first Na35c8c39c6eb402f95bfa7bee9835450
    166 rdf:rest Na0ad2b533fa247f98f2fabfe42b846b2
    167 N21e04df2026449dfb48118cbdf744c1e rdf:first N15dcc730163f41ba8efe6bc7e3e62d7a
    168 rdf:rest Ne157253611d440828172d7833ecf8c9d
    169 N22d73542342b419eb830c314e6f3139a rdf:first N842c2545b99447a39dc197a39a781c83
    170 rdf:rest Ndf3277e82e344bafa25f7ae722ca0f6c
    171 N28525a5fba90438fb34e068fe0e6ecc5 schema:affiliation N441b28b8e42a4b23847427c9d3835f36
    172 schema:familyName Geisler
    173 schema:givenName Tobias
    174 rdf:type schema:Person
    175 N30baa81598244725b0d7d65a5c829d26 rdf:first Na127d82f149247a7ac003f63b23987fc
    176 rdf:rest N93870574407e4ce99b3130bdad7109f8
    177 N34f009bc15b44358bb48a270c0d0a35f rdf:first N518fad377b5e4792b80958a50ea251d9
    178 rdf:rest N717c41a513834cdd872b510450d2ce20
    179 N3a544fe389a74e8da200048a225a2596 schema:issueNumber 4
    180 rdf:type schema:PublicationIssue
    181 N3a81183138354b318daa450c36adda01 rdf:first N91a932a50369452ab56350a5087b653e
    182 rdf:rest Nc55e8ceab0ee4045b3ed01d66d2efac3
    183 N3fa89c460011449fa7cdc04d1a22fe4b schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    184 schema:familyName Gawaz
    185 schema:givenName Meinrad
    186 rdf:type schema:Person
    187 N441b28b8e42a4b23847427c9d3835f36 schema:name Department of Cardiovascular Medicine, University Hospital, Eberhard Karls University of Tübingen, Tübingen, Germany
    188 rdf:type schema:Organization
    189 N449dd32b4f174ca9990d015a0dfe9a16 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    190 schema:familyName Szydlowska
    191 schema:givenName Marta
    192 rdf:type schema:Person
    193 N45ecbb6c2ab2412aba05d39fe90bd4e9 rdf:first N07d41c7df4c74728a80ab433d61ca901
    194 rdf:rest N80a95f824d9d4c6ebb977f05671adb85
    195 N47c2906d43ec42818a2dbad757c17d36 rdf:first N9aee55a7c32f46f7b9161a929da8661d
    196 rdf:rest N967b9b692dba41dba5ae3fc9f93a38ad
    197 N4b5d46eb723f4269bf1e404080c653f2 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
    198 schema:familyName Teijeiro
    199 schema:givenName Ana
    200 rdf:type schema:Person
    201 N4be90856ef2b445d90d8b2e7362d3cb3 schema:affiliation https://www.grid.ac/institutes/grid.411544.1
    202 schema:familyName Bongers
    203 schema:givenName Malte N.
    204 rdf:type schema:Person
    205 N4ca1c1784f8f4a0aa334c35e426208c9 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    206 schema:familyName Withers
    207 schema:givenName Dominic J.
    208 rdf:type schema:Person
    209 N4da29b91ef1e4bfc9d448405dee68d97 rdf:first Ncf0e139f167e4c4c8cf16b2fccc477d1
    210 rdf:rest N00aacab3148a49d1ad1a43732f03d2a4
    211 N4e24df9062f241c18f7bf11828755f25 schema:affiliation https://www.grid.ac/institutes/grid.425902.8
    212 schema:familyName Llovet
    213 schema:givenName Josep M.
    214 rdf:type schema:Person
    215 N50fd09b262de4ac4ad39f25b359c7318 schema:affiliation https://www.grid.ac/institutes/grid.412563.7
    216 schema:familyName Adams
    217 schema:givenName David H.
    218 rdf:type schema:Person
    219 N518fad377b5e4792b80958a50ea251d9 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    220 schema:familyName Anstee
    221 schema:givenName Natasha
    222 rdf:type schema:Person
    223 N51c7f1c45030402e93747e6898c11ba3 rdf:first Nedded7caf2bc42be81af671f360b4415
    224 rdf:rest N7410efb3cc8344babb77cf70ec83d53d
    225 N583af7b48f5047fc8f8e3dd32a288e46 rdf:first N449dd32b4f174ca9990d015a0dfe9a16
    226 rdf:rest N1fc85249fb874368b2bfd6e70e3cecec
    227 N58846de196bc42e1bbeadb50e47b36a4 rdf:first N77a3a967964043958d2a7fc61f897e87
    228 rdf:rest N3a81183138354b318daa450c36adda01
    229 N58b7979e02f04a7b88561e900c22d0f0 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
    230 schema:familyName Helbling
    231 schema:givenName Patrick
    232 rdf:type schema:Person
    233 N5edbf36f2e80490aa839a50bd3cc1f4e schema:affiliation https://www.grid.ac/institutes/grid.6936.a
    234 schema:familyName Knolle
    235 schema:givenName Percy A.
    236 rdf:type schema:Person
    237 N60b3098e988c45eb841b18d60c192cb1 schema:affiliation https://www.grid.ac/institutes/grid.7719.8
    238 schema:familyName Djouder
    239 schema:givenName Nabil
    240 rdf:type schema:Person
    241 N619270c01f5b46b9aacba7880381bf56 rdf:first N6cce8bd2f07c47369693c01fde967597
    242 rdf:rest N58846de196bc42e1bbeadb50e47b36a4
    243 N64f422c976d44189bf3ff28d062af752 schema:affiliation https://www.grid.ac/institutes/grid.454366.6
    244 schema:familyName Weston
    245 schema:givenName Christopher J.
    246 rdf:type schema:Person
    247 N650ef84dd28d481cb2f91e1f271ec6ff rdf:first N5edbf36f2e80490aa839a50bd3cc1f4e
    248 rdf:rest Neec979bccaa240a5ac85ff75d28214dc
    249 N69778c08c6594bc2bfc8b1e8acbb29c5 rdf:first N786b026b62d145b8993495c4ef7b522c
    250 rdf:rest N9333217d000e4f98ba9328125504f5a9
    251 N6c0ce10a0f124116b9db4a15c02d155a schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    252 schema:familyName Gallage
    253 schema:givenName Suchira
    254 rdf:type schema:Person
    255 N6cce8bd2f07c47369693c01fde967597 schema:affiliation https://www.grid.ac/institutes/grid.412301.5
    256 schema:familyName Kroy
    257 schema:givenName Daniela
    258 rdf:type schema:Person
    259 N6d0b09bec8aa498eafe5f1665f397312 rdf:first N6c0ce10a0f124116b9db4a15c02d155a
    260 rdf:rest N583af7b48f5047fc8f8e3dd32a288e46
    261 N6d5341bcc63e42f19cd938c208e3f90e rdf:first N64f422c976d44189bf3ff28d062af752
    262 rdf:rest Nccd2ec8b182d4dfab5028c74520131c3
    263 N6e50a0afb6ad42f180c23dd777df21d7 schema:name doi
    264 schema:value 10.1038/s41591-019-0379-5
    265 rdf:type schema:PropertyValue
    266 N6e723ab7062246c4a48dc6d9345572bf schema:affiliation https://www.grid.ac/institutes/grid.8379.5
    267 schema:familyName Deppermann
    268 schema:givenName Carsten
    269 rdf:type schema:Person
    270 N6fb68c3e86ff4ee9b74b05753ca78396 rdf:first Nac67809e2ba5419fa1efeb7182330df9
    271 rdf:rest N9f896cd08c894eed8909da7472c5a47c
    272 N717c41a513834cdd872b510450d2ce20 rdf:first N4be90856ef2b445d90d8b2e7362d3cb3
    273 rdf:rest N928479762cfd445c9f935c49e8a13cba
    274 N71bdd280bc274f07b3253beeb59fe22a schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    275 schema:familyName Heikenwalder
    276 schema:givenName Mathias
    277 rdf:type schema:Person
    278 N739e4a92af9b40d08571a34bb7a65e1a schema:affiliation https://www.grid.ac/institutes/grid.412301.5
    279 schema:familyName Drescher
    280 schema:givenName Hannah
    281 rdf:type schema:Person
    282 N7410efb3cc8344babb77cf70ec83d53d rdf:first Nf57aa27c118c40c5970acdb741a30784
    283 rdf:rest N34f009bc15b44358bb48a270c0d0a35f
    284 N75390d4a71014284957ecb2dd5d888fa rdf:first N938a8a8a3d464f4f898a48e8bee3be96
    285 rdf:rest Ne4558c535a444ee98a2700cc467edab0
    286 N7550d45b961340ff9c2836d8d85aaf2e schema:affiliation https://www.grid.ac/institutes/grid.4567.0
    287 schema:familyName Unger
    288 schema:givenName Kristian
    289 rdf:type schema:Person
    290 N77301c0b6f0c4911b3c78c2ff5259d31 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
    291 schema:familyName Kubes
    292 schema:givenName Paul
    293 rdf:type schema:Person
    294 N77a3a967964043958d2a7fc61f897e87 schema:affiliation https://www.grid.ac/institutes/grid.412301.5
    295 schema:familyName Krenkel
    296 schema:givenName Oliver
    297 rdf:type schema:Person
    298 N786b026b62d145b8993495c4ef7b522c schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    299 schema:familyName Baku
    300 schema:givenName Florian
    301 rdf:type schema:Person
    302 N78b0cfe2c5174cb983cf5baf798045e1 schema:affiliation https://www.grid.ac/institutes/grid.8379.5
    303 schema:familyName Volz
    304 schema:givenName Julia
    305 rdf:type schema:Person
    306 N7c381ecfbd93478791b65d67bcf42c13 schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    307 schema:familyName Rall
    308 schema:givenName Marcel
    309 rdf:type schema:Person
    310 N7d0cb7935e544296a7a70e7523688e4b rdf:first Nd9e1c88df8e44312831306c44b614acb
    311 rdf:rest N0ff2c89a6cf449d08863f1bc3f3c68ed
    312 N80a95f824d9d4c6ebb977f05671adb85 rdf:first Nf74cabcd808248de8e9a3a4d41e728df
    313 rdf:rest Nf43232f8ce7f46559abbea32acba6627
    314 N82630191f4744b2b8185191a75f51372 schema:name readcube_id
    315 schema:value 620e37c9ee56357d72ff433f42500c51597eed01702273c26669908b2f6f5200
    316 rdf:type schema:PropertyValue
    317 N838c4ff94a76463a9452df96c0d49d17 schema:affiliation https://www.grid.ac/institutes/grid.412004.3
    318 schema:familyName Healy
    319 schema:givenName Marc E.
    320 rdf:type schema:Person
    321 N840c65f3f5914244ace629a4d5ad7444 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    322 schema:familyName Zender
    323 schema:givenName Lars
    324 rdf:type schema:Person
    325 N842c2545b99447a39dc197a39a781c83 schema:affiliation https://www.grid.ac/institutes/grid.6572.6
    326 schema:familyName Sheriff
    327 schema:givenName Lozan
    328 rdf:type schema:Person
    329 N860381d9b92c4333b2de58d4af291ebe schema:name Liver Cancer Translational Research Laboratory, IDIBAPS, Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain
    330 rdf:type schema:Organization
    331 N86cba1e6566a4973bb140281c717a439 schema:name dimensions_id
    332 schema:value pub.1113159070
    333 rdf:type schema:PropertyValue
    334 N8878287751e04e278b15dfe6905b5d6f rdf:first N0194b2191f334c0d8bcf2824d75047bb
    335 rdf:rest Nb1be8f0aff544b2b9be716cc0fbd6ed0
    336 N8cd78cd0c0cf4bdd8c830287893ea9a8 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
    337 schema:familyName Leone
    338 schema:givenName Valentina
    339 rdf:type schema:Person
    340 N91a932a50369452ab56350a5087b653e schema:affiliation https://www.grid.ac/institutes/grid.412301.5
    341 schema:familyName Kohlhepp
    342 schema:givenName Marlene
    343 rdf:type schema:Person
    344 N928479762cfd445c9f935c49e8a13cba rdf:first N090b96a0d6d54418a504c6918b4f4500
    345 rdf:rest Na30cd5caae644fcaa584ed8ca68afbad
    346 N9333217d000e4f98ba9328125504f5a9 rdf:first Na2762676b9754d9b9e5b9d0f6044b1fc
    347 rdf:rest Nf4952e44c95f4345acb107b97aa55e1d
    348 N93870574407e4ce99b3130bdad7109f8 rdf:first Nf963f0cde47545ca9ca21f1898cea98b
    349 rdf:rest N6fb68c3e86ff4ee9b74b05753ca78396
    350 N938a8a8a3d464f4f898a48e8bee3be96 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    351 schema:familyName Rad
    352 schema:givenName Roland
    353 rdf:type schema:Person
    354 N967b9b692dba41dba5ae3fc9f93a38ad rdf:first Nab6c02929fbf49b68f80338a3a6204a5
    355 rdf:rest Nf37c7c49674346a99d578c2a8ab1f5c4
    356 N9771756e849749059319b45146580a62 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    357 schema:familyName Kotsiliti
    358 schema:givenName Elena
    359 rdf:type schema:Person
    360 N9aee55a7c32f46f7b9161a929da8661d schema:affiliation https://www.grid.ac/institutes/grid.1002.3
    361 schema:familyName Rose
    362 schema:givenName Adam J.
    363 rdf:type schema:Person
    364 N9e66197fa9de4debb208008120ff8dcd schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    365 schema:familyName Dauch
    366 schema:givenName Daniel
    367 rdf:type schema:Person
    368 N9f896cd08c894eed8909da7472c5a47c rdf:first N0f091228ca5840deb3b61efcacb5ad34
    369 rdf:rest N47c2906d43ec42818a2dbad757c17d36
    370 Na0ad2b533fa247f98f2fabfe42b846b2 rdf:first N9771756e849749059319b45146580a62
    371 rdf:rest Nb8a1c18967714c94b0bc891d482c1d05
    372 Na127d82f149247a7ac003f63b23987fc schema:affiliation https://www.grid.ac/institutes/grid.1006.7
    373 schema:familyName Mann
    374 schema:givenName Derek A.
    375 rdf:type schema:Person
    376 Na172422a9fbb43a4bd57d68a77a46cb4 rdf:first N838c4ff94a76463a9452df96c0d49d17
    377 rdf:rest Nbd64202c565a4e9ea892202f7e975a55
    378 Na2762676b9754d9b9e5b9d0f6044b1fc schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    379 schema:familyName Borst
    380 schema:givenName Oliver
    381 rdf:type schema:Person
    382 Na30cd5caae644fcaa584ed8ca68afbad rdf:first N28525a5fba90438fb34e068fe0e6ecc5
    383 rdf:rest Nf76b5933b720499480a3b634467d143c
    384 Na35c8c39c6eb402f95bfa7bee9835450 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    385 schema:familyName Inverso
    386 schema:givenName Donato
    387 rdf:type schema:Person
    388 Na6fba1dff48d4d46980422428fb98739 schema:name nlm_unique_id
    389 schema:value 9502015
    390 rdf:type schema:PropertyValue
    391 Na997f3f7938546a4b2ab4b3ef3f3d787 schema:affiliation https://www.grid.ac/institutes/grid.412004.3
    392 schema:familyName Malehmir
    393 schema:givenName Mohsen
    394 rdf:type schema:Person
    395 Nab61b4723f874e29a52e01b91f152fa5 schema:affiliation https://www.grid.ac/institutes/grid.412301.5
    396 schema:familyName Tacke
    397 schema:givenName Frank
    398 rdf:type schema:Person
    399 Nab6c02929fbf49b68f80338a3a6204a5 schema:affiliation https://www.grid.ac/institutes/grid.454366.6
    400 schema:familyName Lalor
    401 schema:givenName Patricia F.
    402 rdf:type schema:Person
    403 Nac67809e2ba5419fa1efeb7182330df9 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    404 schema:familyName Vegiopoulos
    405 schema:givenName Alexandros
    406 rdf:type schema:Person
    407 Nac8642f73fb2449f9eb16087147a6c43 rdf:first N60b3098e988c45eb841b18d60c192cb1
    408 rdf:rest N0c0780e53a5246af99379ebb91516dec
    409 Nace784f3c7f74a43902f0ee2b9c705b6 rdf:first Nfd4cf026be1b4c8ca64e564aeaa24161
    410 rdf:rest Ne3893d0efb184c56a8bb5ac1a0d1de79
    411 Nad5b4200dbe64407ba0141b843567cf8 rdf:first Na997f3f7938546a4b2ab4b3ef3f3d787
    412 rdf:rest Ne5e2b2760e2b477286451a05cc647ac3
    413 Nae3d4ed386574c3bbf287d7ae91ea72b rdf:first N1d34a0b2b3be42478a91fe7a2e2c5efe
    414 rdf:rest N30baa81598244725b0d7d65a5c829d26
    415 Nb1be8f0aff544b2b9be716cc0fbd6ed0 rdf:first Nd030b77413f84cd2918dc73002f5fc6a
    416 rdf:rest N7d0cb7935e544296a7a70e7523688e4b
    417 Nb8a1c18967714c94b0bc891d482c1d05 rdf:first N8cd78cd0c0cf4bdd8c830287893ea9a8
    418 rdf:rest Nec4e19e0222d4ceaaf6d4bcd4fcfebbb
    419 Nbd64202c565a4e9ea892202f7e975a55 rdf:first N9e66197fa9de4debb208008120ff8dcd
    420 rdf:rest N619270c01f5b46b9aacba7880381bf56
    421 Nbf2eef223034433eb81029172ff55a78 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    422 schema:familyName Pfister
    423 schema:givenName Dominik
    424 rdf:type schema:Person
    425 Nc0d699942f384ad7be6918a300cad082 schema:volumeNumber 25
    426 rdf:type schema:PublicationVolume
    427 Nc55e8ceab0ee4045b3ed01d66d2efac3 rdf:first Nc89fab1a37514e5b896c1809141b68d0
    428 rdf:rest Nace784f3c7f74a43902f0ee2b9c705b6
    429 Nc569d685c8684545bf78d3eac83c7993 rdf:first Nfc80c6b5dde9485a950de02b3588c20b
    430 rdf:rest Nebf606947f604f89b2690002a6a4e1de
    431 Nc7845b9c5a5e41dd98ffb6067e77047b rdf:first N6e723ab7062246c4a48dc6d9345572bf
    432 rdf:rest N119f907200e0432dabd281f400d0b3fa
    433 Nc89fab1a37514e5b896c1809141b68d0 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    434 schema:familyName Engleitner
    435 schema:givenName Thomas
    436 rdf:type schema:Person
    437 Ncabb2feef4fb4b96a9fdd3c4e5439e17 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
    438 schema:familyName Wilson
    439 schema:givenName Caroline L.
    440 rdf:type schema:Person
    441 Nccd2ec8b182d4dfab5028c74520131c3 rdf:first N50fd09b262de4ac4ad39f25b359c7318
    442 rdf:rest N22d73542342b419eb830c314e6f3139a
    443 Ncf0e139f167e4c4c8cf16b2fccc477d1 schema:affiliation N860381d9b92c4333b2de58d4af291ebe
    444 schema:familyName Pinyol
    445 schema:givenName Roser
    446 rdf:type schema:Person
    447 Nd030b77413f84cd2918dc73002f5fc6a schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    448 schema:familyName Ali
    449 schema:givenName Adnan
    450 rdf:type schema:Person
    451 Nd31cf50c053a4461af40f7a3e045b43f schema:name pubmed_id
    452 schema:value 30936549
    453 rdf:type schema:PropertyValue
    454 Nd68973189f744c3e91d9432decbd6069 rdf:first N78b0cfe2c5174cb983cf5baf798045e1
    455 rdf:rest Nc7845b9c5a5e41dd98ffb6067e77047b
    456 Nd9e1c88df8e44312831306c44b614acb schema:affiliation https://www.grid.ac/institutes/grid.412004.3
    457 schema:familyName Wolf
    458 schema:givenName Monika Julia
    459 rdf:type schema:Person
    460 Ndf3277e82e344bafa25f7ae722ca0f6c rdf:first N4b5d46eb723f4269bf1e404080c653f2
    461 rdf:rest N51c7f1c45030402e93747e6898c11ba3
    462 Ne157253611d440828172d7833ecf8c9d rdf:first N71bdd280bc274f07b3253beeb59fe22a
    463 rdf:rest rdf:nil
    464 Ne3893d0efb184c56a8bb5ac1a0d1de79 rdf:first Ne9a53b88cb274c8f9f16fac7e7309c2c
    465 rdf:rest Nd68973189f744c3e91d9432decbd6069
    466 Ne3e5bffa96df4756bbd0e52ddb8f22b0 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
    467 schema:familyName Leslie
    468 schema:givenName Jack
    469 rdf:type schema:Person
    470 Ne4558c535a444ee98a2700cc467edab0 rdf:first N0fcd32243f7e4fb6bd423c12dd256005
    471 rdf:rest Nac8642f73fb2449f9eb16087147a6c43
    472 Ne5e2b2760e2b477286451a05cc647ac3 rdf:first Nbf2eef223034433eb81029172ff55a78
    473 rdf:rest N6d0b09bec8aa498eafe5f1665f397312
    474 Ne7653c319f2e42ab924dcda6f72b8627 schema:affiliation https://www.grid.ac/institutes/grid.22072.35
    475 schema:familyName Surewaard
    476 schema:givenName Bas G. J.
    477 rdf:type schema:Person
    478 Ne9a53b88cb274c8f9f16fac7e7309c2c schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    479 schema:familyName Sijmonsma
    480 schema:givenName Tjeerd
    481 rdf:type schema:Person
    482 Nebf606947f604f89b2690002a6a4e1de rdf:first N3fa89c460011449fa7cdc04d1a22fe4b
    483 rdf:rest N21e04df2026449dfb48118cbdf744c1e
    484 Nec4e19e0222d4ceaaf6d4bcd4fcfebbb rdf:first N1912c7ea2aea455c9815526765ba8083
    485 rdf:rest N02cca0340d234524aef86a375fe30725
    486 Ned4262c16bb049c2bffb25e341fa6e77 rdf:first N081d0c9b4d0744eab0e2f40ed6132615
    487 rdf:rest N45ecbb6c2ab2412aba05d39fe90bd4e9
    488 Nedded7caf2bc42be81af671f360b4415 schema:affiliation https://www.grid.ac/institutes/grid.5963.9
    489 schema:familyName Prinz
    490 schema:givenName Marco
    491 rdf:type schema:Person
    492 Neec979bccaa240a5ac85ff75d28214dc rdf:first N7550d45b961340ff9c2836d8d85aaf2e
    493 rdf:rest Nef2659f4635842af8234462922ed305f
    494 Nef2659f4635842af8234462922ed305f rdf:first N840c65f3f5914244ace629a4d5ad7444
    495 rdf:rest Nc569d685c8684545bf78d3eac83c7993
    496 Nef5862fcfbdd4e6ca72b83e2745b0e54 schema:affiliation https://www.grid.ac/institutes/grid.8379.5
    497 schema:familyName Stegner
    498 schema:givenName David
    499 rdf:type schema:Person
    500 Nf1a5339a82bf4ec3a810f0b13ac89ccd rdf:first Ne3e5bffa96df4756bbd0e52ddb8f22b0
    501 rdf:rest Nf406736e3a9e46cda5d2ec82c2d353b3
    502 Nf37c7c49674346a99d578c2a8ab1f5c4 rdf:first N4e24df9062f241c18f7bf11828755f25
    503 rdf:rest N4da29b91ef1e4bfc9d448405dee68d97
    504 Nf406736e3a9e46cda5d2ec82c2d353b3 rdf:first N1a05ed83df53429e963c8213fba434ce
    505 rdf:rest N6d5341bcc63e42f19cd938c208e3f90e
    506 Nf43232f8ce7f46559abbea32acba6627 rdf:first N7c381ecfbd93478791b65d67bcf42c13
    507 rdf:rest N69778c08c6594bc2bfc8b1e8acbb29c5
    508 Nf4952e44c95f4345acb107b97aa55e1d rdf:first Ncabb2feef4fb4b96a9fdd3c4e5439e17
    509 rdf:rest Nf1a5339a82bf4ec3a810f0b13ac89ccd
    510 Nf57aa27c118c40c5970acdb741a30784 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    511 schema:familyName Bogeska
    512 schema:givenName Ruzhica
    513 rdf:type schema:Person
    514 Nf74cabcd808248de8e9a3a4d41e728df schema:affiliation https://www.grid.ac/institutes/grid.10392.39
    515 schema:familyName Hinterleitner
    516 schema:givenName Martina
    517 rdf:type schema:Person
    518 Nf76b5933b720499480a3b634467d143c rdf:first N4ca1c1784f8f4a0aa334c35e426208c9
    519 rdf:rest Nae3d4ed386574c3bbf287d7ae91ea72b
    520 Nf963f0cde47545ca9ca21f1898cea98b schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    521 schema:familyName Augustin
    522 schema:givenName Hellmut G.
    523 rdf:type schema:Person
    524 Nfc80c6b5dde9485a950de02b3588c20b schema:affiliation https://www.grid.ac/institutes/grid.8379.5
    525 schema:familyName Nieswandt
    526 schema:givenName Bernhard
    527 rdf:type schema:Person
    528 Nfd4cf026be1b4c8ca64e564aeaa24161 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    529 schema:familyName Olkus
    530 schema:givenName Alexander
    531 rdf:type schema:Person
    532 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    533 schema:name Medical and Health Sciences
    534 rdf:type schema:DefinedTerm
    535 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    536 schema:name Immunology
    537 rdf:type schema:DefinedTerm
    538 sg:grant.4730734 http://pending.schema.org/fundedItem sg:pub.10.1038/s41591-019-0379-5
    539 rdf:type schema:MonetaryGrant
    540 sg:grant.5051108 http://pending.schema.org/fundedItem sg:pub.10.1038/s41591-019-0379-5
    541 rdf:type schema:MonetaryGrant
    542 sg:grant.7706944 http://pending.schema.org/fundedItem sg:pub.10.1038/s41591-019-0379-5
    543 rdf:type schema:MonetaryGrant
    544 sg:journal.1113716 schema:issn 1078-8956
    545 1546-170X
    546 schema:name Nature Medicine
    547 rdf:type schema:Periodical
    548 sg:pub.10.1007/978-3-642-29423-5_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032340826
    549 https://doi.org/10.1007/978-3-642-29423-5_1
    550 rdf:type schema:CreativeWork
    551 sg:pub.10.1007/s00125-011-2446-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021177494
    552 https://doi.org/10.1007/s00125-011-2446-4
    553 rdf:type schema:CreativeWork
    554 sg:pub.10.1007/s12029-017-9959-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086110547
    555 https://doi.org/10.1007/s12029-017-9959-0
    556 rdf:type schema:CreativeWork
    557 sg:pub.10.1023/b:thro.0000014586.77684.82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000637611
    558 https://doi.org/10.1023/b:thro.0000014586.77684.82
    559 rdf:type schema:CreativeWork
    560 sg:pub.10.1038/bjc.2017.386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092589583
    561 https://doi.org/10.1038/bjc.2017.386
    562 rdf:type schema:CreativeWork
    563 sg:pub.10.1038/cr.2010.183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003266208
    564 https://doi.org/10.1038/cr.2010.183
    565 rdf:type schema:CreativeWork
    566 sg:pub.10.1038/ncb2730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027006637
    567 https://doi.org/10.1038/ncb2730
    568 rdf:type schema:CreativeWork
    569 sg:pub.10.1038/ncomms15559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085712893
    570 https://doi.org/10.1038/ncomms15559
    571 rdf:type schema:CreativeWork
    572 sg:pub.10.1038/ncomms15838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086032438
    573 https://doi.org/10.1038/ncomms15838
    574 rdf:type schema:CreativeWork
    575 sg:pub.10.1038/ng.883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021186053
    576 https://doi.org/10.1038/ng.883
    577 rdf:type schema:CreativeWork
    578 sg:pub.10.1038/ng.884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029833324
    579 https://doi.org/10.1038/ng.884
    580 rdf:type schema:CreativeWork
    581 sg:pub.10.1038/ng.885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050432107
    582 https://doi.org/10.1038/ng.885
    583 rdf:type schema:CreativeWork
    584 sg:pub.10.1038/nm.2515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048275766
    585 https://doi.org/10.1038/nm.2515
    586 rdf:type schema:CreativeWork
    587 sg:pub.10.1038/nm1317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013411158
    588 https://doi.org/10.1038/nm1317
    589 rdf:type schema:CreativeWork
    590 sg:pub.10.1038/nm1780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014323452
    591 https://doi.org/10.1038/nm1780
    592 rdf:type schema:CreativeWork
    593 sg:pub.10.1038/nrcardio.2017.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083860173
    594 https://doi.org/10.1038/nrcardio.2017.18
    595 rdf:type schema:CreativeWork
    596 sg:pub.10.1038/nrdp.2015.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026163676
    597 https://doi.org/10.1038/nrdp.2015.80
    598 rdf:type schema:CreativeWork
    599 sg:pub.10.1038/s41590-018-0044-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1100671496
    600 https://doi.org/10.1038/s41590-018-0044-z
    601 rdf:type schema:CreativeWork
    602 sg:pub.10.1038/s41591-018-0104-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105236508
    603 https://doi.org/10.1038/s41591-018-0104-9
    604 rdf:type schema:CreativeWork
    605 sg:pub.10.1038/srep25533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018773010
    606 https://doi.org/10.1038/srep25533
    607 rdf:type schema:CreativeWork
    608 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
    609 https://doi.org/10.1186/s13059-014-0550-8
    610 rdf:type schema:CreativeWork
    611 https://app.dimensions.ai/details/publication/pub.1074690888 schema:CreativeWork
    612 https://app.dimensions.ai/details/publication/pub.1074702414 schema:CreativeWork
    613 https://app.dimensions.ai/details/publication/pub.1077138395 schema:CreativeWork
    614 https://app.dimensions.ai/details/publication/pub.1082878502 schema:CreativeWork
    615 https://doi.org/10.1002/cyto.10114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000802094
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.1002/hep.27222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036332826
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.1002/hep.28526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036090210
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.1002/hep.29085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074238586
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.1002/hep.30251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106526881
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.1002/jmri.24193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001562281
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.1016/j.ccell.2014.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012515480
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.1016/j.ccell.2016.05.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000483572
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.1016/j.ccell.2017.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091552091
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.1016/j.ccell.2018.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103212575
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.1016/j.cell.2015.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006029874
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.1016/j.cmet.2012.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004439955
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.1016/j.cmet.2016.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048673364
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.1016/j.gtc.2017.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085401501
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.1016/j.jhep.2017.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083757873
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.1016/s0008-6363(97)00109-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054579758
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.1016/s0140-6736(00)02175-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017970852
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.1016/s0140-6736(14)61933-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026026650
    650 rdf:type schema:CreativeWork
    651 https://doi.org/10.1016/s2468-1253(16)30011-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019791539
    652 rdf:type schema:CreativeWork
    653 https://doi.org/10.1053/j.gastro.2015.04.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029532636
    654 rdf:type schema:CreativeWork
    655 https://doi.org/10.1056/nejmoa0904327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038668813
    656 rdf:type schema:CreativeWork
    657 https://doi.org/10.1056/nejmoa1409312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051736615
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.1056/nejmoa1614362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085986666
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.1073/pnas.1209182109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015389307
    664 rdf:type schema:CreativeWork
    665 https://doi.org/10.1074/jbc.m113.511220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045377864
    666 rdf:type schema:CreativeWork
    667 https://doi.org/10.1084/jem.190.6.803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050132287
    668 rdf:type schema:CreativeWork
    669 https://doi.org/10.1084/jem.193.4.459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032036123
    670 rdf:type schema:CreativeWork
    671 https://doi.org/10.1093/bmb/ldw031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059436964
    672 rdf:type schema:CreativeWork
    673 https://doi.org/10.1093/brain/awq359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013802451
    674 rdf:type schema:CreativeWork
    675 https://doi.org/10.1093/nar/gkw377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029021006
    676 rdf:type schema:CreativeWork
    677 https://doi.org/10.1111/apt.12944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014037749
    678 rdf:type schema:CreativeWork
    679 https://doi.org/10.1111/j.1538-7836.2011.04328.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010625129
    680 rdf:type schema:CreativeWork
    681 https://doi.org/10.1111/j.1755-5922.2009.00096.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042146965
    682 rdf:type schema:CreativeWork
    683 https://doi.org/10.1128/cvi.00298-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015168327
    684 rdf:type schema:CreativeWork
    685 https://doi.org/10.1136/gut.2007.144550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001245128
    686 rdf:type schema:CreativeWork
    687 https://doi.org/10.1148/rg.265055711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042117130
    688 rdf:type schema:CreativeWork
    689 https://doi.org/10.1152/ajpgi.00079.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019110566
    690 rdf:type schema:CreativeWork
    691 https://doi.org/10.1159/000444807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012326598
    692 rdf:type schema:CreativeWork
    693 https://doi.org/10.1161/01.cir.0000133317.49796.0e schema:sameAs https://app.dimensions.ai/details/publication/pub.1035818241
    694 rdf:type schema:CreativeWork
    695 https://doi.org/10.1161/circresaha.111.256370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016040197
    696 rdf:type schema:CreativeWork
    697 https://doi.org/10.1161/circulationaha.107.691279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019117629
    698 rdf:type schema:CreativeWork
    699 https://doi.org/10.1172/jci115468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018830464
    700 rdf:type schema:CreativeWork
    701 https://doi.org/10.1172/jci119468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019384180
    702 rdf:type schema:CreativeWork
    703 https://doi.org/10.1172/jci27196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006736246
    704 rdf:type schema:CreativeWork
    705 https://doi.org/10.1172/jci69210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017754773
    706 rdf:type schema:CreativeWork
    707 https://doi.org/10.1172/jci73722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000810990
    708 rdf:type schema:CreativeWork
    709 https://doi.org/10.1172/jci92744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090873728
    710 rdf:type schema:CreativeWork
    711 https://doi.org/10.1182/blood-2002-03-0997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022725292
    712 rdf:type schema:CreativeWork
    713 https://doi.org/10.1182/blood-2002-10-3242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006773292
    714 rdf:type schema:CreativeWork
    715 https://doi.org/10.1182/blood-2003-05-1391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027734750
    716 rdf:type schema:CreativeWork
    717 https://doi.org/10.1182/blood-2006-04-020362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030006582
    718 rdf:type schema:CreativeWork
    719 https://doi.org/10.1182/blood-2009-05-222273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043230273
    720 rdf:type schema:CreativeWork
    721 https://doi.org/10.1182/blood-2012-04-408724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052063370
    722 rdf:type schema:CreativeWork
    723 https://doi.org/10.1371/journal.pone.0138655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041170889
    724 rdf:type schema:CreativeWork
    725 https://doi.org/10.15252/emmm.201708613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105288811
    726 rdf:type schema:CreativeWork
    727 https://doi.org/10.3322/caac.21262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013257560
    728 rdf:type schema:CreativeWork
    729 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
    730 schema:name Nutrient Metabolism and Signalling Lab, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, and Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia
    731 rdf:type schema:Organization
    732 https://www.grid.ac/institutes/grid.1006.7 schema:alternateName Newcastle University
    733 schema:name Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK
    734 rdf:type schema:Organization
    735 https://www.grid.ac/institutes/grid.10392.39 schema:alternateName University of Tübingen
    736 schema:name Department of Cardiology and Circulatory Diseases, Internal Medicine Clinic III, Eberhard Karls University Tübingen, Tübingen, Germany
    737 Department of Internal Medicine VIII, University Hospital Tübingen, Tübingen, Germany
    738 Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, Tübingen, Germany
    739 rdf:type schema:Organization
    740 https://www.grid.ac/institutes/grid.22072.35 schema:alternateName University of Calgary
    741 schema:name Calvin Phoebe & Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
    742 Department of Medical Microbiology, University Medical Center, Utrmeecht, the Netherlands
    743 Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
    744 Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
    745 rdf:type schema:Organization
    746 https://www.grid.ac/institutes/grid.241054.6 schema:alternateName University of Arkansas for Medical Sciences
    747 schema:name Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    748 rdf:type schema:Organization
    749 https://www.grid.ac/institutes/grid.410567.1 schema:alternateName University Hospital of Basel
    750 schema:name Institute of Pathology, University Hospital of Basel, Basel, Switzerland
    751 rdf:type schema:Organization
    752 https://www.grid.ac/institutes/grid.411544.1 schema:alternateName Universitätsklinikum Tübingen
    753 schema:name Department of Diagnostic and Interventional Radiology, University Hospital of Tübingen, Tübingen, Germany
    754 rdf:type schema:Organization
    755 https://www.grid.ac/institutes/grid.412004.3 schema:alternateName University Hospital of Zurich
    756 schema:name Department of Pathology and Molecular Pathology, University and University Hospital Zurich, Zurich, Switzerland
    757 rdf:type schema:Organization
    758 https://www.grid.ac/institutes/grid.412301.5 schema:alternateName Universitätsklinikum Aachen
    759 schema:name Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany
    760 rdf:type schema:Organization
    761 https://www.grid.ac/institutes/grid.412563.7 schema:alternateName University Hospitals Birmingham NHS Foundation Trust
    762 schema:name Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham, UK
    763 Liver Unit, University Hospitals Birmingham NHS Trust, Birmingham, UK
    764 rdf:type schema:Organization
    765 https://www.grid.ac/institutes/grid.425902.8 schema:alternateName Institució Catalana de Recerca i Estudis Avançats
    766 schema:name Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain
    767 Liver Cancer Translational Research Laboratory, IDIBAPS, Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain
    768 Mount Sinai Liver Cancer Program (Divisions of Liver Diseases, Department of Medicine, Department of Pathology, Recanati Miller Transplantation Institute), Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    769 rdf:type schema:Organization
    770 https://www.grid.ac/institutes/grid.454366.6 schema:alternateName NIHR Birmingham Liver Biomedical Research Unit
    771 schema:name Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham, UK
    772 rdf:type schema:Organization
    773 https://www.grid.ac/institutes/grid.4567.0 schema:alternateName Helmholtz Zentrum München
    774 schema:name Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany
    775 Research Unit of Radiation Cytogenetics, Helmholtz Zentrum München, Neuherberg, Germany
    776 rdf:type schema:Organization
    777 https://www.grid.ac/institutes/grid.5963.9 schema:alternateName University of Freiburg
    778 schema:name Center for NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany
    779 Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany
    780 Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany
    781 rdf:type schema:Organization
    782 https://www.grid.ac/institutes/grid.6572.6 schema:alternateName University of Birmingham
    783 schema:name Institute for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    784 rdf:type schema:Organization
    785 https://www.grid.ac/institutes/grid.6936.a schema:alternateName Technical University Munich
    786 schema:name Institute for Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany
    787 Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Munich, Germany
    788 rdf:type schema:Organization
    789 https://www.grid.ac/institutes/grid.7400.3 schema:alternateName University of Zurich
    790 schema:name Hematology, University Hospital and University of Zurich, Zurich, Switzerland
    791 rdf:type schema:Organization
    792 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
    793 schema:name Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK
    794 Metabolic Signalling Group, MRC London Institute of Medical Sciences, London, UK
    795 rdf:type schema:Organization
    796 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
    797 schema:name Center for Translational Cancer Research (TranslaTUM), Technische Universität München, Munich, Germany
    798 DKFZ Junior Group Metabolism and Stem Cell Plasticity, German Cancer Research Center (DKFZ), Heidelberg, Germany
    799 Department of Internal Medicine VIII, University Hospital Tübingen, Tübingen, Germany
    800 Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
    801 Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, Tübingen, Germany
    802 Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany
    803 German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
    804 Institute for Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany
    805 Translational Gastrointestinal Oncology Group, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
    806 rdf:type schema:Organization
    807 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
    808 schema:name DKFZ-ZMBH Alliance, Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
    809 Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany
    810 Division of Experimental Hematology, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
    811 Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany
    812 European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    813 Medical Faculty, University of Heidelberg, Heidelberg, Germany
    814 rdf:type schema:Organization
    815 https://www.grid.ac/institutes/grid.7719.8 schema:alternateName Spanish National Cancer Research Centre
    816 schema:name Cancer Cell Biology Programme, Growth Factors, Nutrients and Cancer Group, Spanish National Cancer Research Centre, CNIO, Madrid, Spain
    817 rdf:type schema:Organization
    818 https://www.grid.ac/institutes/grid.8379.5 schema:alternateName University of Würzburg
    819 schema:name Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany
    820 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...