Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-02-05

AUTHORS

Bernardo Rodriguez-Martin, Eva G. Alvarez, Adrian Baez-Ortega, Jorge Zamora, Fran Supek, Jonas Demeulemeester, Martin Santamarina, Young Seok Ju, Javier Temes, Daniel Garcia-Souto, Harald Detering, Yilong Li, Jorge Rodriguez-Castro, Ana Dueso-Barroso, Alicia L. Bruzos, Stefan C. Dentro, Miguel G. Blanco, Gianmarco Contino, Daniel Ardeljan, Marta Tojo, Nicola D. Roberts, Sonia Zumalave, Paul A. W. Edwards, Joachim Weischenfeldt, Montserrat Puiggròs, Zechen Chong, Ken Chen, Eunjung Alice Lee, Jeremiah A. Wala, Keiran Raine, Adam Butler, Sebastian M. Waszak, Fabio C. P. Navarro, Steven E. Schumacher, Jean Monlong, Francesco Maura, Niccolo Bolli, Guillaume Bourque, Mark Gerstein, Peter J. Park, David C. Wedge, Rameen Beroukhim, David Torrents, Jan O. Korbel, Inigo Martincorena, Rebecca C. Fitzgerald, Peter Van Loo, Haig H. Kazazian, Kathleen H. Burns, Peter J. Campbell, Jose M. C. Tubio

ABSTRACT

About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 38 histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We identified 19,166 somatically acquired retrotransposition events, which affected 35% of samples and spanned a range of event types. Long interspersed nuclear element (LINE-1; L1 hereafter) insertions emerged as the first most frequent type of somatic structural variation in esophageal adenocarcinoma, and the second most frequent in head-and-neck and colorectal cancers. Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes leads to the removal of tumor-suppressor genes, and can induce complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage–fusion–bridge cycles, leading to high-level amplification of oncogenes. These observations illuminate a relevant role of L1 retrotransposition in remodeling the cancer genome, with potential implications for the development of human tumors. More... »

PAGES

306-319

References to SciGraph publications

  • 2001-02-15. Initial sequencing and analysis of the human genome in NATURE
  • 2013-04-25. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions in GENOME BIOLOGY
  • 2014-04-09. Processed pseudogenes acquired somatically during cancer development in NATURE COMMUNICATIONS
  • 2016-09-12. L1-associated genomic regions are deleted in somatic cells of the healthy human brain in NATURE NEUROSCIENCE
  • 2010-10-27. The patterns and dynamics of genomic instability in metastatic pancreatic cancer in NATURE
  • 2020-02-05. Analyses of non-coding somatic drivers in 2,658 cancer whole genomes in NATURE
  • 2004-04-26. L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas in MOLECULAR CANCER
  • 2017-10-30. Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells in NATURE GENETICS
  • 2013-03-13. Retrotransposition of gene transcripts leads to structural variation in mammalian genomes in GENOME BIOLOGY
  • 2000-08. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice in NATURE
  • 2017-06-09. Transposable elements in cancer in NATURE REVIEWS CANCER
  • 2014-07-02. Processed pseudogene insertions in somatic cells in MOBILE DNA
  • 2020-02-05. Genomic basis for RNA alterations in cancer in NATURE
  • 2020-02-05. The evolutionary history of 2,658 cancers in NATURE
  • 2015-01-28. Comprehensive genomic characterization of head and neck squamous cell carcinomas in NATURE
  • 2010-02. The landscape of somatic copy-number alteration across human cancers in NATURE
  • 1997-05. Many human L1 elements are capable of retrotransposition in NATURE GENETICS
  • 2020-02-05. Pan-cancer analysis of whole genomes in NATURE
  • 1994-06. A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion in NATURE GENETICS
  • 2014-03-23. Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia in NATURE
  • 2014-07-09. Comprehensive molecular profiling of lung adenocarcinoma in NATURE
  • 2017-01-18. Telomeres in cancer: tumour suppression and genome instability in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2017-05-17. Non-homologous DNA end joining and alternative pathways to double-strand break repair in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2012-09-09. Comprehensive genomic characterization of squamous cell lung cancers in NATURE
  • Journal

    TITLE

    Nature Genetics

    ISSUE

    3

    VOLUME

    52

    Author Affiliations

  • Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain
  • Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
  • Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
  • Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
  • Department of Human Genetics, University of Leuven, Leuven, Belgium
  • Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK
  • Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
  • Galicia Sur Health Research Institute, Vigo, Spain
  • Faculty of Science and Technology, University of Vic—Central University of Catalonia (UVic-UCC), Vic, Spain
  • Oxford Big Data Institute, University of Oxford, Oxford, UK
  • Department of Biochemistry and Molecular Biology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
  • Medical Research Council (MRC) Cancer Unit, University of Cambridge, Cambridge, UK
  • Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA
  • Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain
  • Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
  • European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany
  • Barcelona Supercomputing Center (BSC-CNS), Barcelona, Spain
  • Department of Genetics and Informatics Institute, University of Alabama at Birmingham (UAB) School of Medicine, Birmingham, AL, USA
  • Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
  • The Broad Institute of Harvard and MIT, Cambridge, MA, USA
  • Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
  • Department of Computer Science, Yale University, New Haven, CT, USA
  • Department of Human Genetics, McGill University, Montreal, Québec, Canada
  • Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
  • Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
  • Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA
  • Department of Haematology, University of Cambridge, Cambridge, UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-019-0562-0

    DOI

    http://dx.doi.org/10.1038/s41588-019-0562-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1124596160

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32024998


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Rearrangement", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Long Interspersed Nucleotide Elements", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retroelements", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain", 
              "id": "http://www.grid.ac/institutes/grid.6312.6", 
              "name": [
                "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rodriguez-Martin", 
            "givenName": "Bernardo", 
            "id": "sg:person.010542146413.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010542146413.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain", 
              "id": "http://www.grid.ac/institutes/grid.6312.6", 
              "name": [
                "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alvarez", 
            "givenName": "Eva G.", 
            "id": "sg:person.013417463113.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013417463113.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baez-Ortega", 
            "givenName": "Adrian", 
            "id": "sg:person.0675077147.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675077147.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
              "id": "http://www.grid.ac/institutes/grid.11794.3a", 
              "name": [
                "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zamora", 
            "givenName": "Jorge", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institucio Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain", 
              "id": "http://www.grid.ac/institutes/grid.425902.8", 
              "name": [
                "Genome Data Science, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain", 
                "Institucio Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Supek", 
            "givenName": "Fran", 
            "id": "sg:person.0642244733.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642244733.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Human Genetics, University of Leuven, Leuven, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "The Francis Crick Institute, London, UK", 
                "Department of Human Genetics, University of Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Demeulemeester", 
            "givenName": "Jonas", 
            "id": "sg:person.01026052267.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026052267.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain", 
              "id": "http://www.grid.ac/institutes/grid.6312.6", 
              "name": [
                "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Santamarina", 
            "givenName": "Martin", 
            "id": "sg:person.011532132626.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011532132626.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea", 
                "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ju", 
            "givenName": "Young Seok", 
            "id": "sg:person.01161542113.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161542113.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
              "id": "http://www.grid.ac/institutes/grid.11794.3a", 
              "name": [
                "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Temes", 
            "givenName": "Javier", 
            "id": "sg:person.013623407463.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013623407463.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
              "id": "http://www.grid.ac/institutes/grid.11794.3a", 
              "name": [
                "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Garcia-Souto", 
            "givenName": "Daniel", 
            "id": "sg:person.01017300045.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017300045.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Galicia Sur Health Research Institute, Vigo, Spain", 
              "id": "http://www.grid.ac/institutes/grid.512379.b", 
              "name": [
                "Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain", 
                "Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain", 
                "Galicia Sur Health Research Institute, Vigo, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Detering", 
            "givenName": "Harald", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Yilong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
              "id": "http://www.grid.ac/institutes/grid.11794.3a", 
              "name": [
                "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rodriguez-Castro", 
            "givenName": "Jorge", 
            "id": "sg:person.01011331237.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011331237.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Faculty of Science and Technology, University of Vic\u2014Central University of Catalonia (UVic-UCC), Vic, Spain", 
              "id": "http://www.grid.ac/institutes/grid.440820.a", 
              "name": [
                "Barcelona Supercomputing Center (BSC-CNS), Barcelona, Spain", 
                "Faculty of Science and Technology, University of Vic\u2014Central University of Catalonia (UVic-UCC), Vic, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dueso-Barroso", 
            "givenName": "Ana", 
            "id": "sg:person.014315334235.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014315334235.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain", 
              "id": "http://www.grid.ac/institutes/grid.6312.6", 
              "name": [
                "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bruzos", 
            "givenName": "Alicia L.", 
            "id": "sg:person.014263156713.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014263156713.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oxford Big Data Institute, University of Oxford, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "The Francis Crick Institute, London, UK", 
                "Experimental Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK", 
                "Oxford Big Data Institute, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dentro", 
            "givenName": "Stefan C.", 
            "id": "sg:person.011464673575.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011464673575.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biochemistry and Molecular Biology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
              "id": "http://www.grid.ac/institutes/grid.11794.3a", 
              "name": [
                "DNA Repair and Genome Integrity, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Department of Biochemistry and Molecular Biology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blanco", 
            "givenName": "Miguel G.", 
            "id": "sg:person.01025271001.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025271001.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Research Council (MRC) Cancer Unit, University of Cambridge, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Medical Research Council (MRC) Cancer Unit, University of Cambridge, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Contino", 
            "givenName": "Gianmarco", 
            "id": "sg:person.01166400742.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166400742.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ardeljan", 
            "givenName": "Daniel", 
            "id": "sg:person.01251155040.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251155040.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain", 
              "id": "http://www.grid.ac/institutes/grid.6312.6", 
              "name": [
                "Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tojo", 
            "givenName": "Marta", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roberts", 
            "givenName": "Nicola D.", 
            "id": "sg:person.01131202135.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131202135.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
              "id": "http://www.grid.ac/institutes/grid.11794.3a", 
              "name": [
                "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zumalave", 
            "givenName": "Sonia", 
            "id": "sg:person.016013731063.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016013731063.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.498239.d", 
              "name": [
                "Department of Pathology, University of Cambridge, Cambridge, UK", 
                "Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Edwards", 
            "givenName": "Paul A. W.", 
            "id": "sg:person.011341701362.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011341701362.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark", 
                "Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark", 
                "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weischenfeldt", 
            "givenName": "Joachim", 
            "id": "sg:person.01350775415.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350775415.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Barcelona Supercomputing Center (BSC-CNS), Barcelona, Spain", 
              "id": "http://www.grid.ac/institutes/grid.10097.3f", 
              "name": [
                "Barcelona Supercomputing Center (BSC-CNS), Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Puiggr\u00f2s", 
            "givenName": "Montserrat", 
            "id": "sg:person.01033774323.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033774323.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetics and Informatics Institute, University of Alabama at Birmingham (UAB) School of Medicine, Birmingham, AL, USA", 
              "id": "http://www.grid.ac/institutes/grid.265892.2", 
              "name": [
                "Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
                "Department of Genetics and Informatics Institute, University of Alabama at Birmingham (UAB) School of Medicine, Birmingham, AL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chong", 
            "givenName": "Zechen", 
            "id": "sg:person.01051671264.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051671264.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
              "id": "http://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Ken", 
            "id": "sg:person.013674745677.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013674745677.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Division of Genetics and Genomics, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA", 
                "The Broad Institute of Harvard and MIT, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Eunjung Alice", 
            "id": "sg:person.016106452303.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016106452303.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of Harvard and MIT, Cambridge, MA, USA", 
                "Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wala", 
            "givenName": "Jeremiah A.", 
            "id": "sg:person.01303624731.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303624731.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raine", 
            "givenName": "Keiran", 
            "id": "sg:person.01251165601.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251165601.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Butler", 
            "givenName": "Adam", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Waszak", 
            "givenName": "Sebastian M.", 
            "id": "sg:person.01273213270.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273213270.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Computer Science, Yale University, New Haven, CT, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA", 
                "Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA", 
                "Department of Computer Science, Yale University, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Navarro", 
            "givenName": "Fabio C. P.", 
            "id": "sg:person.0722704772.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722704772.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of Harvard and MIT, Cambridge, MA, USA", 
                "Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schumacher", 
            "givenName": "Steven E.", 
            "id": "sg:person.01055166050.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055166050.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Human Genetics, McGill University, Montreal, Qu\u00e9bec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Department of Human Genetics, McGill University, Montreal, Qu\u00e9bec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Monlong", 
            "givenName": "Jean", 
            "id": "sg:person.01256031142.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256031142.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy", 
              "id": "http://www.grid.ac/institutes/grid.417893.0", 
              "name": [
                "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK", 
                "Department of Oncology and Onco-Hematology, University of Milan, Milan, Italy", 
                "Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maura", 
            "givenName": "Francesco", 
            "id": "sg:person.0707001004.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707001004.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy", 
              "id": "http://www.grid.ac/institutes/grid.417893.0", 
              "name": [
                "Department of Oncology and Onco-Hematology, University of Milan, Milan, Italy", 
                "Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bolli", 
            "givenName": "Niccolo", 
            "id": "sg:person.01211501151.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211501151.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Human Genetics, McGill University, Montreal, Qu\u00e9bec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.14709.3b", 
              "name": [
                "Department of Human Genetics, McGill University, Montreal, Qu\u00e9bec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bourque", 
            "givenName": "Guillaume", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA", 
                "Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gerstein", 
            "givenName": "Mark", 
            "id": "sg:person.011677655217.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011677655217.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Peter J.", 
            "id": "sg:person.01024612701.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024612701.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oxford Big Data Institute, University of Oxford, Oxford, UK", 
              "id": "http://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "Oxford NIHR Biomedical Research Centre, Oxford, UK", 
                "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK", 
                "Oxford Big Data Institute, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wedge", 
            "givenName": "David C.", 
            "id": "sg:person.01252077430.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252077430.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of Harvard and MIT, Cambridge, MA, USA", 
                "Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beroukhim", 
            "givenName": "Rameen", 
            "id": "sg:person.01310170137.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310170137.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institucio Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain", 
              "id": "http://www.grid.ac/institutes/grid.425902.8", 
              "name": [
                "Barcelona Supercomputing Center (BSC-CNS), Barcelona, Spain", 
                "Institucio Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Torrents", 
            "givenName": "David", 
            "id": "sg:person.01215532237.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215532237.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Korbel", 
            "givenName": "Jan O.", 
            "id": "sg:person.0772174216.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772174216.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martincorena", 
            "givenName": "Inigo", 
            "id": "sg:person.0602760061.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602760061.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Research Council (MRC) Cancer Unit, University of Cambridge, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Medical Research Council (MRC) Cancer Unit, University of Cambridge, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fitzgerald", 
            "givenName": "Rebecca C.", 
            "id": "sg:person.01145426033.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145426033.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Human Genetics, University of Leuven, Leuven, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "The Francis Crick Institute, London, UK", 
                "Department of Human Genetics, University of Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Van Loo", 
            "givenName": "Peter", 
            "id": "sg:person.01017630143.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017630143.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kazazian", 
            "givenName": "Haig H.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA", 
                "Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Burns", 
            "givenName": "Kathleen H.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology, University of Cambridge, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK", 
                "Department of Haematology, University of Cambridge, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Campbell", 
            "givenName": "Peter J.", 
            "id": "sg:person.0716350025.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716350025.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK", 
              "id": "http://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain", 
                "Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain", 
                "Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tubio", 
            "givenName": "Jose M. C.", 
            "id": "sg:person.016450322532.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016450322532.23"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41586-019-1907-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1124588398", 
              "https://doi.org/10.1038/s41586-019-1907-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038580641", 
              "https://doi.org/10.1038/nature13385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2013-14-4-r36", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015459845", 
              "https://doi.org/10.1186/gb-2013-14-4-r36"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-020-1965-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1124590164", 
              "https://doi.org/10.1038/s41586-020-1965-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2013-14-3-r22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045187544", 
              "https://doi.org/10.1186/gb-2013-14-3-r22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006014163", 
              "https://doi.org/10.1038/nature11404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc.2017.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085935508", 
              "https://doi.org/10.1038/nrc.2017.35"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032630541", 
              "https://doi.org/10.1038/nn.4388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022310913", 
              "https://doi.org/10.1038/nature09460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2016.171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000827740", 
              "https://doi.org/10.1038/nrm.2016.171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-3-12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032442566", 
              "https://doi.org/10.1186/1476-4598-3-12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35020592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017226982", 
              "https://doi.org/10.1038/35020592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35057062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042854081", 
              "https://doi.org/10.1038/35057062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-020-1969-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1124593766", 
              "https://doi.org/10.1038/s41586-020-1969-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0694-143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014552572", 
              "https://doi.org/10.1038/ng0694-143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms4644", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016695553", 
              "https://doi.org/10.1038/ncomms4644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-020-1970-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1124596336", 
              "https://doi.org/10.1038/s41586-020-1970-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1759-8753-5-20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037415246", 
              "https://doi.org/10.1186/1759-8753-5-20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092440098", 
              "https://doi.org/10.1038/ng.3984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017979448", 
              "https://doi.org/10.1038/nature13115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2017.48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085422215", 
              "https://doi.org/10.1038/nrm.2017.48"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0597-37", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005219388", 
              "https://doi.org/10.1038/ng0597-37"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010635813", 
              "https://doi.org/10.1038/nature08822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045934545", 
              "https://doi.org/10.1038/nature14129"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-02-05", 
        "datePublishedReg": "2020-02-05", 
        "description": "About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954\u2009cancer genomes from 38\u2009histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We identified 19,166\u2009somatically acquired retrotransposition events, which affected 35% of samples and spanned a range of event types. Long interspersed nuclear element (LINE-1; L1 hereafter) insertions emerged as the first most frequent type of somatic structural variation in esophageal adenocarcinoma, and the second most frequent in head-and-neck and colorectal cancers. Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes leads to the removal of tumor-suppressor genes, and can induce complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage\u2013fusion\u2013bridge cycles, leading to high-level amplification of oncogenes. These observations illuminate a relevant role of L1 retrotransposition in remodeling the cancer genome, with potential implications for the development of human tumors.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41588-019-0562-0", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.100057572", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3535567", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2684537", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438826", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7025792", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7569744", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8493724", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7523598", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3767480", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6952756", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2697619", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2682465", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7082641", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5240271", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440551", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2482221", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5504631", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6798148", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6376055", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5494085", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2476004", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6503652", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5235326", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7751051", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2481687", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3639747", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2521503", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3933509", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3634409", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "52"
          }
        ], 
        "keywords": [
          "pan-cancer analysis", 
          "histological cancer subtypes", 
          "high-level amplification", 
          "colorectal cancer", 
          "somatic retrotransposition", 
          "esophageal adenocarcinoma", 
          "cancer subtypes", 
          "tumor suppressor gene", 
          "human tumors", 
          "frequent type", 
          "cancer", 
          "complex translocation", 
          "cancer genomes", 
          "somatic integration", 
          "LINE-1 retrotransposition", 
          "potential implications", 
          "adenocarcinoma", 
          "relevant role", 
          "tumors", 
          "subtypes", 
          "neck", 
          "oncogenesis", 
          "role", 
          "oncogene", 
          "L1 retrotransposition", 
          "head", 
          "translocation", 
          "megabase-scale regions", 
          "half", 
          "genes", 
          "somatic structural variations", 
          "types", 
          "insertion", 
          "events", 
          "analysis", 
          "event types", 
          "mechanism", 
          "amplification", 
          "patterns", 
          "samples", 
          "retrotransposition events", 
          "development", 
          "Genome Project", 
          "removal", 
          "retrotransposition", 
          "implications", 
          "genome", 
          "rearrangement", 
          "duplication", 
          "cycle", 
          "bridge cycles", 
          "large-scale duplications", 
          "nuclear element (SINE) insertion", 
          "Whole Genomes (PCAWG) project", 
          "observations", 
          "region", 
          "L1 integration", 
          "element insertions", 
          "chromosomes", 
          "variation", 
          "range", 
          "structural variations", 
          "integration", 
          "retrotransposons", 
          "project", 
          "framework"
        ], 
        "name": "Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition", 
        "pagination": "306-319", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1124596160"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41588-019-0562-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "32024998"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41588-019-0562-0", 
          "https://app.dimensions.ai/details/publication/pub.1124596160"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_850.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41588-019-0562-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41588-019-0562-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41588-019-0562-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41588-019-0562-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41588-019-0562-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    753 TRIPLES      21 PREDICATES      122 URIs      90 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41588-019-0562-0 schema:about N1201ab36996f4ca4b463cd8337fb258e
    2 N1c004ea2130f4413ac8c52795a01e029
    3 N49a8427cfbba4adcb2a5a5ce717c1fe3
    4 N8f358cbc7eaf48128f47745590cbd364
    5 Nc244e1bb8020491fbb41c68fbaaa1b2f
    6 Nd77639f4d21a4f94a149b0785257ba65
    7 Nd8c9e2b6d726433fba70e1c447a918ab
    8 anzsrc-for:11
    9 anzsrc-for:1112
    10 schema:author N5ef38ed755044f32b51ba03a2ebd1fbe
    11 schema:citation sg:pub.10.1038/35020592
    12 sg:pub.10.1038/35057062
    13 sg:pub.10.1038/nature08822
    14 sg:pub.10.1038/nature09460
    15 sg:pub.10.1038/nature11404
    16 sg:pub.10.1038/nature13115
    17 sg:pub.10.1038/nature13385
    18 sg:pub.10.1038/nature14129
    19 sg:pub.10.1038/ncomms4644
    20 sg:pub.10.1038/ng.3984
    21 sg:pub.10.1038/ng0597-37
    22 sg:pub.10.1038/ng0694-143
    23 sg:pub.10.1038/nn.4388
    24 sg:pub.10.1038/nrc.2017.35
    25 sg:pub.10.1038/nrm.2016.171
    26 sg:pub.10.1038/nrm.2017.48
    27 sg:pub.10.1038/s41586-019-1907-7
    28 sg:pub.10.1038/s41586-020-1965-x
    29 sg:pub.10.1038/s41586-020-1969-6
    30 sg:pub.10.1038/s41586-020-1970-0
    31 sg:pub.10.1186/1476-4598-3-12
    32 sg:pub.10.1186/1759-8753-5-20
    33 sg:pub.10.1186/gb-2013-14-3-r22
    34 sg:pub.10.1186/gb-2013-14-4-r36
    35 schema:datePublished 2020-02-05
    36 schema:datePublishedReg 2020-02-05
    37 schema:description About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 38 histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We identified 19,166 somatically acquired retrotransposition events, which affected 35% of samples and spanned a range of event types. Long interspersed nuclear element (LINE-1; L1 hereafter) insertions emerged as the first most frequent type of somatic structural variation in esophageal adenocarcinoma, and the second most frequent in head-and-neck and colorectal cancers. Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes leads to the removal of tumor-suppressor genes, and can induce complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage–fusion–bridge cycles, leading to high-level amplification of oncogenes. These observations illuminate a relevant role of L1 retrotransposition in remodeling the cancer genome, with potential implications for the development of human tumors.
    38 schema:genre article
    39 schema:isAccessibleForFree true
    40 schema:isPartOf Nb6325fd2b9844961aadf3e3d858087d9
    41 Ncde18c059c1b438c9e8fedcb1cca2234
    42 sg:journal.1103138
    43 schema:keywords Genome Project
    44 L1 integration
    45 L1 retrotransposition
    46 LINE-1 retrotransposition
    47 Whole Genomes (PCAWG) project
    48 adenocarcinoma
    49 amplification
    50 analysis
    51 bridge cycles
    52 cancer
    53 cancer genomes
    54 cancer subtypes
    55 chromosomes
    56 colorectal cancer
    57 complex translocation
    58 cycle
    59 development
    60 duplication
    61 element insertions
    62 esophageal adenocarcinoma
    63 event types
    64 events
    65 framework
    66 frequent type
    67 genes
    68 genome
    69 half
    70 head
    71 high-level amplification
    72 histological cancer subtypes
    73 human tumors
    74 implications
    75 insertion
    76 integration
    77 large-scale duplications
    78 mechanism
    79 megabase-scale regions
    80 neck
    81 nuclear element (SINE) insertion
    82 observations
    83 oncogene
    84 oncogenesis
    85 pan-cancer analysis
    86 patterns
    87 potential implications
    88 project
    89 range
    90 rearrangement
    91 region
    92 relevant role
    93 removal
    94 retrotransposition
    95 retrotransposition events
    96 retrotransposons
    97 role
    98 samples
    99 somatic integration
    100 somatic retrotransposition
    101 somatic structural variations
    102 structural variations
    103 subtypes
    104 translocation
    105 tumor suppressor gene
    106 tumors
    107 types
    108 variation
    109 schema:name Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
    110 schema:pagination 306-319
    111 schema:productId N37b111bb10d649d3b4e830211236d715
    112 N73a1dfe8646c4c68a17f50b2500ebb41
    113 Nddc0dcfe526d40a98d28935fa3f948de
    114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124596160
    115 https://doi.org/10.1038/s41588-019-0562-0
    116 schema:sdDatePublished 2022-12-01T06:40
    117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    118 schema:sdPublisher N9de35520410a47bb895dcfafc5ad1ded
    119 schema:url https://doi.org/10.1038/s41588-019-0562-0
    120 sgo:license sg:explorer/license/
    121 sgo:sdDataset articles
    122 rdf:type schema:ScholarlyArticle
    123 N011d3e8c1c3d40b9819854c40892697d rdf:first sg:person.01303624731.38
    124 rdf:rest Na96801da8e43448db41f17ac595c8076
    125 N04ebbddec0e44c37b505280a1d78c11d schema:affiliation grid-institutes:grid.512379.b
    126 schema:familyName Detering
    127 schema:givenName Harald
    128 rdf:type schema:Person
    129 N0796319da41b4b42843d90394f3a9f6a rdf:first sg:person.011532132626.09
    130 rdf:rest N641c948e2e9743a386a29d2e3fd1c2f6
    131 N0c0c0212815b4706826294305b713b1d rdf:first sg:person.01310170137.53
    132 rdf:rest N2dc8e60a22c14c87a2b5c8b7631529a1
    133 N1201ab36996f4ca4b463cd8337fb258e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Carcinogenesis
    135 rdf:type schema:DefinedTerm
    136 N17d3ff0fd22f4c94a73ab1b798eb1edb rdf:first sg:person.01024612701.33
    137 rdf:rest N4270f1ebc75e4dd18e48c19b77a47ea8
    138 N1c004ea2130f4413ac8c52795a01e029 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Long Interspersed Nucleotide Elements
    140 rdf:type schema:DefinedTerm
    141 N1ed8ba556b5a4f4989dc9c3ef3275728 rdf:first sg:person.014263156713.07
    142 rdf:rest Nbe8318c0d303423b9e725f17796c694e
    143 N2999ca01acc942ebb681b11c82c9ad59 schema:affiliation grid-institutes:grid.10306.34
    144 schema:familyName Li
    145 schema:givenName Yilong
    146 rdf:type schema:Person
    147 N2dc8e60a22c14c87a2b5c8b7631529a1 rdf:first sg:person.01215532237.43
    148 rdf:rest Nee136c18651849c784457672051278c2
    149 N369c8803924d41f8ad9adf510176d940 rdf:first sg:person.01166400742.14
    150 rdf:rest N6d4f46fb57154d4fa34f681ee0f4d8be
    151 N37b111bb10d649d3b4e830211236d715 schema:name dimensions_id
    152 schema:value pub.1124596160
    153 rdf:type schema:PropertyValue
    154 N3e315541fbb34648b34143c954e46f2c rdf:first sg:person.01026052267.93
    155 rdf:rest N0796319da41b4b42843d90394f3a9f6a
    156 N4015525964ef44559d41656321fae33b rdf:first sg:person.01025271001.79
    157 rdf:rest N369c8803924d41f8ad9adf510176d940
    158 N4270f1ebc75e4dd18e48c19b77a47ea8 rdf:first sg:person.01252077430.47
    159 rdf:rest N0c0c0212815b4706826294305b713b1d
    160 N43b1e33f099d44feba90016e2a0303d4 rdf:first Nbbc290ec97d4412ba473e41f4ae8ba91
    161 rdf:rest Nf3297572d7ca41ef990a95440b4167a1
    162 N4776be90df1649b4b446585946f906a2 rdf:first sg:person.013623407463.99
    163 rdf:rest N5e46fac479b743e484ea0b03d24872d0
    164 N49a8427cfbba4adcb2a5a5ce717c1fe3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Neoplasms
    166 rdf:type schema:DefinedTerm
    167 N4efa8cc47bd441c1aa7a08369883001b rdf:first sg:person.01211501151.59
    168 rdf:rest Nc9bb8cf9fb924daa952c99ca3adf1bb9
    169 N52d979ef68974d358e72647e7483a41f rdf:first sg:person.013674745677.97
    170 rdf:rest N85d7b4c646bd47cf8930f8bbd051a8cd
    171 N53f30d54fc6e4b1c8c4b95e6a8b91b19 rdf:first sg:person.0642244733.67
    172 rdf:rest N3e315541fbb34648b34143c954e46f2c
    173 N54490016627641d9b4a121324b9fe932 rdf:first sg:person.0722704772.17
    174 rdf:rest Ne1d15a8aa5764774ad55407e1c9cc5b2
    175 N5768cb3af1884dfcabfe34d520875f9b rdf:first N2999ca01acc942ebb681b11c82c9ad59
    176 rdf:rest Nb00f4185dc394471b8e0e5668c0c579d
    177 N5e46fac479b743e484ea0b03d24872d0 rdf:first sg:person.01017300045.43
    178 rdf:rest Nb19d2ebd2c954b06b9212d5d35711403
    179 N5ef38ed755044f32b51ba03a2ebd1fbe rdf:first sg:person.010542146413.52
    180 rdf:rest N6513bb943bc14170ad87d2bf94864601
    181 N6165a599400c4fddb6ffbfed0f65cd54 rdf:first sg:person.016013731063.54
    182 rdf:rest Nb3cbc3ee94a142c5a785c7394cbda7bf
    183 N641c948e2e9743a386a29d2e3fd1c2f6 rdf:first sg:person.01161542113.25
    184 rdf:rest N4776be90df1649b4b446585946f906a2
    185 N6513bb943bc14170ad87d2bf94864601 rdf:first sg:person.013417463113.34
    186 rdf:rest Nbc6a478c28cb445280b9a356c196e30b
    187 N6d4f46fb57154d4fa34f681ee0f4d8be rdf:first sg:person.01251155040.58
    188 rdf:rest Nda9140d11d7d49feb8144da779aa14ff
    189 N6d7c627e55a34636a47bac9c015c9026 rdf:first sg:person.01256031142.86
    190 rdf:rest Na9f5b571c1a7421b8895a15848fd3824
    191 N73a1dfe8646c4c68a17f50b2500ebb41 schema:name doi
    192 schema:value 10.1038/s41588-019-0562-0
    193 rdf:type schema:PropertyValue
    194 N7a2e7edac33d4189a4e98579e2e2c772 rdf:first sg:person.016450322532.23
    195 rdf:rest rdf:nil
    196 N810d0a8b778d43bf9e70e1302f91cee1 rdf:first sg:person.0602760061.18
    197 rdf:rest N86edd90bd7cd491fb6a7577515bbaaf6
    198 N85d7b4c646bd47cf8930f8bbd051a8cd rdf:first sg:person.016106452303.30
    199 rdf:rest N011d3e8c1c3d40b9819854c40892697d
    200 N86edd90bd7cd491fb6a7577515bbaaf6 rdf:first sg:person.01145426033.81
    201 rdf:rest Na3355d5a51794c33af875b4143d3bf2f
    202 N89d78d5d378946559e54acefbaeff774 rdf:first sg:person.0716350025.21
    203 rdf:rest N7a2e7edac33d4189a4e98579e2e2c772
    204 N8aee6ca837c144898d8a2082f5cf55ba rdf:first sg:person.014315334235.61
    205 rdf:rest N1ed8ba556b5a4f4989dc9c3ef3275728
    206 N8f358cbc7eaf48128f47745590cbd364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Gene Rearrangement
    208 rdf:type schema:DefinedTerm
    209 N926b79d603494994b621b0e99916f3dd rdf:first Ne313a2b4440a4cc1b198cf120b2c507e
    210 rdf:rest N53f30d54fc6e4b1c8c4b95e6a8b91b19
    211 N9de35520410a47bb895dcfafc5ad1ded schema:name Springer Nature - SN SciGraph project
    212 rdf:type schema:Organization
    213 Na3355d5a51794c33af875b4143d3bf2f rdf:first sg:person.01017630143.46
    214 rdf:rest N43b1e33f099d44feba90016e2a0303d4
    215 Na96801da8e43448db41f17ac595c8076 rdf:first sg:person.01251165601.38
    216 rdf:rest Nf6b54b717fcf401bbed4db7a62101bbb
    217 Na9f5b571c1a7421b8895a15848fd3824 rdf:first sg:person.0707001004.88
    218 rdf:rest N4efa8cc47bd441c1aa7a08369883001b
    219 Nadd2444a07c44165883a2af996feb8ce rdf:first sg:person.01350775415.50
    220 rdf:rest Nb06093ee13b249dd9cde3e9b4767abef
    221 Nb00f4185dc394471b8e0e5668c0c579d rdf:first sg:person.01011331237.20
    222 rdf:rest N8aee6ca837c144898d8a2082f5cf55ba
    223 Nb06093ee13b249dd9cde3e9b4767abef rdf:first sg:person.01033774323.12
    224 rdf:rest Nfe90071cee6d414c89d1e5e1135f2b30
    225 Nb19d2ebd2c954b06b9212d5d35711403 rdf:first N04ebbddec0e44c37b505280a1d78c11d
    226 rdf:rest N5768cb3af1884dfcabfe34d520875f9b
    227 Nb3cbc3ee94a142c5a785c7394cbda7bf rdf:first sg:person.011341701362.19
    228 rdf:rest Nadd2444a07c44165883a2af996feb8ce
    229 Nb436025aa70c4b94975ad9194393597c schema:affiliation grid-institutes:grid.6312.6
    230 schema:familyName Tojo
    231 schema:givenName Marta
    232 rdf:type schema:Person
    233 Nb6325fd2b9844961aadf3e3d858087d9 schema:issueNumber 3
    234 rdf:type schema:PublicationIssue
    235 Nb6f9e7e782d847e1bae827b9d8ff35cc schema:affiliation grid-institutes:grid.14709.3b
    236 schema:familyName Bourque
    237 schema:givenName Guillaume
    238 rdf:type schema:Person
    239 Nb9da4d0ff93348ea8f5c574d76e2a4b8 rdf:first sg:person.01131202135.93
    240 rdf:rest N6165a599400c4fddb6ffbfed0f65cd54
    241 Nbbc290ec97d4412ba473e41f4ae8ba91 schema:affiliation grid-institutes:grid.21107.35
    242 schema:familyName Kazazian
    243 schema:givenName Haig H.
    244 rdf:type schema:Person
    245 Nbc6a478c28cb445280b9a356c196e30b rdf:first sg:person.0675077147.89
    246 rdf:rest N926b79d603494994b621b0e99916f3dd
    247 Nbe8318c0d303423b9e725f17796c694e rdf:first sg:person.011464673575.26
    248 rdf:rest N4015525964ef44559d41656321fae33b
    249 Nc244e1bb8020491fbb41c68fbaaa1b2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    250 schema:name Genome, Human
    251 rdf:type schema:DefinedTerm
    252 Nc9bb8cf9fb924daa952c99ca3adf1bb9 rdf:first Nb6f9e7e782d847e1bae827b9d8ff35cc
    253 rdf:rest Ndcda18e1ec39491482afcc7a10db8256
    254 Ncde18c059c1b438c9e8fedcb1cca2234 schema:volumeNumber 52
    255 rdf:type schema:PublicationVolume
    256 Nd77639f4d21a4f94a149b0785257ba65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    257 schema:name Humans
    258 rdf:type schema:DefinedTerm
    259 Nd8c9e2b6d726433fba70e1c447a918ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    260 schema:name Retroelements
    261 rdf:type schema:DefinedTerm
    262 Nda9140d11d7d49feb8144da779aa14ff rdf:first Nb436025aa70c4b94975ad9194393597c
    263 rdf:rest Nb9da4d0ff93348ea8f5c574d76e2a4b8
    264 Ndcda18e1ec39491482afcc7a10db8256 rdf:first sg:person.011677655217.83
    265 rdf:rest N17d3ff0fd22f4c94a73ab1b798eb1edb
    266 Nddc0dcfe526d40a98d28935fa3f948de schema:name pubmed_id
    267 schema:value 32024998
    268 rdf:type schema:PropertyValue
    269 Ne1d15a8aa5764774ad55407e1c9cc5b2 rdf:first sg:person.01055166050.55
    270 rdf:rest N6d7c627e55a34636a47bac9c015c9026
    271 Ne313a2b4440a4cc1b198cf120b2c507e schema:affiliation grid-institutes:grid.11794.3a
    272 schema:familyName Zamora
    273 schema:givenName Jorge
    274 rdf:type schema:Person
    275 Ne88ae7faa35c4c108642e7e17e238001 schema:affiliation grid-institutes:grid.10306.34
    276 schema:familyName Butler
    277 schema:givenName Adam
    278 rdf:type schema:Person
    279 Nee136c18651849c784457672051278c2 rdf:first sg:person.0772174216.94
    280 rdf:rest N810d0a8b778d43bf9e70e1302f91cee1
    281 Nf3297572d7ca41ef990a95440b4167a1 rdf:first Nf8b16f5ec7834408a94df63270db704f
    282 rdf:rest N89d78d5d378946559e54acefbaeff774
    283 Nf6b54b717fcf401bbed4db7a62101bbb rdf:first Ne88ae7faa35c4c108642e7e17e238001
    284 rdf:rest Nfc2d0757eae748ecb52dc83d681f0505
    285 Nf8b16f5ec7834408a94df63270db704f schema:affiliation grid-institutes:grid.21107.35
    286 schema:familyName Burns
    287 schema:givenName Kathleen H.
    288 rdf:type schema:Person
    289 Nfc2d0757eae748ecb52dc83d681f0505 rdf:first sg:person.01273213270.17
    290 rdf:rest N54490016627641d9b4a121324b9fe932
    291 Nfe90071cee6d414c89d1e5e1135f2b30 rdf:first sg:person.01051671264.18
    292 rdf:rest N52d979ef68974d358e72647e7483a41f
    293 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    294 schema:name Medical and Health Sciences
    295 rdf:type schema:DefinedTerm
    296 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    297 schema:name Oncology and Carcinogenesis
    298 rdf:type schema:DefinedTerm
    299 sg:grant.100057572 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    300 rdf:type schema:MonetaryGrant
    301 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    302 rdf:type schema:MonetaryGrant
    303 sg:grant.2440551 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    304 rdf:type schema:MonetaryGrant
    305 sg:grant.2476004 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    306 rdf:type schema:MonetaryGrant
    307 sg:grant.2481687 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    308 rdf:type schema:MonetaryGrant
    309 sg:grant.2482221 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    310 rdf:type schema:MonetaryGrant
    311 sg:grant.2521503 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    312 rdf:type schema:MonetaryGrant
    313 sg:grant.2682465 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    314 rdf:type schema:MonetaryGrant
    315 sg:grant.2684537 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    316 rdf:type schema:MonetaryGrant
    317 sg:grant.2697619 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    318 rdf:type schema:MonetaryGrant
    319 sg:grant.3535567 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    320 rdf:type schema:MonetaryGrant
    321 sg:grant.3634409 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    322 rdf:type schema:MonetaryGrant
    323 sg:grant.3639747 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    324 rdf:type schema:MonetaryGrant
    325 sg:grant.3767480 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    326 rdf:type schema:MonetaryGrant
    327 sg:grant.3933509 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    328 rdf:type schema:MonetaryGrant
    329 sg:grant.5235326 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    330 rdf:type schema:MonetaryGrant
    331 sg:grant.5240271 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    332 rdf:type schema:MonetaryGrant
    333 sg:grant.5494085 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    334 rdf:type schema:MonetaryGrant
    335 sg:grant.5504631 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    336 rdf:type schema:MonetaryGrant
    337 sg:grant.6376055 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    338 rdf:type schema:MonetaryGrant
    339 sg:grant.6503652 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    340 rdf:type schema:MonetaryGrant
    341 sg:grant.6798148 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    342 rdf:type schema:MonetaryGrant
    343 sg:grant.6952756 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    344 rdf:type schema:MonetaryGrant
    345 sg:grant.7025792 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    346 rdf:type schema:MonetaryGrant
    347 sg:grant.7082641 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    348 rdf:type schema:MonetaryGrant
    349 sg:grant.7523598 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    350 rdf:type schema:MonetaryGrant
    351 sg:grant.7569744 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    352 rdf:type schema:MonetaryGrant
    353 sg:grant.7751051 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    354 rdf:type schema:MonetaryGrant
    355 sg:grant.8493724 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-019-0562-0
    356 rdf:type schema:MonetaryGrant
    357 sg:journal.1103138 schema:issn 1061-4036
    358 1546-1718
    359 schema:name Nature Genetics
    360 schema:publisher Springer Nature
    361 rdf:type schema:Periodical
    362 sg:person.01011331237.20 schema:affiliation grid-institutes:grid.11794.3a
    363 schema:familyName Rodriguez-Castro
    364 schema:givenName Jorge
    365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011331237.20
    366 rdf:type schema:Person
    367 sg:person.01017300045.43 schema:affiliation grid-institutes:grid.11794.3a
    368 schema:familyName Garcia-Souto
    369 schema:givenName Daniel
    370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017300045.43
    371 rdf:type schema:Person
    372 sg:person.01017630143.46 schema:affiliation grid-institutes:grid.5596.f
    373 schema:familyName Van Loo
    374 schema:givenName Peter
    375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017630143.46
    376 rdf:type schema:Person
    377 sg:person.01024612701.33 schema:affiliation grid-institutes:grid.38142.3c
    378 schema:familyName Park
    379 schema:givenName Peter J.
    380 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024612701.33
    381 rdf:type schema:Person
    382 sg:person.01025271001.79 schema:affiliation grid-institutes:grid.11794.3a
    383 schema:familyName Blanco
    384 schema:givenName Miguel G.
    385 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025271001.79
    386 rdf:type schema:Person
    387 sg:person.01026052267.93 schema:affiliation grid-institutes:grid.5596.f
    388 schema:familyName Demeulemeester
    389 schema:givenName Jonas
    390 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026052267.93
    391 rdf:type schema:Person
    392 sg:person.01033774323.12 schema:affiliation grid-institutes:grid.10097.3f
    393 schema:familyName Puiggròs
    394 schema:givenName Montserrat
    395 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033774323.12
    396 rdf:type schema:Person
    397 sg:person.01051671264.18 schema:affiliation grid-institutes:grid.265892.2
    398 schema:familyName Chong
    399 schema:givenName Zechen
    400 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051671264.18
    401 rdf:type schema:Person
    402 sg:person.010542146413.52 schema:affiliation grid-institutes:grid.6312.6
    403 schema:familyName Rodriguez-Martin
    404 schema:givenName Bernardo
    405 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010542146413.52
    406 rdf:type schema:Person
    407 sg:person.01055166050.55 schema:affiliation grid-institutes:grid.65499.37
    408 schema:familyName Schumacher
    409 schema:givenName Steven E.
    410 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055166050.55
    411 rdf:type schema:Person
    412 sg:person.01131202135.93 schema:affiliation grid-institutes:grid.10306.34
    413 schema:familyName Roberts
    414 schema:givenName Nicola D.
    415 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131202135.93
    416 rdf:type schema:Person
    417 sg:person.011341701362.19 schema:affiliation grid-institutes:grid.498239.d
    418 schema:familyName Edwards
    419 schema:givenName Paul A. W.
    420 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011341701362.19
    421 rdf:type schema:Person
    422 sg:person.01145426033.81 schema:affiliation grid-institutes:grid.5335.0
    423 schema:familyName Fitzgerald
    424 schema:givenName Rebecca C.
    425 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145426033.81
    426 rdf:type schema:Person
    427 sg:person.011464673575.26 schema:affiliation grid-institutes:grid.4991.5
    428 schema:familyName Dentro
    429 schema:givenName Stefan C.
    430 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011464673575.26
    431 rdf:type schema:Person
    432 sg:person.011532132626.09 schema:affiliation grid-institutes:grid.6312.6
    433 schema:familyName Santamarina
    434 schema:givenName Martin
    435 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011532132626.09
    436 rdf:type schema:Person
    437 sg:person.01161542113.25 schema:affiliation grid-institutes:grid.10306.34
    438 schema:familyName Ju
    439 schema:givenName Young Seok
    440 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161542113.25
    441 rdf:type schema:Person
    442 sg:person.01166400742.14 schema:affiliation grid-institutes:grid.5335.0
    443 schema:familyName Contino
    444 schema:givenName Gianmarco
    445 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166400742.14
    446 rdf:type schema:Person
    447 sg:person.011677655217.83 schema:affiliation grid-institutes:grid.47100.32
    448 schema:familyName Gerstein
    449 schema:givenName Mark
    450 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011677655217.83
    451 rdf:type schema:Person
    452 sg:person.01211501151.59 schema:affiliation grid-institutes:grid.417893.0
    453 schema:familyName Bolli
    454 schema:givenName Niccolo
    455 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211501151.59
    456 rdf:type schema:Person
    457 sg:person.01215532237.43 schema:affiliation grid-institutes:grid.425902.8
    458 schema:familyName Torrents
    459 schema:givenName David
    460 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215532237.43
    461 rdf:type schema:Person
    462 sg:person.01251155040.58 schema:affiliation grid-institutes:grid.21107.35
    463 schema:familyName Ardeljan
    464 schema:givenName Daniel
    465 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251155040.58
    466 rdf:type schema:Person
    467 sg:person.01251165601.38 schema:affiliation grid-institutes:grid.10306.34
    468 schema:familyName Raine
    469 schema:givenName Keiran
    470 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251165601.38
    471 rdf:type schema:Person
    472 sg:person.01252077430.47 schema:affiliation grid-institutes:grid.4991.5
    473 schema:familyName Wedge
    474 schema:givenName David C.
    475 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252077430.47
    476 rdf:type schema:Person
    477 sg:person.01256031142.86 schema:affiliation grid-institutes:grid.14709.3b
    478 schema:familyName Monlong
    479 schema:givenName Jean
    480 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256031142.86
    481 rdf:type schema:Person
    482 sg:person.01273213270.17 schema:affiliation grid-institutes:grid.4709.a
    483 schema:familyName Waszak
    484 schema:givenName Sebastian M.
    485 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273213270.17
    486 rdf:type schema:Person
    487 sg:person.01303624731.38 schema:affiliation grid-institutes:grid.65499.37
    488 schema:familyName Wala
    489 schema:givenName Jeremiah A.
    490 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303624731.38
    491 rdf:type schema:Person
    492 sg:person.01310170137.53 schema:affiliation grid-institutes:grid.65499.37
    493 schema:familyName Beroukhim
    494 schema:givenName Rameen
    495 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310170137.53
    496 rdf:type schema:Person
    497 sg:person.013417463113.34 schema:affiliation grid-institutes:grid.6312.6
    498 schema:familyName Alvarez
    499 schema:givenName Eva G.
    500 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013417463113.34
    501 rdf:type schema:Person
    502 sg:person.01350775415.50 schema:affiliation grid-institutes:grid.4709.a
    503 schema:familyName Weischenfeldt
    504 schema:givenName Joachim
    505 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350775415.50
    506 rdf:type schema:Person
    507 sg:person.013623407463.99 schema:affiliation grid-institutes:grid.11794.3a
    508 schema:familyName Temes
    509 schema:givenName Javier
    510 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013623407463.99
    511 rdf:type schema:Person
    512 sg:person.013674745677.97 schema:affiliation grid-institutes:grid.240145.6
    513 schema:familyName Chen
    514 schema:givenName Ken
    515 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013674745677.97
    516 rdf:type schema:Person
    517 sg:person.014263156713.07 schema:affiliation grid-institutes:grid.6312.6
    518 schema:familyName Bruzos
    519 schema:givenName Alicia L.
    520 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014263156713.07
    521 rdf:type schema:Person
    522 sg:person.014315334235.61 schema:affiliation grid-institutes:grid.440820.a
    523 schema:familyName Dueso-Barroso
    524 schema:givenName Ana
    525 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014315334235.61
    526 rdf:type schema:Person
    527 sg:person.016013731063.54 schema:affiliation grid-institutes:grid.11794.3a
    528 schema:familyName Zumalave
    529 schema:givenName Sonia
    530 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016013731063.54
    531 rdf:type schema:Person
    532 sg:person.016106452303.30 schema:affiliation grid-institutes:grid.66859.34
    533 schema:familyName Lee
    534 schema:givenName Eunjung Alice
    535 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016106452303.30
    536 rdf:type schema:Person
    537 sg:person.016450322532.23 schema:affiliation grid-institutes:grid.10306.34
    538 schema:familyName Tubio
    539 schema:givenName Jose M. C.
    540 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016450322532.23
    541 rdf:type schema:Person
    542 sg:person.0602760061.18 schema:affiliation grid-institutes:grid.10306.34
    543 schema:familyName Martincorena
    544 schema:givenName Inigo
    545 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602760061.18
    546 rdf:type schema:Person
    547 sg:person.0642244733.67 schema:affiliation grid-institutes:grid.425902.8
    548 schema:familyName Supek
    549 schema:givenName Fran
    550 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642244733.67
    551 rdf:type schema:Person
    552 sg:person.0675077147.89 schema:affiliation grid-institutes:grid.5335.0
    553 schema:familyName Baez-Ortega
    554 schema:givenName Adrian
    555 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675077147.89
    556 rdf:type schema:Person
    557 sg:person.0707001004.88 schema:affiliation grid-institutes:grid.417893.0
    558 schema:familyName Maura
    559 schema:givenName Francesco
    560 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707001004.88
    561 rdf:type schema:Person
    562 sg:person.0716350025.21 schema:affiliation grid-institutes:grid.5335.0
    563 schema:familyName Campbell
    564 schema:givenName Peter J.
    565 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716350025.21
    566 rdf:type schema:Person
    567 sg:person.0722704772.17 schema:affiliation grid-institutes:grid.47100.32
    568 schema:familyName Navarro
    569 schema:givenName Fabio C. P.
    570 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722704772.17
    571 rdf:type schema:Person
    572 sg:person.0772174216.94 schema:affiliation grid-institutes:grid.4709.a
    573 schema:familyName Korbel
    574 schema:givenName Jan O.
    575 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772174216.94
    576 rdf:type schema:Person
    577 sg:pub.10.1038/35020592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017226982
    578 https://doi.org/10.1038/35020592
    579 rdf:type schema:CreativeWork
    580 sg:pub.10.1038/35057062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042854081
    581 https://doi.org/10.1038/35057062
    582 rdf:type schema:CreativeWork
    583 sg:pub.10.1038/nature08822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010635813
    584 https://doi.org/10.1038/nature08822
    585 rdf:type schema:CreativeWork
    586 sg:pub.10.1038/nature09460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022310913
    587 https://doi.org/10.1038/nature09460
    588 rdf:type schema:CreativeWork
    589 sg:pub.10.1038/nature11404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006014163
    590 https://doi.org/10.1038/nature11404
    591 rdf:type schema:CreativeWork
    592 sg:pub.10.1038/nature13115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017979448
    593 https://doi.org/10.1038/nature13115
    594 rdf:type schema:CreativeWork
    595 sg:pub.10.1038/nature13385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038580641
    596 https://doi.org/10.1038/nature13385
    597 rdf:type schema:CreativeWork
    598 sg:pub.10.1038/nature14129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045934545
    599 https://doi.org/10.1038/nature14129
    600 rdf:type schema:CreativeWork
    601 sg:pub.10.1038/ncomms4644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016695553
    602 https://doi.org/10.1038/ncomms4644
    603 rdf:type schema:CreativeWork
    604 sg:pub.10.1038/ng.3984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092440098
    605 https://doi.org/10.1038/ng.3984
    606 rdf:type schema:CreativeWork
    607 sg:pub.10.1038/ng0597-37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005219388
    608 https://doi.org/10.1038/ng0597-37
    609 rdf:type schema:CreativeWork
    610 sg:pub.10.1038/ng0694-143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014552572
    611 https://doi.org/10.1038/ng0694-143
    612 rdf:type schema:CreativeWork
    613 sg:pub.10.1038/nn.4388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032630541
    614 https://doi.org/10.1038/nn.4388
    615 rdf:type schema:CreativeWork
    616 sg:pub.10.1038/nrc.2017.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085935508
    617 https://doi.org/10.1038/nrc.2017.35
    618 rdf:type schema:CreativeWork
    619 sg:pub.10.1038/nrm.2016.171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000827740
    620 https://doi.org/10.1038/nrm.2016.171
    621 rdf:type schema:CreativeWork
    622 sg:pub.10.1038/nrm.2017.48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085422215
    623 https://doi.org/10.1038/nrm.2017.48
    624 rdf:type schema:CreativeWork
    625 sg:pub.10.1038/s41586-019-1907-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124588398
    626 https://doi.org/10.1038/s41586-019-1907-7
    627 rdf:type schema:CreativeWork
    628 sg:pub.10.1038/s41586-020-1965-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1124590164
    629 https://doi.org/10.1038/s41586-020-1965-x
    630 rdf:type schema:CreativeWork
    631 sg:pub.10.1038/s41586-020-1969-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124593766
    632 https://doi.org/10.1038/s41586-020-1969-6
    633 rdf:type schema:CreativeWork
    634 sg:pub.10.1038/s41586-020-1970-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124596336
    635 https://doi.org/10.1038/s41586-020-1970-0
    636 rdf:type schema:CreativeWork
    637 sg:pub.10.1186/1476-4598-3-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032442566
    638 https://doi.org/10.1186/1476-4598-3-12
    639 rdf:type schema:CreativeWork
    640 sg:pub.10.1186/1759-8753-5-20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037415246
    641 https://doi.org/10.1186/1759-8753-5-20
    642 rdf:type schema:CreativeWork
    643 sg:pub.10.1186/gb-2013-14-3-r22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045187544
    644 https://doi.org/10.1186/gb-2013-14-3-r22
    645 rdf:type schema:CreativeWork
    646 sg:pub.10.1186/gb-2013-14-4-r36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015459845
    647 https://doi.org/10.1186/gb-2013-14-4-r36
    648 rdf:type schema:CreativeWork
    649 grid-institutes:grid.10097.3f schema:alternateName Barcelona Supercomputing Center (BSC-CNS), Barcelona, Spain
    650 schema:name Barcelona Supercomputing Center (BSC-CNS), Barcelona, Spain
    651 rdf:type schema:Organization
    652 grid-institutes:grid.10306.34 schema:alternateName Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK
    653 schema:name Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain
    654 Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK
    655 Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    656 Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    657 Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
    658 rdf:type schema:Organization
    659 grid-institutes:grid.11794.3a schema:alternateName Department of Biochemistry and Molecular Biology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    660 Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    661 Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    662 schema:name DNA Repair and Genome Integrity, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    663 Department of Biochemistry and Molecular Biology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    664 Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    665 Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    666 rdf:type schema:Organization
    667 grid-institutes:grid.14709.3b schema:alternateName Department of Human Genetics, McGill University, Montreal, Québec, Canada
    668 schema:name Department of Human Genetics, McGill University, Montreal, Québec, Canada
    669 rdf:type schema:Organization
    670 grid-institutes:grid.21107.35 schema:alternateName Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA
    671 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA
    672 schema:name Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA
    673 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Baltimore, MD, USA
    674 rdf:type schema:Organization
    675 grid-institutes:grid.240145.6 schema:alternateName Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    676 schema:name Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    677 rdf:type schema:Organization
    678 grid-institutes:grid.265892.2 schema:alternateName Department of Genetics and Informatics Institute, University of Alabama at Birmingham (UAB) School of Medicine, Birmingham, AL, USA
    679 schema:name Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    680 Department of Genetics and Informatics Institute, University of Alabama at Birmingham (UAB) School of Medicine, Birmingham, AL, USA
    681 rdf:type schema:Organization
    682 grid-institutes:grid.38142.3c schema:alternateName Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
    683 schema:name Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
    684 rdf:type schema:Organization
    685 grid-institutes:grid.417893.0 schema:alternateName Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    686 schema:name Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK
    687 Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    688 Department of Oncology and Onco-Hematology, University of Milan, Milan, Italy
    689 rdf:type schema:Organization
    690 grid-institutes:grid.425902.8 schema:alternateName Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
    691 schema:name Barcelona Supercomputing Center (BSC-CNS), Barcelona, Spain
    692 Genome Data Science, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain
    693 Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
    694 rdf:type schema:Organization
    695 grid-institutes:grid.440820.a schema:alternateName Faculty of Science and Technology, University of Vic—Central University of Catalonia (UVic-UCC), Vic, Spain
    696 schema:name Barcelona Supercomputing Center (BSC-CNS), Barcelona, Spain
    697 Faculty of Science and Technology, University of Vic—Central University of Catalonia (UVic-UCC), Vic, Spain
    698 rdf:type schema:Organization
    699 grid-institutes:grid.4709.a schema:alternateName European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany
    700 schema:name Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
    701 European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany
    702 Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
    703 rdf:type schema:Organization
    704 grid-institutes:grid.47100.32 schema:alternateName Department of Computer Science, Yale University, New Haven, CT, USA
    705 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
    706 schema:name Department of Computer Science, Yale University, New Haven, CT, USA
    707 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
    708 Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA
    709 rdf:type schema:Organization
    710 grid-institutes:grid.498239.d schema:alternateName Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
    711 schema:name Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
    712 Department of Pathology, University of Cambridge, Cambridge, UK
    713 rdf:type schema:Organization
    714 grid-institutes:grid.4991.5 schema:alternateName Oxford Big Data Institute, University of Oxford, Oxford, UK
    715 schema:name Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK
    716 Experimental Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK
    717 Oxford Big Data Institute, University of Oxford, Oxford, UK
    718 Oxford NIHR Biomedical Research Centre, Oxford, UK
    719 The Francis Crick Institute, London, UK
    720 rdf:type schema:Organization
    721 grid-institutes:grid.512379.b schema:alternateName Galicia Sur Health Research Institute, Vigo, Spain
    722 schema:name Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain
    723 Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain
    724 Galicia Sur Health Research Institute, Vigo, Spain
    725 rdf:type schema:Organization
    726 grid-institutes:grid.5335.0 schema:alternateName Department of Haematology, University of Cambridge, Cambridge, UK
    727 Medical Research Council (MRC) Cancer Unit, University of Cambridge, Cambridge, UK
    728 Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    729 schema:name Cancer Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Cambridge, UK
    730 Department of Haematology, University of Cambridge, Cambridge, UK
    731 Medical Research Council (MRC) Cancer Unit, University of Cambridge, Cambridge, UK
    732 Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    733 rdf:type schema:Organization
    734 grid-institutes:grid.5596.f schema:alternateName Department of Human Genetics, University of Leuven, Leuven, Belgium
    735 schema:name Department of Human Genetics, University of Leuven, Leuven, Belgium
    736 The Francis Crick Institute, London, UK
    737 rdf:type schema:Organization
    738 grid-institutes:grid.6312.6 schema:alternateName Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain
    739 Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain
    740 schema:name Biomedical Research Centre (CINBIO), University of Vigo, Vigo, Spain
    741 Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain
    742 Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    743 Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    744 rdf:type schema:Organization
    745 grid-institutes:grid.65499.37 schema:alternateName Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
    746 schema:name Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
    747 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
    748 The Broad Institute of Harvard and MIT, Cambridge, MA, USA
    749 rdf:type schema:Organization
    750 grid-institutes:grid.66859.34 schema:alternateName The Broad Institute of Harvard and MIT, Cambridge, MA, USA
    751 schema:name Division of Genetics and Genomics, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
    752 The Broad Institute of Harvard and MIT, Cambridge, MA, USA
    753 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...