Tumor mutational load predicts survival after immunotherapy across multiple cancer types View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Robert M. Samstein, Chung-Han Lee, Alexander N. Shoushtari, Matthew D. Hellmann, Ronglai Shen, Yelena Y. Janjigian, David A. Barron, Ahmet Zehir, Emmet J. Jordan, Antonio Omuro, Thomas J. Kaley, Sviatoslav M. Kendall, Robert J. Motzer, A. Ari Hakimi, Martin H. Voss, Paul Russo, Jonathan Rosenberg, Gopa Iyer, Bernard H. Bochner, Dean F. Bajorin, Hikmat A. Al-Ahmadie, Jamie E. Chaft, Charles M. Rudin, Gregory J. Riely, Shrujal Baxi, Alan L. Ho, Richard J. Wong, David G. Pfister, Jedd D. Wolchok, Christopher A. Barker, Philip H. Gutin, Cameron W. Brennan, Viviane Tabar, Ingo K. Mellinghoff, Lisa M. DeAngelis, Charlotte E. Ariyan, Nancy Lee, William D. Tap, Mrinal M. Gounder, Sandra P. D’Angelo, Leonard Saltz, Zsofia K. Stadler, Howard I. Scher, Jose Baselga, Pedram Razavi, Christopher A. Klebanoff, Rona Yaeger, Neil H. Segal, Geoffrey Y. Ku, Ronald P. DeMatteo, Marc Ladanyi, Naiyer A. Rizvi, Michael F. Berger, Nadeem Riaz, David B. Solit, Timothy A. Chan, Luc G. T. Morris

ABSTRACT

Immune checkpoint inhibitor (ICI) treatments benefit some patients with metastatic cancers, but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor mutational burden (TMB) may predict clinical response to ICI. To examine this association more broadly, we analyzed the clinical and genomic data of 1,662 advanced cancer patients treated with ICI, and 5,371 non-ICI-treated patients, whose tumors underwent targeted next-generation sequencing (MSK-IMPACT). Among all patients, higher somatic TMB (highest 20% in each histology) was associated with better overall survival. For most cancer histologies, an association between higher TMB and improved survival was observed. The TMB cutpoints associated with improved survival varied markedly between cancer types. These data indicate that TMB is associated with improved survival in patients receiving ICI across a wide variety of cancer types, but that there may not be one universal definition of high TMB. More... »

PAGES

202-206

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41588-018-0312-8

DOI

http://dx.doi.org/10.1038/s41588-018-0312-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111273884

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30643254


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