Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-08

AUTHORS

Matthew C Altman, Michelle A Gill, Elizabeth Whalen, Denise C Babineau, Baomei Shao, Andrew H Liu, Brett Jepson, Rebecca S Gruchalla, George T O'Connor, Jacqueline A Pongracic, Carolyn M Kercsmar, Gurjit K Khurana Hershey, Edward M Zoratti, Christine C Johnson, Stephen J Teach, Meyer Kattan, Leonard B Bacharier, Avraham Beigelman, Steve M Sigelman, Scott Presnell, James E Gern, Peter J Gergen, Lisa M Wheatley, Alkis Togias, William W Busse, Daniel J Jackson

ABSTRACT

Respiratory infections are common precursors to asthma exacerbations in children, but molecular immune responses that determine whether and how an infection causes an exacerbation are poorly understood. By using systems-scale network analysis, we identify repertoires of cellular transcriptional pathways that lead to and underlie distinct patterns of asthma exacerbation. Specifically, in both virus-associated and nonviral exacerbations, we demonstrate a set of core exacerbation modules, among which epithelial-associated SMAD3 signaling is upregulated and lymphocyte response pathways are downregulated early in exacerbation, followed by later upregulation of effector pathways including epidermal growth factor receptor signaling, extracellular matrix production, mucus hypersecretion, and eosinophil activation. We show an additional set of multiple inflammatory cell pathways involved in virus-associated exacerbations, in contrast to squamous cell pathways associated with nonviral exacerbations. Our work introduces an in vivo molecular platform to investigate, in a clinical setting, both the mechanisms of disease pathogenesis and therapeutic targets to modify exacerbations. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41590-019-0347-8

DOI

http://dx.doi.org/10.1038/s41590-019-0347-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113300809

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30962590


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Virginia Mason Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.416879.5", 
          "name": [
            "Department of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA. maltman@benaroyaresearch.org.", 
            "Systems Immunology Program, Benaroya Research Institute, Seattle, WA, USA. maltman@benaroyaresearch.org."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Altman", 
        "givenName": "Matthew C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gill", 
        "givenName": "Michelle A", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virginia Mason Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.416879.5", 
          "name": [
            "Systems Immunology Program, Benaroya Research Institute, Seattle, WA, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Whalen", 
        "givenName": "Elizabeth", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rho Federal Systems (United States)", 
          "id": "https://www.grid.ac/institutes/grid.281094.6", 
          "name": [
            "Rho, Inc., Chapel Hill, NC, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Babineau", 
        "givenName": "Denise C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shao", 
        "givenName": "Baomei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Allergy and Immunology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Andrew H", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rho Federal Systems (United States)", 
          "id": "https://www.grid.ac/institutes/grid.281094.6", 
          "name": [
            "Rho, Inc., Chapel Hill, NC, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jepson", 
        "givenName": "Brett", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gruchalla", 
        "givenName": "Rebecca S", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Boston University School of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.475010.7", 
          "name": [
            "Department of Medicine, Boston University School of Medicine, Boston, MA, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "O'Connor", 
        "givenName": "George T", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lurie Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413808.6", 
          "name": [
            "Ann Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pongracic", 
        "givenName": "Jacqueline A", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Cincinnati Children's Hospital, Cincinnati, OH, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kercsmar", 
        "givenName": "Carolyn M", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cincinnati Children's Hospital Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239573.9", 
          "name": [
            "Cincinnati Children's Hospital, Cincinnati, OH, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khurana Hershey", 
        "givenName": "Gurjit K", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Henry Ford Health System", 
          "id": "https://www.grid.ac/institutes/grid.239864.2", 
          "name": [
            "Henry Ford Health System, Detroit, MI, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zoratti", 
        "givenName": "Edward M", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Henry Ford Health System", 
          "id": "https://www.grid.ac/institutes/grid.239864.2", 
          "name": [
            "Henry Ford Health System, Detroit, MI, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "Christine C", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s National Health System", 
          "id": "https://www.grid.ac/institutes/grid.239560.b", 
          "name": [
            "Children's National Health System, Washington, DC, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teach", 
        "givenName": "Stephen J", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Columbia University College of Physicians and Surgeons, New York, NY, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kattan", 
        "givenName": "Meyer", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Allergy, Immunology, and Pulmonary Medicine, Washington University, St. Louis, MO, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bacharier", 
        "givenName": "Leonard B", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Allergy, Immunology, and Pulmonary Medicine, Washington University, St. Louis, MO, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beigelman", 
        "givenName": "Avraham", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sigelman", 
        "givenName": "Steve M", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virginia Mason Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.416879.5", 
          "name": [
            "Systems Immunology Program, Benaroya Research Institute, Seattle, WA, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Presnell", 
        "givenName": "Scott", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "University of Wisconsin School of Medicine and Public Health, Madison, WI, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gern", 
        "givenName": "James E", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gergen", 
        "givenName": "Peter J", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wheatley", 
        "givenName": "Lisa M", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Togias", 
        "givenName": "Alkis", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "University of Wisconsin School of Medicine and Public Health, Madison, WI, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Busse", 
        "givenName": "William W", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "University of Wisconsin School of Medicine and Public Health, Madison, WI, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jackson", 
        "givenName": "Daniel J", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jaci.2010.01.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001942832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1003059107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002612993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2015.02.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002658426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201406-1039oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003824489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1009705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003923843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)80083-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004844813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)80083-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004844813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2014.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006946461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0900695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010358735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200807-1126oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010414863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2013.11.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010578120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.157.6.9609040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010613413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1003554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012060888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012425816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm/145.4_pt_1.900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013743012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.178.11.7310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015161330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2014.07.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015387137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)60988-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015540360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)60988-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015540360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016098431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2012-202741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016606190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thoraxjnl-2012-202741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016606190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0707413104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016706328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018245324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2011.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018841918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019417609", 
          "https://doi.org/10.1038/ng.2830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2015.02.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019779338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.163.6.9901105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020275551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-9-559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020312314", 
          "https://doi.org/10.1186/1471-2105-9-559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2011.10.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020501429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2011.10.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020501429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrdp.2015.25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021525312", 
          "https://doi.org/10.1038/nrdp.2015.25"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201109-1635oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026620444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btv015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026692902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026744197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/1744666x.2014.932249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028585470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gku1003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029045446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri.2016.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029307492", 
          "https://doi.org/10.1038/nri.2016.95"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.159.2.9804022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029789601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2014.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029822085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2014.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029822085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029845730", 
          "https://doi.org/10.1038/nri3642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)61380-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030498291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.00075-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033122753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/28.18.3442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033785567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2007.09.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035572892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037086706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2011.11.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037433401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2014.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039978467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2008.211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039987283", 
          "https://doi.org/10.1038/nprot.2008.211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2012.06.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042011774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047319287", 
          "https://doi.org/10.1038/ng.323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047610281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.163.2.2001038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047940236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.1239303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052744398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btu638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053282140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-016-1140-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053890711", 
          "https://doi.org/10.1186/s13059-016-1140-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-016-1140-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053890711", 
          "https://doi.org/10.1186/s13059-016-1140-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.310.6989.1225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062771887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.310.6989.1225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062771887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201512-2452oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063365502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/019262339802600301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063753231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/019262339802600301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063753231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201604-0866oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079364839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083115722", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/all.13222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085965761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2017.07.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091212971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2017.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092404739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2017.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092404739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/jcm6120112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093055286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2018.03.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101524727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2018.03.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101524727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2018.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103631652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2018.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103631652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1804092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104131250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejme1806037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104137343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2018.08.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106930697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2018.08.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106930697"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04-08", 
    "datePublishedReg": "2019-04-08", 
    "description": "Respiratory infections are common precursors to asthma exacerbations in children, but molecular immune responses that determine whether and how an infection causes an exacerbation are poorly understood. By using systems-scale network analysis, we identify repertoires of cellular transcriptional pathways that lead to and underlie distinct patterns of asthma exacerbation. Specifically, in both virus-associated and nonviral exacerbations, we demonstrate a set of core exacerbation modules, among which epithelial-associated SMAD3 signaling is upregulated and lymphocyte response pathways are downregulated early in exacerbation, followed by later upregulation of effector pathways including epidermal growth factor receptor signaling, extracellular matrix production, mucus hypersecretion, and eosinophil activation. We show an additional set of multiple inflammatory cell pathways involved in virus-associated exacerbations, in contrast to squamous cell pathways associated with nonviral exacerbations. Our work introduces an in vivo molecular platform to investigate, in a clinical setting, both the mechanisms of disease pathogenesis and therapeutic targets to modify exacerbations.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41590-019-0347-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3803980", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1022778", 
        "issn": [
          "1529-2908", 
          "1529-2916"
        ], 
        "name": "Nature Immunology", 
        "type": "Periodical"
      }
    ], 
    "name": "Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children.", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41590-019-0347-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113300809"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100941354"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30962590"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41590-019-0347-8", 
      "https://app.dimensions.ai/details/publication/pub.1113300809"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-16T06:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106822_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/s41590-019-0347-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41590-019-0347-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41590-019-0347-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41590-019-0347-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41590-019-0347-8'


 

This table displays all metadata directly associated to this object as RDF triples.

451 TRIPLES      20 PREDICATES      90 URIs      16 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41590-019-0347-8 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N98e592317199400e93b88fb7877769fa
4 schema:citation sg:pub.10.1038/ng.2830
5 sg:pub.10.1038/ng.323
6 sg:pub.10.1038/nprot.2008.211
7 sg:pub.10.1038/nrdp.2015.25
8 sg:pub.10.1038/nri.2016.95
9 sg:pub.10.1038/nri3642
10 sg:pub.10.1186/1471-2105-9-559
11 sg:pub.10.1186/s13059-016-1140-8
12 https://app.dimensions.ai/details/publication/pub.1083115722
13 https://doi.org/10.1016/j.ajpath.2012.06.043
14 https://doi.org/10.1016/j.celrep.2018.08.033
15 https://doi.org/10.1016/j.coi.2017.07.017
16 https://doi.org/10.1016/j.ejphar.2018.03.017
17 https://doi.org/10.1016/j.jaci.2007.09.029
18 https://doi.org/10.1016/j.jaci.2010.01.059
19 https://doi.org/10.1016/j.jaci.2011.06.002
20 https://doi.org/10.1016/j.jaci.2011.10.038
21 https://doi.org/10.1016/j.jaci.2011.11.035
22 https://doi.org/10.1016/j.jaci.2013.11.025
23 https://doi.org/10.1016/j.jaci.2014.04.007
24 https://doi.org/10.1016/j.jaci.2014.07.013
25 https://doi.org/10.1016/j.jaci.2015.02.026
26 https://doi.org/10.1016/j.jaci.2015.02.035
27 https://doi.org/10.1016/j.jaci.2017.10.004
28 https://doi.org/10.1016/j.jaci.2018.04.003
29 https://doi.org/10.1016/j.rmed.2014.08.008
30 https://doi.org/10.1016/j.stem.2014.05.009
31 https://doi.org/10.1016/s0140-6736(05)80083-2
32 https://doi.org/10.1016/s0140-6736(10)61380-3
33 https://doi.org/10.1016/s0140-6736(12)60988-x
34 https://doi.org/10.1056/nejme1806037
35 https://doi.org/10.1056/nejmoa1009705
36 https://doi.org/10.1056/nejmoa1804092
37 https://doi.org/10.1073/pnas.0707413104
38 https://doi.org/10.1073/pnas.1003059107
39 https://doi.org/10.1084/jem.20041901
40 https://doi.org/10.1093/bioinformatics/btp120
41 https://doi.org/10.1093/bioinformatics/btu638
42 https://doi.org/10.1093/bioinformatics/btv015
43 https://doi.org/10.1093/nar/28.18.3442
44 https://doi.org/10.1093/nar/gkn923
45 https://doi.org/10.1093/nar/gku1003
46 https://doi.org/10.1093/nar/gkv007
47 https://doi.org/10.1093/nar/gkv350
48 https://doi.org/10.1093/nar/gkv412
49 https://doi.org/10.1101/gr.1239303
50 https://doi.org/10.1111/all.13222
51 https://doi.org/10.1128/jcm.00075-14
52 https://doi.org/10.1136/bmj.310.6989.1225
53 https://doi.org/10.1136/thoraxjnl-2012-202741
54 https://doi.org/10.1164/ajrccm.157.6.9609040
55 https://doi.org/10.1164/ajrccm.159.2.9804022
56 https://doi.org/10.1164/ajrccm.163.2.2001038
57 https://doi.org/10.1164/ajrccm.163.6.9901105
58 https://doi.org/10.1164/ajrccm/145.4_pt_1.900
59 https://doi.org/10.1164/rccm.200807-1126oc
60 https://doi.org/10.1164/rccm.201109-1635oc
61 https://doi.org/10.1164/rccm.201406-1039oc
62 https://doi.org/10.1164/rccm.201512-2452oc
63 https://doi.org/10.1164/rccm.201604-0866oc
64 https://doi.org/10.1177/019262339802600301
65 https://doi.org/10.1586/1744666x.2014.932249
66 https://doi.org/10.3390/jcm6120112
67 https://doi.org/10.4049/jimmunol.0900695
68 https://doi.org/10.4049/jimmunol.1003554
69 https://doi.org/10.4049/jimmunol.178.11.7310
70 schema:datePublished 2019-04-08
71 schema:datePublishedReg 2019-04-08
72 schema:description Respiratory infections are common precursors to asthma exacerbations in children, but molecular immune responses that determine whether and how an infection causes an exacerbation are poorly understood. By using systems-scale network analysis, we identify repertoires of cellular transcriptional pathways that lead to and underlie distinct patterns of asthma exacerbation. Specifically, in both virus-associated and nonviral exacerbations, we demonstrate a set of core exacerbation modules, among which epithelial-associated SMAD3 signaling is upregulated and lymphocyte response pathways are downregulated early in exacerbation, followed by later upregulation of effector pathways including epidermal growth factor receptor signaling, extracellular matrix production, mucus hypersecretion, and eosinophil activation. We show an additional set of multiple inflammatory cell pathways involved in virus-associated exacerbations, in contrast to squamous cell pathways associated with nonviral exacerbations. Our work introduces an in vivo molecular platform to investigate, in a clinical setting, both the mechanisms of disease pathogenesis and therapeutic targets to modify exacerbations.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree false
76 schema:isPartOf sg:journal.1022778
77 schema:name Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children.
78 schema:productId N353c13bffcf145cb9c85da2b4686cbd0
79 N8b426a96ed0c49fcab05e1e0809e0770
80 Nd9e8f237bed0473c8b5235f047f676d3
81 Nf781d5014e6d48d79a6ac914d9d3f42d
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113300809
83 https://doi.org/10.1038/s41590-019-0347-8
84 schema:sdDatePublished 2019-04-16T06:23
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N15868901a7304ac8afa5de0e57728e32
87 schema:url http://www.nature.com/articles/s41590-019-0347-8
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N02b871cfb90448cd8402e552ae331996 rdf:first N3b841e9cdf594ffdad8e98fb985d5cbc
92 rdf:rest N1418499424ef4597bd1b2194591d40ae
93 N0676e2a9e08a495e880f44b68b155310 schema:affiliation https://www.grid.ac/institutes/grid.416879.5
94 schema:familyName Whalen
95 schema:givenName Elizabeth
96 rdf:type schema:Person
97 N08719c3e033b4b5b959fac79a198d457 rdf:first N7610a5914f6045568666a6bc69640c71
98 rdf:rest N20e80db2036246878b7c0b02a41ae998
99 N0a6ab4f8f35b4f84a3bce1d123d42fe7 rdf:first N857b6a386c6c4d578321ae9e962f55c0
100 rdf:rest N3168c4de88d94eb2b427769a39336d15
101 N0f611dc71a424ace91e170c0c4a13475 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
102 schema:familyName Kercsmar
103 schema:givenName Carolyn M
104 rdf:type schema:Person
105 N1418499424ef4597bd1b2194591d40ae rdf:first N97018aed62174d17b5d51f4eac86d07d
106 rdf:rest Nc4ecf0f092774926ba0ac86d2573f95c
107 N15868901a7304ac8afa5de0e57728e32 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N17873e4d7ef7414499307da67ea8254c rdf:first Nb68e7438afee422cbc91631994bda764
110 rdf:rest N81e3be14452844438973bddbef041696
111 N1adde7840cbd4817b87f11df3ff3c7e1 rdf:first Ndf83026cdf1a45b595a940aafa07caa7
112 rdf:rest N08719c3e033b4b5b959fac79a198d457
113 N1fdc51da64324c6ba9442cfe8b6c011b schema:affiliation https://www.grid.ac/institutes/grid.239864.2
114 schema:familyName Johnson
115 schema:givenName Christine C
116 rdf:type schema:Person
117 N20e80db2036246878b7c0b02a41ae998 rdf:first Nbe313a0edc4240b5baefe02f6cddc26b
118 rdf:rest N38452dbf7e0c4bc3ab21cb8c616c4875
119 N21d1794c84bd4ef9ba5a59dfa2def7fc schema:affiliation https://www.grid.ac/institutes/grid.14003.36
120 schema:familyName Busse
121 schema:givenName William W
122 rdf:type schema:Person
123 N251bffbb2fe74988b290daa53e175fe5 rdf:first Nb692a2c2850f4b8cbb31fdcf0dfcdfe0
124 rdf:rest rdf:nil
125 N2c2b270451b34716a54ef4822e0a6efa rdf:first N79d6710627a74a07821a7cfe6e18092b
126 rdf:rest N0a6ab4f8f35b4f84a3bce1d123d42fe7
127 N3168c4de88d94eb2b427769a39336d15 rdf:first Nc0feb5c088bc4425966f2f46aadd85dd
128 rdf:rest Nfdc3cf93623243b88ed73bca62c6666d
129 N353c13bffcf145cb9c85da2b4686cbd0 schema:name dimensions_id
130 schema:value pub.1113300809
131 rdf:type schema:PropertyValue
132 N38452dbf7e0c4bc3ab21cb8c616c4875 rdf:first N40852766488448839bf2822eab1e561f
133 rdf:rest N79bc348a995342c9982b076fadc88cd3
134 N3b841e9cdf594ffdad8e98fb985d5cbc schema:affiliation https://www.grid.ac/institutes/grid.416879.5
135 schema:familyName Presnell
136 schema:givenName Scott
137 rdf:type schema:Person
138 N3c41e3bc0c574f4a95ec074abce6b4e0 schema:affiliation https://www.grid.ac/institutes/grid.416879.5
139 schema:familyName Altman
140 schema:givenName Matthew C
141 rdf:type schema:Person
142 N40852766488448839bf2822eab1e561f schema:affiliation https://www.grid.ac/institutes/grid.4367.6
143 schema:familyName Beigelman
144 schema:givenName Avraham
145 rdf:type schema:Person
146 N41b44a20f4b6445db07839a006c50220 rdf:first N442b832f8a8445ab8913ad61665a856c
147 rdf:rest N2c2b270451b34716a54ef4822e0a6efa
148 N442b832f8a8445ab8913ad61665a856c schema:affiliation https://www.grid.ac/institutes/grid.281094.6
149 schema:familyName Jepson
150 schema:givenName Brett
151 rdf:type schema:Person
152 N4a1275f90d894d0d87655e89213496cf schema:affiliation Ne551fbcae6f44aeeaa6c03e493217df1
153 schema:familyName Liu
154 schema:givenName Andrew H
155 rdf:type schema:Person
156 N4baa4f4e94894091be9fbe8742a3f32d schema:affiliation https://www.grid.ac/institutes/grid.267313.2
157 schema:familyName Shao
158 schema:givenName Baomei
159 rdf:type schema:Person
160 N4e7d27e1b11242fabc5e2b0d949e6fd8 rdf:first N0676e2a9e08a495e880f44b68b155310
161 rdf:rest N964edc1b26e8437783dd02570fe5187a
162 N4fd1a382a94145faa774f80656887fa9 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
163 schema:familyName Gergen
164 schema:givenName Peter J
165 rdf:type schema:Person
166 N54113864ad8f4e8d95ae2e246ad4a92e rdf:first N1fdc51da64324c6ba9442cfe8b6c011b
167 rdf:rest N1adde7840cbd4817b87f11df3ff3c7e1
168 N56647221da574b558c75286b8e2dbc7d rdf:first N4baa4f4e94894091be9fbe8742a3f32d
169 rdf:rest Ndd5ad07c9bf44c54984805de2c23a018
170 N56a53ab925fd48b18378b9ccc2a44e75 rdf:first Nfd0abc8ed4eb4385bfe04dc54e5fa7dc
171 rdf:rest N4e7d27e1b11242fabc5e2b0d949e6fd8
172 N6905e85acbf144549205bd6a49f59845 schema:affiliation https://www.grid.ac/institutes/grid.239864.2
173 schema:familyName Zoratti
174 schema:givenName Edward M
175 rdf:type schema:Person
176 N7421c931016441dd88853779368a73ff schema:affiliation https://www.grid.ac/institutes/grid.281094.6
177 schema:familyName Babineau
178 schema:givenName Denise C
179 rdf:type schema:Person
180 N7610a5914f6045568666a6bc69640c71 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
181 schema:familyName Kattan
182 schema:givenName Meyer
183 rdf:type schema:Person
184 N79bc348a995342c9982b076fadc88cd3 rdf:first Nea4981811efd4d9193aeebd4388512dd
185 rdf:rest N02b871cfb90448cd8402e552ae331996
186 N79d6710627a74a07821a7cfe6e18092b schema:affiliation https://www.grid.ac/institutes/grid.267313.2
187 schema:familyName Gruchalla
188 schema:givenName Rebecca S
189 rdf:type schema:Person
190 N81e3be14452844438973bddbef041696 rdf:first Neea99850692e4dbda0e7654668f14185
191 rdf:rest Naf1b95daed314a8194848b5a42fc8437
192 N857b6a386c6c4d578321ae9e962f55c0 schema:affiliation https://www.grid.ac/institutes/grid.475010.7
193 schema:familyName O'Connor
194 schema:givenName George T
195 rdf:type schema:Person
196 N89e4acb57a0e401da06f5ad0761aa659 rdf:first Nc29ca53826d44d0fbf719db092c8b539
197 rdf:rest Ndd8583665eed4f949948882627acb9ac
198 N8b426a96ed0c49fcab05e1e0809e0770 schema:name doi
199 schema:value 10.1038/s41590-019-0347-8
200 rdf:type schema:PropertyValue
201 N964edc1b26e8437783dd02570fe5187a rdf:first N7421c931016441dd88853779368a73ff
202 rdf:rest N56647221da574b558c75286b8e2dbc7d
203 N97018aed62174d17b5d51f4eac86d07d schema:affiliation https://www.grid.ac/institutes/grid.14003.36
204 schema:familyName Gern
205 schema:givenName James E
206 rdf:type schema:Person
207 N98e592317199400e93b88fb7877769fa rdf:first N3c41e3bc0c574f4a95ec074abce6b4e0
208 rdf:rest N56a53ab925fd48b18378b9ccc2a44e75
209 Naf1b95daed314a8194848b5a42fc8437 rdf:first N21d1794c84bd4ef9ba5a59dfa2def7fc
210 rdf:rest N251bffbb2fe74988b290daa53e175fe5
211 Nb68e7438afee422cbc91631994bda764 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
212 schema:familyName Wheatley
213 schema:givenName Lisa M
214 rdf:type schema:Person
215 Nb692a2c2850f4b8cbb31fdcf0dfcdfe0 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
216 schema:familyName Jackson
217 schema:givenName Daniel J
218 rdf:type schema:Person
219 Nbe313a0edc4240b5baefe02f6cddc26b schema:affiliation https://www.grid.ac/institutes/grid.4367.6
220 schema:familyName Bacharier
221 schema:givenName Leonard B
222 rdf:type schema:Person
223 Nc0feb5c088bc4425966f2f46aadd85dd schema:affiliation https://www.grid.ac/institutes/grid.413808.6
224 schema:familyName Pongracic
225 schema:givenName Jacqueline A
226 rdf:type schema:Person
227 Nc29ca53826d44d0fbf719db092c8b539 schema:affiliation https://www.grid.ac/institutes/grid.239573.9
228 schema:familyName Khurana Hershey
229 schema:givenName Gurjit K
230 rdf:type schema:Person
231 Nc4ecf0f092774926ba0ac86d2573f95c rdf:first N4fd1a382a94145faa774f80656887fa9
232 rdf:rest N17873e4d7ef7414499307da67ea8254c
233 Nd9e8f237bed0473c8b5235f047f676d3 schema:name pubmed_id
234 schema:value 30962590
235 rdf:type schema:PropertyValue
236 Ndd5ad07c9bf44c54984805de2c23a018 rdf:first N4a1275f90d894d0d87655e89213496cf
237 rdf:rest N41b44a20f4b6445db07839a006c50220
238 Ndd8583665eed4f949948882627acb9ac rdf:first N6905e85acbf144549205bd6a49f59845
239 rdf:rest N54113864ad8f4e8d95ae2e246ad4a92e
240 Ndf83026cdf1a45b595a940aafa07caa7 schema:affiliation https://www.grid.ac/institutes/grid.239560.b
241 schema:familyName Teach
242 schema:givenName Stephen J
243 rdf:type schema:Person
244 Ne551fbcae6f44aeeaa6c03e493217df1 schema:name Department of Allergy and Immunology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.
245 rdf:type schema:Organization
246 Nea4981811efd4d9193aeebd4388512dd schema:affiliation https://www.grid.ac/institutes/grid.419681.3
247 schema:familyName Sigelman
248 schema:givenName Steve M
249 rdf:type schema:Person
250 Neea99850692e4dbda0e7654668f14185 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
251 schema:familyName Togias
252 schema:givenName Alkis
253 rdf:type schema:Person
254 Nf781d5014e6d48d79a6ac914d9d3f42d schema:name nlm_unique_id
255 schema:value 100941354
256 rdf:type schema:PropertyValue
257 Nfd0abc8ed4eb4385bfe04dc54e5fa7dc schema:affiliation https://www.grid.ac/institutes/grid.267313.2
258 schema:familyName Gill
259 schema:givenName Michelle A
260 rdf:type schema:Person
261 Nfdc3cf93623243b88ed73bca62c6666d rdf:first N0f611dc71a424ace91e170c0c4a13475
262 rdf:rest N89e4acb57a0e401da06f5ad0761aa659
263 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
264 schema:name Medical and Health Sciences
265 rdf:type schema:DefinedTerm
266 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
267 schema:name Immunology
268 rdf:type schema:DefinedTerm
269 sg:grant.3803980 http://pending.schema.org/fundedItem sg:pub.10.1038/s41590-019-0347-8
270 rdf:type schema:MonetaryGrant
271 sg:journal.1022778 schema:issn 1529-2908
272 1529-2916
273 schema:name Nature Immunology
274 rdf:type schema:Periodical
275 sg:pub.10.1038/ng.2830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019417609
276 https://doi.org/10.1038/ng.2830
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/ng.323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047319287
279 https://doi.org/10.1038/ng.323
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/nprot.2008.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039987283
282 https://doi.org/10.1038/nprot.2008.211
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/nrdp.2015.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021525312
285 https://doi.org/10.1038/nrdp.2015.25
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/nri.2016.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029307492
288 https://doi.org/10.1038/nri.2016.95
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nri3642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029845730
291 https://doi.org/10.1038/nri3642
292 rdf:type schema:CreativeWork
293 sg:pub.10.1186/1471-2105-9-559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020312314
294 https://doi.org/10.1186/1471-2105-9-559
295 rdf:type schema:CreativeWork
296 sg:pub.10.1186/s13059-016-1140-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053890711
297 https://doi.org/10.1186/s13059-016-1140-8
298 rdf:type schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1083115722 schema:CreativeWork
300 https://doi.org/10.1016/j.ajpath.2012.06.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042011774
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.celrep.2018.08.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106930697
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.coi.2017.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091212971
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.ejphar.2018.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101524727
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.jaci.2007.09.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035572892
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.jaci.2010.01.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001942832
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.jaci.2011.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018841918
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.jaci.2011.10.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020501429
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.jaci.2011.11.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037433401
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.jaci.2013.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010578120
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.jaci.2014.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006946461
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.jaci.2014.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015387137
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.jaci.2015.02.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779338
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/j.jaci.2015.02.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002658426
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/j.jaci.2017.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092404739
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/j.jaci.2018.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103631652
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/j.rmed.2014.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039978467
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/j.stem.2014.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029822085
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/s0140-6736(05)80083-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004844813
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/s0140-6736(10)61380-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030498291
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1016/s0140-6736(12)60988-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015540360
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1056/nejme1806037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104137343
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1056/nejmoa1009705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003923843
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1056/nejmoa1804092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104131250
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1073/pnas.0707413104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016706328
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1073/pnas.1003059107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002612993
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1084/jem.20041901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037086706
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1093/bioinformatics/btp120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012425816
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1093/bioinformatics/btu638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053282140
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1093/bioinformatics/btv015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026692902
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1093/nar/28.18.3442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033785567
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1093/nar/gkn923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047610281
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1093/nar/gku1003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029045446
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1093/nar/gkv007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016098431
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1093/nar/gkv350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026744197
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1093/nar/gkv412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018245324
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1101/gr.1239303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052744398
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1111/all.13222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085965761
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1128/jcm.00075-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033122753
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1136/bmj.310.6989.1225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062771887
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1136/thoraxjnl-2012-202741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016606190
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1164/ajrccm.157.6.9609040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010613413
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1164/ajrccm.159.2.9804022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029789601
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1164/ajrccm.163.2.2001038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047940236
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1164/ajrccm.163.6.9901105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020275551
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1164/ajrccm/145.4_pt_1.900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013743012
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1164/rccm.200807-1126oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1010414863
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1164/rccm.201109-1635oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1026620444
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1164/rccm.201406-1039oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1003824489
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1164/rccm.201512-2452oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1063365502
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1164/rccm.201604-0866oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1079364839
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1177/019262339802600301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063753231
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1586/1744666x.2014.932249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028585470
405 rdf:type schema:CreativeWork
406 https://doi.org/10.3390/jcm6120112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093055286
407 rdf:type schema:CreativeWork
408 https://doi.org/10.4049/jimmunol.0900695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010358735
409 rdf:type schema:CreativeWork
410 https://doi.org/10.4049/jimmunol.1003554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012060888
411 rdf:type schema:CreativeWork
412 https://doi.org/10.4049/jimmunol.178.11.7310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015161330
413 rdf:type schema:CreativeWork
414 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
415 schema:name University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
416 rdf:type schema:Organization
417 https://www.grid.ac/institutes/grid.21729.3f schema:alternateName Columbia University
418 schema:name Columbia University College of Physicians and Surgeons, New York, NY, USA.
419 rdf:type schema:Organization
420 https://www.grid.ac/institutes/grid.239560.b schema:alternateName Children’s National Health System
421 schema:name Children's National Health System, Washington, DC, USA.
422 rdf:type schema:Organization
423 https://www.grid.ac/institutes/grid.239573.9 schema:alternateName Cincinnati Children's Hospital Medical Center
424 schema:name Cincinnati Children's Hospital, Cincinnati, OH, USA.
425 rdf:type schema:Organization
426 https://www.grid.ac/institutes/grid.239864.2 schema:alternateName Henry Ford Health System
427 schema:name Henry Ford Health System, Detroit, MI, USA.
428 rdf:type schema:Organization
429 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
430 schema:name Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
431 rdf:type schema:Organization
432 https://www.grid.ac/institutes/grid.281094.6 schema:alternateName Rho Federal Systems (United States)
433 schema:name Rho, Inc., Chapel Hill, NC, USA.
434 rdf:type schema:Organization
435 https://www.grid.ac/institutes/grid.413808.6 schema:alternateName Lurie Children's Hospital
436 schema:name Ann Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
437 rdf:type schema:Organization
438 https://www.grid.ac/institutes/grid.416879.5 schema:alternateName Virginia Mason Medical Center
439 schema:name Department of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA. maltman@benaroyaresearch.org.
440 Systems Immunology Program, Benaroya Research Institute, Seattle, WA, USA.
441 Systems Immunology Program, Benaroya Research Institute, Seattle, WA, USA. maltman@benaroyaresearch.org.
442 rdf:type schema:Organization
443 https://www.grid.ac/institutes/grid.419681.3 schema:alternateName National Institute of Allergy and Infectious Diseases
444 schema:name Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
445 rdf:type schema:Organization
446 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
447 schema:name Division of Allergy, Immunology, and Pulmonary Medicine, Washington University, St. Louis, MO, USA.
448 rdf:type schema:Organization
449 https://www.grid.ac/institutes/grid.475010.7 schema:alternateName Boston University School of Medicine
450 schema:name Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
451 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...