Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-05-20

AUTHORS

Raoul J. P. Bonnal, Grazisa Rossetti, Enrico Lugli, Marco De Simone, Paola Gruarin, Jolanda Brummelman, Lorenzo Drufuca, Marco Passaro, Ramona Bason, Federica Gervasoni, Giulia Della Chiara, Claudia D’Oria, Martina Martinovic, Serena Curti, Valeria Ranzani, Chiara Cordiglieri, Giorgia Alvisi, Emilia Maria Cristina Mazza, Stefania Oliveto, Ylenia Silvestri, Elena Carelli, Saveria Mazzara, Roberto Bosotti, Maria Lucia Sarnicola, Chiara Godano, Valeria Bevilacqua, Mariangela Lorenzo, Salvatore Siena, Emanuela Bonoldi, Andrea Sartore-Bianchi, Alessio Amatu, Giulia Veronesi, Pierluigi Novellis, Marco Alloisio, Alessandro Giani, Nicola Zucchini, Enrico Opocher, Andrea Pisani Ceretti, Nicolò Mariani, Stefano Biffo, Daniele Prati, Alberto Bardelli, Jens Geginat, Antonio Lanzavecchia, Sergio Abrignani, Massimiliano Pagani

ABSTRACT

Regulatory T (Treg) cells are a barrier for tumor immunity and a target for immunotherapy. Using single-cell transcriptomics, we found that CD4+ T cells infiltrating primary and metastatic colorectal cancer and non-small-cell lung cancer are highly enriched for two subsets of comparable size and suppressor function comprising forkhead box protein P3+ Treg and eomesodermin homolog (EOMES)+ type 1 regulatory T (Tr1)-like cells also expressing granzyme K and chitinase-3-like protein 2. EOMES+ Tr1-like cells, but not Treg cells, were clonally related to effector T cells and were clonally expanded in primary and metastatic tumors, which is consistent with their proliferation and differentiation in situ. Using chitinase-3-like protein 2 as a subset signature, we found that the EOMES+ Tr1-like subset correlates with disease progression but is also associated with response to programmed cell death protein 1–targeted immunotherapy. Collectively, these findings highlight the heterogeneity of Treg cells that accumulate in primary tumors and metastases and identify a new prospective target for cancer immunotherapy. More... »

PAGES

735-745

References to SciGraph publications

  • 2013-05-17. The plasticity and stability of regulatory T cells in NATURE REVIEWS IMMUNOLOGY
  • 2015-10-14. Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis in SCIENTIFIC REPORTS
  • 2018-06-25. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing in NATURE MEDICINE
  • 2020-10-12. Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans in NATURE IMMUNOLOGY
  • 2003-03-03. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells in NATURE IMMUNOLOGY
  • 2016-10-28. FACS Analysis of Memory T Lymphocytes in T-CELL DIFFERENTIATION
  • 2012-04-01. Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β in NATURE
  • 2009-10-07. The functional plasticity of T cell subsets in NATURE REVIEWS IMMUNOLOGY
  • 2015-05-25. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α in NATURE MEDICINE
  • 2013-04-28. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells in NATURE MEDICINE
  • 2018-12-03. Dimensionality reduction for visualizing single-cell data using UMAP in NATURE BIOTECHNOLOGY
  • 2019-12-02. Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma in NATURE MEDICINE
  • 2015-04-29. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation in NATURE
  • 2018-02-06. SCANPY: large-scale single-cell gene expression data analysis in GENOME BIOLOGY
  • 2018-10-29. Lineage tracking reveals dynamic relationships of T cells in colorectal cancer in NATURE
  • 2012-05-16. PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells in NATURE
  • 2019-06-03. Development, application and computational analysis of high-dimensional fluorescent antibody panels for single-cell flow cytometry in NATURE PROTOCOLS
  • 2016-12-20. Regulatory T cells in cancer immunotherapy in CELL RESEARCH
  • 2019-01-31. Regulatory T cells in cancer immunosuppression — implications for anticancer therapy in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2020-05-25. Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer in NATURE GENETICS
  • 2011-11-15. Immunotherapy with IL-10- and IFN-γ-producing CD4 effector cells modulate “Natural” and “Inducible” CD4 TReg cell subpopulation levels: observations in four cases of patients with ovarian cancer in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • Journal

    TITLE

    Nature Immunology

    ISSUE

    6

    VOLUME

    22

    Author Affiliations

  • FIRC Institute of Molecular Oncology (IFOM), Milan, Italy
  • Flow Cytometry Core, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
  • Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA
  • Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy
  • Laboratory of Translational Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
  • Division of Hematopathology, European Institute of Oncology (IEO) IRCCS, Milan, Italy
  • Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy
  • Pathology and Cytogenetics Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy
  • Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy
  • Division of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy
  • Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
  • Department of Surgery, Milano-Bicocca University, San Gerardo Hospital, Monza, Italy
  • Department of Pathology, San Gerardo Hospital, Monza, Italy
  • Department of Health Sciences, Università degli Studi di Milano, Milan, Italy
  • Unità Operativa Chirurgia Epatobiliopancreatica e Digestiva, Ospedale San Paolo, Milan, Italy
  • Department of Biosciences, University of Milan, Milan, Italy
  • Department of Transfusion Medicine and Hematology, IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
  • Department of Oncology, University of Torino, Turin, Italy
  • Department of Clinical Sciences and Community Health, Università degli Studi, Milan, Italy
  • Department of Medical Biotechnology and Translational Medicine, Università degli Studi, Milan, Italy
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41590-021-00930-4

    DOI

    http://dx.doi.org/10.1038/s41590-021-00930-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1138206635

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34017124


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