EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Maria C. Donaldson-Collier, Stephanie Sungalee, Marie Zufferey, Daniele Tavernari, Natalya Katanayeva, Elena Battistello, Marco Mina, Kyle M. Douglass, Timo Rey, Franck Raynaud, Suliana Manley, Giovanni Ciriello, Elisa Oricchio

ABSTRACT

Chromatin is organized into topologically associating domains (TADs) enriched in distinct histone marks. In cancer, gain-of-function mutations in the gene encoding the enhancer of zeste homolog 2 protein (EZH2) lead to a genome-wide increase in histone-3 Lys27 trimethylation (H3K27me3) associated with transcriptional repression. However, the effects of these epigenetic changes on the structure and function of chromatin domains have not been explored. Here, we found a functional interplay between TADs and epigenetic and transcriptional changes mediated by mutated EZH2. Altered EZH2 (p.Tyr646* (EZH2Y646X)) led to silencing of entire domains, synergistically inactivating multiple tumor suppressors. Intra-TAD gene silencing was coupled with changes of interactions between gene promoter regions. Notably, gene expression and chromatin interactions were restored by pharmacological inhibition of EZH2Y646X. Our results indicate that EZH2Y646X alters the topology and function of chromatin domains to promote synergistic oncogenic programs. More... »

PAGES

517-528

References to SciGraph publications

  • 2012-12. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations in NATURE
  • 2018-12. Comparison of computational methods for the identification of topologically associating domains in GENOME BIOLOGY
  • 2013-10-23. Topology of mammalian developmental enhancers and their regulatory landscapes in NATURE
  • 2010-02. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin in NATURE GENETICS
  • 2013-11. A high-resolution map of the three-dimensional chromatin interactome in human cells in NATURE
  • 2010-04. Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia in NATURE CELL BIOLOGY
  • 2012-10. The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma in BRITISH JOURNAL OF CANCER
  • 2016-12. Maintaining cell identity: PRC2-mediated regulation of transcription and cancer in NATURE REVIEWS CANCER
  • 2015-10. The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development in NATURE MEDICINE
  • 2012-04-11. Spatial partitioning of the regulatory landscape of the X-inactivation centre in NATURE
  • 2017-07. Genome-wide characterization of mammalian promoters with distal enhancer functions in NATURE GENETICS
  • 2004-01. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 in NATURE
  • 2011-07. The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor in ONCOGENE
  • 2016-11. Organization and function of the 3D genome in NATURE REVIEWS GENETICS
  • 2017-05-17. An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data in NATURE COMMUNICATIONS
  • 2008-02. The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing in ONCOGENE
  • 2013-11. Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer in NATURE REVIEWS GENETICS
  • 2012-05. F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest in ONCOGENE
  • 2016-08. UMI-4C for quantitative and targeted chromosomal contact profiling in NATURE METHODS
  • 2012-07. A tumour suppressor network relying on the polyamine–hypusine axis in NATURE
  • 2012-04-11. Topological domains in mammalian genomes identified by analysis of chromatin interactions in NATURE
  • 2014-02. Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma in NATURE GENETICS
  • 2009-06. Characterization and evaluation of similarity measures for pairs of clusterings in KNOWLEDGE AND INFORMATION SYSTEMS
  • 2016-01. Super-resolution imaging reveals distinct chromatin folding for different epigenetic states in NATURE
  • 2016-01. Insulator dysfunction and oncogene activation in IDH mutant gliomas in NATURE
  • 2006-10. Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM) in NATURE METHODS
  • 2017-01. Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking in NATURE GENETICS
  • 2016-06. An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-018-0338-y

    DOI

    http://dx.doi.org/10.1038/s41588-018-0338-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111675142

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30692681


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
              "id": "https://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Science, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Donaldson-Collier", 
            "givenName": "Maria C.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
              "id": "https://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Science, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sungalee", 
            "givenName": "Stephanie", 
            "id": "sg:person.01215767104.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215767104.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Institute of Bioinformatics", 
              "id": "https://www.grid.ac/institutes/grid.419765.8", 
              "name": [
                "Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland", 
                "Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zufferey", 
            "givenName": "Marie", 
            "id": "sg:person.016064726123.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016064726123.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Institute of Bioinformatics", 
              "id": "https://www.grid.ac/institutes/grid.419765.8", 
              "name": [
                "Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland", 
                "Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tavernari", 
            "givenName": "Daniele", 
            "id": "sg:person.07616006037.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07616006037.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
              "id": "https://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Science, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Katanayeva", 
            "givenName": "Natalya", 
            "id": "sg:person.01106222204.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106222204.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Institute of Bioinformatics", 
              "id": "https://www.grid.ac/institutes/grid.419765.8", 
              "name": [
                "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Science, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland", 
                "Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland", 
                "Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Battistello", 
            "givenName": "Elena", 
            "id": "sg:person.011650501703.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011650501703.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Institute of Bioinformatics", 
              "id": "https://www.grid.ac/institutes/grid.419765.8", 
              "name": [
                "Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland", 
                "Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mina", 
            "givenName": "Marco", 
            "id": "sg:person.01050466067.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050466067.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
              "id": "https://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Institute of Physics, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Douglass", 
            "givenName": "Kyle M.", 
            "id": "sg:person.0616240404.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616240404.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
              "id": "https://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Institute of Physics, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rey", 
            "givenName": "Timo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Institute of Bioinformatics", 
              "id": "https://www.grid.ac/institutes/grid.419765.8", 
              "name": [
                "Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland", 
                "Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raynaud", 
            "givenName": "Franck", 
            "id": "sg:person.011605155031.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011605155031.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
              "id": "https://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Institute of Physics, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Manley", 
            "givenName": "Suliana", 
            "id": "sg:person.0750557474.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750557474.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Institute of Bioinformatics", 
              "id": "https://www.grid.ac/institutes/grid.419765.8", 
              "name": [
                "Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland", 
                "Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ciriello", 
            "givenName": "Giovanni", 
            "id": "sg:person.0610155374.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610155374.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
              "id": "https://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Science, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oricchio", 
            "givenName": "Elisa", 
            "id": "sg:person.0732056545.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732056545.07"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature11606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000463489", 
              "https://doi.org/10.1038/nature11606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001723375", 
              "https://doi.org/10.1038/ng.518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001723375", 
              "https://doi.org/10.1038/ng.518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004787340", 
              "https://doi.org/10.1038/nature11049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006119577", 
              "https://doi.org/10.1038/nrg3554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1181369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007401642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1181369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007401642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2013-07-509885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007438227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20132120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011062426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011169792", 
              "https://doi.org/10.1038/nature11126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.201517.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011394843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv1505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014098537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1012525107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014787558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015438319", 
              "https://doi.org/10.1038/ng.2856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015654200", 
              "https://doi.org/10.1038/sj.onc.1210774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017311368", 
              "https://doi.org/10.1038/nature16490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-11-321208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018424481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018882864", 
              "https://doi.org/10.1038/nmeth929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018882864", 
              "https://doi.org/10.1038/nmeth929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0437996100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019566251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12644", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019700652", 
              "https://doi.org/10.1038/nature12644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020812278", 
              "https://doi.org/10.1038/onc.2011.35"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2016.05.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020980620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021190740", 
              "https://doi.org/10.1038/onc.2011.432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021190740", 
              "https://doi.org/10.1038/onc.2011.432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022177933", 
              "https://doi.org/10.1038/ng.3722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2012.380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022625054", 
              "https://doi.org/10.1038/bjc.2012.380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.09.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023322306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023475926", 
              "https://doi.org/10.1038/nature12753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.01.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025469351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc.2016.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027309366", 
              "https://doi.org/10.1038/nrc.2016.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027685693", 
              "https://doi.org/10.1038/nmeth.3922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.06.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028271489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aad9024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028359583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg.2016.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029513141", 
              "https://doi.org/10.1038/nrg.2016.112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-14-0622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030773998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2008.07.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031569784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036170624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036170624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10115-008-0150-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036184033", 
              "https://doi.org/10.1007/s10115-008-0150-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10115-008-0150-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036184033", 
              "https://doi.org/10.1007/s10115-008-0150-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040271530", 
              "https://doi.org/10.1038/nature11082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2013.04.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041556749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043834713", 
              "https://doi.org/10.1038/nm.4092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043845720", 
              "https://doi.org/10.1038/ncb2037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043845720", 
              "https://doi.org/10.1038/ncb2037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044812533", 
              "https://doi.org/10.1038/nature16496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1873-3468.12071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046135460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.11.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047951603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20110846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048584192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048891965", 
              "https://doi.org/10.1038/nature02284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048891965", 
              "https://doi.org/10.1038/nature02284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049809460", 
              "https://doi.org/10.1038/nm.3943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.241422.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051139500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/msb.20156492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052510203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms15454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085424187", 
              "https://doi.org/10.1038/ncomms15454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms15454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085424187", 
              "https://doi.org/10.1038/ncomms15454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2017.04.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085442330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085862021", 
              "https://doi.org/10.1038/ng.3884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085862021", 
              "https://doi.org/10.1038/ng.3884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.aak9969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090390279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.220640.117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091435103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-018-1596-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110518207", 
              "https://doi.org/10.1186/s13059-018-1596-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-018-1596-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110518207", 
              "https://doi.org/10.1186/s13059-018-1596-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-018-1596-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110518207", 
              "https://doi.org/10.1186/s13059-018-1596-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-018-1596-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110518207", 
              "https://doi.org/10.1186/s13059-018-1596-9"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03", 
        "datePublishedReg": "2019-03-01", 
        "description": "Chromatin is organized into topologically associating domains (TADs) enriched in distinct histone marks. In cancer, gain-of-function mutations in the gene encoding the enhancer of zeste homolog 2 protein (EZH2) lead to a genome-wide increase in histone-3 Lys27 trimethylation (H3K27me3) associated with transcriptional repression. However, the effects of these epigenetic changes on the structure and function of chromatin domains have not been explored. Here, we found a functional interplay between TADs and epigenetic and transcriptional changes mediated by mutated EZH2. Altered EZH2 (p.Tyr646* (EZH2Y646X)) led to silencing of entire domains, synergistically inactivating multiple tumor suppressors. Intra-TAD gene silencing was coupled with changes of interactions between gene promoter regions. Notably, gene expression and chromatin interactions were restored by pharmacological inhibition of EZH2Y646X. Our results indicate that EZH2Y646X alters the topology and function of chromatin domains to promote synergistic oncogenic programs.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41588-018-0338-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4057133", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "51"
          }
        ], 
        "name": "EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains", 
        "pagination": "517-528", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "acc4f31abc5f430dac62892a1f075bab03ee86257e8bc1ee80b65164a59ce44a"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30692681"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9216904"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41588-018-0338-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111675142"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41588-018-0338-y", 
          "https://app.dimensions.ai/details/publication/pub.1111675142"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113676_00000005.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41588-018-0338-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41588-018-0338-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41588-018-0338-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41588-018-0338-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41588-018-0338-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    346 TRIPLES      21 PREDICATES      82 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41588-018-0338-y schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N2efffc193f4d4793ad4f758568b24da1
    4 schema:citation sg:pub.10.1007/s10115-008-0150-6
    5 sg:pub.10.1038/bjc.2012.380
    6 sg:pub.10.1038/nature02284
    7 sg:pub.10.1038/nature11049
    8 sg:pub.10.1038/nature11082
    9 sg:pub.10.1038/nature11126
    10 sg:pub.10.1038/nature11606
    11 sg:pub.10.1038/nature12644
    12 sg:pub.10.1038/nature12753
    13 sg:pub.10.1038/nature16490
    14 sg:pub.10.1038/nature16496
    15 sg:pub.10.1038/ncb2037
    16 sg:pub.10.1038/ncomms15454
    17 sg:pub.10.1038/ng.2856
    18 sg:pub.10.1038/ng.3722
    19 sg:pub.10.1038/ng.3884
    20 sg:pub.10.1038/ng.518
    21 sg:pub.10.1038/nm.3943
    22 sg:pub.10.1038/nm.4092
    23 sg:pub.10.1038/nmeth.3922
    24 sg:pub.10.1038/nmeth929
    25 sg:pub.10.1038/nrc.2016.83
    26 sg:pub.10.1038/nrg.2016.112
    27 sg:pub.10.1038/nrg3554
    28 sg:pub.10.1038/onc.2011.35
    29 sg:pub.10.1038/onc.2011.432
    30 sg:pub.10.1038/sj.onc.1210774
    31 sg:pub.10.1186/s13059-018-1596-9
    32 https://doi.org/10.1002/1873-3468.12071
    33 https://doi.org/10.1016/j.ccr.2013.04.011
    34 https://doi.org/10.1016/j.cell.2008.06.028
    35 https://doi.org/10.1016/j.cell.2011.09.035
    36 https://doi.org/10.1016/j.cell.2012.01.010
    37 https://doi.org/10.1016/j.cell.2014.11.021
    38 https://doi.org/10.1016/j.cell.2015.04.004
    39 https://doi.org/10.1016/j.molcel.2016.05.018
    40 https://doi.org/10.1016/j.molcel.2017.04.028
    41 https://doi.org/10.1016/j.tcb.2008.07.004
    42 https://doi.org/10.1073/pnas.0437996100
    43 https://doi.org/10.1073/pnas.1012525107
    44 https://doi.org/10.1084/jem.20110846
    45 https://doi.org/10.1084/jem.20132120
    46 https://doi.org/10.1093/nar/gkv1505
    47 https://doi.org/10.1101/gad.241422.114
    48 https://doi.org/10.1101/gr.201517.115
    49 https://doi.org/10.1101/gr.220640.117
    50 https://doi.org/10.1126/science.1181369
    51 https://doi.org/10.1126/science.aad9024
    52 https://doi.org/10.1126/scitranslmed.aak9969
    53 https://doi.org/10.1158/2159-8290.cd-14-0622
    54 https://doi.org/10.1182/blood-2010-11-321208
    55 https://doi.org/10.1182/blood-2013-07-509885
    56 https://doi.org/10.15252/msb.20156492
    57 schema:datePublished 2019-03
    58 schema:datePublishedReg 2019-03-01
    59 schema:description Chromatin is organized into topologically associating domains (TADs) enriched in distinct histone marks. In cancer, gain-of-function mutations in the gene encoding the enhancer of zeste homolog 2 protein (EZH2) lead to a genome-wide increase in histone-3 Lys27 trimethylation (H3K27me3) associated with transcriptional repression. However, the effects of these epigenetic changes on the structure and function of chromatin domains have not been explored. Here, we found a functional interplay between TADs and epigenetic and transcriptional changes mediated by mutated EZH2. Altered EZH2 (p.Tyr646* (EZH2<sup>Y646X</sup>)) led to silencing of entire domains, synergistically inactivating multiple tumor suppressors. Intra-TAD gene silencing was coupled with changes of interactions between gene promoter regions. Notably, gene expression and chromatin interactions were restored by pharmacological inhibition of EZH2<sup>Y646X</sup>. Our results indicate that EZH2<sup>Y646X</sup> alters the topology and function of chromatin domains to promote synergistic oncogenic programs.
    60 schema:genre research_article
    61 schema:inLanguage en
    62 schema:isAccessibleForFree false
    63 schema:isPartOf N1d7d26e7c1fa43508977f1f343948d6b
    64 N4ef7623cb5874b41b9ec6d75d239b1a7
    65 sg:journal.1103138
    66 schema:name EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains
    67 schema:pagination 517-528
    68 schema:productId N425ff557eafa44479e6737456b5f48ab
    69 N5390ff22852f4280a1d3903a847ba30d
    70 N62eb217126f94068b8b43283c973b7a8
    71 N7f7933b1bc1f4bd79c8eb49cceed6aef
    72 Na748e99ee34c4af28f3a0b2b0353f62f
    73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111675142
    74 https://doi.org/10.1038/s41588-018-0338-y
    75 schema:sdDatePublished 2019-04-11T10:38
    76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    77 schema:sdPublisher N1d8d5e216b3140278c08fb451c2507a3
    78 schema:url https://www.nature.com/articles/s41588-018-0338-y
    79 sgo:license sg:explorer/license/
    80 sgo:sdDataset articles
    81 rdf:type schema:ScholarlyArticle
    82 N02047cb41e014cb19a6e6e7976cb2f29 rdf:first N79b031f99f2c4f6890a3f6c8a877d729
    83 rdf:rest N0d1f6d3cc3984e508004dea834691132
    84 N0d1f6d3cc3984e508004dea834691132 rdf:first sg:person.011605155031.00
    85 rdf:rest N9204dcce56b9445abda6510e00ce4bc0
    86 N1d7d26e7c1fa43508977f1f343948d6b schema:issueNumber 3
    87 rdf:type schema:PublicationIssue
    88 N1d8d5e216b3140278c08fb451c2507a3 schema:name Springer Nature - SN SciGraph project
    89 rdf:type schema:Organization
    90 N2efffc193f4d4793ad4f758568b24da1 rdf:first Nc4067b674d43405781005e96e06b4552
    91 rdf:rest N560718c06dfe46dc915c869dcf907090
    92 N2f308a6e60514d0c8bf71c8cf937c175 rdf:first sg:person.07616006037.48
    93 rdf:rest Nf68c08e19d8f45c0859a0acd8c47f128
    94 N3e9049dca4eb40648338e7f702b83a24 rdf:first sg:person.016064726123.93
    95 rdf:rest N2f308a6e60514d0c8bf71c8cf937c175
    96 N425ff557eafa44479e6737456b5f48ab schema:name doi
    97 schema:value 10.1038/s41588-018-0338-y
    98 rdf:type schema:PropertyValue
    99 N4a46993c1cb947669113f5829d19524d rdf:first sg:person.0610155374.73
    100 rdf:rest Nf593af25855848ee9cf94d35cf8eb59f
    101 N4ef7623cb5874b41b9ec6d75d239b1a7 schema:volumeNumber 51
    102 rdf:type schema:PublicationVolume
    103 N5390ff22852f4280a1d3903a847ba30d schema:name readcube_id
    104 schema:value acc4f31abc5f430dac62892a1f075bab03ee86257e8bc1ee80b65164a59ce44a
    105 rdf:type schema:PropertyValue
    106 N560718c06dfe46dc915c869dcf907090 rdf:first sg:person.01215767104.54
    107 rdf:rest N3e9049dca4eb40648338e7f702b83a24
    108 N62eb217126f94068b8b43283c973b7a8 schema:name pubmed_id
    109 schema:value 30692681
    110 rdf:type schema:PropertyValue
    111 N6f576a30f7494c88867c4b21d53b3863 rdf:first sg:person.0616240404.48
    112 rdf:rest N02047cb41e014cb19a6e6e7976cb2f29
    113 N79b031f99f2c4f6890a3f6c8a877d729 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
    114 schema:familyName Rey
    115 schema:givenName Timo
    116 rdf:type schema:Person
    117 N7f7933b1bc1f4bd79c8eb49cceed6aef schema:name dimensions_id
    118 schema:value pub.1111675142
    119 rdf:type schema:PropertyValue
    120 N9204dcce56b9445abda6510e00ce4bc0 rdf:first sg:person.0750557474.72
    121 rdf:rest N4a46993c1cb947669113f5829d19524d
    122 N986bfa8ef7fa40f59bdd66fb57f2c585 rdf:first sg:person.01050466067.52
    123 rdf:rest N6f576a30f7494c88867c4b21d53b3863
    124 N9b3fb3dbd2df45d99d705c1805d1ac3a rdf:first sg:person.011650501703.93
    125 rdf:rest N986bfa8ef7fa40f59bdd66fb57f2c585
    126 Na748e99ee34c4af28f3a0b2b0353f62f schema:name nlm_unique_id
    127 schema:value 9216904
    128 rdf:type schema:PropertyValue
    129 Nc4067b674d43405781005e96e06b4552 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
    130 schema:familyName Donaldson-Collier
    131 schema:givenName Maria C.
    132 rdf:type schema:Person
    133 Nf593af25855848ee9cf94d35cf8eb59f rdf:first sg:person.0732056545.07
    134 rdf:rest rdf:nil
    135 Nf68c08e19d8f45c0859a0acd8c47f128 rdf:first sg:person.01106222204.17
    136 rdf:rest N9b3fb3dbd2df45d99d705c1805d1ac3a
    137 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    138 schema:name Biological Sciences
    139 rdf:type schema:DefinedTerm
    140 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    141 schema:name Genetics
    142 rdf:type schema:DefinedTerm
    143 sg:grant.4057133 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-018-0338-y
    144 rdf:type schema:MonetaryGrant
    145 sg:journal.1103138 schema:issn 1061-4036
    146 1546-1718
    147 schema:name Nature Genetics
    148 rdf:type schema:Periodical
    149 sg:person.01050466067.52 schema:affiliation https://www.grid.ac/institutes/grid.419765.8
    150 schema:familyName Mina
    151 schema:givenName Marco
    152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050466067.52
    153 rdf:type schema:Person
    154 sg:person.01106222204.17 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
    155 schema:familyName Katanayeva
    156 schema:givenName Natalya
    157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106222204.17
    158 rdf:type schema:Person
    159 sg:person.011605155031.00 schema:affiliation https://www.grid.ac/institutes/grid.419765.8
    160 schema:familyName Raynaud
    161 schema:givenName Franck
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011605155031.00
    163 rdf:type schema:Person
    164 sg:person.011650501703.93 schema:affiliation https://www.grid.ac/institutes/grid.419765.8
    165 schema:familyName Battistello
    166 schema:givenName Elena
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011650501703.93
    168 rdf:type schema:Person
    169 sg:person.01215767104.54 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
    170 schema:familyName Sungalee
    171 schema:givenName Stephanie
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215767104.54
    173 rdf:type schema:Person
    174 sg:person.016064726123.93 schema:affiliation https://www.grid.ac/institutes/grid.419765.8
    175 schema:familyName Zufferey
    176 schema:givenName Marie
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016064726123.93
    178 rdf:type schema:Person
    179 sg:person.0610155374.73 schema:affiliation https://www.grid.ac/institutes/grid.419765.8
    180 schema:familyName Ciriello
    181 schema:givenName Giovanni
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610155374.73
    183 rdf:type schema:Person
    184 sg:person.0616240404.48 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
    185 schema:familyName Douglass
    186 schema:givenName Kyle M.
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616240404.48
    188 rdf:type schema:Person
    189 sg:person.0732056545.07 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
    190 schema:familyName Oricchio
    191 schema:givenName Elisa
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732056545.07
    193 rdf:type schema:Person
    194 sg:person.0750557474.72 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
    195 schema:familyName Manley
    196 schema:givenName Suliana
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750557474.72
    198 rdf:type schema:Person
    199 sg:person.07616006037.48 schema:affiliation https://www.grid.ac/institutes/grid.419765.8
    200 schema:familyName Tavernari
    201 schema:givenName Daniele
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07616006037.48
    203 rdf:type schema:Person
    204 sg:pub.10.1007/s10115-008-0150-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036184033
    205 https://doi.org/10.1007/s10115-008-0150-6
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/bjc.2012.380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022625054
    208 https://doi.org/10.1038/bjc.2012.380
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nature02284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048891965
    211 https://doi.org/10.1038/nature02284
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nature11049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004787340
    214 https://doi.org/10.1038/nature11049
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nature11082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040271530
    217 https://doi.org/10.1038/nature11082
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nature11126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011169792
    220 https://doi.org/10.1038/nature11126
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nature11606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000463489
    223 https://doi.org/10.1038/nature11606
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/nature12644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019700652
    226 https://doi.org/10.1038/nature12644
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/nature12753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023475926
    229 https://doi.org/10.1038/nature12753
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/nature16490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017311368
    232 https://doi.org/10.1038/nature16490
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/nature16496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044812533
    235 https://doi.org/10.1038/nature16496
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/ncb2037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043845720
    238 https://doi.org/10.1038/ncb2037
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/ncomms15454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085424187
    241 https://doi.org/10.1038/ncomms15454
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/ng.2856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015438319
    244 https://doi.org/10.1038/ng.2856
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/ng.3722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022177933
    247 https://doi.org/10.1038/ng.3722
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/ng.3884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085862021
    250 https://doi.org/10.1038/ng.3884
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/ng.518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001723375
    253 https://doi.org/10.1038/ng.518
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nm.3943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049809460
    256 https://doi.org/10.1038/nm.3943
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/nm.4092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043834713
    259 https://doi.org/10.1038/nm.4092
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/nmeth.3922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027685693
    262 https://doi.org/10.1038/nmeth.3922
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nmeth929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018882864
    265 https://doi.org/10.1038/nmeth929
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/nrc.2016.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027309366
    268 https://doi.org/10.1038/nrc.2016.83
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/nrg.2016.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029513141
    271 https://doi.org/10.1038/nrg.2016.112
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/nrg3554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006119577
    274 https://doi.org/10.1038/nrg3554
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/onc.2011.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020812278
    277 https://doi.org/10.1038/onc.2011.35
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/onc.2011.432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021190740
    280 https://doi.org/10.1038/onc.2011.432
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/sj.onc.1210774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015654200
    283 https://doi.org/10.1038/sj.onc.1210774
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1186/s13059-018-1596-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110518207
    286 https://doi.org/10.1186/s13059-018-1596-9
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1002/1873-3468.12071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046135460
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.ccr.2013.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041556749
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.cell.2008.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028271489
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.cell.2011.09.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023322306
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.cell.2012.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025469351
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.cell.2014.11.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047951603
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.cell.2015.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036170624
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.molcel.2016.05.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020980620
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/j.molcel.2017.04.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085442330
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/j.tcb.2008.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031569784
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1073/pnas.0437996100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019566251
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1073/pnas.1012525107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014787558
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1084/jem.20110846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048584192
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1084/jem.20132120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011062426
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1093/nar/gkv1505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014098537
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1101/gad.241422.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051139500
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1101/gr.201517.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011394843
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1101/gr.220640.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091435103
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1126/science.1181369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007401642
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1126/science.aad9024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028359583
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1126/scitranslmed.aak9969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090390279
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1158/2159-8290.cd-14-0622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030773998
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1182/blood-2010-11-321208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018424481
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1182/blood-2013-07-509885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007438227
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.15252/msb.20156492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052510203
    337 rdf:type schema:CreativeWork
    338 https://www.grid.ac/institutes/grid.419765.8 schema:alternateName Swiss Institute of Bioinformatics
    339 schema:name Department of Computational Biology, University of Lausanne (UNIL), Lausanne, Switzerland
    340 Swiss Institute for Experimental Cancer Research (ISREC), School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
    341 Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
    342 rdf:type schema:Organization
    343 https://www.grid.ac/institutes/grid.5333.6 schema:alternateName École Polytechnique Fédérale de Lausanne
    344 schema:name Institute of Physics, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
    345 Swiss Institute for Experimental Cancer Research (ISREC), School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
    346 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...