Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

Delphine Gomez, Richard A. Baylis, Brittany G. Durgin, Alexandra A. C. Newman, Gabriel F. Alencar, Sidney Mahan, Cynthia St. Hilaire, Werner Müller, Ari Waisman, Sheila E. Francis, Emmanuel Pinteaux, Gwendalyn J. Randolph, Hermann Gram, Gary K. Owens

ABSTRACT

Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis is that reducing inflammation may improve advanced plaque stability, as recently tested in the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial, in which post-myocardial infarction subjects were treated with an IL-1β antibody. Here, we performed intervention studies in which smooth muscle cell (SMC) lineage-tracing Apoe-/- mice with advanced atherosclerosis were treated with anti-IL-1β or IgG control antibodies. Surprisingly, we found that IL-1β antibody treatment between 18 and 26 weeks of Western diet feeding induced a marked reduction in SMC and collagen content, but increased macrophage numbers in the fibrous cap. Moreover, although IL-1β antibody treatment had no effect on lesion size, it completely inhibited beneficial outward remodeling. We also found that SMC-specific knockout of Il1r1 (encoding IL-1 receptor type 1) resulted in smaller lesions nearly devoid of SMCs and lacking a fibrous cap, whereas macrophage-selective loss of IL-1R1 had no effect on lesion size or composition. Taken together, these results show that IL-1β has multiple beneficial effects in late-stage murine atherosclerosis, including promotion of outward remodeling and formation and maintenance of an SMC- and collagen-rich fibrous cap. More... »

PAGES

1418-1429

References to SciGraph publications

  • 2016-02. Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis in NATURE REVIEWS CARDIOLOGY
  • 2012-02. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques in NATURE IMMUNOLOGY
  • 2009-12. GAGE: generally applicable gene set enrichment for pathway analysis in BMC BIOINFORMATICS
  • 2008-01. G12-G13–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension in NATURE MEDICINE
  • 2014-12. Safety and tolerability of canakinumab, an IL-1β inhibitor, in type 2 diabetes mellitus patients: a pooled analysis of three randomised double-blind studies in CARDIOVASCULAR DIABETOLOGY
  • 1999-08. Conditional gene targeting in macrophages and granulocytes using LysMcre mice in TRANSGENIC RESEARCH
  • 2013-02. Detection of histone modifications at specific gene loci in single cells in histological sections in NATURE METHODS
  • 2014-12. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2013-09. Local proliferation dominates lesional macrophage accumulation in atherosclerosis in NATURE MEDICINE
  • 2015-06. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis in NATURE MEDICINE
  • 2010-04. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals in NATURE
  • 2010-01. Macrophage death and defective inflammation resolution in atherosclerosis in NATURE REVIEWS IMMUNOLOGY
  • 2016-06. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41591-018-0124-5

    DOI

    http://dx.doi.org/10.1038/s41591-018-0124-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105714182

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30038218


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