Challenges and future directions for studying effects of host genetics on the gut microbiome View Full Text


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Article Info

DATE

2022-02-03

AUTHORS

Serena Sanna, Alexander Kurilshikov, Adriaan van der Graaf, Jingyuan Fu, Alexandra Zhernakova

ABSTRACT

The human gut microbiome is a complex ecosystem that is involved in its host’s metabolism, immunity and health. Although interindividual variations in gut microbial composition are mainly driven by environmental factors, some gut microorganisms are heritable and thus can be influenced by host genetics. In the past 5 years, 12 microbial genome-wide association studies (mbGWAS) with >1,000 participants have been published, yet only a few genetic loci have been consistently confirmed across multiple studies. Here we discuss the state of the art for mbGWAS, focusing on current challenges such as the heterogeneity of microbiome measurements and power issues, and we elaborate on potential future directions for genetic analysis of the microbiome. More... »

PAGES

100-106

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    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-021-00983-z

    DOI

    http://dx.doi.org/10.1038/s41588-021-00983-z

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    338 Department of Pediatrics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    339 schema:name Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    340 Department of Pediatrics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    341 Institute for Genetic and Biomedical Research (IRGB), National Research Council (CNR), Monserrato, Cagliari, Italy
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    343 grid-institutes:grid.9851.5 schema:alternateName Department of Computational Biology, University of Lausanne, Lausanne, Switzerland
    344 schema:name Department of Computational Biology, University of Lausanne, Lausanne, Switzerland
    345 Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
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