Crystal structure of the endogenous agonist-bound prostanoid receptor EP3 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01

AUTHORS

Kazushi Morimoto, Ryoji Suno, Yunhong Hotta, Keitaro Yamashita, Kunio Hirata, Masaki Yamamoto, Shuh Narumiya, So Iwata, Takuya Kobayashi

ABSTRACT

Prostanoids are a series of bioactive lipid metabolites that function in an autacoid manner via activation of cognate G-protein-coupled receptors (GPCRs). Here, we report the crystal structure of human prostaglandin (PG) E receptor subtype EP3 bound to endogenous ligand PGE2 at 2.90 Å resolution. The structure reveals important insights into the activation mechanism of prostanoid receptors and provides a molecular basis for the binding modes of endogenous ligands. More... »

PAGES

8-10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41589-018-0171-8

DOI

http://dx.doi.org/10.1038/s41589-018-0171-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110288623

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30510192


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