IRF3 and IRF7 require SIRT1 for liquid–liquid phase separation and transactivation of IFN-1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-07-25

ABSTRACT

Deacetylation of specific lysine residues in the DNA-binding domain of the transcription factors IRF3 and IRF7 by SIRT1 is necessary for liquid–liquid phase separation and transactivation of type I interferons. SIRT1 agonists partially restored the impaired innate immune responses in senescent cells and aged mice, suggestive of a possible strategy for preventing innate immunosenescence. More... »

PAGES

1144-1145

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41590-022-01270-7

DOI

http://dx.doi.org/10.1038/s41590-022-01270-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1149723338

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35879453


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