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Article Info

DATE

2019-06-03

AUTHORS

Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff, Xiuqing Guo, Audrey E. Hendricks, Tugce Karaderi, Adelheid Lempradl, Adam E. Locke, Anubha Mahajan, Eirini Marouli, Suthesh Sivapalaratnam, Kristin L. Young, Tamuno Alfred, Mary F. Feitosa, Nicholas G. D. Masca, Alisa K. Manning, Carolina Medina-Gomez, Poorva Mudgal, Maggie C. Y. Ng, Alex P. Reiner, Sailaja Vedantam, Sara M. Willems, Thomas W. Winkler, Gonçalo Abecasis, Katja K. Aben, Dewan S. Alam, Sameer E. Alharthi, Matthew Allison, Philippe Amouyel, Folkert W. Asselbergs, Paul L. Auer, Beverley Balkau, Lia E. Bang, Inês Barroso, Lisa Bastarache, Marianne Benn, Sven Bergmann, Lawrence F. Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A. Böger, Jette Bork-Jensen, Michiel L. Bots, Erwin P. Bottinger, Donald W. Bowden, Ivan Brandslund, Gerome Breen, Murray H. Brilliant, Linda Broer, Marco Brumat, Amber A. Burt, Adam S. Butterworth, Peter T. Campbell, Stefania Cappellani, David J. Carey, Eulalia Catamo, Mark J. Caulfield, John C. Chambers, Daniel I. Chasman, Yii-Der I. Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y. Chu, Massimiliano Cocca, Francis S. Collins, James P. Cook, Janie Corley, Jordi Corominas Galbany, Amanda J. Cox, David S. Crosslin, Gabriel Cuellar-Partida, Angela D’Eustacchio, John Danesh, Gail Davies, Paul I. W. Bakker, Mark C. H. Groot, Renée Mutsert, Ian J. Deary, George Dedoussis, Ellen W. Demerath, Martin Heijer, Anneke I. Hollander, Hester M. Ruijter, Joe G. Dennis, Josh C. Denny, Emanuele Di Angelantonio, Fotios Drenos, Mengmeng Du, Marie-Pierre Dubé, Alison M. Dunning, Douglas F. Easton, Todd L. Edwards, David Ellinghaus, Patrick T. Ellinor, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, I. Sadaf Farooqi, Jessica D. Faul, Sascha Fauser, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C. Florez, Ian Ford, Myriam Fornage, Oscar H. Franco, Andre Franke, Paul W. Franks, Nele Friedrich, Ruth Frikke-Schmidt, Tessel E. Galesloot, Wei Gan, Ilaria Gandin, Paolo Gasparini, Jane Gibson, Vilmantas Giedraitis, Anette P. Gjesing, Penny Gordon-Larsen, Mathias Gorski, Hans-Jörgen Grabe, Struan F. A. Grant, Niels Grarup, Helen L. Griffiths, Megan L. Grove, Vilmundur Gudnason, Stefan Gustafsson, Jeff Haessler, Hakon Hakonarson, Anke R. Hammerschlag, Torben Hansen, Kathleen Mullan Harris, Tamara B. Harris, Andrew T. Hattersley, Christian T. Have, Caroline Hayward, Liang He, Nancy L. Heard-Costa, Andrew C. Heath, Iris M. Heid, Øyvind Helgeland, Jussi Hernesniemi, Alex W. Hewitt, Oddgeir L. Holmen, G. Kees Hovingh, Joanna M. M. Howson, Yao Hu, Paul L. Huang, Jennifer E. Huffman, M. Arfan Ikram, Erik Ingelsson, Anne U. Jackson, Jan-Håkan Jansson, Gail P. Jarvik, Gorm B. Jensen, Yucheng Jia, Stefan Johansson, Marit E. Jørgensen, Torben Jørgensen, J. Wouter Jukema, Bratati Kahali, René S. Kahn, Mika Kähönen, Pia R. Kamstrup, Stavroula Kanoni, Jaakko Kaprio, Maria Karaleftheri, Sharon L. R. Kardia, Fredrik Karpe, Sekar Kathiresan, Frank Kee, Lambertus A. Kiemeney, Eric Kim, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S. Kooner, Charles Kooperberg, Tellervo Korhonen, Peter Kovacs, Helena Kuivaniemi, Zoltán Kutalik, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A. Lakka, David Lamparter, Ethan M. Lange, Leslie A. Lange, Claudia Langenberg, Eric B. Larson, Nanette R. Lee, Terho Lehtimäki, Cora E. Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Honghuang Lin, Keng-Hung Lin, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J. Liu, Yongmei Liu, Ken S. Lo, Artitaya Lophatananon, Andrew J. Lotery, Anu Loukola, Jian’an Luan, Steven A. Lubitz, Leo-Pekka Lyytikäinen, Satu Männistö, Gaëlle Marenne, Angela L. Mazul, Mark I. McCarthy, Roberta McKean-Cowdin, Sarah E. Medland, Karina Meidtner, Lili Milani, Vanisha Mistry, Paul Mitchell, Karen L. Mohlke, Leena Moilanen, Marie Moitry, Grant W. Montgomery, Dennis O. Mook-Kanamori, Carmel Moore, Trevor A. Mori, Andrew D. Morris, Andrew P. Morris, Martina Müller-Nurasyid, Patricia B. Munroe, Mike A. Nalls, Narisu Narisu, Christopher P. Nelson, Matt Neville, Sune F. Nielsen, Kjell Nikus, Pål R. Njølstad, Børge G. Nordestgaard, Dale R. Nyholt, Jeffrey R. O’Connel, Michelle L. O’Donoghue, Loes M. Olde Loohuis, Roel A. Ophoff, Katharine R. Owen, Chris J. Packard, Sandosh Padmanabhan, Colin N. A. Palmer, Nicholette D. Palmer, Gerard Pasterkamp, Aniruddh P. Patel, Alison Pattie, Oluf Pedersen, Peggy L. Peissig, Gina M. Peloso, Craig E. Pennell, Markus Perola, James A. Perry, John R. B. Perry, Tune H. Pers, Thomas N. Person, Annette Peters, Eva R. B. Petersen, Patricia A. Peyser, Ailith Pirie, Ozren Polasek, Tinca J. Polderman, Hannu Puolijoki, Olli T. Raitakari, Asif Rasheed, Rainer Rauramaa, Dermot F. Reilly, Frida Renström, Myriam Rheinberger, Paul M. Ridker, John D. Rioux, Manuel A. Rivas, David J. Roberts, Neil R. Robertson, Antonietta Robino, Olov Rolandsson, Igor Rudan, Katherine S. Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J. Samani, Yadav Sapkota, Naveed Sattar, Robert E. Schoen, Pamela J. Schreiner, Matthias B. Schulze, Robert A. Scott, Marcelo P. Segura-Lepe, Svati H. Shah, Wayne H.-H. Sheu, Xueling Sim, Andrew J. Slater, Kerrin S. Small, Albert V. Smith, Lorraine Southam, Timothy D. Spector, Elizabeth K. Speliotes, John M. Starr, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E. Stirrups, Konstantin Strauch, Heather M. Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Amy J. Swift, Hayato Tada, Katherine E. Tansey, Jean-Claude Tardif, Kent D. Taylor, Alexander Teumer, Deborah J. Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H. Thuesen, Anke Tönjes, Gerard Tromp, Stella Trompet, Emmanouil Tsafantakis, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Jonathan P. Tyrer, Rudolf Uher, André G. Uitterlinden, Matti Uusitupa, Sander W. Laan, Cornelia M. Duijn, Nienke Leeuwen, Jessica van Setten, Mauno Vanhala, Anette Varbo, Tibor V. Varga, Rohit Varma, Digna R. Velez Edwards, Sita H. Vermeulen, Giovanni Veronesi, Henrik Vestergaard, Veronique Vitart, Thomas F. Vogt, Uwe Völker, Dragana Vuckovic, Lynne E. Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A. Wang, Shuai Wang, Yiqin Wang, Erin B. Ware, Nicholas J. Wareham, Helen R. Warren, Dawn M. Waterworth, Jennifer Wessel, Harvey D. White, Cristen J. Willer, James G. Wilson, Daniel R. Witte, Andrew R. Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Pang Yao, Laura M. Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, Wei Zhao, Wei Zhou, Krina T Zondervan, Jerome I. Rotter, John A. Pospisilik, Fernando Rivadeneira, Ingrid B. Borecki, Panos Deloukas, Timothy M. Frayling, Guillaume Lettre, Kari E. North, Cecilia M. Lindgren, Joel N. Hirschhorn, Ruth J. F. Loos

ABSTRACT

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

PAGES

1191-1192

Journal

TITLE

Nature Genetics

ISSUE

7

VOLUME

51

Author Affiliations

  • Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada
  • Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  • Human Genetics Center, University of Texas School of Public Health, University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA
  • Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
  • Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, USA
  • Quantinuum Research, LLC, San Diego, CA, USA
  • Estonian Genome Center, University of Tartu, Tartu, Estonia
  • Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA
  • Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA
  • Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO, USA
  • Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus
  • Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
  • McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
  • Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
  • William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Department of Haematology, University of Cambridge, Cambridge, UK
  • Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  • Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
  • NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK
  • Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA
  • Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands
  • Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA
  • Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA
  • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
  • MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK
  • Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany
  • Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
  • Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands
  • School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada
  • Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia
  • Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA
  • Université de Lille, U1167, RID-AGE, Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France
  • Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK
  • Zilber School of Public Health, University of Wisconsin– Milwaukee, Milwaukee, WI, USA
  • INSERM U1018, Centre de Recherche en Épidémiologie et Santé des Populations (CESP), Villejuif, France
  • Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • NIHR Cambridge Biomedical Research Centre, Wellcome Trust–MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK
  • Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA
  • Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • Swiss Institute of Bioinformatics, Lausanne, Switzerland
  • Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
  • Department of Medicine, University of Leipzig, Leipzig, Germany
  • Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany
  • Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA
  • Department of Nephrology, University Hospital Regensburg, Regensburg, Germany
  • Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
  • Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA
  • Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark
  • NIHR Biomedical Research Centre for Mental Health, South London and Maudsley Hospital, London, UK
  • Marshfield Clinic Research Institute, Marshfield, WI, USA
  • Department of Medical Sciences, University of Trieste, Trieste, Italy
  • Department of Medicine, University of Washington, Seattle, WA, USA
  • NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  • Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA
  • Institute for Maternal and Child Health, IRCCS ‘Burlo Garofolo’, Trieste, Italy
  • Weis Center for Research, Geisinger Health System, Danville, PA, USA
  • NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Imperial College Healthcare NHS Trust, London, UK
  • Harvard Medical School, Boston, MA, USA
  • MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  • Medical Department, Lillebaelt Hospital, Vejle, Denmark
  • Genetics and Pharmacogenomics, Merck, Sharp & Dohme, Boston, MA, USA
  • Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
  • Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA
  • Department of Biostatistics, University of Liverpool, Liverpool, UK
  • Department of Psychology, University of Edinburgh, Edinburgh, UK
  • Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands
  • Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia
  • Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA
  • QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
  • British Heart Foundation Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, UK
  • Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands
  • Utrecht Institute for Pharmaceutical Sciences, Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, the Netherlands
  • Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
  • Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece
  • Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
  • Department of Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands
  • Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands
  • Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  • MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK
  • Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
  • Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada
  • Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
  • Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
  • Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
  • Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
  • Department of Health Sciences, University of Leicester, Leicester, UK
  • Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA
  • Department of Ophthalmology, University of Cologne, Cologne, Germany
  • Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
  • Toulouse University School of Medicine, Toulouse, France
  • University of Glasgow, Glasgow, UK
  • Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA
  • Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands
  • Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden
  • Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
  • Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Research Unit, AREA Science Park, Trieste, Italy
  • Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK
  • Geriatrics, Department of Public Health, Uppsala University, Uppsala, Sweden
  • Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
  • German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany
  • Division of Endocrinology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
  • Vision Sciences, Clinical Neurosciences Research Group, Faculty of Medicine, University of Southampton, Southampton, UK
  • School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
  • Icelandic Heart Association, Kopavogur, Iceland
  • Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
  • Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  • Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands
  • Department of Sociology, University of North Carolina, Chapel Hill, NC, USA
  • Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA
  • University of Exeter Medical School, University of Exeter, Exeter, UK
  • MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
  • Department of Public Health, University of Helsinki, Helsinki, Finland
  • Department of Neurology, Boston University School of Medicine, Boston, MA, USA
  • Department of Psychiatry, Washington University, St. Louis, MO, USA
  • Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
  • KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway
  • Department of Clinical Chemistry, Finnish Cardiovascular Research Center–Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
  • Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
  • KG Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
  • Department of Vascular Medicine, AMC, Amsterdam, the Netherlands
  • Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China
  • Massachusetts General Hospital, Boston, MA, USA
  • Department of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands
  • Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
  • Research Unit Skellefteå, Skellefteå, Sweden
  • Department of Genome Sciences, University of Washington, Seattle, WA, USA
  • Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, Denmark
  • Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
  • Steno Diabetes Center Copenhagen, Gentofte, Denmark
  • Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark
  • Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands
  • Centre for Brain Research, Indian Institute of Science, Bangalore, India
  • Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands
  • Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
  • Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark
  • National Institute for Health and Welfare, Helsinki, Finland
  • Echinos Medical Centre, Echinos, Greece
  • Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK
  • UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast, UK
  • Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
  • MRC-PHE Centre for Environment and Health, Imperial College London, London, UK
  • Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
  • IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
  • Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
  • Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland
  • Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
  • Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
  • Department of Health Services, University of Washington, Seattle, WA, USA
  • USC–Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines
  • Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
  • Department of Medicine, Boston University School of Medicine, Boston, MA, USA
  • Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan
  • Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden
  • Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
  • Department of Public Health Sciences, Institute for Personalized Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA
  • Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
  • Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK
  • Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
  • Wellcome Trust Sanger Institute, Hinxton, UK
  • Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
  • German Center for Diabetes Research, Neuherberg, Germany
  • Westmead Millennium Institute of Medical Research, Centre for Vision Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, Australia
  • Department of Medicine, Kuopio University Hospital, Kuopio, Finland
  • Department of Public Health, University Hospital of Strasbourg, Strasbourg, France
  • Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
  • Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands
  • INTERVAL Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  • School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
  • Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
  • German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany
  • Data Tecnica International, Glen Echo, MD, USA
  • Department of Cardiology, Heart Center, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
  • Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
  • Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
  • Division of Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
  • Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA
  • Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK
  • Laboratory of Clinical Chemistry and Hematology, Division of Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, the Netherlands
  • School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia, Australia
  • Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland
  • Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
  • Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany
  • Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark
  • School of Medicine, University of Split, Split, Croatia
  • Central Hospital of Southern Ostrobothnia, Seinäjoki, Finland
  • Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
  • Centre for Non-Communicable Diseases, Karachi, Pakistan
  • Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
  • Department of Biobank Research, Umeå University, Umeå, Sweden
  • Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
  • BRC Haematology Theme and Radcliffe Department of Medicine, University of Oxford, Oxford, UK
  • Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
  • Department of Public Health and Clinical Medicine, Unit of Family Medicine, Umeå University, Umeå, Sweden
  • Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK
  • Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  • Departments of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
  • Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
  • Duke Molecular Physiology Institute, Duke University, Durham, NC, USA
  • School of Medicine, National Yang-Ming University, Taipei, Taiwan
  • Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore
  • OmicSoft at Qiagen Company, Cary, NC, USA
  • Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK
  • Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
  • Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK
  • deCODE Genetics/Amgen, Inc., Reykjavik, Iceland
  • Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany
  • Kanazawa University, Kanazawa, Japan
  • College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK
  • Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
  • Center for Pediatric Research, Department for Women’s and Child Health, University of Leipzig, Leipzig, Germany
  • Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
  • Anogia Medical Centre, Anogia, Greece
  • Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
  • Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
  • Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
  • Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands
  • Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands
  • Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland
  • Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden
  • USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
  • Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA
  • Research Center on Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy
  • Cardiometabolic Disease, Merck, Sharp & Dohme, Kenilworth, NJ, USA
  • Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
  • Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle, UK
  • Department of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
  • Genetics, Target Sciences, GlaxoSmithKline, King of Prussia, PA, USA
  • Departments of Epidemiology and Medicine, Diabetes Translational Research Center, Fairbanks School of Public Health and School of Medicine, Indiana University, Indianapolis, IN, USA
  • Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand
  • Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA
  • Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA
  • Department of Public Health, Aarhus University, Aarhus, Denmark
  • GlaxoSmithKline, King of Prussia, PA, USA
  • Department of Clinical Sciences, Quantitative Biomedical Research Center, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA
  • Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
  • Endometriosis CaRe Centre, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK
  • Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, NC, USA
  • Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK
  • Department of Pediatrics, Harvard Medical School, Boston, MA, USA
  • Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-019-0447-2

    DOI

    http://dx.doi.org/10.1038/s41588-019-0447-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1116491931

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31160809


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