Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-02-03

AUTHORS

Youwen Qin, Aki S. Havulinna, Yang Liu, Pekka Jousilahti, Scott C. Ritchie, Alex Tokolyi, Jon G. Sanders, Liisa Valsta, Marta Brożyńska, Qiyun Zhu, Anupriya Tripathi, Yoshiki Vázquez-Baeza, Rohit Loomba, Susan Cheng, Mohit Jain, Teemu Niiranen, Leo Lahti, Rob Knight, Veikko Salomaa, Michael Inouye, Guillaume Méric

ABSTRACT

Human genetic variation affects the gut microbiota through a complex combination of environmental and host factors. Here we characterize genetic variations associated with microbial abundances in a single large-scale population-based cohort of 5,959 genotyped individuals with matched gut microbial metagenomes, and dietary and health records (prevalent and follow-up). We identified 567 independent SNP–taxon associations. Variants at the LCT locus associated with Bifidobacterium and other taxa, but they differed according to dairy intake. Furthermore, levels of Faecalicatena lactaris associated with ABO, and suggested preferential utilization of secreted blood antigens as energy source in the gut. Enterococcus faecalis levels associated with variants in the MED13L locus, which has been linked to colorectal cancer. Mendelian randomization analysis indicated a potential causal effect of Morganella on major depressive disorder, consistent with observational incident disease analysis. Overall, we identify and characterize the intricate nature of host–microbiota interactions and their association with disease. More... »

PAGES

134-142

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  • Journal

    TITLE

    Nature Genetics

    ISSUE

    2

    VOLUME

    54

    Author Affiliations

  • School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia
  • Institute for Molecular Medicine Finland, FIMM-HiLIFE, Helsinki, Finland
  • Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia
  • Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
  • British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK
  • Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
  • Cornell Institute for Host-Microbe Interaction and Disease, Cornell University, Ithaca, NY, USA
  • Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
  • Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA
  • Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA
  • Department of Computer Science & Engineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA
  • NAFLD Research Center, Department of Medicine, University of California San Diego, La Jolla, CA, USA
  • Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
  • Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA
  • Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland
  • Department of Computing, University of Turku, Turku, Finland
  • The Alan Turing Institute, London, UK
  • Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria, Australia
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-021-00991-z

    DOI

    http://dx.doi.org/10.1038/s41588-021-00991-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1145227073

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35115689


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