Multitier mechanics control stromal adaptations in the swelling lymph node View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-07-11

AUTHORS

Frank P. Assen, Jun Abe, Miroslav Hons, Robert Hauschild, Shayan Shamipour, Walter A. Kaufmann, Tommaso Costanzo, Gabriel Krens, Markus Brown, Burkhard Ludewig, Simon Hippenmeyer, Carl-Philipp Heisenberg, Wolfgang Weninger, Edouard Hannezo, Sanjiv A. Luther, Jens V. Stein, Michael Sixt

ABSTRACT

Lymph nodes (LNs) comprise two main structural elements: fibroblastic reticular cells that form dedicated niches for immune cell interaction and capsular fibroblasts that build a shell around the organ. Immunological challenge causes LNs to increase more than tenfold in size within a few days. Here, we characterized the biomechanics of LN swelling on the cellular and organ scale. We identified lymphocyte trapping by influx and proliferation as drivers of an outward pressure force, causing fibroblastic reticular cells of the T-zone (TRCs) and their associated conduits to stretch. After an initial phase of relaxation, TRCs sensed the resulting strain through cell matrix adhesions, which coordinated local growth and remodeling of the stromal network. While the expanded TRC network readopted its typical configuration, a massive fibrotic reaction of the organ capsule set in and countered further organ expansion. Thus, different fibroblast populations mechanically control LN swelling in a multitier fashion. More... »

PAGES

1246-1255

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41590-022-01257-4

    DOI

    http://dx.doi.org/10.1038/s41590-022-01257-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1149372778

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35817845


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    353 grid-institutes:grid.9851.5 schema:alternateName Department of Immunobiology, University of Lausanne, Epalinges, Switzerland
    354 schema:name Department of Immunobiology, University of Lausanne, Epalinges, Switzerland
    355 rdf:type schema:Organization
     




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