BCR affinity differentially regulates colonization of the subepithelial dome and infiltration into germinal centers within Peyer’s patches View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Adi Biram, Anneli Strömberg, Eitan Winter, Liat Stoler-Barak, Ran Salomon, Yoseph Addadi, Rony Dahan, Gur Yaari, Mats Bemark, Ziv Shulman

ABSTRACT

Gut-derived antigens trigger immunoglobulin A (IgA) immune responses that are initiated by cognate B cells in Peyer's patches (PPs). These cells colonize the subepithelial domes (SEDs) of the PPs and subsequently infiltrate pre-existing germinal centers (GCs). Here we defined the pre-GC events and the micro-anatomical site at which affinity-based B cell selection occurred in PPs. Using whole-organ imaging, we showed that the affinity of the B cell antigen receptor (BCR) regulated the infiltration of antigen-specific B cells into GCs but not clonal competition in the SED. Follicular helper-like T cells resided in the SED and promoted its B cell colonization, independently of the magnitude of BCR affinity. Imaging and immunoglobulin sequencing indicated that selective clonal expansion ensued during infiltration into GCs. Thus, in contrast to the events in draining lymph nodes and spleen, in PPs, T cells promoted mainly the population expansion of B cells without clonal selection during pre-GC events. These findings have major implications for the design of oral vaccines. More... »

PAGES

482-492

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41590-019-0325-1

    DOI

    http://dx.doi.org/10.1038/s41590-019-0325-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112512526

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30833793


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

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    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41590-019-0325-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41590-019-0325-1'

    RDF/XML is a standard XML format for linked data.

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