Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes View Full Text


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Article Info

DATE

2018-03

AUTHORS

Mengyun Zhang, Yong Dong, Fangxiao Hu, Dan Yang, Qianhao Zhao, Cui Lv, Ying Wang, Chengxiang Xia, Qitong Weng, Xiaofei Liu, Chen Li, Peiqing Zhou, Tongjie Wang, Yuxian Guan, Rongqun Guo, Lijuan Liu, Yang Geng, Hongling Wu, Juan Du, Zheng Hu, Sheng Xu, Jiekai Chen, Aibin He, Bing Liu, Demin Wang, Yong-Guang Yang, Jinyong Wang

ABSTRACT

Deletion of master regulators of the B cell lineage reprograms B cells into T cells. Here we found that the transcription factor Hoxb5, which is expressed in uncommitted hematopoietic progenitor cells but is not present in cells committed to the B cell or T cell lineage, was able to reprogram pro-pre-B cells into functional early T cell lineage progenitors. This reprogramming started in the bone marrow and was completed in the thymus and gave rise to T lymphocytes with transcriptomes, hierarchical differentiation, tissue distribution and immunological functions that closely resembled those of their natural counterparts. Hoxb5 repressed B cell 'master genes', activated regulators of T cells and regulated crucial chromatin modifiers in pro-pre-B cells and ultimately drove the B cell fate-to-T cell fate conversion. Our results provide a de novo paradigm for the generation of functional T cells through reprogramming in vivo. More... »

PAGES

279-290

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41590-018-0046-x

    DOI

    http://dx.doi.org/10.1038/s41590-018-0046-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100925180

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29434353


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