Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-09-24

AUTHORS

Daria V. Zhernakova, Trang H. Le, Alexander Kurilshikov, Biljana Atanasovska, Marc Jan Bonder, Serena Sanna, Annique Claringbould, Urmo Võsa, Patrick Deelen, Lude Franke, Rudolf A. de Boer, Folkert Kuipers, Mihai G. Netea, Marten H. Hofker, Cisca Wijmenga, Alexandra Zhernakova, Jingyuan Fu, LifeLines cohort study, BIOS consortium

ABSTRACT

Despite a growing body of evidence, the role of the gut microbiome in cardiovascular diseases is still unclear. Here, we present a systems-genome-wide and metagenome-wide association study on plasma concentrations of 92 cardiovascular-disease-related proteins in the population cohort LifeLines-DEEP. We identified genetic components for 73 proteins and microbial associations for 41 proteins, of which 31 were associated to both. The genetic and microbial factors identified mostly exert additive effects and collectively explain up to 76.6% of inter-individual variation (17.5% on average). Genetics contribute most to concentrations of immune-related proteins, while the gut microbiome contributes most to proteins involved in metabolism and intestinal health. We found several host–microbe interactions that impact proteins involved in epithelial function, lipid metabolism, and central nervous system function. This study provides important evidence for a joint genetic and microbial effect in cardiovascular disease and provides directions for future applications in personalized medicine. More... »

PAGES

1524-1532

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  • Journal

    TITLE

    Nature Genetics

    ISSUE

    11

    VOLUME

    50

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-018-0224-7

    DOI

    http://dx.doi.org/10.1038/s41588-018-0224-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107129402

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30250126


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