Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10-29

AUTHORS

A. Marieke Oudelaar, James O.J. Davies, Lars L.P. Hanssen, Jelena M. Telenius, Ron Schwessinger, Yu Liu, Jill M. Brown, Damien J. Downes, Andrea M. Chiariello, Simona Bianco, Mario Nicodemi, Veronica J. Buckle, Job Dekker, Douglas R. Higgs, Jim R. Hughes

ABSTRACT

The promoters of mammalian genes are commonly regulated by multiple distal enhancers, which physically interact within discrete chromatin domains. How such domains form and how the regulatory elements within them interact in single cells is not understood. To address this we developed Tri-C, a new chromosome conformation capture (3C) approach, to characterize concurrent chromatin interactions at individual alleles. Analysis by Tri-C identifies heterogeneous patterns of single-allele interactions between CTCF boundary elements, indicating that the formation of chromatin domains likely results from a dynamic process. Within these domains, we observe specific higher-order structures that involve simultaneous interactions between multiple enhancers and promoters. Such regulatory hubs provide a structural basis for understanding how multiple cis-regulatory elements act together to establish robust regulation of gene expression. More... »

PAGES

1744-1751

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-018-0253-2

    DOI

    http://dx.doi.org/10.1038/s41588-018-0253-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107713170

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30374068


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