Activated β-Catenin in Foxp3+ Regulatory T cells Links Inflammatory Environments to Autoimmunity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10-29

AUTHORS

Tomokazu Sumida, Matthew R Lincoln, Chinonso M Ukeje, Donald M Rodriguez, Hiroshi Akazawa, Tetsuo Noda, Atsuhiko T Naito, Issei Komuro, Margarita Dominguez-Villar, David A Hafler

ABSTRACT

Foxp3+ regulatory T cells (Treg cells) are the central component of peripheral immune tolerance. Whereas a dysregulated Treg cytokine signature has been observed in autoimmune diseases, the regulatory mechanisms underlying pro- and anti-inflammatory cytokine production are elusive. Here, we identify an imbalance between the cytokines IFN-γ and IL-10 as a shared Treg signature present in patients with multiple sclerosis and under high-salt conditions. RNA-sequencing analysis on human Treg subpopulations revealed β-catenin as a key regulator of IFN-γ and IL-10 expression. The activated β-catenin signature was enriched in human IFN-γ+ Treg cells, as confirmed in vivo with Treg-specific β-catenin-stabilized mice exhibiting lethal autoimmunity with a dysfunctional Treg phenotype. Moreover, we identified prostaglandin E receptor 2 (PTGER2) as a regulator of IFN-γ and IL-10 production under a high-salt environment, with skewed activation of the β-catenin-SGK1-Foxo axis. Our findings reveal a novel PTGER2-β-catenin loop in Treg cells linking environmental high-salt conditions to autoimmunity. More... »

PAGES

1391-1402

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41590-018-0236-6

DOI

http://dx.doi.org/10.1038/s41590-018-0236-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107804221

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30374130


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