c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05

AUTHORS

Leona Gabryšová, Marisol Alvarez-Martinez, Raphaëlle Luisier, Luke S. Cox, Jan Sodenkamp, Caroline Hosking, Damián Pérez-Mazliah, Charlotte Whicher, Yashaswini Kannan, Krzysztof Potempa, Xuemei Wu, Leena Bhaw, Hagen Wende, Michael H. Sieweke, Greg Elgar, Mark Wilson, James Briscoe, Vicki Metzis, Jean Langhorne, Nicholas M. Luscombe, Anne O’Garra

ABSTRACT

The transcription factor c-Maf induces the anti-inflammatory cytokine IL-10 in CD4+ T cells in vitro. However, the global effects of c-Maf on diverse immune responses in vivo are unknown. Here we found that c-Maf regulated IL-10 production in CD4+ T cells in disease models involving the TH1 subset of helper T cells (malaria), TH2 cells (allergy) and TH17 cells (autoimmunity) in vivo. Although mice with c-Maf deficiency targeted to T cells showed greater pathology in TH1 and TH2 responses, TH17 cell-mediated pathology was reduced in this context, with an accompanying decrease in TH17 cells and increase in Foxp3+ regulatory T cells. Bivariate genomic footprinting elucidated the c-Maf transcription-factor network, including enhanced activity of NFAT; this led to the identification and validation of c-Maf as a negative regulator of IL-2. The decreased expression of the gene encoding the transcription factor RORγt (Rorc) that resulted from c-Maf deficiency was dependent on IL-2, which explained the in vivo observations. Thus, c-Maf is a positive and negative regulator of the expression of cytokine-encoding genes, with context-specific effects that allow each immune response to occur in a controlled yet effective manner. More... »

PAGES

497-507

References to SciGraph publications

  • 2011-05. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells in NATURE IMMUNOLOGY
  • 2002-10. Dec1 and Dec2 are regulators of the mammalian molecular clock in NATURE
  • 2008-09. A new MAFia in cancer in NATURE REVIEWS CANCER
  • 2013-12. Target analysis by integration of transcriptome and ChIP-seq data with BETA in NATURE PROTOCOLS
  • 2010-09. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27 in NATURE IMMUNOLOGY
  • 2013-12. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position in NATURE METHODS
  • 2010-09. NFAT, immunity and cancer: a transcription factor comes of age in NATURE REVIEWS IMMUNOLOGY
  • 2014-12. Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation in NATURE COMMUNICATIONS
  • 2018-02. c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont in NATURE
  • 2011-12. Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells in NATURE IMMUNOLOGY
  • 2014. The Regulation of IL-10 Expression in INTERLEUKIN-10 IN HEALTH AND DISEASE
  • 2014-06. Motif-based analysis of large nucleotide data sets using MEME-ChIP in NATURE PROTOCOLS
  • 2012-06. PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells in NATURE
  • 2017-01. CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation in MUCOSAL IMMUNOLOGY
  • 2015-06. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α in NATURE MEDICINE
  • 2007-02. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells in NATURE IMMUNOLOGY
  • 2009-02. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells in NATURE IMMUNOLOGY
  • 2012-09-19. BATF–JUN is critical for IRF4-mediated transcription in T cells in NATURE
  • 2012-09-19. Compensatory dendritic cell development mediated by BATF–IRF interactions in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41590-018-0083-5

    DOI

    http://dx.doi.org/10.1038/s41590-018-0083-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103270329

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29662170


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